Rebound metabolic acidosis following intentional amygdalin supplement overdose

References

• Holstege CP, Kirk MA, Cyanide and hydrogen sulfide. In Hoffman RS, Howland MA, Lewin NA, Nelson LS, Goldfrank LR, editors. Goldfrank’s toxicologic emergencies, 10th ed. New York: McGraw-Hill Education, 2015; p. 1602–1611.
   Google Scholar
• Greenberg DM. The case against laetrile: the fraudulent cancer remedy. Cancer. 1980;45:799–807.
   PubMed Web of Science ®Google Scholar
• Jaswal V, Palanivelu J, Ramalingam C. Effects of the gut microbiota on amygdalin and its use as an anti-cancer therapy: substantial review on the key components involved in altering dose efficacy and toxicity. Biochem Biophys Rep. 2018;14:125–132.
   PubMedGoogle Scholar
• Milazzo S, Horneber M. Laetrile treatment for cancer. Cochrane Database Syst Rev. 2015;4:CD005476.
   Google Scholar
• Braico KT, Humbert JR, Terplan KL, et al. Laetrile intoxication. Report of a fatal case. N Engl J Med. 1979;300:238–240.
   PubMed Web of Science ®Google Scholar
• Sadoff L, Fuchs K, Hollander J. Rapid death associated with laetrile ingestion. JAMA. 1978;239:1532.
   PubMed Web of Science ®Google Scholar
• Bromley J, Hughes BG, Leong DC, et al. Life-threatening interaction between complementary medicines: cyanide toxicity following ingestion of amygdalin and vitamin C. Ann Pharmacother. 2005;39:1566–1569.
   PubMed Web of Science ®Google Scholar
• Sauer H, Wollny C, Oster I. Severe cyanide poisoning from an alternative medicine treatment with amygdalin and apricot kernels in a 4-year-old child. Wien Med Wochenschr. 2015;165:185–188.
   PubMed Web of Science ®Google Scholar
• Dang T, Nguyen C, Tran PN. Physician beware: severe cyanide toxicity from amygdalin tablets ingestion. Case Rep Emerg Med. 2017;2017:4289527.
   PubMedGoogle Scholar
• Moss M, Khalil N, Gray J. Deliberate self-poisoning with Laetrile. CMAJ. 1981;125:1126–1127.
   PubMed Web of Science ®Google Scholar
• Koenig S, Truwit J. Ventilator-associated pneumonia: diagnosis, treatment and prevention. Clin Microbiol Rev. 2006; 19:637–657.
   PubMed Web of Science ®Google Scholar
• Lab test: cyanide (blood) level. In: Busti A, Bailey C, Dupont SC, et al., editors. Evidence-based medicine. Milbrook, NY: EBM Consulting Services, Inc.; 2018. (https://www.ebmconsult.com/)
   Google Scholar
• Hall AH, Rumack BH. Clinical toxicology of cyanide. Ann Emerg Med. 1986;15:1067–1074.
   PubMed Web of Science ®Google Scholar
• Baud FJ, Borron SW, Mégarbane B, et al. Value of lactic acidosis in the assessment of the severity of acute cyanide poisoning. Crit Care Med. 2002;30:2044–2050.
   PubMed Web of Science ®Google Scholar
• Carter JH, McLafferty MA, Goldman P. Role of the gastrointestinal microflora in amygdalin (laetrile)-induced cyanide toxicity. Biochem Pharmacol. 1980;29:301–304.
   PubMed Web of Science ®Google Scholar
• American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists. Position Paper: single-dose activated charcoal. Clin Toxicol (Phila). 2005;43(2):61–87.
   PubMed Web of Science ®Google Scholar
• Benson BE, Hoppu K, Troutman WG, et al. Position paper update: gastric lavage for gastrointestinal decontamination. Clin Toxicol (Phila). 2013;51:140–146.
   PubMed Web of Science ®Google Scholar
• Lambert RJ, Kindler BL, Schaeffer DJ. The efficacy of superactivated charcoal in treating rats exposed to a lethal oral dose of potassium cyanide. Ann Emerg Med. 1988;17:595–598.
   PubMed Web of Science ®Google Scholar
• D-Amygdalin, CID = 656516. National Center for Biotechnology information. PubChem Database. 2019. https://pubchem.ncbi.nlm.nih.gov/compound/656516.
   Google Scholar
• Cigolini D, Ricci G, Zannoni M, et al. Hydroxocobalamin treatment of acute cyanide poisoning from apricot kernels. Emerg Med J. 2011;9:804–805.
   Google Scholar
• Newton GW, Schmidt ES, Lewis JP, et al. Amygdalin toxicity studies in rats predict chronic cyanide poisoning in humans. West J Med. 1981;134:97–103.
   PubMedGoogle Scholar
• Leiken JB, McFee RB, editors. Hydroxocobalamin. In: Nuclear, biological, and chemical agent exposures. Boca Raton, FL: CRC Press; 2007. p. 91–92.
   Google Scholar
• Zakharov S, Vaneckova M, Seidl Z, et al. Successful use of hydroxocobalamin and sodium thiosulfate in acute cyanide poisoning: a case report with follow-up. Basic Clin Pharmacol Toxicol. 2015;117:209–212.
   PubMed Web of Science ®Google Scholar
• Borron SW, Baud FJ, Barriot P, et al. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg Med. 2007;49:794–801.
   PubMed Web of Science ®Google Scholar
• Cope C. The importance of oxygen in the treatment of cyanide poisoning. JAMA. 1961;175:1061–1064.
   PubMed Web of Science ®Google Scholar
• Manini AF, Nair AP, Vedanthan R, et al. Validation of the prognostic utility of the electrocardiogram for acute drug overdose. J Am Heart Assoc. 2017;6:pii: e004320.
   Web of Science ®Google Scholar
• Katzman GM, Penney DG. Electrocardiographic responses to carbon monoxide and cyanide in the conscious rat. Toxicol Lett. 1993;69:139–153.
   PubMed Web of Science ®Google Scholar
• Muncy TA, Bebarta VS, Varney SM, et al. Acute electrocardiographic ST segment elevation may predict hypotension in a swine model of severe cyanide toxicity. J Med Toxicol. 2012;8:285–290.
   PubMedGoogle Scholar
• Kuppermann N, Park J, Glatter K, et al. Prolonged QT interval corrected for heart rate during diabetic ketoacidosis in children. Arch Pediatr Adolesc Med. 2008;162:544–549.
   PubMedGoogle Scholar
• Yenigun EC, Aypak C, Turgut D, et al. Effect of metabolic acidosis on QT intervals in patients with chronic kidney disease. Int J Artif Organs.2016;39:272–276.
   PubMed Web of Science ®Google Scholar
• Cunliffe J, Decary-Hetu D, Pollak TA. Nonmedical prescription psychiatric drug use and the darknet: a cryptomarket analysis. Int J Drug Policy 2019;pii: S0955-3959(19)30024-6. [Epub ahead of print].
   Web of Science ®Google Scholar
• Gabay M. Regulation of Internet pharmacies: a continuing challenge. Hosp Pharm. 2015;50:681–682.
   PubMedGoogle Scholar