Advanced search
Publication Cover
Clinical Toxicology Volume 60, 2022 - Issue 4
Submit an article Journal homepage
1,700
Views
2
CrossRef citations to date
0
Altmetric
Clinical Research

Fomepizole dosing during continuous renal replacement therapy – an observational study

Yvonne E. Laoa Norwegian National Unit for CBRNE Medicine, Department of Acute Medicine, Oslo University Hospital, Oslo, NorwayCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-2744-6390
ORCID Icon,
Trond Vartdalb Department of Internal Medicine, Baerum Hospital, Gjettum, Norway
,
Sten Froeyshovc Department of Acute Medicine, Oslo University Hospital, Oslo, Norway
,
Brian Latimerd Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA, USA
,
Christiane Kvaernere Department of Pulmonary Medicine, Akershus University Hospital, Nordbyhagen, Norway
,
Marija Mataricf Department of Anesthesiology and Intensive Care Medicine, Levanger Hospital, Levanger, Norway
,
Peter Holmg Intensive Care Unit, Ostfold Hospital Kalnes, Graalum, Norway
,
Siri Foreidh Departement of Pharmacology, Oslo University Hospital, Oslo, Norway
,
Dag Jacobsenc Department of Acute Medicine, Oslo University Hospital, Oslo, Norway;i Institute for Clinical Medicine, University of Oslo, Oslo, Norway
,
Kenneth McMartind Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA, USA
&
Knut Erik Hovdaa Norwegian National Unit for CBRNE Medicine, Department of Acute Medicine, Oslo University Hospital, Oslo, Norway
 show all
Pages 451-457 | Received 12 Aug 2021, Accepted 09 Sep 2021, Published online: 29 Sep 2021

References

  • Rostrup M, Edwards JK, Abukalish M, et al. The methanol poisoning outbreaks in Libya 2013 and Kenya 2014. PLoS One. 2016;11(3):e0152676.
  • Hassanian-Moghaddam H, Zamani N, Kolahi AA, et al. Double trouble: methanol outbreak in the wake of the COVID-19 pandemic in Iran-a cross-sectional assessment. Crit Care. 2020;24(1):402.
  • Karlson-Stiber C, Persson H. Ethylene glycol poisoning: experiences from an epidemic in Sweden. J Toxicol Clin Toxicol. 1992;30(4):565–574.
  • Hovda KE, Julsrud J, Øvreb ØS, et al. Studies on ethylene glycol poisoning: one patient – 154 admissions. Clin Toxicol. 2011;49(6):478–484.
  • McMartin K, Jacobsen D, Hovda KE. Antidotes for poisoning by alcohols that form toxic metabolites. Br J Clin Pharmacol. 2016;81(3):505–515.
  • McMartin KE, Hedstrom KG, Tolf BR, et al. Studies on the metabolic interactions between 4-methylpyrazole and methanol using the monkey as an animal model. Arch Biochem Biophys. 1980;199(2):606–614.
  • McMartin KE, Makar AB, Martin G, et al. Methanol poisoning. I. The role of formic acid in the development of metabolic acidosis in the monkey and the reversal by 4-methylpyrazole. Biochem Med. 1975;13(4):319–333.
  • Kraut JA, Mullins ME. Toxic alcohols. N Engl J Med. 2018;378(3):270–280.
  • Zakharov S, Pelclova D, Navratil T, et al. Intermittent hemodialysis is superior to continuous veno-venous hemodialysis/hemodiafiltration to eliminate methanol and formate during treatment for methanol poisoning. Kidney Int. 2014;86(1):199–207.
  • Zakharov S, Pelclova D, Navratil T, et al. Efficiency of acidemia correction on intermittent versus continuous hemodialysis in acute methanol poisoning. Clin Toxicol. 2017;55(2):123–132.
  • Zakharov S, Rulisek J, Nurieva O, et al. Intermittent versus continuous renal replacement therapy in acute methanol poisoning: comparison of clinical effectiveness in mass poisoning outbreaks. Ann Intensive Care. 2017;7(1):1–11.
  • Jobard E, Harry P, Turcant A, et al. 4-Methylpyrazole and hemodialysis in ethylene glycol poisoning. J Toxicol Clin Toxicol. 1996;34(4):373–377.
  • Faessel H, Houze P, Baud FJ, et al. 4-Methylpyrazole monitoring during haemodialysis of ethylene glycol intoxicated patients. Eur J Clin Pharmacol. 1995;49(3):211–213.
  • Brent J. Fomepizole for ethylene glycol and methanol poisoning. N Engl J Med. 2009;360(21):2216–2223.
  • McMartin KE, Sebastian CS, Dies D, et al. Kinetics and metabolism of fomepizole in healthy humans. Clin Toxicol. 2012;50(5):375–383.
  • Mueller BA, Golper TA. Drug removal in continuous renal replacement therapy. UpToDate [Internet]. [cited 2020 Apr 29]. Available from: https://www.uptodate.com/contents/drug-removal-in-continuous-renal-replacement-therapy?csi=d48f8ef3-4790-4017-9dd5-e3879a637157&source=contentShare.
  • Bugge JF. Pharmacokinetics and drug dosing adjustments during continuous venovenous hemofiltration or hemodiafiltration in critically ill patients. Acta Anaesthesiol Scand. 2001;45(8):929–934.
  • Wu D, Cederbaum AI. Induction of liver cytochrome P4502E1 by pyrazole and 4-methylpyrazole in neonatal rats. J Pharmacol Exp Ther. 1993;264(3):1468–1473.
  • Feierman DE, Cederbaum AI. Oxidation of the alcohol dehydrogenase inhibitor pyrazole to 4-hydroxypyrazole by microsomes. Effect of cytochrome P-450 inducing agents. Drug Metab Dispos. 1987;15(5):634–639.
  • Jacobsen D, Sebastian CS, Barron SK, et al. Effects of 4-methylpyrazole, methanol/ethylene glycol antidote, in healthy humans. J Emerg Med. 1990;8(4):455–461.
  • Brent J, McMartin K, Phillips S, et al. Fomepizole for the treatment of ethylene glycol poisoning. Methylpyrazole for toxic alcohols study group. N Engl J Med. 1999;340(11):832–838.
  • Rasamison R, Besson H, Berleur M-P, et al. Analysis of fomepizole safety based on a 16-year post-marketing experience in France. Clin Toxicol. 2020;58(7):742–747.
  • Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Workgroup. KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl. 2012;2(2):1–138.
  • Schetz M, Ferdinande P, Van Den Berghe G, et al. Pharmacokinetics of continuous renal replacement therapy. Intensive Care Med. 1995;21(7):612–620.
  • Mayersohn M, Owens SM, Anaya AL, et al. 4-Methylpyrazole disposition in the dog: evidence for saturable elimination. J Pharm Sci. 1985;74(8):895–896.
  • McMartin KE, Collins TD. Distribution of oral 4-methylpyrazole in the rat: inhibition of elimination by ethanol. J Toxicol Clin Toxicol. 1988;26(7):451–466.
  • Wallemacq PE, Vanbinst R, Haufroid V, et al. Plasma and tissue determination of 4-methylpyrazole for pharmacokinetic analysis in acute adult and pediatric methanol/ethylene glycol poisoning. Ther Drug Monit. 2004;26(3):258–262.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.