Genetic variants associated with ALT elevation from therapeutic acetaminophen

References

• Katarey D, Verma S. Drug-induced liver injury. Clin Med. 2016;16(Suppl 6):s104–s109.
   PubMedGoogle Scholar
• Chalasani N, Bonkovsky HL, Fontana R, et al. Features and outcomes of 899 patients with drug-induced liver injury: the DILIN prospective study. Gastroenterology. 2015;148(7):1340–1352.e7.
   PubMed Web of Science ®Google Scholar
• Robles-Diaz M, Lucena MI, Kaplowitz N, et al. Use of Hy’s law and a new composite algorithm to predict acute liver failure in patients with drug-induced liver injury. Gastroenterology. 2014;147(1):109–118 e5.
   PubMed Web of Science ®Google Scholar
• Daly AK, Donaldson PT, Bhatnagar P, et al. HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Nat Genet. 2009;41(7):816–819.
   PubMed Web of Science ®Google Scholar
• Levano KS, Jaramillo‐Valverde L, Tarazona DD, et al. Allelic and genotypic frequencies of NAT2, CYP2E1, and AADAC genes in a cohort of Peruvian tuberculosis patients. Mol Genet Genomic Med. 2021;9:e1764.
   PubMed Web of Science ®Google Scholar
• Monte AA, Sonn B, Saben J, et al. The genomics of elevated ALT and adducts in therapeutic acetaminophen treatment: a pilot study. J Med Toxicol. 2021;17(2):160–167.
   PubMed Web of Science ®Google Scholar
• Mazaleuskaya LL, Sangkuhl K, Thorn CF, et al. PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses. Pharmacogenet Genomics. 2015;25(8):416–426.
   PubMed Web of Science ®Google Scholar
• Heard K, Green JL, Anderson V, et al. A randomized, placebo-controlled trial to determine the course of aminotransferase elevation during prolonged acetaminophen administration. BMC Pharmacol Toxicol. 2014;15:39.
   PubMed Web of Science ®Google Scholar
• Sonn BJ, Heard KJ, Heard SM, et al. Metabolomic markers predictive of hepatic adaptation to therapeutic dosing of acetaminophen. Clin Toxicol. 2022;60(2):221–230.
   PubMed Web of Science ®Google Scholar
• A global reference for human genetic variation. The 1000 Genomes Project Consortium, Nature. 2015;526:68–74.
   Google Scholar
• Genome in a Bottle reference dataset. International HapMap Constortium. A second generation human haplotype map of over 3.1 million SNPs. Nature, 2007;449:851–862.
   Google Scholar
• Purcell S, Neale B, Todd-Brown K, et al. PLINK: a toolset for whole-genome association and population-based linkage analysis. Am J Hum Genet. 2007;81(13):559–575.
   PubMedGoogle Scholar
• Conomos MP, Reiner AP, Weir BS, et al. Model-free estimation of recent genetic relatedness. Am J Hum Genet. 2016;98(1):127–148.
   PubMed Web of Science ®Google Scholar
• Wang K, Li M, Hadley D, et al. PennCNV: an integrated hidden Markov model designed for high-resolution copy number variation detection in whole-genome SNP genotyping data. Genome Res. 2007;17(11):1665–1674.
   PubMed Web of Science ®Google Scholar
• Gogarten SM, Sofer T, Chen H, et al. Genetic association testing using the GENESIS R/bioconductor package. Bioinformatics. 2019;35(24):5346–5348.
   PubMed Web of Science ®Google Scholar
• Pan W, Kwak IY, Wei P. A powerful pathway-based adaptive test for genetic association with common or rare variants. Am J Hum Genet. 2015;97(1):86–98.
   PubMed Web of Science ®Google Scholar
• Wang T, Elston RC. Improved power by use of a weighted score test for linkage disequilibrium mapping. Am J Hum Genet. 2007;80(2):353–360.
   PubMed Web of Science ®Google Scholar
• Liu L, Klaassen CD. Different mechanism of saturation of acetaminophen sulfate conjugation in mice and rats. Toxicol Appl Pharmacol. 1996;139(1):128–134.
   PubMed Web of Science ®Google Scholar
• Li J, Chiew AL, Isbister GK, et al. Sulfate conjugation may be the key to hepatotoxicity in paracetamol overdose. Br J Clin Pharmacol. 2021;87(5):2392–2396.
   PubMed Web of Science ®Google Scholar
• Yamamoto A, Liu M-Y, Kurogi K, et al. Sulphation of acetaminophen by the human cytosolic sulfotransferases: a systematic analysis. J Biochem. 2015;158(6):497–504.
   PubMed Web of Science ®Google Scholar
• Adjei AA, Gaedigk A, Simon SD, et al. Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects. Birth Defects Res A Clin Mol Teratol. 2008;82(3):155–165.
   PubMedGoogle Scholar
• Lindsay J, Wang L-L, Li Y, et al. Structure, function and polymorphism of human cytosolic sulfotransferases. Curr Drug Metab. 2008;9(2):99–105.
   PubMed Web of Science ®Google Scholar
• McGill MR, Jaeschke H. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. Pharm Res. 2013;30(9):2174–2187.
   PubMed Web of Science ®Google Scholar
• Hautekeete ML, Horsmans Y, van Waeyenberge C, et al. HLA association of amoxicillin-clavulanate–induced hepatitis. Gastroenterology. 1999;117(5):1181–1186.
   PubMed Web of Science ®Google Scholar
• Johnson P, Ruffell B. CD44 and its role in inflammation and inflammatory diseases. Inflamm Allergy Drug Targets. 2009;8(3):208–220.
   PubMedGoogle Scholar
• Liang JB, Chen Y, Chen RL, et al. CD8(+) T cells actively penetrate hepatocytes via the CD44/p-ERM/F-actin pathway in autoimmune hepatitis. J Dig Dis. 2021;22(6):351–362.
   PubMed Web of Science ®Google Scholar
• Wang J, Guo C, Liu S, et al. Annexin A11 in disease. Clin Chim Acta. 2014;431:164–168.
   PubMed Web of Science ®Google Scholar
• Bustamante JJ, Copple BL, Soares MJ, et al. Gene profiling of maternal hepatic adaptations to pregnancy. Liver Int. 2010;30(3):406–415.
   PubMed Web of Science ®Google Scholar
• Court MH, Freytsis M, Wang X, et al. The UDP-glucuronosyltransferase (UGT) 1A polymorphism c.2042C > G (rs8330) is associated with increased human liver acetaminophen glucuronidation, increased UGT1A exon 5a/5b splice variant mRNA ratio, and decreased risk of unintentional acetaminophen-induced acute liver failure. J Pharmacol Exp Ther. 2013;345(2):297–307.
   PubMed Web of Science ®Google Scholar
• Court MH, Peter I, Hazarika S, et al. Candidate gene polymorphisms in patients with acetaminophen-induced acute liver failure. Drug Metab Dispos. 2014;42(1):28–32.
   PubMed Web of Science ®Google Scholar