Advanced search
Publication Cover
Clinical Toxicology Volume 60, 2022 - Issue 3
Submit an article Journal homepage
361
Views
3
CrossRef citations to date
0
Altmetric
Basic Research

Development of sodium tetrathionate as a cyanide and methanethiol antidote

Adriano Chana Department of Medicine, University of California, San Diego, La Jolla, CA, USAView further author information
,
Jangwoen Leeb Beckman Laser Institute, University of California, Irvine, Irvine, CA, USAView further author information
,
Subrata Bhadrac Department of Chemistry and Biochemistry, South Dakota State University, Brookings, SD, USAView further author information
,
Nesta Bortey-Samd Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USAView further author information
,
Tara B. Hendry-Hofere Department of Emergency Medicine, University of Colorado, Aurora, CO, USAView further author information
,
Vikhyat S. Bebartae Department of Emergency Medicine, University of Colorado, Aurora, CO, USAORCID Iconhttps://orcid.org/0000-0001-8816-1199View further author information
ORCID Icon,
Sari B. Mahonb Beckman Laser Institute, University of California, Irvine, Irvine, CA, USAView further author information
,
Matthew Brennerb Beckman Laser Institute, University of California, Irvine, Irvine, CA, USAView further author information
,
Brian Loguec Department of Chemistry and Biochemistry, South Dakota State University, Brookings, SD, USAView further author information
,
Renate B. Pilza Department of Medicine, University of California, San Diego, La Jolla, CA, USAView further author information
&
Gerry R. Bossa Department of Medicine, University of California, San Diego, La Jolla, CA, USACorrespondence[email protected]
View further author information
 show all
Pages 332-341 | Received 09 Apr 2021, Accepted 03 Jul 2021, Published online: 30 Jul 2021

References

  • Cyanide: understanding the risk, enhancing preparedness. Clin Toxicol. 2006;44 (Suppl 1):47–63.
  • Cummings TF. The treatment of cyanide poisoning. Occup Med. 2004;54(2):82–85.
  • Kelly DP, Chambers LA, Trudinger PA. Cyanolysis and spectrophotometric estimation of trithionate in mixture with thiosulfate and tetrathionate. Anal Chem. 1969;41(7):898–901.
  • Baskin SI, Kirby SD. The effect of sodium tetrathionate on cyanide conversion to thiocyanate by enzymatic and non-enzymatic mechanisms. J Appl Toxicol. 1990;10(5):379–382.
  • Hebting J. Versuche überentgiftung der Blausäure durch schwefelabspaltende substanzen. Biochem Zeitschrift. 1910;28:208–212.
  • Binet L, Wellers G, Dubrisay J. [Value and mechanism of the antidote action of sodium tetrathionate in hydrocyanic poisoning. Presse Med. 1951;59(32):641–643. ].
  • Nitescu II, Craiu R, Wassermann N. Cyanides and anticyanides. The action of sodium tetrathionate as an antidote in hydrocyanic poisoning. Rum Med Rev. 1961;5:203–204.
  • Chen KK, Rose CL, Clowes GHA. Comparative values of several antidotes in cyanide poisoning. Am J Med Sci. 1937;188:767–781.
  • Chistoni A, Foresti B. L'antidotismo del tetrationato sodico nelle intossicazioni da acido cianidrico. Arch Internat de Pharmacod. 1932;42:140–171.
  • Hatch RC, Laflamme DP, Jain AV. Effects of various known and potential cyanide antagonists and a glutathione depletor on acute toxicity of cyanide in mice. Vet Hum Toxicol. 1990;32:9–16.
  • Gilman A, Philips FS. The metabolic reduction and nephrotoxic action of tetrathionate in relation to a possible interaction with sulfhydryl compounds. Am J Physiol. 1946;147:115–126.
  • Hendry-Hofer TB, Witeof AE, Ng PC, et al. Intramuscular sodium tetrathionate as an antidote in a clinically relevant swine model of acute cyanide toxicity. Clin Toxicol. 2020;58(1):29–35.
  • Tansy MF, Kendall FM, Fantasia J, et al. Acute and subchronic toxicity studies of rats exposed to vapors of methyl mercaptan and other reduced-sulfur compounds. J Toxicol Environ Health. 1981;8(1–2):71–88.
  • Fairchild EJ, Stokinger HE. Toxicologic studies on organic sulfur compounds. I. Acute toxicity of some aliphatic and aromatic thiols (mercaptans). Am Ind Hyg Assoc J. 1958;19(3):171–189.
  • Wilms J, Lub J, Wever R. Reactions of mercaptans with cytochrome c oxidase and cytochrome c. Biochim Biophys Acta. 1980;589(2):324–335.
  • Waller RL. Methanethiol inhibition of mitochondrial respiration. Toxicol Appl Pharmacol. 1977;42(1):111–117.
  • Kangas J, Jappinen P, Savolainen H. Exposure to hydrogen sulfide, mercaptans and sulfur dioxide in pulp industry. Am Ind Hyg Assoc J. 1984;45(12):787–790.
  • Occupational safety and health guideline for methyl mercaptan. Washington, D.C.: US Department of Health and Human Services National Institute for Occupational Safety and Health Division of Standards Development and Technology Transfer; 1988. p. 1–6.
  • Toxicological profile for methyl mercaptan. Atlanta, GA: Agency for Toxic Substances and Disease Registry US Public Health Service; 1982. p. 1–62.
  • Widener A. Four killed at DuPont plant. Chem Eng News. 2014;92:4. Available from: https://cen.acs.org/articles/92/i47/Four-killed-DuPont-plant.html
  • Atofina settlement. Miosha News. 2002;6:1–18. Available from: https://www.michigan.gov/documents/CIS_WSH_minwssm02_59600_7.pdf
  • Brenner M, Kim JG, Mahon SB, et al. Intramuscular cobinamide sulfite in a rabbit model of sublethal cyanide toxicity. Ann Emerg Med. 2010;55(4):352–362.
  • Chan A, Jiang J, Fridman A, et al. Nitrocobinamide, a new cyanide antidote that can be administered by intramuscular injection. J Med Chem. 2015;58(4):1750–1759.
  • Bebarta VS, Brittain M, Chan A, et al. Sodium nitrite and sodium thiosulfate are effective against acute cyamide poisoning when administered by intramuscular injection. Ann Emerg Med. 2017;69(6):718–725.
  • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem. 1976;72:248–254.
  • Dutta S, Sengupta P. Men and mice: relating their ages. Life Sci. 2016;152:244–248.
  • US Department of Health and Human Services F. Product development under the animal rule. Washington, D.C.: Guidance for Industry; 2014. p. 1–48.
  • Bloom N, Forbes G, Policoff L. Toxicity of sodium tetrathionate. Proc Soc Exp Biol Med. 1949;72(1):207–209.
  • Sloan H. Production of experimental uremia by sodium tetrathionate. Proc Soc Exp Biol Med. 1951;76(2):344–346.
  • MacMillan VH. Cerebral energy metabolism in cyanide encephalopathy. J Cereb Blood Flow Metab. 1989;9(2):156–162.
  • Hendry-Hofer TB, Ng PC, McGrath AM, et al. Intramuscular cobinamide as an antidote to methyl mercaptan poisoning. Inhal Toxicol. 2021;33(1):25–32.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.