Does vitamin B12 deficiency explain psychiatric symptoms in recreational nitrous oxide users? A narrative review

References

• Kaar SJ, Ferris J, Waldron J, et al. Up: the rise of nitrous oxide abuse. An international survey of contemporary nitrous oxide use. J Psychopharmacol. 2016;30(4):395–401.
   PubMed Web of Science ®Google Scholar
• Ehirim EM, Naughton DP, Petróczi A. No laughing matter: presence, consumption trends, drug awareness, and perceptions of "Hippy Crack" (nitrous oxide) among young adults in England. Front Psychiatry. 2017;8:312.
   PubMed Web of Science ®Google Scholar
• Howard MO, Bowen SE, Garland EL. Substance-related disorders. In: Sadock BJ, Sadock VA, Ruiz P, editors. Kaplan & Sadock's comprehensive textbook of psychiatry. 10th ed. Philadelphia, PA: Lippincott Williams And Wilkins; 2017. p. 1328–1342.
   Google Scholar
• Global Drug Survey. 2019. GDS2019 key finding report; [published 2019 May 16; cited 2020 Mar 11]. Available from: https://issuu.com/globaldrugsurvey/docs/gds2019_key_findings_report_may_16
   Google Scholar
• Global Drug Survey. 2014. Last 12 month prevalence of top 20 drugs; [published 2014 Apr; cited 2020 Mar 11]. Available from: https://www.globaldrugsurvey.com/wp-content/uploads/2014/04/last-12-months-drug-prevalence.pdf
   Google Scholar
• GOV.UK. Drug misuse: findings from the 2018 to 2019 CSEW; [published 2019 Sep 19; cited 2020 Mar 11]. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/832533/drug-misuse-2019-hosb2119.pdf
   Google Scholar
• Guo CJ, Kaufman BS. Inhalational Anesthetics. In: Nelson LS, Howland M, Lewin NA, Smith SW, Goldfrank LR, Hoffman RS, editors. Goldfrank's Toxicologic Emergencies [Internet]. 11th ed. New York City: McGraw-Hill; 2019 [cited 2020 May 5]. p. 1–14. Available from: https://accessemergencymedicine.mhmedical.com/content.aspx?bookid=2569&sectionid=210274345
   Google Scholar
• Kwok MMK, de Lemos J, Sharaf EM. Drug-induced psychosis and neurological effects following nitrous oxide misuse: a case report. BCMJ. 2019;61(10):385–387.
   Web of Science ®Google Scholar
• Lassen HCA, Henriksen E, Neukirch F, et al. Treatment of tetanus; severe bone-marrow depression after prolonged nitrous-oxide anaesthesia. Lancet. 1956;270(6922):527–530.
   PubMedGoogle Scholar
• Van Amsterdam J, Nabben T, van den Brink W. Recreational nitrous oxide use: prevalence and risks. Regul Toxicol Pharmacol. 2015;73(3):790–796.
   PubMed Web of Science ®Google Scholar
• Sethi NK, Mullin P, Torgovnick J, et al. Nitrous oxide "whippit" abuse presenting with cobalamin responsive psychosis. J Med Toxicol. 2006;2(2):71–74.
   PubMedGoogle Scholar
• Chiang T, Hung C, Wang W, et al. Recreational nitrous oxide abuse-induced vitamin B12 deficiency in a patient presenting with hyperpigmentation of the skin. Case Rep Dermatol. 2013;5(2):186–191.
   PubMedGoogle Scholar
• Garakani A, Jaffe RJ, Savla D, et al. Neurologic, psychiatric, and other medical manifestations of nitrous oxide abuse: a systematic review of the case literature. Am J Addict. 2016;25(5):358–369.
   PubMed Web of Science ®Google Scholar
• Dutch Poisons Information Center (DPIC), University Medical Center Utrecht, The Netherlands. Meer vergiftigingen door lachgas in 2019; [cited 2020 Nov 4]. Available from: https://www.umcutrecht.nl/nieuws/meer-vergiftigingen-met-lachgas-in-2019
   Google Scholar
• Sheldon RJG, Reid M, Schon F, et al. Just say N2O – nitrous oxide misuse: essential information for psychiatrists. BJPsych Advances. 2020;26(2):72–81.
   Google Scholar
• World Health Organization. Mental health: mental disorders; [cited 2020 June 1]. Available from: https://www.who.int/mental_health/management/en/
   Google Scholar
• Layzer RB. Myeloneuropathy after prolonged exposure to nitrous oxide. Lancet. 1978;2(8102):1227–1230.
   PubMed Web of Science ®Google Scholar
• Alderman CP, Nyfort‐Hansen K. Nitrous oxide abuse in a community setting: case report. Aust J Hosp Pharm. 2000;30(3):109–110.
   Google Scholar
• Brett A. Myeloneuropathy from whipped cream bulbs presenting as conversion disorder. Aust N Z J Psychiatry. 1997;31(1):131–132.
   PubMed Web of Science ®Google Scholar
• Brodsky L, Zuniga J. Nitrous oxide: a psychotogenic agent. Compr Psychiatry. 1975;16(2):185–188.
   PubMed Web of Science ®Google Scholar
• Chen T, Zhong N, Jiang H, et al. Neuropsychiatric symptoms induced by large doses of nitrous oxide inhalation: a case report. Shanghai Arch Psychiatry. 2018;30(1):56–59.
   PubMedGoogle Scholar
• Chien WH, Huang MC, Chen LY. Psychiatric and other medical manifestations of nitrous oxide abuse: implications from case series. J Clin Psychopharmacol. 2020;40(1):80–83.
   PubMed Web of Science ®Google Scholar
• Chin J, Forzani B, Chowdhury N, et al. Rehabilitation essential in the recovery of multifactorial subacute combined degeneration. Ann Phys Rehabil Med. 2015;58(3):190–192.
   PubMed Web of Science ®Google Scholar
• Cousaert C, Heylens G, Audenaert K. Laughing gas abuse is no joke. An overview of the implications for psychiatric practice. Clin Neurol Neurosurg. 2013;115(7):859–862.
   PubMed Web of Science ®Google Scholar
• Grigg JR. Nitrous oxide mood disorder. J Psychoactive Drugs. 1988;20(4):449–450.
   PubMed Web of Science ®Google Scholar
• Hew A, Lai E, Radford E. Nitrous oxide abuse presenting with acute psychosis and peripheral neuropathy. Aust N Z J Psychiatry. 2018;52(4):388.
   PubMed Web of Science ®Google Scholar
• Hughes G, Moran E, Dedicoat MJ. Encephalitis secondary to nitrous oxide and vitamin B12 deficiency. BMJ Case Rep. 2019;12(12):e229380.
   PubMedGoogle Scholar
• Iwata K, O'Keefe GB, Karanas A. Neurologic problems associated with chronic nitrous oxide abuse in a non-healthcare worker. Am J Med Sci. 2001;322(3):173–174.
   PubMed Web of Science ®Google Scholar
• Johnson K, Mikhail P, Kim MG, et al. Recreational nitrous oxide-associated neurotoxicity. J Neurol Neurosurg Psychiatry. 2018;89(8):897–898.
   PubMed Web of Science ®Google Scholar
• Kim S, Lee SH, Bang M. Double-sidedness of "laughing gas" on the N-methyl-d-aspartate receptor: a case report of acute psychosis associated with nitrous oxide-induced hyperhomocysteinemia. Schizophr Res. 2019;208:475–476.
   PubMed Web of Science ®Google Scholar
• Lundin MS, Cherian J, Andrew MN, et al. One month of nitrous oxide abuse causing acute vitamin B 12 deficiency with severe neuropsychiatric symptoms. BMJ Case Rep. 2019;12(2):e228001.
   Google Scholar
• Luo D, Xu J, Hu L, et al. Hyperbaric oxygen therapy to improve cognitive dysfunction and encephalatrophy induced by N2O for recreational use: a case report. Neuropsychiatr Dis Treat. 2018;14:1963–1967.
   PubMed Web of Science ®Google Scholar
• Pratt DN, Patterson KC, Quin K. Venous thrombosis after nitrous oxide abuse, a case report. J Thromb Thrombolysis. 2020;49(3):501–503.
   PubMed Web of Science ®Google Scholar
• Roberts D, Farahmand P, Wolkin A. Nitrous oxide inhalant use disorder preceding symptoms concerning for primary psychotic illness. Am J Addict. 2020;29(6):525–527.
   PubMed Web of Science ®Google Scholar
• Sterman AB, Coyle PK. Subacute toxic delirium following nitrous oxide abuse. Arch Neurol. 1983;40(7):446–467.
   PubMedGoogle Scholar
• Trivette ET, Hoedebecke K, Berry-Cabán CS, et al. Megaloblastic hematopoiesis in a 20 year old pregnant female. Am J Case Rep. 2013;14:10–12.
   PubMedGoogle Scholar
• Vive MG, Anguelova GV, Duim S, et al. Metabolic encephalopathy caused by nitrous oxide (‘laughing gas’) induced hyperammonaemia. BMJ Case Rep. 2019;12(11):e232163.
   PubMedGoogle Scholar
• Wong SL, Harrison R, Mattman A, et al. Nitrous oxide (N2O)-induced acute psychosis. Can J Neurol Sci. 2014;41(5):672–674.
   PubMed Web of Science ®Google Scholar
• Matorin AA, Shah AA, Ruiz P. Clinical manifestations of psychiatric disorders. In: Sadock BJ, Sadock VA, Ruiz P, editors. Kaplan & Sadock's comprehensive textbook of psychiatry. 10th ed. Philadelphia, PA: Lippincott Williams And Wilkins; 2017. p. 1114–1150.
   Google Scholar
• Jevtovic-Todorovic V, Todorovic SM, Mennerick S, et al. Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin. Nat Med. 1998;4(4):460–463.
   PubMed Web of Science ®Google Scholar
• Metzler D, Miller WH, Edwards CS. Psychiatric manifestation of vitamin B-12 deficiency: an update. JJP. 1991;9(2):43–48.
   Google Scholar
• Catalano G, Catalano MC, Rosenberg EI, et al. Catatonia. Another neuropsychiatric presentation of vitamin B12 deficiency? Psychosomatics. 1998;39(5):456–460.
   PubMed Web of Science ®Google Scholar
• Malamed SF. Pharmacology, anatomy and physiology. In: Malamed SF, editor. Sedation: a guide to patient management. 6th ed. St. Louis, MO: Elsevier; 2017 p. 190–202.
   Google Scholar
• Chanarin I. Cobalamins and nitrous oxide: a review. J Clin Pathol. 1980;33(10):909–916.
   PubMed Web of Science ®Google Scholar
• Pema PJ, Horak HA, Wyatt RH. Myelopathy caused by nitrous oxide toxicity. Am J Neuroradiol. 1998;19(5):894–896.
   PubMed Web of Science ®Google Scholar
• Edirisinghe SP. Homocysteine-induced thrombosis. Br J Biomed Sci. 2004;61(1):40–47.
   PubMed Web of Science ®Google Scholar
• Norris F, Mallia P. Lesson of the month 2: a case of nitrous oxide-induced pancytopenia. Clin Med. 2019;19(2):129–130.
   PubMed Web of Science ®Google Scholar
• Emmanouil DE, Quock RM. Advances in understanding the actions of nitrous oxide. Anesth Prog. 2007;54(1):9–18.
   PubMedGoogle Scholar
• Virarkar M, Alappat L, Bradford PG, et al. L-arginine and nitric oxide in CNS function and neurodegenerative diseases. Crit Rev Food Sci Nutr. 2013;53(11):1157–1167.
   PubMed Web of Science ®Google Scholar
• Bernstein HG, Stanarius a, Baumann B, et al. Nitric oxide synthase-containing neurons in the human hypothalamus: reduced number of immunoreactive cells in the paraventricular nucleus of depressive patients and schizophrenics. Neuroscience. 1998;83(3):867–875.
   PubMed Web of Science ®Google Scholar
• Sakamoto S, Nakao S, Masuzawa M, et al. The differential effects of nitrous oxide and xenon on extracellular dopamine levels in the rat nucleus accumbens: a microdialysis study. Anesth Analg. 2006;103(6):1459–1463.
   PubMed Web of Science ®Google Scholar
• Burvill PW, Jackson JM, Smith WG. Psychiatric symptoms due to vitamin B12 deficiency without anaemia. Med J Aust. 1969;2(8):388–390.
   PubMed Web of Science ®Google Scholar
• Masalha R, Chudakov B, Morad M, et al. Cobalamin responsive psychosis as the sole manifestation of vitamin B12 deficiency. Isr Med Assoc J. 2001;3(9):701–703.
   PubMed Web of Science ®Google Scholar
• Jayaram N, Rao MR, Narasimha A, et al. Vitamin B12 levels and psychiatric symptomatology: a case series. J Neuropsychiatry Clin Neurosci. 2013;25(2):150–152.
   PubMed Web of Science ®Google Scholar
• Smith ADM. Megaloblastic madness. Br Med J. 1960;2(5216):1840–1845.
   PubMedGoogle Scholar
• Van Tiggelen CJM, Peperkamp JPC, Tertoolen JFW. Vitamin-B12 levels of cerebrospinal fluid in patients with organic mental disorder. J Orthomol Psychiatry. 1983;12:305–311.
   Google Scholar
• Zhang Y, Hodgson NW, Trivedi MS, et al. Decreased brain levels of vitamin B12 in aging, autism and schizophrenia. PLOS One. 2016;11(1):e0146797.
   PubMed Web of Science ®Google Scholar
• Domisse J. Subtle vitamin deficiency and psychiatry: a largely unnoticed but devastating relationship? Med Hypotheses. 1991;34:137–140.
   Web of Science ®Google Scholar
• Berry N, Sagar R, Tripathi BM. Catatonia and other psychiatric symptoms with vitamin B12 deficiency. Acta Psychiatr Scand. 2003;108(2):156–159.
   PubMed Web of Science ®Google Scholar
• Bolann BJ, Solli JD, Schneede J, et al. Evaluation of indicators of cobalamin deficiency defined as cobalamin-induced reduction in increased serum methylmalonic acid. Clin Chem. 2000;46(11):1744–1750.
   PubMed Web of Science ®Google Scholar
• Bhat AS, Srinivasan K, Kurpad SS, Galgali RB. Psychiatric presentations of vitamin B12 deficiency. J Indian Med Assoc. 2007;105(7):395–396.
   PubMedGoogle Scholar
• Raveendranathan D, Shiva L, Venkatasubramanian G, et al. Vitamin B12 deficiency masquerading as clozapine-resistant psychotic symptoms in schizophrenia. J Neuropsychiatry Clin Neurosci. 2013;25(2):E34–35.
   PubMed Web of Science ®Google Scholar
• Xiang W, Xue H, Wang B, et al. Efficacy of N-butylphthalide and hyperbaric oxygen therapy on cognitive dysfunction in patients with delayed encephalopathy after acute carbon monoxide poisoning. Med Sci Monit. 2017;23:1501–1506.
   PubMed Web of Science ®Google Scholar
• Substance Abuse and Mental Health Services Administration. Key substance use and mental health indicators in the United States: results from the 2018 National Survey on Drug Use and Health; [published 2019 Aug; cited 2020 Mar 11]. Available from: https://www.samhsa.gov/data/sites/default/files/cbhsq-reports/NSDUHNationalFindingsReport2018/NSDUHNationalFindingsReport2018.pdf
   Google Scholar
• Baigent M. Managing patients with dual diagnosis in psychiatric practice. Curr Opin Psychiatry. 2012;25(3):201–205.
   PubMed Web of Science ®Google Scholar
• Santucci K. Psychiatric disease and drug abuse. Curr Opin Pediatr. 2012;24(2):233–237.
   PubMed Web of Science ®Google Scholar
• Green R, Allen LH, Bjørke-Monsen A, et al. Vitamin B12 deficiency. Nat Rev Dis Primers. 2017;3:17040.
   PubMed Web of Science ®Google Scholar
• Yazici AB, Ciner OA, Yazici E, et al. Comparison of vitamin B12, vitamin D and folic acid blood levels in patients with schizophrenia, drug addiction and controls. J Clin Neurosci. 2019;65:11–16.
   PubMed Web of Science ®Google Scholar