Effects of intravenous lipid emulsions on the reversal of pacing-induced ventricular arrhythmias and electrophysiological alterations in an animal model of ropivacaine toxicity

References

• Dillane D, Finucane BT. Local anesthetic systemic toxicity. Can J Anaesth. 2010;57(4):368–380.
   PubMed Web of Science ®Google Scholar
• Calenda E, Baste JM, Hajjej R, et al. Toxic plasma concentration of ropivacaine after a paravertebral block in a patient suffering from severe hypoalbuminemia. J Clin Anesth. 2014;26(2):149–151.
   PubMedGoogle Scholar
• Petitjeans F, Mion G, Puidupin M, et al. Tachycardia and convulsions induced by accidental intravascular ropivacaine injection during sciatic block. Acta Anaesthesiol Scand. 2002;46(5):616–617.
   PubMedGoogle Scholar
• Chazalon P, Tourtier JP, Villevielle T, et al. Ropivacaine-induced cardiac arrest after peripheral nerve block: successful resuscitation. Anesthesiology. 2003;99(6):1449–1451.
   PubMedGoogle Scholar
• Arlock P. Actions of three local anaesthetics: lidocaine, bupivacaine and ropivacaine on guinea pig papillary muscle sodium channels (vmax). Pharmacol Toxicol. 1988;63(2):96–104.
   PubMedGoogle Scholar
• Groban L, Deal DD, Vernon JC, et al. Ventricular arrhythmias with or without programmed electrical stimulation after incremental overdosage with lidocaine, bupivacaine, levobupivacaine, and ropivacaine. Anesth Analg. 2000;91(5):1103–1111.
   PubMedGoogle Scholar
• Feldman HS, Arthur GR, Covino BG. Comparative systemic toxicity of convulsant and supraconvulsant doses of intravenous ropivacaine, bupivacaine, and lidocaine in the conscious dog. Anesth Analg. 1989;69(6):794–801.
   PubMed Web of Science ®Google Scholar
• Bourne E, Wright C, Royse C. A review of local anesthetic cardiotoxicity and treatment with lipid emulsion. Local Reg Anesth. 2010;3:11–19.
   PubMedGoogle Scholar
• Candela D, Louart G, Bousquet PJ, et al. Reversal of bupivacaine-induced cardiac electrophysiologic changes by two lipid emulsions in anesthetized and mechanically ventilated piglets. Anesth Analg. 2010;110(5):1473–1479. 01
   PubMedGoogle Scholar
• Stehr SN, Ziegeler JC, Pexa A, et al. The effects of lipid infusion on myocardial function and bioenergetics in l-bupivacaine toxicity in the isolated rat heart. Anesth Analg. 2007;104(1):186–192.
   PubMed Web of Science ®Google Scholar
• Fettiplace MR, Weinberg G. The mechanisms underlying lipid resuscitation therapy. Reg Anesth Pain Med. 2018;43(2):138–149.
   PubMed Web of Science ®Google Scholar
• Ok SH, Hong JM, Lee SH, et al. Lipid emulsion for treating local anesthetic systemic toxicity. Int J Med Sci. 2018;15(7):713–722. 14
   PubMed Web of Science ®Google Scholar
• Gosselin S, Hoegberg LC, Hoffman RS, et al. Evidence-based recommendations on the use of intravenous lipid emulsion therapy in poisoning. Clin Toxicol. 2016;54(10):899–923.
   PubMed Web of Science ®Google Scholar
• French D, Smollin C, Ruan W, et al. Partition constant and volume of distribution as predictors of clinical efficacy of lipid rescue for toxicological emergencies. Clin Toxicol. 2011;49(9):801–809.
   PubMed Web of Science ®Google Scholar
• Zausig YA, Zink W, Keil M, et al. Lipid emulsion improves recovery from bupivacaine-induced cardiac arrest, but not from ropivacaine- or mepivacaine-induced cardiac arrest. Anesth Analg. 2009;109(4):1323–1326.
   PubMedGoogle Scholar
• Zaballos M, Sevilla R, González J, et al. Analysis of the temporal regression of the QRS widening induced by bupivacaine after intralipid administration. Study in an experimental porcine model. Rev Esp Anestesiol Reanim. 2016;63(1):13–21.
   PubMedGoogle Scholar
• Boschert K, Flecknell PA, Fosse RT, et al. Ketamine and its use in the pig. Recommendations of the consensus meeting on ketamine anaesthesia in pigs, bergen 1994. Ketamine consensus working group. Lab Anim. 1996;30(3):209–219.
   PubMedGoogle Scholar
• Holmström A, Akeson J. Cerebral blood flow at 0.5 and 1.0 minimal alveolar concentrations of desflurane or sevoflurane compared with isoflurane in normoventilated pigs. J Neurosurg Anesthesiol. 2003;15(2):90–97.
   PubMedGoogle Scholar
• Zaballos M, Callejo D, Sevilla R, et al. Comparative effects of sodium bicarbonate and intravenous lipid emulsions on reversing bupivacaine-induced electrophysiological toxicity in a porcine experimental model. Anesth Analg. 2019;129(1):63–72.
   PubMedGoogle Scholar
• Hummel JD, Strickberger SA, Daoud E, et al. Results and efficiency of programmed ventricular stimulation with four extrastimuli compared with one, two, and three extrastimuli. Circulation. 1994;90(6):2827–2832.
   PubMedGoogle Scholar
• Surawicz B, Childers R, Deal BJ, et al. AHA/ACCF/HRS recommendations for the standardization and interpretation of the electrocardiogram: part III: intraventricular conduction disturbances: a scientific statement from the american heart association electrocardiography and arrhythmias committee, council on clinical cardiology; the american college of cardiology foundation; and the heart rhythm society. Endorsed by the international society for computerized electrocardiology. J Am Coll Cardiol. 2009;53(11):976–981.
   PubMed Web of Science ®Google Scholar
• Szabó A, Szentandrássy N, Birinyi P, et al. Effects of ropivacaine on action potential configuration and ion currents in isolated canine ventricular cardiomyocytes. Anesthesiology. 2008;108(4):693–702.
   PubMedGoogle Scholar
• Buckenmaier CC, 3rd, Capacchione J, Mielke AR, et al. The effect of lipid emulsion infusion on postmortem ropivacaine concentrations in swine: endeavoring to comprehend a soldier's death. Anesth Analg. 2012;114(4):894–900.
   PubMed Web of Science ®Google Scholar
• Fettiplace MR, Ripper R, Lis K, et al. Rapid cardiotonic effects of lipid emulsion infusion. Crit Care Med. 2013;41(8):e156-62–e162.
   PubMedGoogle Scholar
• Hoegberg LC, Bania TC, Lavergne V, et al. Systematic review of the effect of intravenous lipid emulsion therapy for local anesthetic toxicity. Clin Toxicol. 2016;54(3):167–193.
   PubMed Web of Science ®Google Scholar
• Mazoit JX, Le Guen R, Beloeil H, et al. Binding of long-lasting local anesthetics to lipid emulsions. Anesthesiology. 2009;110(2):380–386.
   PubMedGoogle Scholar
• Yoshimoto M, Horiguchi T, Kimura T, et al. Recovery from Ropivacaine-Induced or Levobupivacaine-Induced cardiac arrest in rats: comparison of lipid emulsion effects. Anesth Analg. 2017;125(5):1496–1502.
   PubMed Web of Science ®Google Scholar
• El-Boghdadly K, Pawa A, Chin KJ. Local anesthetic systemic toxicity: current perspectives. Local Reg Anesth. 2018;11:35–44.
   PubMed Web of Science ®Google Scholar
• Neal JM, Barrington MJ, Fettiplace MR, et al. The third american society of regional anesthesia and pain medicine practice advisory on local anesthetic systemic toxicity: executive summary 2017. Reg Anesth Pain Med. 2018;43(2):113–123.
   PubMed Web of Science ®Google Scholar
• Wang QG, Wu C, Xia Y, et al. Epinephrine deteriorates pulmonary gas exchange in a rat model of bupivacaine-induced cardiotoxicity: a threshold dose of epinephrine. Reg Anesth Pain Med. 2017;42(3):342–350.
   PubMedGoogle Scholar
• Epstein AE, Olshansky B, Naccarelli GV, et al. Practical management guide for clinicians who treat patients with amiodarone. Am J Med. 2016;129(5):468–475.
   PubMed Web of Science ®Google Scholar
• Kodama I, Kamiya K, Toyama J. Amiodarone: ionic and cellular mechanisms of action of the most promising class III agent. Am J Cardiol. 1999;84(9A):20R–28R.
   PubMedGoogle Scholar
• Fettiplace MR, Pichurko AB. Heterogeneity and bias in animal models of lipid emulsion therapy: a systematic review and meta-analysis. Clin Toxicol. 2021;59(1):1–11.
   PubMed Web of Science ®Google Scholar
• Bedocs P, Capacchione J, Potts L, et al. Hypersensitivity reactions to intravenous lipid emulsion in swine: relevance for lipid resuscitation studies. Anesth Analg. 2014;119(5):1094–1101.
   PubMed Web of Science ®Google Scholar
• Weinberg GL, Bedocs P, Fettiplace MR. Pigs and paradigms: stop using swine to study lipid resuscitation. Anesth Analg. 2019;129(1):4–7.
   PubMed Web of Science ®Google Scholar
• Udelsmann A, Melo MDS. Hemodynamic changes with high infusion rates of lipid emulsion. Experimental study in swine. Acta Cir Bras. 2015;30(11):720–726.
   PubMedGoogle Scholar
• Udelsmann A, Melo MDS. Hemodynamic changes with two lipid emulsions for treatment of bupivacaine toxicity in swines. Acta Cir Bras. 2015;30(2):87–93.
   PubMedGoogle Scholar
• Fettiplace MR, McCabe DJ. Lipid emulsion improves survival in animal models of local anesthetic toxicity: a meta-analysis. Clin Toxicol. 2017;55(7):617–623.
   PubMed Web of Science ®Google Scholar
• Suzuki Y, Yeung AC, Ikeno F. The representative porcine model for human cardiovascular disease. J Biomed Biotechnol. 2011;2011:195483.
   PubMedGoogle Scholar
• Swindle MM, Makin A, Herron AJ, et al. Swine as models in biomedical research and toxicology testing. Vet Pathol. 2012;49(2):344–356.
   PubMed Web of Science ®Google Scholar