The association of cannabis use and cardiac dysrhythmias: a systematic review

References

• United Nations. World Drug Report 2019. [cited 2019 Dec 18]. Available from: https://wdr.unodc.org/wdr2019/prelaunch/WDR19_Booklet_5_CANNABIS_HALLUCINOGENS.pdf.
   Google Scholar
• Substance Abuse and Mental Health Services Administration (SAMHSA). 2018 National Survey on Drug Use and Health (NSDUH). [cited 2019 Dec 18]. Available from: https://www.samhsa.gov/data/sites/default/files/cbhsq-reports/NSDUHNationalFindingsReport2018/NSDUHNationalFindingsReport2018.pdf.
   Google Scholar
• Sultan SR, Millar SA, O’Sullivan SE, et al. A systematic review and meta-analysis of the in vivo haemodynamic effects of Δ8-tetrahydrocannabinol. Pharmaceuticals (Basel). 2018;11(1):13.
   Google Scholar
• Johnson S, Domino EF. Some cardiovascular effects of marihuana smoking in normal volunteers. Clin Pharmacol Ther. 1971;12(5):762–768.
   PubMed Web of Science ®Google Scholar
• Beaconsfield P, Ginsburg J, Rainsbury R. Marihuana smoking. Cardiovascular effects in man and possible mechanisms. N Engl J Med. 1972;287(5):209–212.
   PubMed Web of Science ®Google Scholar
• Weiss JL, Watanabe AM, Lemberger L, et al. Cardiovascular effects of delta-9-tetrahydrocannabinol in man. Clin Pharmacol Ther. 1972;13(5part1):671–684.
   PubMedGoogle Scholar
• Karniol IG, Carlini EA. Comparative studies in man and in laboratory animals on 8- and 9-trans-tetrahydrocannabinol. Pharmacology. 1973;9(2):115–126.
   PubMed Web of Science ®Google Scholar
• Kochar MS, Hosko MJ. Electrocardiographic effects of marihuana. JAMA. 1973;225(1):25–27.
   PubMed Web of Science ®Google Scholar
• Roth WT, Tinklenberg JR, Kopell BS, et al. Continuous electrocardiographic monitoring during marihuana intoxication. Clin Pharmacol Ther. 1973;14(4 part 1):533–540.
   PubMed Web of Science ®Google Scholar
• Clark SC, Greene C, Karr GW, et al. Cardiovascular effects of marihuana in man. Can J Physiol Pharmacol. 1974;52(3):706–719.
   PubMed Web of Science ®Google Scholar
• Domino EF, Rennick P, Pearl JH. Dose-effect relations of marijuana smoking on various physiological parameters in experienced male users. Observations on limits of self-titration of intake. Clin Pharmacol Ther. 1974;15(5):514–520.
   PubMed Web of Science ®Google Scholar
• Karniol IG, Shirakawa I, Takahashi RN, et al. Effects of delta9-tetrahydrocannabinol and cannabinol in man. Pharmacology. 1975;13(6):502–512.
   PubMed Web of Science ®Google Scholar
• Kanakis C, Jr, Pouget JM, Rosen KM. The effects of delta-9-tetrahydrocannabinol (Cannabis) on cardiac performance with and without beta blockade. Circulation. 1976;53(4):703–707.
   PubMed Web of Science ®Google Scholar
• Miller RH, Dhingra RC, Kanakis C Jr, et al. The electrophysiological effects of delta-9-tetrahydrocannabinol (Cannabis) on cardiac conduction in man. Am Heart J. 1977;94(6):740–747.
   PubMed Web of Science ®Google Scholar
• Heishman SJ, Stitzer ML, Yingling JE. Effects of tetrahydrocannabinol content on marijuana smoking behavior, subjective reports, and performance. Pharmacol Biochem Behav. 1989;34(1):173–179.
   PubMed Web of Science ®Google Scholar
• Petronis KR, Anthony JC. An epidemiologic investigation of marijuana- and cocaine-related palpitations. Drug Alcohol Depend. 1989;23(3):219–226.
   PubMed Web of Science ®Google Scholar
• Wachtel SR, ElSohly MA, Ross SA, et al. Comparison of the subjective effects of delta(9)-tetrahydrocannabinol and marijuana in humans. Psychopharmacology (Berl). 2002;161(4):331–339.
   PubMed Web of Science ®Google Scholar
• Cooper ZD, Haney M. Comparison of subjective, pharmacokinetic, and physiological effects of marijuana smoked as joints and blunts. Drug Alcohol Depend. 2009;103(3):107–113.
   PubMed Web of Science ®Google Scholar
• Schwope DM, Bosker WM, Ramaekers JG, et al. Psychomotor performance, subjective and physiological effects and whole blood Δ9-tetrahydrocannabinol concentrations in heavy, chronic cannabis smokers following acute smoked cannabis. J Anal Toxicol. 2012;36(6):405–412.
   PubMed Web of Science ®Google Scholar
• Korantzopoulos P, Liu T, Papaioannides D, et al. Atrial fibrillation and marijuana smoking. Int J Clin Pract. 2007;62(2):308–313.
   PubMed Web of Science ®Google Scholar
• Krishnamoorthy S, Lip GY, Lane DA. Alcohol and illicit drug use as precipitants of atrial fibrillation in young adults: a case series and literature review. Am J Med. 2009;122(9):851–856.e3.
   PubMed Web of Science ®Google Scholar
• Zaurova M, Hoffman RS, Vlahov D, et al. Clinical effects of synthetic cannabinoid receptor agonists compared with marijuana in emergency department patients with acute drug overdose. J Med Toxicol. 2016;12(4):335–340.
   PubMed Web of Science ®Google Scholar
• Desai R, Patel U, Sharma S, et al. Recreational marijuana use and acute myocardial infarction: insights from nationwide inpatient sample in the United States. Cureus. 2017;9(11):e1816.
   PubMed Web of Science ®Google Scholar
• Adegbala O, Adejumo AC, Olakanmi O, et al. Relation of cannabis use and atrial fibrillation among patients hospitalized for heart failure. Am J Cardiol. 2018;122(1):129–134.
   PubMed Web of Science ®Google Scholar
• Desai R, Patel U, Deshmukh A, et al. Burden of arrhythmia in recreational marijuana users. Int J Cardiol. 2018;264:91–92.
   PubMed Web of Science ®Google Scholar
• Robinson J, Somasegar S, Shivapour J, et al. ECG findings in pediatric patients under the influence of marijuana. Cannabis. 2018;1(1):28–34.
   Google Scholar
• Desai R, Fong HK, Shah K, et al. Rising trends in hospitalizations for cardiovascular events among young cannabis users (18–39 years) without other substance abuse. Medicina (Kaunas). 2019;55(8):PMID:31387198.
   Web of Science ®Google Scholar
• Jaladi PR, Patel V, Kuduva Rajan S, et al. Arrhythmia-related hospitalization and comorbid cannabis use disorder: trend analysis in US hospitals (2010–2014). Cureus. 2019;11(9):e5607.
   PubMed Web of Science ®Google Scholar
• Winhusen T, Theobald J, Kaelber DC, et al. The association between regular cannabis use, with and without tobacco co-use, and adverse cardiovascular outcomes: cannabis may have a greater impact in non-tobacco smokers. Am J Drug Alcohol Abuse. 2019:1–8. [Epub ahead of print].
   PubMed Web of Science ®Google Scholar
• Kariyanna PT, Wengrofsky P, Jayarangaiah A, et al. Marijuana and cardiac arrhythmias: a scoping study. Int J Clin Res Trials. 2019;4(1):132.
   Google Scholar
• Kosior DA, Filipiak KJ, Stolarz P, et al. Paroxysmal atrial fibrillation following marijuana intoxication: a two-case report of possible association. Int J Cardiol. 2001;78(2):183–184.
   PubMed Web of Science ®Google Scholar
• Casier I, Vanduynhoven P, Haine S, et al. Is recent cannabis use associated with acute coronary syndromes? An illustrative case series. Acta Cardiol. 2014;69(2):131–136.
   PubMed Web of Science ®Google Scholar
• Hartung B, Kauferstein S, Ritz-Timme S, et al. Sudden unexpected death under acute influence of cannabis. Forensic Sci Int. 2014;237:e11–e13.
   PubMed Web of Science ®Google Scholar
• Akins D, Awdeh MR. Marijuana and second-degree AV block. South Med J. 1981;74(3):371–373.
   PubMed Web of Science ®Google Scholar
• Collins JS, Higginson JD, Boyle DM, et al. Myocardial infarction during marijuana smoking in a young female. Eur Heart J. 1985;6(7):637–638.
   PubMed Web of Science ®Google Scholar
• Kosior DA, Filipiak KJ, Stolarz P, et al. Paroxysmal atrial fibrillation in a young female patient following marijuana intoxication–a case report of possible association. Med Sci Monit. 2000;6(2):386–389.
   PubMedGoogle Scholar
• Singh GK. Atrial fibrillation associated with marijuana use. Pediatr Cardiol. 2000;21(3):284–284.
   PubMed Web of Science ®Google Scholar
• Rezkalla SH, Sharma P, Kloner RA. Coronary no-flow and ventricular tachycardia associated with habitual marijuana use. Ann Emerg Med. 2003;42(3):365–369.
   PubMed Web of Science ®Google Scholar
• Charbonney E, Sztajzel JM, Poletti PA, et al. Paroxysmal atrial fibrillation after recreational marijuana smoking: another “holiday heart”? Swiss Med Wkly. 2005;135(27–28):412–414.
   PubMed Web of Science ®Google Scholar
• Fisher BA, Ghuran A, Vadamalai V, et al. Cardiovascular complications induced by cannabis smoking: a case report and review of the literature. Emerg Med J. 2005;22(9):679–680.
   PubMed Web of Science ®Google Scholar
• Lehavi A, Shay M, Gilony C, et al. [Marijuana smoking and paroxysmal atrial fibrillation]. Harefuah. 2005;144(1):2–3.
   PubMedGoogle Scholar
• Lindsay AC, Foale RA, Warren O, et al. Cannabis as a precipitant of cardiovascular emergencies. Int J Cardiol. 2005;104(2):230–232.
   PubMed Web of Science ®Google Scholar
• Heeralall R, Koradia N, Hoo J, et al. Chronic marijuana use presenting as complete heart block. J Investigat Med. 2006;54:S265.
   Web of Science ®Google Scholar
• Daccarett M, Freih M, Machado C. Acute cannabis intoxication mimicking Brugada-like ST segment abnormalities. Int J Cardiol. 2007;119(2):235–236.
   PubMed Web of Science ®Google Scholar
• Tatli E, Yilmaztepe M, Altun G, et al. Cannabis-induced coronary artery thrombosis and acute anterior myocardial infarction in a young man. Int J Cardiol. 2007;120(3):420–422.
   PubMed Web of Science ®Google Scholar
• Baranchuk A, Johri AM, Simpson CS, et al. Ventricular fibrillation triggered by marijuana use in a patient with ischemic cardiomyopathy: a case report. Cases J. 2008;1(1):373.
   PubMedGoogle Scholar
• Cappelli F, Lazzeri C, Gensini GF, et al. Cannabis: a trigger for acute myocardial infarction? A case report. J Cardiovasc Med (Hagerstown). 2008;9(7):725–728.
   PubMed Web of Science ®Google Scholar
• Sánchez Lázaro IJ, Almenar Bonet L, Sancho-Tello MJ, et al. Ventricular tachycardia due to marijuana use in a heart transplant patient. Rev Esp Cardiol. 2009;62(4):459–461.
   Web of Science ®Google Scholar
• Sattout AH, Nicol MF. Cardiac arrest following cannabis use: a case report. Cases J. 2009;2:208.
   PubMedGoogle Scholar
• Fernández-Fernández FJ, Caínzos-Romero T, Mesías Prego A, et al. Ectopic atrial rhythm associated with cannabis use. Minerva Cardioangiol. 2011;59:119–120.
   PubMed Web of Science ®Google Scholar
• Pratap B, Korniyenko A. Toxic effects of marijuana on the cardiovascular system. Cardiovasc Toxicol. 2012;12(2):143–148.
   PubMed Web of Science ®Google Scholar
• Romero-Puche AJ, Trigueros-Ruiz N, Cerdán-Sánchez MC, et al. Brugada electrocardiogram pattern induced by cannabis. Rev Esp Cardiol (Engl Ed). 2012;65(9):856–858.
   PubMed Web of Science ®Google Scholar
• Khouzam RN, Kabra R, Soufi MK. Marijuana, bigeminal premature ventricular contractions and sluggish coronary flow: Are they related?. J Cardiol Cases. 2013;8(4):121–124.
   PubMedGoogle Scholar
• Menahem S. Cardiac asystole following cannabis (marijuana) usage—additional mechanism for sudden death? Forensic Sci Int. 2013;233(1–3):e3–5.
   PubMed Web of Science ®Google Scholar
• Singh D, Huntwork M, Shetty V, et al. Prolonged atrial fibrillation precipitated by new-onset seizures and marijuana abuse. Pediatrics. 2014;133(2):e443–6.
   PubMed Web of Science ®Google Scholar
• Alonso JV, Teo BH, Pozo FJ, et al. Brugada electrocardiogram pattern induced by cannabis; is cannabis safe? Am J Emerg Med. 2016;34(8):1738.e1–4.
   PubMed Web of Science ®Google Scholar
• Brancheau D, Blanco J, Gholkar G, et al. Cannabis induced asystole. J Electrocardiol. 2016;49(1):15–17.
   PubMed Web of Science ®Google Scholar
• Hayiroglu MI, Kaya A, Avsar S, et al. Intracoronary thrombus in an 18 year-old teenager. Hong Kong Med J. 2016;22:396–398.
   PubMed Web of Science ®Google Scholar
• Orsini J, Blaak C, Rajayer S, et al. Prolonged cardiac arrest complicating a massive ST-segment elevation myocardial infarction associated with marijuana consumption. J Community Hosp Intern Med Perspect. 2016;6(4):31695.
   PubMed Web of Science ®Google Scholar
• Co MLF, Das A, Okwuosa T. Pseudo-Wellens syndrome after heavy marijuana use. Cleve Clin J Med. 2017;84(8):590–591.
   PubMed Web of Science ®Google Scholar
• Doctorian T, Chou E. Cannabis-induced Brugada Syndrome presenting as cardiac arrest. J Cardiol Cardiovasc Ther. 2017;6:555678.
   Google Scholar
• Rickner SS, Cao D, Kleinschmidt K, et al. A little “dab” will do ya’ in: a case report of neuro-and cardiotoxicity following use of cannabis concentrates. Clin Toxicol (Phila). 2017;55(9):1011–1013.
   PubMed Web of Science ®Google Scholar
• Grieve-Eglin L, Haseeb S, Wamboldt R, et al. Symptomatic sinus arrest induced by acute marijuana use. J Thorac Dis. 2018;10(2):1121–1123.
   PubMed Web of Science ®Google Scholar
• Kariyanna PT, Jayarangaiah A, Hegde S, et al. Marijuana induced type I Brugada pattern: a case report. Am J Med Case Rep. 2018;6:134–136.
   Google Scholar
• Chaphekar A, Campbell M, Middleman AB. With a high, comes a low: a case of heavy marijuana use and bradycardia in an adolescent. Clin Pediatr (Phila). 2019;58(14):1550–1553.
   PubMed Web of Science ®Google Scholar
• Iqbal AM, Mubarik A, Cheetirala VG, et al. Marijuana induced sick sinus syndrome: a case report. Am J Case Rep. 2019;20:882–885.
   PubMed Web of Science ®Google Scholar
• Kariyanna PT, Jayarangaiah A, Yurevich O, et al. Atrioventricular Nodal reentrant tachycardia triggered by marijuana use: a case report and review of the literature. Am J Med Case Rep. 2019;7:193–196.
   Google Scholar
• Mithawala P, Shah P, Koomson E. Complete heart block from chronic marijuana use. Am J Med Sci. 2019;357(3):255–257.
   PubMed Web of Science ®Google Scholar
• Van Keer JM. Cannabis-induced third-degree AV block. Case Rep Emerg Med. 2019;2019:5037356.
   PubMedGoogle Scholar
• Richards JR. Cannabinoid hyperemesis syndrome: a disorder of the HPA axis and sympathetic nervous system? Med Hypotheses. 2017;103:90–95.
   PubMed Web of Science ®Google Scholar
• Banister SD, Arnold JC, Connor M, et al. Dark classics in chemical neuroscience: Δ(9)-Tetrahydrocannabinol. ACS Chem Neurosci. 2019;10(5):2160–2175.
   PubMed Web of Science ®Google Scholar
• Goyal H, Awad HH, Ghali JK. Role of cannabis in cardiovascular disorders. J Thorac Dis. 2017;9(7):2079–2092.
   PubMed Web of Science ®Google Scholar
• Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement. PLoS Med. 2009;6(7):e1000097.
   PubMed Web of Science ®Google Scholar
• Oxford Centre for Evidence-Based Medicine. Levels of Evidence. [cited 2019 Dec 20]. Available from: https://www.cebm.net/2009/06/oxford-centre-evidence-based-medicine-levels-evidence-march-2009.
   Google Scholar
• Singh A, Saluja S, Kumar A, et al. Cardiovascular complications of marijuana and related substances: a review. Cardiol Ther. 2018;7(1):45–59.
   PubMed Web of Science ®Google Scholar
• Tasker JG, Chen C, Fisher MO, et al. Endocannabinoid regulation of neuroendocrine systems. Int Rev Neurobiol. 2015;125:163–201.
   PubMed Web of Science ®Google Scholar
• Gash A, Karliner JS, Janowsky D, et al. Effects of smoking marihuana on left ventricular performance and plasma norepinephrine: studies in normal men. Ann Intern Med. 1978;89(4):448–452.
   PubMed Web of Science ®Google Scholar
• Oliveira RS, Alonso S, Campos FO, et al. Ectopic beats arise from micro-reentries near infarct regions in simulations of a patient-specific heart model. Sci Rep. 2018;8(1):16392.
   PubMedGoogle Scholar
• Valderrábano M. Influence of anisotropic conduction properties in the propagation of the cardiac action potential. Prog Biophys Mol Biol. 2007;94(1–2):144–168.
   PubMed Web of Science ®Google Scholar
• Misier AR, Opthof T, van Hemel NM, et al. Increased dispersion of “refractoriness” in patients with idiopathic paroxysmal atrial fibrillation. J Am Coll Cardiol. 1992;19:1531–1535.
   PubMed Web of Science ®Google Scholar
• Mahida S, Sacher F, Derval N, et al. Science linking pulmonary veins and atrial fibrillation. Arrhythm Electrophysiol Rev. 2015;4:40–43.
   PubMed Web of Science ®Google Scholar
• Hill MN, Sun JC, Tse MT, et al. Altered responsiveness of serotonin receptor subtypes following long-term cannabinoid treatment. Int J Neuropsychopharm. 2006;9 (3):277–286.
   PubMed Web of Science ®Google Scholar
• Rodríguez de Fonseca F, Fernández-Ruiz JJ, Murphy L, et al. Effects of delta-9-tetrahydrocannabinol exposure on adrenal medullary function: evidence of an acute effect and development of tolerance in chronic treatments. Pharmacol Biochem Behav. 1991;40:593–598.
   PubMed Web of Science ®Google Scholar
• Tan CMJ, Green P, Tapoulal N, et al. The role of Neuropeptide Y in cardiovascular health and disease. Front Physiol. 2018;9:1281.
   PubMed Web of Science ®Google Scholar
• Mathew RJ, Wilson WH, Davis R. Postural syncope after marijuana: a transcranial Doppler study of the hemodynamics. Pharmacol Biochem Behav. 2003;75:309–318.
   PubMed Web of Science ®Google Scholar
• ElSohly MA, Mehmedic Z, Foster S, et al. Changes in cannabis potency over the last 2 decades (1995–2014): analysis of current data in the United States. Biol Psychiatry. 2016;79:613–619.
   PubMed Web of Science ®Google Scholar
• De Petrocellis L, Nabissi M, Santoni G, et al. Actions and regulation of ionotropic cannabinoid receptors. Adv Pharmacol. 2017;80:249–289.
   PubMedGoogle Scholar
• Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol. 2011;163:1344–1364.
   PubMed Web of Science ®Google Scholar
• Berg CJ, Stratton E, Schauer GL, et al. Perceived harm, addictiveness, and social acceptability of tobacco products and marijuana among young adults: marijuana, hookah, and electronic cigarettes win. Subst Use Misuse. 2015;50:79–89.
   PubMed Web of Science ®Google Scholar