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Letters to the Editor: Original Scientific Contribution

Serial plasma and urine measurements of a patient with acute intoxication of zolpidem and flunitrazepam resulting in QT prolongation and ventricular tachycardia

Hong Joon AhnDepartment of Emergency Medicine, Chungnam National University Hospital, Daejeon, South Korea;

Won Joon JeongDepartment of Emergency Medicine, Chungnam National University Hospital, Daejeon, South Korea; Correspondence[email protected]

http://orcid.org/0000-0002-6320-230X

Kwan Jae KimDepartment of Emergency Medicine, Chungnam National University Hospital, Daejeon, South Korea;

Sun Cheun KimForensic Toxicology Division, Daejeon Institute, National Forensic Service, Daejeon, South Korea;

Dong Woo KimForensic Toxicology Division, Daejeon Institute, National Forensic Service, Daejeon, South Korea;

Hye Jin ChangForensic Toxicology Division, Daejeon Institute, National Forensic Service, Daejeon, South Korea;

Chang Shin KangDepartment of Emergency Medicine, Chungnam National University Hospital, Daejeon, South Korea;

Se Kwang OhDepartment of Emergency Medicine, Chungnam National University Hospital, Daejeon, South Korea;

http://orcid.org/0000-0001-8606-9620

Sung Uk ChoDepartment of Emergency Medicine, Chungnam National University Hospital, Daejeon, South Korea;

Jin Hong MinDepartment of Emergency Medicine, Chungnam National University Hospital, Daejeon, South Korea;

Yong Chul ChoDepartment of Emergency Medicine, Chungnam National University Hospital, Daejeon, South Korea;

Jung Soo ParkDepartment of Emergency Medicine, Chungnam National University Hospital, Daejeon, South Korea;

Seung RyuDepartment of Emergency Medicine, Chungnam National University Hospital, Daejeon, South Korea;

Yeon Ho YouDepartment of Emergency Medicine, Chungnam National University Hospital, Daejeon, South Korea;

Jing Woong LeeDepartment of Emergency Medicine, Chungnam National University Hospital, Daejeon, South Korea;

Min Su KimDepartment of Cardiology, Chungnam National University Hospital, Daejeon, South Korea

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References

Letsas KP, Filippatos GS, Kounas SP, et al. QT interval prolongation and Torsades de Pointes in a patient receiving zolpidem and amiodarone. Cardiology. 2006;105(3):146–147.
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Roden DM. Drug-induced prolongation of the QT interval. N Engl J Med.. 2004;350(10):1013–1022.
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Jehle J, Ficker E, Wan X, et al. Mechanisms of zolpidem-induced long QT syndrome: acute inhibition of recombinant hERG K(+) channels and action potential prolongation in human cardiomyocytes derived from induced pluripotent stem cells. Br J Pharmacol. 2013;168(5):1215–1229.
PubMed Web of Science ®Google Scholar
von Moltke LL, Weemhoff JL, Perloff MD, et al. Effect of zolpidem on human cytochrome P450 activity, and on transport mediated by P-glycoprotein. Biopharm Drug Dispos. 2002;23(9):361–367.
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Hesse LM, Venkatakrishnan K, Moltke LL. V, et al. CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam. Drug Metab Dispos. 2001;29(2):133–140.
PubMed Web of Science ®Google Scholar

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Serial plasma and urine measurements of a patient with acute intoxication of zolpidem and flunitrazepam resulting in QT prolongation and ventricular tachycardia

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Serial plasma and urine measurements of a patient with acute intoxication of zolpidem and flunitrazepam resulting in QT prolongation and ventricular tachycardia

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