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Letters to the Editor: Original Scientific Contributions

QTc prolongation and Torsade de Pointes induced by extreme eperisone overdose

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Pages 67-68 | Received 30 Oct 2018, Accepted 01 Mar 2019, Published online: 21 Mar 2019

References

  • Eisai Co., Ltd. Myonal® Tablets 50mg (Product information). [cited 2018 Aug 29] Available from https://medical.eisai.jp/products/di/EPI/MYO_T-G_EPI.pdf
  • Tanno K, Narimatsu E, Takeyama Y, et al. Infantile case of seizure induced by intoxication after accidental consumption of eperisone hydrochloride, an antispastic agent. Am J Emerg Med. 2007;25:481–482.
  • Yamagiwa T, Amino M, Morita S, et al. A case of torsades de pointes induced by severe QT prolongation after an overdose of eperisone and triazolam in a patient receiving nifedipine. Clin Toxicol. 2010;48:149–152.
  • Yamagiwa T, Morita S, Amino M, et al. Serum concentration of eperisone hydrochloride correlates with QT interval. Am J Emerg Med. 2014;32:75–77.
  • Ryu J-H, Kim J-I, Kim HS, et al. Pharmacokinetic interactions between pelubiprofen and eperisone hydrochloride: a randomized, open-label, crossover study of healthy Korean men. Clin Ther. 2017;39:138–149.

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