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Clinical Research

The serum glycolate concentration: its prognostic value and its correlation to surrogate markers in ethylene glycol exposures

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Pages 798-807 | Received 29 Sep 2021, Accepted 01 Mar 2022, Published online: 24 Mar 2022

References

  • Gummin DD, Mowry JB, Beuhler MC, et al. 2019 Annual report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 37th annual report. Clin Toxicol. 2020;58(12):1360–1541.
  • Mardini J, Lavergne V, Roberts D, et al. Case reports of extracorporeal treatments in poisoning: historical trends. Semin Dial. 2014;27(4):402–406.
  • Ghannoum M, Lavergne V, Gosselin S, et al. Practice trends in the use of extracorporeal treatments for poisoning in four countries. Semin Dial. 2016;29(1):71–80.
  • Jacobsen D, Ovrebo S, Ostborg J, et al. Glycolate causes the acidosis in ethylene glycol poisoning and is effectively removed by hemodialysis. Acta Med Scand. 1984;216(4):409–416.
  • Clay KL, Murphy RC. On the metabolic acidosis of ethylene glycol intoxication. Toxicol Appl Pharmacol. 1977;39(1):39–49.
  • Brent J, McMartin K, Phillips S, et al. Fomepizole for the treatment of ethylene glycol poisoning. Methylpyrazole for toxic alcohols study group. N Engl J Med. 1999;340(11):832–838.
  • Porter WH. Ethylene glycol poisoning: quintessential clinical toxicology; analytical conundrum. Clin Chim Acta. 2012;413(3–4):365–377.
  • Tuero G, Gonzalez J, Sahuquillo L, et al. Value of glycolic acid analysis in ethylene glycol poisoning: a clinical case report and systematic review of the literature. Forensic Sci Int. 2018;290:e9–e14.
  • Perier C, Frey J, Auboyer C, et al. Accumulation of glycolic acid and glyoxylic acid in serum in cases of transient hyperglycinemia after transurethral surgery. Clin Chem. 1988;34(7):1471–1473.
  • Corey HE. Stewart and beyond: new models of acid-base balance. Kidney Int. 2003;64(3):777–787.
  • Gomez H, Kellum JA. Understanding acid base disorders. Crit Care Clin. 2015;31(4):849–860.
  • Aouizerate P, Dume L, Astier A. Simultaneous determination of ethylene glycol and its metabolites in acute poisoning [French]. Journal de Pharmacie Clinique. 1999;18:321–324.
  • Lopez A, Ceppa F, Graine H, et al. Intoxication by ethylene glycol. Ann Biol Clin. 2001;59(5):655–659.
  • Viinamaki J, Sajantila A, Ojanpera I. Ethylene glycol and metabolite concentrations in fatal ethylene glycol poisonings. J Anal Toxicol. 2015;39(6):481–485.
  • Bowen DA, Minty PS, Sengupta A. Two fatal cases of ethylene glycol poisoning. Med Sci Law. 1978;18(2):101–107.
  • Rosano TG, Swift TA, Kranick CJ, et al. Ethylene glycol and glycolic acid in postmortem blood from fatal poisonings. J Anal Toxicol. 2009;33(8):508–513.
  • Hayden JA, Cote P, Bombardier C. Evaluation of the quality of prognosis studies in systematic reviews. Ann Intern Med. 2006;144(6):427–437.
  • Gabow PA, Clay K, Sullivan JB, et al. Organic acids in ethylene glycol intoxication. Ann Intern Med. 1986;105(1):16–20.
  • Hewlett TP, McMartin KE, Lauro AJ, et al. Ethylene glycol poisoning. The value of glycolic acid determinations for diagnosis and treatment. J Toxicol Clin Toxicol. 1986;24(5):389–402.
  • Jacobsen D, Hewlett TP, Webb R, et al. Ethylene glycol intoxication: evaluation of kinetics and crystalluria. Am J Med. 1988;84(1):145–152.
  • Ullman B, Malmlund HO, Berg A. Treatment of various stages of ethylene glycol poisoning. Lakartidningen. 1989;86(13):1183–1185.
  • Aarstad K, Dale O, Aakervik O, et al. A rapid gas chromatographic method for determination of ethylene glycol in serum and urine. J Anal Toxicol. 1993;17(4):218–221.
  • Fraser AD, MacNeil W. Colorimetric and gas chromatographic procedures for glycolic acid in serum: the major toxic metabolite of ethylene glycol. J Toxicol Clin Toxicol. 1993;31(3):397–405.
  • Christiansson LK, Kaspersson KE, Kulling PE, et al. Treatment of severe ethylene glycol intoxication with continuous arteriovenous hemofiltration dialysis. J Toxicol Clin Toxicol. 1995;33(3):267–270.
  • Yao HH, Porter WH. Simultaneous determination of ethylene glycol and its major toxic metabolite, glycolic acid, in serum by gas chromatography. Clin Chem. 1996;42(2):292–297.
  • Kowalczyk M, Halvorsen S, Ovrebo S, et al. Ethanol treatment in ethylene glycol poisoned patients. Vet Hum Toxicol. 1998;40(4):225–228.
  • Wahl A, Azaroual N, Imbenotte M, et al. Poisoning with methanol and ethylene glycol:1H NMR spectroscopy as an effective clinical tool for diagnosis and quantification. Toxicology. 1998;128(1):73–81.
  • Porter WH, Rutter PW, Bush BA, et al. Ethylene glycol toxicity: the role of serum glycolic acid in hemodialysis. J Toxicol Clin Toxicol. 2001;39(6):607–615.
  • Fraser AD. Clinical toxicologic implications of ethylene glycol and glycolic acid poisoning. Ther Drug Monit. 2002;24(2):232–238.
  • Pien K, van Vlem B, van Coster R, et al. An inherited metabolic disorder presenting as ethylene glycol intoxication in a young adult. Am J Forensic Med Pathol. 2002;23:96–100.
  • Carstens J, Csanady GA, Faller TH, et al. Human inhalation exposure to ethylene glycol. Arch Toxicol. 2003;77(8):425–432.
  • Woo MY, Greenway DC, Nadler SP, et al. Artifactual elevation of lactate in ethylene glycol poisoning. J Emerg Med. 2003;25(3):289–293.
  • Youssef GM, Hirsch DJ. Validation of a method to predict required dialysis time for cases of methanol and ethylene glycol poisoning. Am J Kidney Dis. 2005;46(3):509–511.
  • Lovric M, Granic P, Cubrilo-Turek M, et al. Ethylene glycol poisoning. Forensic Sci Int. 2007;170:213–215.
  • Schorn R, Kalicki R, Remschmidt C, et al. Sweet and sour – a patient with life-threatening metabolic acidosis and acute renal failure. NDT Plus. 2008;1:433–436.
  • Holland MG, Stork CM, Hodgman MJ, et al. Elevated glycolate levels after unintentional pediatric ethylene glycol ingestion. Clin Toxicol. 2009;47:737–738.
  • Manini AF, Hoffman RS, McMartin KE, et al. Relationship between serum glycolate and falsely elevated lactate in severe ethylene glycol poisoning. J Anal Toxicol. 2009;33(3):174–176.
  • Murphy N, Keefe L, Magee K, et al. Methemoglobinemia from radiator antifreeze ingestion: toxicity from an additive. Clin Toxicol. 2009;47(7):759.
  • Meng QH, Adeli K, Zello GA, et al. Elevated lactate in ethylene glycol poisoning: true or false? Clin Chim Acta. 2010;411(7–8):601–604.
  • Hovda KE, Julsrud J, Ovrebo S, et al. Studies on ethylene glycol poisoning: one patient – 154 admissions. Clin Toxicol. 2011;49(6):478–484.
  • Latus J, Kimmel M, Alscher MD, et al. Ethylene glycol poisoning: a rare but life-threatening cause of metabolic acidosis-a single-centre experience. Clin Kidney J. 2012;5(2):120–123.
  • Hlozek T, Bursova M, Cabala R. Fast determination of ethylene glycol, 1,2-propylene glycol and glycolic acid in blood serum and urine for emergency and clinical toxicology by GC-FID. Talanta. 2014;130:470–474.
  • Hlozek T, Bursova M, Coufal P, et al. Identification and quantification of acidosis inducing metabolites in cases of alcohols intoxication by GC-MS for emergency toxicology. J Pharm Biomed Anal. 2015;114:16–21.
  • Sugunaraj JP, Thakur LK, Jha KK, et al. Sequential episodes of ethylene glycol poisoning in the same person. BMJ Case Reports. 2017;2017:bcr-2017-220108.
  • Porter WH. Personal case file. 2021.
  • Hovda KE, Hunderi OH, Ovrebo S, et al. Diagnosis in metabolic acidosis of unknown origin. Tidsskr nor Laegeforen. 2004;124(24):3203–3205.
  • Savitz D, Solomon AK. Tracer determinations of human red cell membrane permeability to small nonelectrolytes. J Gen Physiol. 1971;58(3):259–266.
  • Iliuta IA, Lachance P, Ghannoum M, et al. Prediction and validation of the duration of hemodialysis sessions for the treatment of acute ethylene glycol poisoning. Kidney Int. 2017;92(2):453–460.
  • Coulter CV, Farquhar SE, McSherry CM, et al. Methanol and ethylene glycol acute poisonings – predictors of mortality. Clin Toxicol. 2011;49(10):900–906.
  • Roth B, Forrester M, Labat L. Correlation of the surrogate markers of anion gap, osmolar gap, and drowsiness to outcome in a large case series of ethylene glycol exposures. Clin Toxicol. 2008;46:599.
  • Puka J, Szajewski J. Acute ethylene glycol poisoning–205 cases treated at the acute poison control center. Pol Arch Med Wewn. 1988;80(2–3):88–98.
  • Hylander B, Kjellstrand CM. Prognostic factors and treatment of severe ethylene glycol intoxication. Intensive Care Med. 1996;22(6):546–552.
  • Czyewska S, Winnicka R, Rzepecki J, et al. [Acute ethylene glycol poisoning among patients of Nofer institute of occupational medicine in Lodz, toxicology unit, hospitalized in the years 2000-2009]. Przegl Lek. 2013;70(8):500–505.
  • Lung DD, Kearney TE, Brasiel JA, et al. Predictors of death and prolonged renal insufficiency in ethylene glycol poisoning. J Intensive Care Med. 2015;30(5):270–277.
  • Grigorasi G, Nistor I, Corlade-Andrei M, et al. Analysis of prognostic factors for survival in a large cohort of ethylene glycol intoxication cases. Nephrol Dial Transplant. 2018;33(suppl_1):i50–i1.
  • Karlson-Stiber C, Persson H. Ethylene glycol poisoning: experiences from an epidemic in Sweden. J Toxicol Clin Toxicol. 1992;30(4):565–574.
  • Krenova M, Pelclova D. Analysis of the renal damage following ethylene glycol poisoning. Clin Toxicol. 2006;44:565–566.
  • Thanacoody RH, Gilfillan C, Bradberry SM, et al. Management of poisoning with ethylene glycol and methanol in the UK: a prospective study conducted by the national poisons information service (NPIS). Clinical Toxicology. 2016;54(2):134–140.
  • Sabeel AI, Kurkus J, Lindholm T. Intensified dialysis treatment of ethylene glycol intoxication. Scand J Urol Nephrol. 1995;29(2):125–129.
  • Stankova E, Gesheva M, Mechkarska B. Early haemodyalysis in acute ethylene glycol poisonings? Clin Toxicol. 2008;46:418.
  • Rzepecki J, Stasiak M, Kolacinski Z. [Clinical symptomatology and laboratory diagnosis of 75 cases of ethylene glycol poisonings]. Pol Merkuriusz Lek. 1998;5:74–79.
  • Kraut JA, Mullins ME. Toxic alcohols. N Engl J Med. 2018;378(3):270–280.
  • Sagar AS, Jimenez CA, McKelvy BJ. Lactate gap as a tool in identifying ethylene glycol poisoning. BMJ Case Rep. 2018. DOI:https://doi.org/10.1136/bcr-2018-224243
  • Brindley PG. Ethylene glycol poisoning and why respiratory therapists should always "mind the gap. Can J Respir Ther. 2010;46:29–32.
  • Verelst S, Vermeersch P, Desmet K. Ethylene glycol poisoning presenting with a falsely elevated lactate level. Clin Toxicol. 2009;47(3):236–238.
  • Soghoian S, Sinert R, Wiener SW, et al. Ethylene glycol toxicity presenting with non-anion gap metabolic acidosis. Basic Clin Pharmacol Toxicol. 2009;104(1):22–26.
  • Heckerling PS. Ethylene glycol poisoning with a normal anion gap due to occult bromide intoxication. Ann Emerg Med. 1987;16(12):1384–1386.
  • Leon M, Graeber C. Absence of high anion gap metabolic acidosis in severe ethylene glycol poisoning: a potential effect of simultaneous lithium carbonate ingestion. Am J Kidney Dis. 1994;23(2):313–316.
  • Moreau CL, Kerns W, 2nd, Tomaszewski CA, et al. Glycolate kinetics and hemodialysis clearance in ethylene glycol poisoning. META study group. J Toxicol Clin Toxicol. 1998;36(7):659–666.

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