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Letters to the Editor: Original Scientific Contributions

Loperamide associated torsades de pointes, in the setting of complete heart block at marginally supratherapeutic dosing (20mg/day)

ORCID Icon, , , , &
Pages 1123-1124 | Received 09 Jan 2019, Accepted 29 Jan 2019, Published online: 19 Feb 2019

References

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  • Vaz RJ, Kang J, Luo Y, et al. Molecular determinants of loperamide and N-desmethyl loperamide binding in the hERG cardiac K + channel. Bioorg Med Chem Lett. 2018;28:446–451.
  • Swank KA, Wu E, Kortepeter C, et al. Adverse event detection using the FDA post-marketing drug safety surveillance system: Cardiotoxicity associated with loperamide abuse and misuse. J Am Pharm Assoc. 2017;57:S63–S67.
  • Hurtado-Torres GF, Sandoval-Munro RL. An additional clinical scenario of risk for loperamide cardiac-induced toxicity. Am J Med. 2016;129:e33.
  • Enakpene EO, Riaz IB, Shirazi FM, et al. The long QT teaser: loperamide abuse. Am J Med. 2015;128:1083–1086.

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