Delayed resolution of amitriptyline toxicity secondary to CYP2D6 deficiency

Muhammad Masood KhalidFellow in Medical Toxicology, Department of Emergency Medicine, Division of Medical Toxicology, Drexel University College of Medicine, Philadelphia, PA, USA;

http://orcid.org/0000-0001-9384-8008

Maricel Dela CruzFellow in Medical Toxicology, Department of Emergency Medicine, Division of Medical Toxicology, Drexel University College of Medicine, Philadelphia, PA, USA; Correspondence[email protected]

http://orcid.org/0000-0002-1678-5899

David VearrierDepartment of Emergency Medicine, Division of Medical Toxicology, Drexel University College of Medicine, Philadelphia, PA, USA

Michael I. GreenbergDepartment of Emergency Medicine, Division of Medical Toxicology, Drexel University College of Medicine, Philadelphia, PA, USA

References

Olesen OV, Linnet K. Metabolism of the tricyclic antidepressant amitriptyline by cDNA-expressed human cytochrome P450 enzymes. Pharmacology. 1997;55:235–243.
PubMed Web of Science ®Google Scholar
Hicks JK, Swen JJ, Thorn CF, et al. Clinical pharmacogenetics implementation consortium guideline for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants. Clin Pharmacol Ther. 2013;93:402–408.
PubMed Web of Science ®Google Scholar
Acosta D, Ramos K. Cardiotoxicity of tricyclic antidepressants in primary cultures of rat myocardial cells. J Toxicol Environ Health. 1984;14:137–143.
PubMed Web of Science ®Google Scholar
Bijl MJ, Visser LE, Hofman A, et al. Influence of the CYP2D6*4 polymorphism on dose, switching and discontinuation of antidepressants. Br J Clin Pharmacol. 2008;65:558–564.
PubMed Web of Science ®Google Scholar

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Delayed resolution of amitriptyline toxicity secondary to CYP2D6 deficiency

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