Advanced search
Publication Cover
Clinical Toxicology Volume 60, 2022 - Issue 10
Submit an article Journal homepage
640
Views
3
CrossRef citations to date
0
Altmetric
Clinical Research

Population pharmacokinetic analysis of acetaminophen overdose with immediate release, extended release and modified release formulations

Daniel A. Spykera Oregon Health & Science University, Portland, OR, USACorrespondence[email protected]
View further author information
,
Richard C. Dartb Rocky Mountain Poison and Drug Center, Denver, CO, USAView further author information
,
Luke Yipb Rocky Mountain Poison and Drug Center, Denver, CO, USAView further author information
,
Kate Reynoldsb Rocky Mountain Poison and Drug Center, Denver, CO, USAView further author information
,
Scott Brittainc Pharmacoexcellence, Atlanta, GA, USAView further author information
&
Mark Yaremad Poison and Drug Information Service, Calgary, Alberta, CA, USAView further author information
Pages 1113-1121 | Received 06 Mar 2022, Accepted 31 Jul 2022, Published online: 15 Sep 2022

References

  • Salmonson H, Sjoberg G, Brogren J. The standard treatment protocol for paracetamol poisoning may be inadequate following overdose with modified release formulation: a pharmacokinetic and clinical analysis of 53 cases. Clin Toxicol. 2018;56(1):63–68.
  • Hoegberg LCG, Refsgaard F, Pedersen SH, et al. Potential pharmacobezoar formation of large size extended-release tablets and their dissolution – an in vitro study. Clin Toxicol. 2019;57(4):271–281.
  • Chiew AL, Isbister GK, Page CB, et al. Modified release paracetamol overdose: a prospective observational study (ATOM-3). Clin Toxicol. 2018;56(9):810–819.
  • European Medicines Agency. Modified-release paracetamol-containing products to be suspended from EU market, EMA/811872/2017. [cited 2017 December 15]. Available from: https://www.ema.europa.eu/en/news/modified-release-paracetamol-containing-products-be-suspended-eu-market#:∼:text=The%20CMDh%5B1%5D%20has%20endorsed,usual%20immediate%2Drelease%20products.
  • Stork CM, Rees S, Howland MA, et al. Pharmacokinetics of extended relief vs regular release tylenol in simulated human overdose. J Toxicol Clin Toxicol. 1996;34(2):157–162.
  • Douglas DR, Sholal JB, Smilkstein MJ. A pharmacokinetic comparison of acetaminophen products (tylenol extended relief vs regular tylenol). Acad Emerg Med. 1996;3(8):740–744.
  • Pond SM, Tong TG, Kaysen GA, et al. Massive intoxication with acetaminophen and propoxyphene: unexpected survival and unusual pharmacokinetics of acetaminophen. J Toxicol Clin Toxicol. 1982;19(1):1–16.
  • Doyon S, Klein-Schwartz W. Hepatotoxicity despite early administration of intravenous N-acetylcysteine for acute acetaminophen overdose. Acad Emerg Med. 2009;16(1):34–39.
  • Gelotte CK, Auiler JF, Lynch JM, et al. Disposition of acetaminophen at 4, 6, and 8 g/day for 3 days in healthy young adults. Clin Pharmacol Ther. 2007;81(6):840–848.
  • Wolchok JD, Williams L, Pinto JT, et al. Phase I trial of high dose paracetamol and carmustine in patients with metastatic melanoma. Melanoma Res. 2003;13(2):189–196.
  • Yarema MC, Johnson DW, Berlin RJ, et al. Comparison of the 20-hour intravenous and 72-hour oral acetylcysteine protocols for the treatment of acute acetaminophen poisoning. Ann Emerg Med. 2009;54(4):606–614.
  • Smilkstein MJ, Knapp GL, Kulig KW, et al. Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985). N Engl J Med. 1988;319(24):1557–1562.
  • Heard K, Rumack BH, Green JL, et al. A single-arm clinical trial of a 48-hour intravenous N-acetylcysteine protocol for treatment of acetaminophen poisoning. Clin Toxicol. 2014;52(5):512–518.
  • Kirschner RI, Rozier CM, Smith LM, et al. Nomogram line crossing after acetaminophen combination product overdose. Clin Toxicol. 2016;54(1):40–46.
  • Faber K, Walter M, Rauber-Lüthy C, et al. Delayed absorption of paracetamol due to co-ingestion of a bezoar-forming pharmaceutical. Clin Toxicol. 2018;56(6):453–608.
  • Melethil S, Poklis A, Schwartz HS. Estimation of the amount of drug absorbed in acetaminophen poisoning: a case report. Vet Hum Toxicol. 1981;23(6):421–423.
  • Reynolds K, Dart RC, Spyker DA. Retrospective analysis of reported acetaminophen concentrations in acetaminophen extended release formulation exposures reported to Rocky Mountain Poison and Drug Center. Unpublished data, 2021.
  • Bizovi KE, Aks SE, Paloucek F, et al. Late increase in acetaminophen concentration after overdose of tylenol extended relief. Ann Emerg Med. 1996;28(5):549–551.
  • Burda T, Sigg T. Double peak and prolonged absorption after large acetaminophen extended release and diphenhydramine ingestion. Am J Ther. 2012;19(2):e101-104–e104.
  • Cetaruk EW, Dart RC, Hurlbut KM, et al. Tylenol extended relief overdose. Ann Emerg Med. 1997;30(1):104–108.
  • Vassallo S, Khan AN, Howland MA. Use of the Rumack-Matthew nomogram in cases of extended-release acetaminophen toxicity. Ann Intern Med. 1996;125(11):940.
  • Roberts DM, Buckley NA. Prolonged absorption and delayed peak paracetamol concentration following poisoning with extended-release formulation. Med J Aust. 2008;188(5):310–311.
  • Ng CM, Spyker DA, Green JL, et al. Population exposure model of patients following acetaminophen overdose. Clin Toxicol. 2008;46:624–624.
  • Desrochers J, Wojciechowski J, Klein-Schwartz W, et al. Bayesian forecasting tool to predict the need for antidote in acute acetaminophen overdose. Pharmacotherapy. 2017;37(8):916–926.
  • van der Heijden LT, Mian P, Hias J, et al. Highly variable paracetamol pharmacokinetics after multiple oral dosing in frail older people: a population pharmacokinetic analysis. Drugs Aging. 2021;17:1–3.
  • Li J, Chiew AL, Isbister GK, et al. Population pharmacokinetics of immediate-release and modified-release paracetamol and its major metabolites in a supratherapeutic dosing study. Clin Toxicol. 2022;60(1):25–32.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.