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Clinical Toxicology Volume 59, 2021 - Issue 3
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Clinical Research

Long term use of donepezil and QTc prolongation

Jason Khoa Department of Cardiology and Internal Medicine, Wexham Park Hospital, Frimley Health NHS Foundation Trust, Slough, UKORCID Iconhttps://orcid.org/0000-0003-3377-4750
ORCID Icon,
Adam Ioannoub Royal Free Hospital, Royal Free London NHS Foundation Trust, Camden, UK
,
Amit K. J. Mandala Department of Cardiology and Internal Medicine, Wexham Park Hospital, Frimley Health NHS Foundation Trust, Slough, UK
,
Andrew Coxa Department of Cardiology and Internal Medicine, Wexham Park Hospital, Frimley Health NHS Foundation Trust, Slough, UK
,
Ashraf Nasima Department of Cardiology and Internal Medicine, Wexham Park Hospital, Frimley Health NHS Foundation Trust, Slough, UK
,
Sofia Metaxaa Department of Cardiology and Internal Medicine, Wexham Park Hospital, Frimley Health NHS Foundation Trust, Slough, UK
&
Constantinos G. Missourisa Department of Cardiology and Internal Medicine, Wexham Park Hospital, Frimley Health NHS Foundation Trust, Slough, UK;c Medical School, University of Cyprus, Nicosia, CyprusCorrespondence[email protected]
 show all
Pages 208-214 | Received 12 May 2020, Accepted 20 Jun 2020, Published online: 01 Jul 2020

References

  • Kitt J, Irons R, Al-Obaidi M, et al. A case of donepezil-related torsades de pointes. BMJ Case Rep. 2015;2015:bcr2015211900.
  • Mandal AKJ, Khan UF, Missouris CG. Ventricular tachycardia in a patient with sigmoid volvulus on treatment with donepezil. Clin Toxicol. 2019;57(12):1157–1159.
  • Malik BH, Hamid P, Khan S, et al. Correlation between donepezil and QTc prolongation and torsades de pointes: a very rare phenomenon. Cureus. 2019;11(12):e6451.
  • Takaya T, Okamoto M, Yodoi K, et al. Torsades de Pointes with QT prolongation related to donepezil use. J Cardiol. 2009;54(3):507–511.
  • Bordier P, Garrigue S, Barold SS, et al. Significance of syncope in patients with Alzheimer’s disease treated with cholinesterase inhibitors. Europace. 2003;5(4):429–431.
  • Hernandez RK, Farwell W, Cantor MD, et al. Cholinesterase inhibitors and incidence of bradycardia in patients with dementia in the veterans affairs new England healthcare system. J Am Geriatr Soc. 2009;57(11):1997–2003.
  • Bordier P, Garrigue S, Lanusse S, et al. Cardiovascular effects and risk of syncope related to donepezil in patients with Alzheimer’s disease. CNS Drugs. 2006;20(5):411–417.
  • Igeta H, Suzuki Y, Tajiri M, et al. Cardiovascular pharmacodynamics of donepezil hydrochloride on the PR and QT intervals in patients with dementia. Hum Psychopharmacol Clin Exp. 2014;29(3):292–294.
  • Wang D, Wu Y, Wang A, et al. Electrocardiogram changes of donepezil administration in elderly patients with ischemic heart disease. Cardiol Res Pract. 2018;2018:9141320.
  • Donepezil Hydrochloride: side-effects [Internet]. London (UK): BMJ Group and Pharmaceutical Press; 2020 [Accessed on 2020 April 16]. Available from: http://www.medicinescomplete.com
  • Aricept (Donepezil Hydrochloride) [Internet]. New Hampshire (MD): United States Food and Drug Administration; 2012 [Accessed on 2020 April 16]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020690s035,021720s008,022568s005lbl.pdf
  • Rowland JP, Rigby J, Harper AC, et al. Cardiovascular monitoring with acetylcholinesterase inhibitors: a clinical protocol. Adv Psychiatr Treat. 2007;13(3):178–184.
  • Chan A, Isbister GK, Kirkpatrick CM, et al. Drug-induced QT prolongation and torsades de pointes: evaluation of a QT nomogram. QJM. 2007;100(10):609–615.
  • Talbot S. QT interval in right and left bundle-branch block. Br Heart J. 1973;35(3):288–291.
  • Roden DM. Keep the QT interval: it is a reliable predictor of ventricular arrhythmias. Heart Rhythm. 2008;5(8):1213–1215.
  • Malik M, Batchvarov VN. Measurement, interpretation and clinical potential of QT dispersion. J Am Coll Cardiol. 2000;36(6):1749–1766.
  • Li K, Cheng N, Li XT. Inhibitory effects of cholinesterase inhibitor donepezil on the Kv1.5 potassium channel. Sci Rep. 2017;7:41509.
  • Isik AT, Bozoglu E, Yay A, et al. Which cholinesterase inhibitor is the safest for the heart in elderly patients with Alzheimer’s disease? Am J Alzheimers Dis Other Demen. 2012;27(3):171–174.
  • Rabkin SW, Cheng XJ, Thompson DJ. Detailed analysis of the impact of age on the QT interval. J Geriatr Cardiol. 2016;13(9):740–748.
  • Rabkin SW. Impact of age and sex on QT prolongation in patients receiving psychotropics. Can J Psychiatry. 2015;60(5):206–214.
  • Tan MP, Newton JL, Reeve P, et al. Results of carotid sinus massage in a tertiary referral unit–is carotid sinus syndrome still relevant? Age Ageing. 2009;38(6):680–686.
  • Kumar NP, Thomas A, Mudd P, et al. The usefulness of carotid sinus massage in different patient groups. Age Ageing. 2003;32(6):666–669.
  • Kerr SR, Pearce MS, Brayne C, et al. Carotid sinus hypersensitivity in asymptomatic older persons: implications for diagnosis of syncope and falls. Arch Intern Med. 2006;166(5):515–520.
  • Tsutsui JM, Falcão SN, Dourado PM, Lima MF, et al. Gender differences in chronotropic and hemodynamic responses during dobutamine-atropine stress echocardiography. Echocardiography. 2007;24(8):843–850.
  • Sato K, Urbano R, Yu C, et al. The effect of donepezil treatment on cardiovascular mortality. Clin Pharmacol Ther. 2010;88(3):335–338.
  • Park-Wyllie LY, Mamdani MM, Li P, et al. Cholinesterase inhibitors and hospitalization for bradycardia: a population-based study. PLoS Med. 2009;6(9):e1000157.
  • Courtney C, Farrell D, Gray R, et al. Long-term donepezil treatment in 565 patients with Alzheimer’s disease (AD2000): randomised double-blind trial. Lancet. 2004;363(9427):2105–2115.

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