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Clinical Toxicology Volume 59, 2021 - Issue 12
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Short Communication

Acute toxicity from the synthetic cathinone N-ethylpentylone (ephylone) in the United Kingdom

Georgina Blancoa Clinical Toxicology, Guy’s and St Thomas’ NHS Foundation Trust, London, UKCorrespondence[email protected]
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,
Dan Vidlerb NIHR Health Protection Research Unit for Chemical Threats and Hazards, Newcastle University, Newcastle, UKView further author information
,
Clair Roperb NIHR Health Protection Research Unit for Chemical Threats and Hazards, Newcastle University, Newcastle, UKView further author information
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David M. Wooda Clinical Toxicology, Guy’s and St Thomas’ NHS Foundation Trust, London, UK;c Faculty of Life Sciences and Medicine, King’s College London, London, UKView further author information
,
Paul I. Dargana Clinical Toxicology, Guy’s and St Thomas’ NHS Foundation Trust, London, UK;c Faculty of Life Sciences and Medicine, King’s College London, London, UKView further author information
,
Liza Keatingd Royal Berkshire NHS Foundation Trust, Reading, UKView further author information
,
Rebecca Macfarlanee Epsom and St Helier NHS Trust, Carshalton, UKView further author information
,
Stevan Emmettf Royal United Hospitals Bath NHS Foundation Trust, Bath, UKView further author information
,
Graham Johnsong University Hospitals of Derby, Burton NHS Foundation Trust, Derby, UKORCID Iconhttps://orcid.org/0000-0001-6004-6244View further author information
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Michael Eddlestonh Clinical Toxicology, Newcastle Hospitals NHS Foundation Trust, Newcastle, UKORCID Iconhttps://orcid.org/0000-0002-6857-3441View further author information
ORCID Icon,
Simon L. Hillh Clinical Toxicology, Newcastle Hospitals NHS Foundation Trust, Newcastle, UKORCID Iconhttps://orcid.org/0000-0002-0581-6389View further author information
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Simon H. L. Thomasb NIHR Health Protection Research Unit for Chemical Threats and Hazards, Newcastle University, Newcastle, UK;h Clinical Toxicology, Newcastle Hospitals NHS Foundation Trust, Newcastle, UKView further author information
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Pages 1270-1273 | Received 12 Jan 2021, Accepted 23 Mar 2021, Published online: 15 Apr 2021

References

  • World Health Organisation. 2018. Critical review report: N-ethylnorpentylone. https://www.who.int/medicines/access/controlled-substances/N-Ethylnorpentylone.pdf (Accessed 7th January 2021)
  • Costa JL, Cunha KF, Lanaro R, et al. Analytical quantification, intoxication case series, and pharmacological mechanism of action for N-ethylnorpentylone (N-ethylpentylone or ephylone). Drug Test Anal. 2019;11(3):461–471.
  • Thirakul P, Hair LS, Bergen KL, et al. Clinical presentation, autopsy results and toxicology findings in an acute n-ethylpentylone fatality. J Anal Toxicol. 2017;41:342–346.
  • Ikeji C, Sittambalam CD, Camire LM, et al. Fatal intoxication with N-ethylpentylone: a case report. J Community Hosp Intern Med Perspect. 2018;8(5):307–310.
  • Atherton D, Dye D, Robinson CA, et al. n-Ethyl pentylone-related deaths in Alabama. J Forensic Sci. 2019;64(1):304–308.
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  • Krotulski AJ, Papsun DM, De Martinis BS, et al. N-Ethyl pentylone (ephylone) intoxications: quantitative confirmation and metabolite identification in authentic human biological specimens. J Anal Toxicol. 2018;42(7):467–475.
  • Hill SL, Najafi J, Dunn M, et al. Clinical toxicity following analytically confirmed use of the synthetic cannabinoid receptor agonist MDMB-CHMICA. A report from the Identification Of Novel psychoActive substances (IONA) study. Clin Toxicol (Phila). 2016;54(8):638–643.
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  • Wood DM, Ceronie B, Dargan PI. Healthcare professionals are less confident in managing acute toxicity related to the use of new psychoactive substances (NPS) compared with classical recreational drugs. QJM. 2016;109(8):527–529.
  • Noseda R, Schmid Y, Scholz I, Euro-DEN Research Group, et al. MDMA-related presentations to the emergency departments of the European Drug Emergencies Network plus (Euro-DEN Plus) over the four-year period 2014–2017. Clin Toxicol (Phila). 2021;59(2):131–137.

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