Efficacy of lipid emulsion therapy in treating cardiotoxicity from diphenhydramine ingestion: a review and analysis of case reports

References

• Simons FER, Simons KJ. Histamine and H1-antihistamines: celebrating a century of progress. J Allergy Clin Immunol. 2011;128(6):1139–1150.
   PubMed Web of Science ®Google Scholar
• Gummin DD, Mowry JB, Spyker DA, et al. 2016 Annual report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 34th Annual Report. Clin Toxicol (Phila). 2017;55(10):1072–1254.
   PubMed Web of Science ®Google Scholar
• Jang DH, Manini AF, Trueger NS, et al. Status epilepticus and wide-complex tachycardia secondary to diphenhydramine overdose. Clin Toxicol (Phila). 2010;48(9):945–948.
   PubMed Web of Science ®Google Scholar
• Kim YS, Shin YK, Lee C-S, et al. Block of sodium currents in rat dorsal root ganglion neurons by diphenhydramine. Brain Res. 2000;881(2):190–198.
   PubMed Web of Science ®Google Scholar
• Suessbrich H, Waldegger S, Lang F, et al. Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole. FEBS Lett. 1996;385(1–2):77–80.
   PubMed Web of Science ®Google Scholar
• Sirianni AJ, Osterhoudt KC, Calello DP, et al. Use of lipid emulsion in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and lamotrigine. Ann Emerg Med. 2008;51(4):412–415.
   PubMed Web of Science ®Google Scholar
• Finn SDH, Uncles DR, Willers J, et al. Early treatment of a quetiapine and sertraline overdose with Intralipid®. Anaesthesia. 2009;64(2):191–194.
   PubMed Web of Science ®Google Scholar
• French D, Armenian P, Ruan W, et al. Serum verapamil concentrations before and after Intralipid® therapy during treatment of an overdose. Clin Toxicol (Phila). 2011;49(4):340–344.
   PubMed Web of Science ®Google Scholar
• Brumfield E, Bernard KRL, Kabrhel C. Life-threatening flecainide overdose treated with intralipid and extracorporeal membrane oxygenation. Am J Emerg Med. 2015;33:1840–18e3.
   PubMed Web of Science ®Google Scholar
• Abdelmalek D, Schwarz ES, Sampson C, et al. Life-threatening diphenhydramine toxicity presenting with seizures and a wide complex tachycardia improved with intravenous fat emulsion. Am J Ther. 2014;21(6):542–544.
   PubMed Web of Science ®Google Scholar
• Yu JH, Chen DY, Chen HY, et al. Intravenous lipid-emulsion therapy in a patient with cardiac arrest after overdose of diphenhydramine. J Formos Med Assoc. 2016;115(11):1017–1018.
   PubMed Web of Science ®Google Scholar
• Abdi A, Rose E, Levine M. Diphenhydramine overdose with intraventricular conduction delay treated with hypertonic sodium bicarbonate and IV lipid emulsion. West J Emerg Med. 2014;15(7):855–858.
   PubMedGoogle Scholar
• Li K, Gugelmann H, Tabas JA. Young woman with seizures. Ann Emerg Med. 2015;66:363.
   PubMed Web of Science ®Google Scholar
• Cherukuri SV, Purvis AW, Tosto ST, et al. IV lipid emulsion infusion in the treatment of severe diphenhydramine overdose. Am J Case Rep. 2019;20:758–763.
   PubMed Web of Science ®Google Scholar
• Varney SM, Bebarta VS, Boudreau SM, et al. Intravenous lipid emulsion therapy for severe diphenhydramine toxicity: a randomized, controlled pilot study in a swine model. Ann Emerg Med. 2016;67(2):196–205.e3. [cited 2021 Apr 27]. Available from: https://pubmed.ncbi.nlm.nih.gov/26164644/.
   PubMed Web of Science ®Google Scholar
• American College of Medical Toxicology. ACMT position statement: guidance for the use of intravenous lipid emulsion. J Med Toxicol. 2017. 13:124–125.
   PubMed Web of Science ®Google Scholar
• Clemons J, Jandu A, Stein B, et al. Early intravenous lipid emulsion therapy for diphenhydramine overdose: a case report. Toxicol Commun. 2021;5(1):15–18.
   Google Scholar
• Nishino T, Wakai S, Aoki H, et al. Cardiac arrest caused by diphenhydramine overdose. Acute Med Surg. 2018;5(4):380–383.
   PubMed Web of Science ®Google Scholar
• Labarinas S, Meulmester K, Greene S, et al. Extracorporeal cardiopulmonary resuscitation after diphenhydramine ingestion. J Med Toxicol. 2018;14(3):253–256.
   PubMed Web of Science ®Google Scholar
• Mullins ME, Pinnick RV, Terhes JM. Life-threatening diphenhydramine overdose treated with charcoal hemoperfusion and hemodialysis. Ann Emerg Med. 1999;33(1):104–107.
   PubMed Web of Science ®Google Scholar
• Sharma AN, Hexdall AH, Chang EK, et al. Diphenhydramine-induced wide complex dysrhythmia responds to treatment with sodium bicarbonate. Am J Emerg Med. 2003;21(3):212–215.
   PubMed Web of Science ®Google Scholar
• Rinder CS, D’Amato SL, Rinder HM, et al. Survival in complicated diphenhydramine overdose. Crit Care Med. 1988;16(11):1161–1162.
   PubMed Web of Science ®Google Scholar
• Thakur AC, Aslam AK, Aslam AF, et al. QT interval prolongation in diphenhydramine toxicity. Int J Cardiol. 2005;98(2):341–343.
   PubMed Web of Science ®Google Scholar
• Husain Z, Hussain K, Nair R, et al. Diphenhydramine induced QT prolongation and torsade de pointes: an uncommon effect of a common drug. Cardiol J. 2010;17(5):509–511.
   PubMed Web of Science ®Google Scholar
• Joshi AK, Sljapic T, Borghei H, et al. Case of polymorphic ventricular tachycardia in diphenhydramine poisoning. J Cardiovasc Electrophysiol. 2004;15(5):591–593.
   PubMed Web of Science ®Google Scholar
• Tanaka T, Takasu A, Yoshino A, et al. Diphenhydramine overdose mimicking serotonin syndrome. Psychiatry Clin Neurosci. 2011;65(5):534.
   PubMed Web of Science ®Google Scholar
• Padilla RB, Pollack ML. The use of physostigmine in diphenhydramine overdose. Am J Emerg Med. 2002;20(6):569–570.
   PubMed Web of Science ®Google Scholar
• Clark RF, Vance MV. Massive diphenhydramine poisoning resulting in a wide-complex tachycardia: Successful treatment with sodium bicarbonate. Ann Emerg Med. 1992;21(3):318–321.
   PubMed Web of Science ®Google Scholar
• López-Barbeito B, Lluis M, Delgado V, et al. Diphenhydramine overdose and brugada sign. Pacing Clin Electrophysiol. 2005;28(7):730–732.
   PubMed Web of Science ®Google Scholar
• Jeffery AD, Lytle-Saddler T. Diphenhydramine overdose in a 26-year-old woman. J Emerg Nurs. 2008;34(6):543–544.
   PubMed Web of Science ®Google Scholar
• Mercado P, Weinberg GL. Local anesthetic systemic toxicity: prevention and treatment. Anesthesiol Clin. 2011;29(2):233–242.
   PubMedGoogle Scholar
• Gosselin S, Hoegberg LCG, Hoffman RS, et al. Evidence-based recommendations on the use of intravenous lipid emulsion therapy in poisoning. Clin Toxicol (Phila). 2016;54(10):899–923.
   PubMed Web of Science ®Google Scholar