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Basic Research

Pathophysiological profile of awake and anesthetized pigs following systemic exposure to the highly lethal ricin toxin

, , , , , , , , & ORCID Icon show all
Pages 76-82 | Received 18 Mar 2021, Accepted 18 May 2021, Published online: 03 Jun 2021

References

  • Crompton R, Gall D. Georgi Markov-death in a pellet. Med Leg J. 1980;48(2):51–62.
  • Ricin threat: cologne anti-terror police search flats. BBC NEWS, 2018 Jun 15. Avaialble from: https://www.bbc.com/news/world-europe-44494010
  • Breaking bad fan jailed over dark web ricin plot. BBC NEWS, 2015 Sep 18. Available from: https://www.bbc.com/news/uk-england-34288380
  • Suspected ricin detected in mail sent to Trump, Pentagon. CNN Politics. 2018 Oct 3. Available from: https://edition.cnn.com/2018/10/02/politics/pentagon-ricin-mail/index.html
  • Coopman V, De Leeuw M, Cordonnier J, et al. Suicidal death after injection of a castor bean extract (Ricinus communis L.). Forensic Sci Int. 2009;189(1–3):e13–e20.
  • Feldberg L, Elhanany E, Laskar O, et al. Rapid, sensitive and reliable ricin identification in serum samples using LC–MS/MS. Toxins. 2021;13(2):79.
  • Gal Y, Mazor O, Alcalay R, et al. Antibody/doxycycline combined therapy for pulmonary ricinosis: attenuation of inflammation improves survival of ricin-intoxicated mice. Toxicol Rep. 2014;1:496–504.
  • Katalan S, Falach R, Rosner A, et al. A novel swine model of ricin-induced acute respiratory distress syndrome. Dis Model Mech. 2017;10(2):173–183.
  • Kokes J, Assaad A, Pitt L, et al. Acute pulmonary response of rats exposed to a sublethal dose of ricin aerosol. FASEB J. 1994;8:A144.
  • Griffiths GD, Rice P, Allenby AC, et al. Upshall DG inhalation toxicology and histopathology of ricin and abrin toxins. Inhal Toxicol. 1995;7(2):269–288.
  • Wilhelmsen CL, Pitt ML. Lesions of acute inhaled lethal ricin intoxication in rhesus monkeys. Vet Pathol. 1996;33(3):296–302.
  • Brown RF, White DE. Ultrastructure of rat lung following inhalation of ricin aerosol. Int J Exp Pathol. 1997;78(4):267–276.
  • Griffiths GD, Phillips GJ, Holley J. Inhalation toxicology of ricin preparations: animal models, prophylactic and therapeutic approaches to protection. Inhal Toxicol. 2007;19(10):873–887.
  • Wong J, Korcheva V, Jacoby DB, et al. Intrapulmonary delivery of ricin at high dosage triggers a systemic inflammatory response and glomerular damage. Am J Pathol. 2007;170(5):1497–1510.
  • Benson JM, Gomez AP, Wolf ML, et al. The acute toxicity, tissue distribution, and histopathology of inhaled ricin in Sprague Dawley rats and BALB/c mice. Inhal Toxicol. 2011;23(5):247–256.
  • Sapoznikov A, Rosner A, Falach R, et al. Intramuscular ricin poisoning of mice leads to widespread damage in the heart, spleen, and bone marrow. Toxins. 2019;11(6):344.
  • Meurens F, Summerfield A, Nauwynck H, et al. The pig: a model for human infectious diseases. Trends Microbiol. 2012;20(1):50–57.
  • Ospina-Tascón GA, Umaña M, Bermúdez WF, et al. Can venous-to-arterial carbon dioxide differences reflect microcirculatory alterations in patients with septic shock? Intensive Care Med. 2016;42(2):211–221.
  • Pincus SH, Bhaskaran M, Brey RN, et al. Clinical and pathological findings associated with aerosol exposure of macaques to ricin toxin. Toxins. 2015;7(6):2121–2133.
  • Mallat J, Lemyze M, Tronchon L, et al. Use of venous-to-arterial carbon dioxide tension difference to guide resuscitation therapy in septic shock. World J Crit Care Med. 2016;5(1):47–56.
  • Hofmaier F, Dinger K, Braun R, et al. Range of blood lactate values in farm pigs prior to experimental surgery. Lab Anim. 2013;47(2):130–132.
  • Kakihana Y, Takashi I, Nakahara M, et al. T. Sepsis-induced myocardial dysfunction: pathophysiology and management. J Int Care. 2016;4:22.
  • Lord MJ, Jolliffe NA, Marsden CJ, et al. Ricin. Mechanisms of cytotoxicity. Toxicol Rev. 2003;22(1):53–64.
  • Simmons J, Ventetuolo CE. Cardiopulmonary monitoring of shock. Curr Opin Crit Care. 2017;23(3):223–231.
  • Walley KR. Sepsis-induced myocardial dysfunction. Curr Opin Crit Care. 2018;24(4):292–299.
  • Rovas A, Mareen Seidel L, Vink H, et al. Association of sublingual microcirculation parameters and endothelial glycocalyx dimensions in resuscitated sepsis. Crit Care. 2019;23(1):260.
  • De Backer D, Donadello K, Sakr Y, et al. Microcirculatory alterations in patients with severe sepsis: impact of time of assessment and relationship with outcome. Crit Care Med. 2013;41(3):791–799.
  • Bateman RM, Sharpe MD, Ellis CG. Bench-to-bedside review: Microvascular dysfunction in sepsis, hemodynamics, oxygen transport, and nitric oxide. Crit Care. 2003;7(5):359–573.
  • Falach R, Sapoznikov A, Evgy Y, et al. Post-exposure anti-ricin treatment protects swine against lethal systemic and pulmonary exposures. Toxins. 2020;12(6):354.

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