461
Views
1
CrossRef citations to date
0
Altmetric
Basic Research

In vitro analysis of n-acetylcysteine (NAC) interference with the international normalized ratio (INR)

ORCID Icon, ORCID Icon, , , &
Pages 489-492 | Received 08 Jun 2021, Accepted 31 Aug 2021, Published online: 22 Sep 2021

References

  • Rumack BH. Acetaminophen hepatotoxicity: the first 35 years. J Toxicol Clin Toxicol. 2002;40(1):3–20.
  • Hendrickson RG. What is the most appropriate dose of N-acetylcysteine after massive acetaminophen overdose? Clin Toxicol. 2019;57(8):686–691.
  • Jang DH, Weaver MD, Pizon AF. In vitro study of N-acetylcysteine on coagulation factors in plasma samples from healthy subjects. J Med Toxicol. 2013;9(1):49–53.
  • Pizon AF, Jang DH, Wang HE. The in vitro effect of N‐acetylcysteine on prothrombin time in plasma samples from healthy subjects. Acad Emerg Med. 2011;18(4):351–354.
  • Owens KH, Medlicott NJ, Zacharias M, et al. Population pharmacokinetic-pharmacodynamic modelling to describe the effects of paracetamol and N-acetylcysteine on the international normalized ratio . Clin Exp Pharmacol Physiol. 2015;42(1):102–108.
  • Rumack BH, Bateman DN. Acetaminophen and acetylcysteine dose and duration: past, present and future. Clin Toxicol. 2012;50(2):91–98.
  • O’Grady JG, Alexander GJ, Hayllar KM, et al. Early indicators of prognosis in fulminant hepatic failure. Gastroenterology. 1989;97(2):439–445.
  • Jepsen S, Hansen A. The influence of N-acetylcysteine on the measurement of prothrombin time and activated partial thromboplastin time in healthy subjects. Scand J Clin Lab Invest. 1994;54(7):543–547.
  • Schmidt LE, Knudsen TT, Dalhoff K, et al. Effect of acetylcysteine on prothrombin index in paracetamol poisoning without hepatocellular injury. The Lancet. 2002;360(9340):1151–1152.
  • Prescott L, Donovan J, Jarvie D, et al. The disposition and kinetics of intravenous N-acetylcysteine in patients with paracetamol overdosage. Eur J Clin Pharmacol. 1989;37(5):501–506.
  • Koterba AP, Smolen S, Joseph A, et al. Coagulation protein function. II. Influence of thiols upon acetaldehyde effects. Alcohol. 1995;12(1):49–57.
  • Lee WM, Stravitz RT, Larson AM. Introduction to the revised american association for the study of liver diseases position paper on acute liver failure 2011. Hepatology. 2012;55(3):965–967.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.