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Review

Xylazine poisoning: a systematic review

, , , , ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & show all
Pages 892-901 | Received 10 Dec 2021, Accepted 01 Apr 2022, Published online: 20 Apr 2022

References

  • Greene S, Thurmon J. Xylazine-a review of its pharmacology and use in veterinary medicine. J Vet Pharmacol Ther. 1988;11(4):295–313.
  • Ruiz-Colón K, Chavez-Arias C, Díaz-Alcalá J, et al. Xylazine intoxication in humans and its importance as an emerging adulterant in abused drugs: a comprehensive review of the literature. Forensic Sci Int. 2014;240:1–8.
  • Thangada S, Clinton H, Ali S, et al. Notes from the field: xylazine, a veterinary tranquilizer, identified as an emerging novel substance in drug overdose deaths – Connecticut, 2019–2020. MMWR Morb Mortal Wkly Rep. 2021;70(37):1303–1304.
  • Nunez J, DeJoseph ME, Gill JR. Xylazine, a veterinary tranquilizer, detected in 42 accidental fentanyl intoxication deaths. Am J Forensic Med Pathol. 2021;142(1):9–11.
  • Bowles JM, McDonald K, Maghsoudi N, et al. Xylazine detected in unregulated opioids and drug administration equipment in toronto, Canada: clinical and social implications. Harm Reduct J. 2021;18(1):104.
  • Tobias S, Shapiro A, Wu H, et al. Xylazine identified in the unregulated drug supply in British Columbia, Canada. Can J Addict. 2020;11(3):28–32.
  • Korn W, Stone M, Haviland K, et al. High prevalence of xylazine among fentanyl screen-positive urines from hospitalized patients, philadelphia, 2021. Clin Chim Acta. 2021;521:151–154.
  • Johnson J, Pizzicato L, Johnson C, et al. Increasing presence of xylazine in heroin and/or fentanyl deaths, Philadelphia, Pennsylvania, 2010–2019. Inj Prev. 2021;27(4):395–398.
  • Reyes J, Negrón J, Colón H, et al. The emerging of xylazine as a new drug of abuse and its health consequences among drug users in Puerto Rico. J Urban Health. 2012;89(3):519–526.
  • Drug Enforcement Administration Diversion Control Division: Drug & Chemical Evaluation Section. Xylazine (trade and other names: Rompun®, Sedazine®, AnaSed®). DEA PRB # 2021-15; 2021 [cited 2021 Oct 26]. Available from: https://www.deadiversion.usdoj.gov/drug_chem_info/Xylazine.pdf.
  • Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.
  • The Joanna Briggs Institute. Checklist for case reports; 2017. Available from: https://jbi.global/sites/default/files/2019-05/JBI_Critical_Appraisal-Checklist_for_Case_Reports2017_0.pdf.
  • Andresen-Streichert H, Iwersen-Bergmann S, Mueller A, et al. Attempted drug-facilitated sexual assault-xylazine intoxication in a child. J Forensic Sci. 2017;62(1):270–273.
  • Arican FO, Okan T, Badak O, et al. An unusual presentation from xylazine-ketamine. Vet Hum Toxicol. 2004;46(6):324–325.
  • Capraro AJ, Wiley JF, Tucker JR. Severe intoxication from xylazine inhalation. Pediatr Emerg Care. 2001;17(6):447–448.
  • Carruthers S, Nelson M, Wexler H, et al. Xylazine hydrochloridine (rompun) overdose in man. Clin Toxicol. 1979;15(3):281–285.
  • Elejalde JI, Louis CJ, Elcuaz R, et al. Drug abuse with inhalated xylazine. Eur J Emerg Med. 2003;10(3):252–253.
  • Gallanosa A, Spyker D, Shipe J, et al. Human xylazine overdose: a comparative review with clonidine, phenothiazines, and tricyclic antidepressants. Clin Toxicol. 1981;18(6):663–678.
  • Hoffmann U, Meister C, Golle K, et al. Severe intoxication with the veterinary tranquilizer xylazine in humans. J Anal Toxicol. 2001;25(4):245–249.
  • Liu CM, Chiu MJ, Fang CC, et al. Xylazine abuse: a rare cause of syncope. Clin Toxicol. 2007;45(3):309–311.
  • Meyer GM, Meyer MR, Mischo B, et al. Case report of accidental poisoning with the tranquilizer xylazine and the anesthetic ketamine confirmed by qualitative and quantitative toxicological analysis using GC-MS and LC-MS(n.). Drug Test Anal. 2013;5(9–10):785–789.
  • Poklis A, Mackell MA, Case ME. Xylazine in human tissue and fluids in a case of fatal drug abuse. J Anal Toxicol. 1985;9(5):234–236.
  • Ramon MF, Ballesteros S, Martinez-Arrieta R, et al. Volatile substance and other drug abuse inhalation in Spain. J Toxicol Clin Toxicol. 2003;41(7):931–936.
  • Samanta A, Roffe C, Woods KL. Accidental self administration of xylazine in a veterinary nurse. Postgrad Med J. 1990;66(773):244–245.
  • Stillwell ME. A reported case involving impaired driving following self-administration of xylazine. Forensic Sci Int. 2003;134(1):25–28.
  • Velez LI, Shepherd G, Mills LD, et al. Systemic toxicity after an ocular exposure to xylazine hydrochloride. J Emerg Med. 2006;30(4):407–410.
  • Krongvorakul J, Auparakkitanon S, Trakulsrichai S, et al. Use of xylazine in drug-facilitated crimes. J Forensic Sci. 2018;63(4):1325–1330.
  • Spoerke DG, Hall AH, Grimes MJ, et al. Human overdose with the veterinary tranquilizer xylazine. Am J Emerg Med. 1986;4(3):222–224.
  • Forrester MB. Xylazine exposures reported to Texas poison centers. J Emerg Med. 2016;51(4):389–393.
  • McCloskey K, Vearrier D, Mckeever R, et al. Xylazine intoxication from oral ingestion. Clin Toxicol. 2016;54(8):737.
  • Snow J, Kao L, Williams K. Profound QT prolongation after attempted suicide with intravenous xylazine hydrochloride. Clin Toxicol. 52(7):811.
  • Isbister GK, Heppell SP, Page CB, et al. Adult clonidine overdose: prolonged bradycardia and central nervous system depression, but not severe toxicity. Clin Toxicol. 2017;55(3):187–192.
  • Baumgartner K, Mullins M. M. Pediatric clonidine and guanfacine poisoning: a single-center retrospective review. Toxicol Commun. 2021;5(1):61–65.
  • Seger DL, Loden JK. Naloxone reversal of clonidine toxicity: dose, dose, dose. Clin Toxicol. 2018;56(10):873–879.
  • Lowry JA, Brown JT. Significance of the imidazoline receptors in toxicology. Clin Toxicol. 2014;52(5):454–469.
  • Fyffe JJ. Effects of xylazine on humans: a review. Aust Vet J. 1994;71(9):294–295.
  • Hikasa Y, Masuda K, Asakura Y, et al. Identification and characterization of platelet α2-adrenoceptors and imidazoline receptors in rats, rabbits, cats, dogs, cattle, and horses. Eur J Pharmacol. 2013;720(1-3):363–375.

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