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Clinical Toxicology Volume 58, 2020 - Issue 12
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Original Scientific Contributions

Does cannabidiol induce cannabinoid hyperemesis syndrome?

Hervé Laborde-CasterotCentre AntiPoison et de Toxicovigilance de Paris – Fédération de toxicologie de l’APHP (FeTox), Hôpital Fernand-Widal - APHP, Paris, France
,
Islam Amine LarabiLaboratoire de Pharmacologie-Toxicologie, Centre Hospitalier Universitaire Raymond Poincaré - APHP, Garches, France;Plateforme de Spectrométrie de Masse MassSpecLab, INSERM UMR 1173, UFR des Sciences de la Santé Simone Veil, Université Versailles Saint-Quentin, Montigny le Bretonneux, France
,
Laurène DufayetCentre AntiPoison et de Toxicovigilance de Paris – Fédération de toxicologie de l’APHP (FeTox), Hôpital Fernand-Widal - APHP, Paris, France;Optimisation Thérapeutique en Neuropsychopharmacologie, INSERM UMR-S 1144, Faculté de Pharmacie, Paris, France;UFR de médecine, Université de Paris, Paris, France
,
Isabelle EttingLaboratoire de Pharmacologie-Toxicologie, Centre Hospitalier Universitaire Raymond Poincaré - APHP, Garches, France
,
Jean-Claude AlvarezLaboratoire de Pharmacologie-Toxicologie, Centre Hospitalier Universitaire Raymond Poincaré - APHP, Garches, France;Plateforme de Spectrométrie de Masse MassSpecLab, INSERM UMR 1173, UFR des Sciences de la Santé Simone Veil, Université Versailles Saint-Quentin, Montigny le Bretonneux, France
&
Dominique VodovarCentre AntiPoison et de Toxicovigilance de Paris – Fédération de toxicologie de l’APHP (FeTox), Hôpital Fernand-Widal - APHP, Paris, France;Optimisation Thérapeutique en Neuropsychopharmacologie, INSERM UMR-S 1144, Faculté de Pharmacie, Paris, France;Urgences Médico-Judiciaires, Hôpital Hôtel Dieu - APHP, Paris, FranceCorrespondence[email protected]
Pages 1351-1352 | Received 06 Jan 2020, Accepted 20 Feb 2020, Published online: 12 Mar 2020

References

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  • Albert K, Sivilotti MLA, Gareri J, et al. Hair cannabinoid concentrations in emergency patients with cannabis hyperemesis syndrome. CJEM. 2019;21(4):477–481.
  • Millar SA, Stone NL, Yates AS, et al. A systematic review on the pharmacokinetics of cannabidiol in humans. Front Pharmacol. 2018;9:1365.
  • Richards JR. Cannabinoid hyperemesis syndrome: a disorder of the HPA axis and sympathetic nervous system? Med Hypotheses. 2017;103:90–95.
  • Tham M, Yilmaz O, Alaverdashvili M, et al. Allosteric and orthosteric pharmacology of cannabidiol and cannabidiol-dimethylheptyl at the type 1 and type 2 cannabinoid receptors. Br J Pharmacol. 2019;176(10):1455–1469.
  • Richards JR, Lapoint JM, Burillo-Putze G. Cannabinoid hyperemesis syndrome: potential mechanisms for the benefit of capsaicin and hot water hydrotherapy in treatment. Clin Toxicol. 2018;56(1):15–24.
  • Simonetto DA, Oxentenko AS, Herman ML, et al. Cannabinoid hyperemesis: a case series of 98 patients. Mayo Clin Proc. 2012;87(2):114–119.

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