277
Views
0
CrossRef citations to date
0
Altmetric
Basic Research

Can isosorbide dinitrate oral spray serve as an immediate bridging therapy for a mass cyanide poisoning?

, &
Pages 734-739 | Received 26 Sep 2020, Accepted 13 Nov 2020, Published online: 04 Dec 2020

References

  • Rockwood GA. A bona fide need for a non-intravenous cyanide medical countermeasure. Clin Toxicol (Phila)). 2019;57(4):300.
  • Lavon O. Early administration of isosorbide dinitrate improves survival of cyanide-poisoned rabbits. Clin Toxicol (Phila)). 2015;53(1):22–27.
  • Thompson A, Dunn M, Jefferson RD, et al. Modest and variable efficacy of pre-exposure hydroxocobalamin and dicobalt edetate in a porcine model of acute cyanide salt poisoning. Clin Toxicol (Phila)). 2020;58(3):190–200.
  • Seifert SA. Nitrates and nitrites. In: Dart RC, Cavarati EM, McGuigan MA, eds. Medical toxicology, 3rd ed. Philadelphia: Lippincot Williams & Wilkins, 2003. p. 1177–1178.
  • Murad F. Drugs used for treatment of angina: organic nitrates, calcium channel blockers and beta-adrenergic antagonists. In: Gilman AG, Rall TW, Nies AS, eds. Goodman and Gilman's the pharmacological basis of therapeutics, 8th ed. New York: Pergam Press, 1990. p. 764–773.
  • Lavon O, Avrahami A, Eisenkraft A. Effectiveness of isosorbide dinitrate in cyanide poisoning as a function of the administration timing. BMC Pharmacol Toxicol. 2017;18(1):13.
  • Sun P, Borowitz JL, Kanthasamy AG, et al. Antagonism of cyanide toxicity by isosorbide dinitrite: possible role of nitric oxide. Toxicology. 1995;104(1-3):105–111.
  • Lavon O, Bentur Y. Does amyl nitrite have a role in the management of pre-hospital mass casualty cyanide poisoning? Clin Toxicol (Phila)). 2010;48(6):477–484.
  • Belani KG, Singh H, Beebe DS, et al. Cyanide toxicity in juvenile pigs and its reversal by a new prodrug, sulfanegen sodium. Anesth Analg. 2012;114:956–961.
  • Hendry-Hofer TB, Witeof AE, Lippner DS, et al. Intramuscular dimethyl trisulfide: efficacy in a large swine model of acute severe cyanide toxicity. Clin Toxicol (Phila)). 2019;57(4):265–270.
  • Hendry-Hofer TB, Witeof AE, Ng PC, et al. Intramuscular sodium tetrathionate as an antidote in a clinically relevant swine model of acute cyanide toxicity. Clin Toxicol (Phila)). 2020;58(1):29–35.
  • Musser JB, Bentley TB, Griffith S, et al. Hemorrhagic shock in swine: nitric oxide and potassium sensitive adenosine triphosphate channel activation. Anesthesiology. 2004;101(2):399–408.
  • Haitsma DB, Merkus D, Vermeulen J, et al. Nitric oxide production is maintained in exercising swine with chronic left ventricular dysfunction. Am J Physiol Heart Circ Physiol. 2002;282(6):H2198–209.
  • Johnson WS, Hall AH, Rumack BH. Cyanide poisoning successfully treated without 'therapeutic methemoglobin levels. Am J Emerg Med. 1989;7(4):437–440.
  • Zweier JL, Wang P, Samouilov A, et al. Enzyme-independent formation of nitric oxide in biological tissues. Nat Med. 1995;1(8):804–809.
  • Leavesley HB, Li L, Prabhakaran K, et al. Interaction of cyanide and nitric oxide with cytochrome c oxidase: Implications for acute cyanide toxicity. Toxicol Sci. 2008;101(1):101–111.
  • Leavesley HB, Li L, Mukhopadhyay S, et al. Nitrite-mediated antagonism of cyanide inhibition of cytochrome c oxidase in dopamine neurons. Toxicol Sci. 2010;115(2):569–576.
  • Pintus F, Spanò D, Bellelli A, et al. Nitric oxide, substrate of Euphorbia characias peroxidase, switches off the CN(-) inhibitory effect. FEBS Open Bio. 2012;2:305–312.
  • Patel MN, Peoples RW, Yim GK, et al. Enhancement of NMDA-mediated responses by cyanide. Neurochem Res. 1994;19(10):1319–1323.
  • Persson SA, Cassel G, Sellström A. Acute cyanide intoxication and central transmitter systems. Fundam Appl Toxicol. 1985;5(6 Pt 2):S150–S159.
  • Lipton SA, Choi YB, Pan ZH, et al. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature. 1993;364(6438):626–632.
  • Vogt D, Trenk D, Bonn R, et al. Pharmacokinetics and haemodynamic effects of ISDN following different dosage forms and routes of administration. Eur J Clin Pharmacol. 1994;46(4):319–324.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.