A pilot clinical study of the neuromuscular blocker rocuronium to reduce the duration of ventilation after organophosphorus insecticide poisoning

References

• Karalliedde L, Eddleston M, Murray V. The global picture of organophosphate insecticide poisoning. In: Karalliedde L, Feldman S, Henry J, Marrs T, editors. Organophosphates and health. London: Imperial College Press; 2001. p. 431–471.
   Google Scholar
• Jeyaratnam J. Acute pesticide poisoning: a major global health problem. Wld Hlth Statist Quart. 1990;43:139–144.
   PubMedGoogle Scholar
• Eddleston M, Phillips MR. Self poisoning with pesticides. BMJ. 2004;328:42–44.
   PubMed Web of Science ®Google Scholar
• Gunnell D, Eddleston M, Phillips MR, et al. The global distribution of fatal pesticide self-poisoning: systematic review. BMC Public Health. 2007;7:357.
   PubMed Web of Science ®Google Scholar
• Mew EJ, Padmanathan P, Konradsen F, et al. The global burden of fatal self-poisoning with pesticides 2006-15: systematic review. J Affect Disord. 2017;219:93–104.
   PubMed Web of Science ®Google Scholar
• Lotti M. Clinical toxicology of anticholinesterase agents in humans. In: Krieger RI, Doull J, editors. Handbook of pesticide toxicology volume 2 Agents. San Diego: Academic Press; 2001. p. 1043–1085.
   Google Scholar
• Peter JV, Sudarsan TI, Moran JL. Clinical features of organophosphate poisoning: a review of different classification systems and approaches. Indian J Crit Care Med. 2014;18:735–745.
   PubMedGoogle Scholar
• Vale A, Lotti M. Organophosphorus and carbamate insecticide poisoning. Handb Clin Neurol. 2015;131:149–168.
   PubMedGoogle Scholar
• Eddleston M. Novel clinical toxicology and pharmacology of organophosphorus insecticide self-poisoning. Annu Rev Pharmacol Toxicol. 2019;59:341–360.
   PubMed Web of Science ®Google Scholar
• Abedin MJ, Sayeed AA, Basher A, et al. Open-label randomized clinical trial of atropine bolus injection versus incremental boluses plus infusion for organophosphate poisoning in Bangladesh. J Med Toxicol. 2012;8:108–117.
   PubMedGoogle Scholar
• Eddleston M, Chowdhury FR. Pharmacological treatment of organophosphorus insecticide poisoning: the old and the (possible) new. Br J Clin Pharmacol. 2016;81:462–470.
   PubMed Web of Science ®Google Scholar
• Buckley NA, Eddleston M, Li Y, et al. Oximes for acute organophosphate pesticide poisoning. Cochrane Database Systemat Rev. 2011.
   Web of Science ®Google Scholar
• Blumenberg A, Benabbas R, deSouza IS, et al. Utility of 2-pyridine aldoxime methyl chloride (2-PAM) for acute organophosphate poisoning: a systematic review and meta-analysis. J Med Toxicol. 2018;14:91–98.
   PubMed Web of Science ®Google Scholar
• Eddleston M, Mohamed F, Davies JOJ, et al. Respiratory failure in acute organophosphorus pesticide self-poisoning. Q J Med. 2006;99:513–522.
   Google Scholar
• Karalliedde L, Baker D, Marrs TC. Organophosphate-induced intermediate syndrome: aetiology and relationships with myopathy. Toxicol Rev. 2006;25:1–14.
   PubMedGoogle Scholar
• Hulse EJ, Davies JO, Simpson AJ, et al. Respiratory complications of organophosphorus nerve agent and insecticide poisoning. Implications for respiratory and critical care. Am J Respir Crit Care Med. 2014;190:1342–1354.
   PubMed Web of Science ®Google Scholar
• Senanayake N, Karalliedde L. Neurotoxic effects of organophosphorus insecticides. An intermediate syndrome. N Engl J Med. 1987;316:761–763.
   PubMed Web of Science ®Google Scholar
• Bleecker JLD. The intermediate syndrome in organophosphate poisoning: an overview of experimental and clinical observations. J Toxicol Clin Toxicol. 1995;33:683.
   PubMed Web of Science ®Google Scholar
• Sheridan RD, Smith AP, Turner SR, et al. Nicotinic antagonists in the treatment of nerve agent intoxication. J R Soc Med. 2005;98:114–115.
   PubMed Web of Science ®Google Scholar
• Besser R, Vogt T, Gutmann L. Pancuronium improves the neuromuscular transmission defect of human organophosphate intoxication. Neurology. 1990;40:1275–1277.
   PubMed Web of Science ®Google Scholar
• Bird SB, Krajacic P, Sawamoto K, et al. Pharmacotherapy to protect the neuromuscular junction after acute organophosphorus pesticide poisoning. Ann N Y Acad Sci. 2016;1374:86–93.
   PubMed Web of Science ®Google Scholar
• Hansen-Flaschen J, Cowen J, Raps EC. Neuromuscular blockade in the intensive care unit. More than we bargained for. Am Rev Respir Dis. 1993;147:234–236.
   PubMed Web of Science ®Google Scholar
• Murray MJ, DeBlock H, Erstad B, et al. Clinical practice guidelines for sustained neuromuscular blockade in the adult critically ill patient. Crit Care Med. 2016;44:2079–2103.
   PubMed Web of Science ®Google Scholar
• Latronico N, Bolton CF. Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis. Lancet Neurol. 2011;10:931–941.
   PubMed Web of Science ®Google Scholar
• Eddleston M. Applied clinical pharmacology and public health in rural Asia–preventing deaths from organophosphorus pesticide and yellow oleander poisoning. Br J Clin Pharmacol. 2013;75:1175–1188.
   PubMed Web of Science ®Google Scholar
• Jonsson M, Gurley D, Dabrowski M, et al. Distinct pharmacologic properties of neuromuscular blocking agents on human neuronal nicotinic acetylcholine receptors: a possible explanation for the train-of-four fade. Anesthesiology. 2006;105:521–533.
   PubMed Web of Science ®Google Scholar
• Farooq K, Hunter JM. Neuromuscular blocking agents and reversal agents. Anaesth Intens Care Med. 2011;18:279–284.
   Google Scholar
• Eddleston M, Dawson A, Karalliedde L, et al. Early management after self-poisoning with an organophosphorus or carbamate pesticide – a treatment protocol for junior doctors. Crit Care. 2004;8:R391–R397.
   PubMed Web of Science ®Google Scholar
• Fuchs‐Buder T, Schreiber JU, Meistelman C. Monitoring neuromuscular block: an update. Anaesthesia. 2009;64:82–89.
   PubMed Web of Science ®Google Scholar
• Leon-s FE, Pradilla G, Vesga E. Neurological effects of organophosphate pesticides. BMJ. 1996;313:690.
   PubMedGoogle Scholar
• Worek F, Mast U, Kiderlen D, et al. Improved determination of acetylcholinesterase activity in human whole blood. Clin Chim Acta. 1999;288:73–90.
   PubMed Web of Science ®Google Scholar
• Worek F, Eyer P, Thiermann H. Determination of acetylcholinesterase activity by the Ellman assay: a versatile tool for in vitro research on medical countermeasures against organophosphate poisoning. Drug Test Anal. 2012;4:282–291.
   PubMed Web of Science ®Google Scholar
• Eddleston M, Worek F, Eyer P, et al. Poisoning with the S-Alkyl organophosphorus insecticides profenofos and prothiofos. QJM. 2009;102:785–792.
   PubMed Web of Science ®Google Scholar
• Senanayake N, de Silva HJ, Karalliedde L. A scale to assess severity in organophosphorus intoxication: POP scale. Hum Exp Toxicol. 1993;12:297–299.
   PubMed Web of Science ®Google Scholar
• Davies JOJ, Eddleston M, Buckley NA. Predicting outcome in organophosphorus poisoning with a poison severity score or Glasgow Coma Scale. Q J Med. 2008;101:371–379.
   Google Scholar
• Knipe DW, Chang SS, Dawson A, et al. Suicide prevention through means restriction: impact of the 2008-2011 pesticide restrictions on suicide in Sri Lanka. PLoS One. 2017;12:e0172893.
   PubMed Web of Science ®Google Scholar
• Rathish D, Agampodi S, Jayasumana C. Acetylcholinesterase inhibitor insecticides related acute poisoning, availability and sales: trends during the post-insecticide-ban period of Anuradhapura, Sri Lanka. Environ Health Prev Med. 2018;23:27.
   PubMed Web of Science ®Google Scholar
• Besser R, Gutmann L. A quantitative study of the pancuronium antagonism at the motor endplate in human organophosphorus intoxication. Muscle Nerve. 1995;18:956–960.
   PubMed Web of Science ®Google Scholar
• Besser R, Vogt T, Gutmann L, et al. High pancuronium sensitivity of axonal nicotinic-acetylcholine receptors in humans during organophosphate intoxication. Muscle Nerve. 1991;14:1197–1201.
   PubMed Web of Science ®Google Scholar
• Singh G, Avasthi G, Khurana D, et al. Neurophysiological monitoring of pharmacological manipulation in acute organophosphate (OP) poisoning. The effects of pralidoxime, magnesium sulphate and pancuronium. Electroencephalogr Clin Neurophysiol. 1998;107:140–148.
   PubMedGoogle Scholar
• Naguib M. Sugammadex: another milestone in clinical neuromuscular pharmacology. Anesth Analg. 2007;104:575–581.
   PubMed Web of Science ®Google Scholar
• Eyer P, Worek F, Thiermann H, et al. Paradox findings may challenge orthodox reasoning in acute organophosphate poisoning. Chem Biol Interact. 2010;187:270–278.
   PubMed Web of Science ®Google Scholar