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Clinical Toxicology Volume 60, 2022 - Issue 3
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Variability in insulin pharmacokinetics following high-dose insulin therapy

Darren M. Robertsa Drug Health Services, Royal Prince Alfred Hospital, Camperdown, NSW, Australia;b Department of Clinical Pharmacology and Toxicology, St Vincent’s Hospital, Darlinghurst, NSW, Australia;c St Vincent’s Clinical School, University of New South Wales, Darlinghurst, NSW, AustraliaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-9101-7577
ORCID Icon,
Haddijatou K. Hughesa Drug Health Services, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
,
Paul S. Habera Drug Health Services, Royal Prince Alfred Hospital, Camperdown, NSW, Australia;d Central Clinical School, University of Sydney, Camperdown, NSW, AustraliaORCID Iconhttps://orcid.org/0000-0001-8915-8872
ORCID Icon &
Graham R. D. Jonesc St Vincent’s Clinical School, University of New South Wales, Darlinghurst, NSW, Australia;e Chemical Pathology, SydPath, St Vincent’s Hospital, Darlinghurst, NSW, AustraliaORCID Iconhttps://orcid.org/0000-0001-9109-7255
ORCID Icon
Pages 389-391 | Received 14 Apr 2021, Accepted 07 Aug 2021, Published online: 15 Sep 2021

References

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  • Holger JS, Stellpflug SJ, Cole JB, et al. High-dose insulin: a consecutive case series in toxin-induced cardiogenic shock. Clin Toxicol. 2011;49(7):653–658.
  • Corcoran JN, Jacoby KJ, Olives TD, et al. Persistent hyperinsulinemia following high-dose insulin therapy: a case report. J Med Toxicol. 2020;16(4):465–469.
  • Duckworth WC, Bennett RG, Hamel FG. Insulin degradation: progress and potential. Endocr Rev. 1998;19(5):608–624.
  • Mégarbane B, Deye N, Bloch V, et al. Intentional overdose with insulin: prognostic factors and toxicokinetic/toxicodynamic profiles. Crit Care. 2007;11(5):R115.
  • Parfitt C, Church D, Armston A, et al. Commercial insulin immunoassays fail to detect commonly prescribed insulin analogues. Clin Biochem. 2015;48(18):1354–1357.
  • Gawedzki P, Paloucek FP. Additional considerations for persistent hyperinsulinemia. J Med Toxicol. 2021;17(2):233–234.
  • Corcoran JN, Jacoby KJ, Olives TD, et al. In reply: "on insulin kinetics following high-dose insulin therapy, and when to stop therapy". J Med Toxicol. 2021;17(2):235–236.

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