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Basic Research

Bad things come in small packages”: predicting venom-induced coagulopathy in Bothrops atrox bites using snake ontogenetic parameters

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Pages 388-396 | Received 09 May 2019, Accepted 20 Jul 2019, Published online: 06 Aug 2019

References

  • Wen FH, Monteiro WM, Moura da Silva AM, et al. Snakebites and scorpion stings in the Brazilian Amazon: identifying research priorities for a largely neglected problem. PLOS Negl Trop Dis. 2015;9:e0003701.
  • Bernarde PS. Serpentes Peçonhentas e Acidentes Ofídicos no Brasil. São Paulo: Anolis Books, 2014.
  • Campbell JA, Lamar WW. The venomous reptiles of Latin America. Ithaca, NY: Cornell University Press, 1989.
  • Calvete JJ, Marcinkiewicz C, Monleón D, et al. Snake venom disintegrins: evolution of structure and function. Toxicon. 2005;45:1063–1074.
  • Calvete JJ, Sanz L, Pérez A, et al. Snake population venomics and antivenomics of Bothrops atrox: paedomorphism along its transamazonian dispersal and implications of geographic venom variability on snakebite management. J Proteom. 2011;74:510–527.
  • Sousa LF, Portes-Junior JA, Nicolau CA, et al. Functional proteomic analyses of Bothrops atrox venom reveals phenotypes associated with habitat variation in the Amazon. J Proteom. 2017;159:32–46.
  • Brito-Sousa JD, Sachett JAG, Oliveira SS, et al. Accuracy of the Lee—white clotting time performed in the hospital routine to detect coagulopathy in Bothrops atrox envenomation. Am J Trop Med Hyg. 2018;98:1547–1551.
  • Assakura MT, Salomão MG, Puorto G, et al. Hemorrhagic, fibrinogenolytic and edema-forming activities of the venom of the colubrid snake Philodryas olfersii (green snake). Toxicon. 1992;30:427–438.
  • Cintra AC, De Toni LG, Sartim MA, et al. Batroxase, a new metalloproteinase from B. atrox snake venom with strong fibrinolytic activity. Toxicon. 2012;60:70–82.
  • Sanchez EF, Schneider FS, Yarleque A, et al. The novel metalloproteinase atroxlysin-I from Peruvian Bothrops atrox (Jergón) snake venom acts both on blood vessel ECM and platelets. Arch Biochem Biophys. 2010;496:9–20.
  • Freitas-de-Sousa LA, Amazonas DR, Sousa LF, et al. Comparison of venoms from wild and long-term captive Bothrops atrox snakes and characterization of Batroxrhagin, the predominant class PIII metalloproteinase from the venom of this species. Biochimie. 2015;118:60–70.
  • Freitas-de-Sousa LA, Colombini M, Lopes-Ferreira M, et al. Insights into the mechanisms involved in strong hemorrhage and dermonecrosis induced by atroxlysin-Ia, a PI-class snake venom metalloproteinase. Toxins. 2017;9:239.
  • Pardal PP, Souza SM, Monteiro MR, et al. Clinical trial of two antivenoms for the treatment of Bothrops and Lachesis bites in the north eastern Amazon region of Brazil. Trans R Soc Trop Med Hyg. 2004;98:28–42.
  • Guércio RA, Shevchenko A, Shevchenko A, et al. Ontogenetic variations in the venom proteome of the Amazonian snake Bothrops atrox. Proteome Sci. 2006;4:11.
  • Menezes MC, Furtado MF, Travaglia-Cardoso SR, et al. Sex-based individual variation of snake venom proteome among eighteen Bothrops jararaca siblings. Toxicon. 2006;47:304–312.
  • Amazonas DR, Portes-Junior JA, Nishiyama MY Jr, et al. Molecular mechanisms underlying intraspecific variation in snake venom. J Proteom. 2018;181:60–72.
  • Daltry JC, Wuster W, Thorpe RS. Diet and snake venom evolution. Nature. 1996;379:537–579.
  • Antunes TC, Yamashita KM, Barbaro KC, et al. Comparative analysis of newborn and adult Bothrops jararaca snake venoms. Toxicon. 2010;56:1443–1458.
  • Kouyoumdjian JA, Polizelli C. Acidentes ofidicos causados por Bothrops moojeni: correlação do quadro clínico com o tamanho da serpente. Rev Inst Med Trop S Paulo. 1989;31:84–90. In Portuguese.
  • Ribeiro LA, Jorge MT. Alteração do tempo de coagulação sangüínea em pacientes picados por serpente Bothrops jararaca adulta e filhote. Rev Hosp Clin Fac Med Univ São Paulo. 1989;14:143–145.
  • Ribeiro LA, Jorge MT. Epidemiology and clinical picture of accidents by adult and young snakes Bothrops jararaca. Rev Inst Med Trop S Paulo.. 1990;32:436–442.
  • Brazilian Ministry of Health. Manual de Diagnóstico e Tratamento de Acidentes por Animais Peçonhentos - 2001. Brasília: Ministério da Saúde, 2001.
  • Cardoso JLC, França FOS, Fan HW, et al. Animais Peçonhentos no Brasil. Biologia, Clínica e Terapêutica dos Acidentes. 1. ed. São Paulo: Sarvier/Fapesp, 2003.
  • Stevens DL, Bisno AL, Chambers HF, et al. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America. Clin Infect Dis. 2014;59:1–43.
  • Kellum JA, Lameire N, KDIGO AKI Guideline Work Group. Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1). Crit Care. 2013;17:204.
  • Martins M, Oliveira ME. Natural history of snakes in forests of the Manaus region, Central Amazonia, Brazil. Herpetol Nat Hist. 1999;6:78–150.
  • Silva FM, Oliveira LS, Nascimento RLS, et al. Sexual dimorphism and ontogenetic changes of Amazonian pit vipers (Bothrops atrox). Zoologischer Anzeiger. 2017;271:15–24.
  • Marques OAV, Eterovic A, Endo W. Seasonal activity of snakes in the Atlantic forest in southeastern Brazil. Amphib Reptilia. 2000;22:103–111.
  • Sazima I. [Um estudo de biologia comportamental da jararaca, Bothrops jararaca, com uso de marcas naturais.]. Mem Inst Butantan. 1988;50:83–99. In Portuguese.
  • Bisneto PF, Kaefer IL. Reproductive and feeding biology of the common lancehead Bothrops atrox (Serpentes, Viperidae) from central and southwestern Brazilian Amazonia. Acta Amaz. 2019;49:105–113.
  • Sazima I, Haddad C. Répteis da Serra do Japi: Notas sobre história natural In: Morellatto L. (Ed.). História Natural da Serra do Japi: Ecologia e Preservação de uma área florestal no Sudeste do Brasil. Campinas: Unicamp/Fapesp, 1992.
  • Oliveira SS, Alves EC, Santos AS, et al. Factors associated with systemic bleeding in Bothrops envenomation in a tertiary hospital in the brazilian amazon. Toxins. 2019;11:22.
  • López-Lozano JL, Sousa MV, Ricart CA, et al. Ontogenetic variation of metalloproteinases and plasma coagulant activity in venoms of wild Bothrops atrox specimens from Amazonian rain forest. Toxicon. 2002;40:997–1006.
  • Moretto Del-Rei TH, Sousa LF, Rocha MMT, et al. Functional variability of Bothrops atrox venoms from three distinct areas across the Brazilian Amazon and consequences for human envenomings. Toxicon. 2019;164:61–70.
  • Sousa LF, Zdenek CN, Dobson JS, et al. Coagulotoxicity of Bothrops (Lancehead Pit-Vipers) venoms from Brazil: differential biochemistry and antivenom efficacy resulting from prey-driven venom variation. Toxins. 2018;10:411.
  • Saldarriaga MM, Otero R, Núñez V, et al. Ontogenetic variability of Bothrops atrox and Bothrops asper snake venoms from Colombia. Toxicon. 2003;42:405–411.
  • Sachett JAG, Silva IM, Alves EC, et al. Poor efficacy of preemptive amoxicillin clavulanate for preventing secondary infection from Bothrops snakebites in the Brazilian Amazon: a randomized controlled clinical trial. PLOS Negl Trop Dis. 2017;11:e0005745.
  • Clissa PB, Laing GD, Theakston RD, et al. The effect of jararhagin, a metalloproteinase from Bothrops jararaca venom, on pro-inflammatory cytokines released by murine peritoneal adherent cells. Toxicon. 2001;39:1567–1573.
  • Lopes DS, Faquim-Mauro E, Magalhães GS, et al. Gene expression of inflammatory mediators induced by jararhagin on endothelial cells. Toxicon. 2012;60:1072–1084.
  • Kanashiro MM, Cássia M, Escocard R, et al. Biochemical and biological properties of phospholipases A2 from Bothrops atrox snake venom. Biochem Pharmacol. 2002;64:1179–1186.
  • Bernardoni JL, Sousa LF, Wermelinger LS, et al. Functional variability of snake venom metalloproteinases: adaptive advantages in targeting different prey and implications for human envenomation. PLoS One. 2014;9:e109651.

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