The critical time period for administering antivenom: golden hours and missed opportunities

References

• Maduwage K, Buckley NA, de Silva HJ, et al. Snake antivenom for snake venom induced consumption coagulopathy. Cochrane Database Syst Rev. 2015;(6):CD011428.
   Google Scholar
• Ranawaka UK, Lalloo DG, de Silva HJ. Neurotoxicity in snakebite–the limits of our knowledge. PLoS Negl Trop Dis. 2013;7(10):e2302. doi:10.1371/journal.pntd.0002302.
   PubMed Web of Science ®Google Scholar
• Noutsos T, Currie BJ, Lek RA, et al. Snakebite associated thrombotic microangiopathy: a systematic review of clinical features, outcomes, and evidence for interventions including plasmapheresis. PLoS Negl Trop Dis. 2020;14(12):e0008936. doi:10.1371/journal.pntd.0008936.
   PubMed Web of Science ®Google Scholar
• Maduwage K, Isbister GK. Current treatment for venom-induced consumption coagulopathy resulting from snakebite. PLoS Negl Trop Dis. 2014;8(10):e3220. doi:10.1371/journal.pntd.0003220.
   PubMed Web of Science ®Google Scholar
• Mion G, Larréché S, Benois A, et al. Hemostasis dynamics during coagulopathy resulting from echis envenomation. Toxicon. 2013;76:103–109. doi:10.1016/j.toxicon.2013.09.003.
   PubMed Web of Science ®Google Scholar
• Winter KL, Isbister GK, Jacoby T, et al. An in vivo comparison of the efficacy of CSL box jellyfish antivenom with antibodies raised against nematocyst-derived chironex fleckeri venom. Toxicol Lett. 2009;187(2):94–98. doi:10.1016/j.toxlet.2009.02.008.
   PubMed Web of Science ®Google Scholar
• Currie BJ, Jacups SP. Prospective study of chironex fleckeri and other box jellyfish stings in the “top end” of Australia’s Northern Territory. Med J Aust. 2005;183(11-12):631–636. doi:10.5694/j.1326-5377.2005.tb00062.x.
   PubMed Web of Science ®Google Scholar
• Piontek M, Seymour JE, Wong Y, et al. The pathology of chironex fleckeri venom and known biological mechanisms. Toxicon X. 2020;6:100026. doi:10.1016/j.toxcx.2020.100026.
   PubMedGoogle Scholar
• Isbister GK, O'Leary M, Miller M, et al. A comparison of serum antivenom concentrations after intravenous and intramuscular administration of redback (widow) spider antivenom. Br J Clin Pharmacol. 2008;65(1):139–143. doi:10.1111/j.1365-2125.2007.03004.x.
   PubMed Web of Science ®Google Scholar
• Johnston CI, Brown SG, O’Leary MA, et al. Mulga snake (pseudechis australis) envenoming: a spectrum of myotoxicity, anticoagulant coagulopathy, haemolysis and the role of early antivenom therapy – Australian Snakebite Project (ASP-19). Clin Toxicol. 2013;51(5):417–424. doi:10.3109/15563650.2013.787535.
   Web of Science ®Google Scholar
• Lalloo DG, Trevett AJ, Korinhona A, et al. Snake bites by the Papuan taipan (Oxyuranus scutellatus canni): paralysis, hemostatic and electrocardiographic abnormalities, and effects of antivenom. Am J Trop Med Hyg. 1995;52(6):525–531. doi:10.4269/ajtmh.1995.52.525.
   PubMed Web of Science ®Google Scholar
• Churchman A, O'Leary MA, Buckley NA, et al. Clinical effects of red-bellied black snake (pseudechis porphyriacus) envenoming and correlation with venom concentrations: Australian snakebite project (ASP-11). Med J Aust. 2010;193(11-12):696–700. doi:10.5694/j.1326-5377.2010.tb04108.x.
   PubMed Web of Science ®Google Scholar
• Silva A, Cristofori-Armstrong B, Rash LD, et al. Defining the role of post-synaptic alpha-neurotoxins in paralysis due to snake envenoming in humans. Cell Mol Life Sci. 2018;75(23):4465–4478. doi:10.1007/s00018-018-2893-x.
   PubMed Web of Science ®Google Scholar
• Silva A, Scorgie FE, Lincz LF, et al. Indian polyvalent antivenom accelerates recovery from venom-induced consumption coagulopathy (VICC) in Sri Lankan Russell’s Viper (Daboia russelii) envenoming. Front Med. 2022;9:852651. doi:10.3389/fmed.2022.852651.
   Web of Science ®Google Scholar
• Johnston CI, Ryan NM, O'Leary MA, et al. Australian taipan (Oxyuranus spp.) envenoming: clinical effects and potential benefits of early antivenom therapy – Australian snakebite project (ASP-25). Clin Toxicol. 2017;55(2):115–122. doi:10.1080/15563650.2016.1250903.
   PubMed Web of Science ®Google Scholar
• Anderson VE, Gerardo CJ, Rapp-Olsson M, et al. Early administration of fab antivenom resulted in faster limb recovery in copperhead snake envenomation patients. Clin Toxicol. 2019;57(1):25–30. doi:10.1080/15563650.2018.1491982.
   PubMed Web of Science ®Google Scholar
• Sanhajariya S, Duffull SB, Isbister GK. Pharmacokinetics of Snake Venom. Toxins. 2018;10(2):73. doi:10.3390/toxins10020073.
   PubMed Web of Science ®Google Scholar
• Hart AJ, Hodgson WC, O'Leary M, et al. Pharmacokinetics and pharmacodynamics of the myotoxic venom of Pseudechis australis (mulga snake) in the anesthetised rat. Clin Toxicol. 2014;52(6):604–610. doi:10.3109/15563650.2014.914526.
   Web of Science ®Google Scholar
• Ownby CL, Colberg TR, Odell GV. In vivo ability of antimyotoxin a serum plus polyvalent (crotalidae) antivenom to neutralize prairie rattlesnake (Crotalus viridis viridis) venom. Toxicon. 1986;24(2):197–200. doi:10.1016/0041-0101(86)90122-4.
   PubMed Web of Science ®Google Scholar
• Johnston CI, Isbister GK. Australian snakebite myotoxicity (ASP-23). Clin Toxicol. 2021;59(7):611–618. doi:10.1080/15563650.2020.1836377.
   PubMed Web of Science ®Google Scholar
• Sanhajariya S, Duffull SB, Isbister GK. Population pharmacokinetics of pseudechis porphyriacus (red-bellied black snake) venom in snakebite patients. Clin Toxicol. 2021;59(11):956–962. doi:10.1080/15563650.2021.1896731.
   PubMed Web of Science ®Google Scholar
• Ownby CL, Colberg TR. Ability of polyvalent (Crotalidae) antivenom to neutralize local myonecrosis induced by Crotalus atrox venom. Toxicon. 1986;24(2):201–203. doi:10.1016/0041-0101(86)90123-6.
   PubMed Web of Science ®Google Scholar
• Silva A, Hlusicka J, Siribaddana N, et al. Time delays in treatment of snakebite patients in rural Sri Lanka and the need for rapid diagnostic tests. PLoS Negl Trop Dis. 2020;14(11):e0008914. doi:10.1371/journal.pntd.0008914.
   PubMed Web of Science ®Google Scholar
• de Silva HA, Ryan NM, de Silva HJ. Adverse reactions to snake antivenom, and their prevention and treatment. Br J Clin Pharmacol. 2016;81(3):446–452. doi:10.1111/bcp.12739.
   PubMed Web of Science ®Google Scholar
• Ratnayake I, Mohamed F, Buckley NA, et al. Early identification of acute kidney injury in russell’s viper (Daboia russelii) envenoming using renal biomarkers. PLoS Negl Trop Dis. 2019;13(7):e0007486. doi:10.1371/journal.pntd.0007486.
   PubMed Web of Science ®Google Scholar
• Isbister GK, Mirajkar N, Fakes K, et al. Phospholipase A2 (PLA(2)) as an early indicator of envenomation in Australian elapid snakebites (ASP-27). Biomedicines. 2020;8(11):459. doi:10.3390/biomedicines8110459.
   PubMed Web of Science ®Google Scholar
• Kularatne SA, Silva A, Weerakoon K, et al. Revisiting Russell’s viper (Daboia russelii) bite in Sri Lanka: is abdominal pain an early feature of systemic envenoming? PLoS One. 2014;9(2):e90198. doi:10.1371/journal.pone.0090198.
   PubMed Web of Science ®Google Scholar