Potency of Five Structurally Different Acetylcholinesterase Reactivators to Reactivate Human Brain Cholinesterases Inhibited by Cyclosarin

References

• Bajgar J. Organophosphates/nerve agent poisoning: Mechanism of action, diagnosis, prophylaxis, and treatment. Adv Clin Chem 2004; 38: 151–216
   PubMed Web of Science ®Google Scholar
• Kassa J. Review of oximes in the antidotal treatment of poisoning by organophosphorus nerve agents. J Toxicol Clin Toxicol 2002; 40: 803–816
   PubMed Web of Science ®Google Scholar
• Kuca K, Jun D, Musilek K. Structural requirements of acetylcholinesterase reactivators. Mini Rev Med Chem 2006; 6: 269–277
   PubMed Web of Science ®Google Scholar
• Kim TH, Kuca K, Jun D, Jung YS. Design and synthesis of new bis-pyridinium oximes as cyclosarin-inhibited acetylcholinesterase reactivators. Bioorg Med Chem Lett 2005; 15: 2914–2917
   PubMed Web of Science ®Google Scholar
• Pang YP, Kollmeyer TM, Hong F, Lee JC, Hammond PI, Haugabouk SP, Brimijoin S. Rational design of alkylene-linked bis-pyridiniumaldoximes as improved acetylcholinesterase reactivators. Chem Biol 2003; 10: 491–502
   PubMed Web of Science ®Google Scholar
• Musilek K, Kuca K, Jun D, Dohnal V, Dolezal M. Synthesis of the novel series of bispyridinium compounds bearing xylene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase. J Enzyme Inhib Med Chem 2005; 20: 409–415
   PubMed Web of Science ®Google Scholar
• Picha J, Kuca K, Kivala M, Kohout M, Cabal J, Liska F. New group of monoquaternary reactivators of the acetylcholinesterase inhibited by nerve agents. J Enzyme Inhib Med Chem 2005; 20: 233–237
   PubMed Web of Science ®Google Scholar
• Kassa J, Cabal J. A comparison of the efficacy of a new asymmetric bispyridinium oxime BI-6 with presently used oximes and H oximes against sarin by in vitro and in vivo methods. Hum Exp Toxicol 1999; 18: 560–5
   PubMed Web of Science ®Google Scholar
• Worek F, Backer M, Thiermann H, Szinicz L, Mast U, Klimmek R, Eyer P. Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning. Hum Exp Toxicol 1997; 16: 466–72
   PubMed Web of Science ®Google Scholar
• Krejcova G, Kuca K, Sevelova L. Cyclosarin - current position of an organophosphate nerve agent. Def Sci J 2005; 55: 105–115
   Web of Science ®Google Scholar
• Kassa J, Cabal J. A comparison of the efficacy of acetylcholine reactivators against cyclohexyl methylphosphonofluoridate (GF agent) by in vitro and in vivo methods. Pharmacol Toxicol 1999; 84: 41–46
   PubMedGoogle Scholar
• Kassa J, Fusek J. The influence of oxime selection on the efficacy of antidotal treatment of soman-poisoned rats. Acta Medica (Hradec Kralove) 2002; 45: 19–27
   PubMedGoogle Scholar
• Cabal J, Kuca K, Kassa J. Specification of the structure of oximes able to reactivate tabun inhibited acetylcholinesterase. Bas Clin Pharmacol Toxicol 2004; 95: 81–86
   PubMed Web of Science ®Google Scholar
• Balali-Mood M, Shariat M. Treatment of organophosphate poisoning. Experience of nerve agents and acute pesticide poisoning on the effects of oximes. J Physiology (Paris) 1998; 92: 375–8
   PubMedGoogle Scholar
• Jun D, Kuca K, Hronek M, Opletal L. Effect of some acetylcholinesterase reactivators on human platelet aggregation in vitro. J Appl Toxicol 2006; 26: 262–8
   PubMedGoogle Scholar
• Bismuth C, Ins RH, Marrs TC. Efficacy, toxicity and clinical use of oxime in anticholinesterase poisoning. Clinical and experimental toxicology of organophosphates and carbamates, B Ballantyne, TC Marrs, WN Aldrige. Butterworth-Heinmann Ltd, Oxford, England 1992; 555–577
   Google Scholar
• Musilek K, Kuca K, Jun D, Dohnal V, Dolezal M. Synthesis of the novel series of bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase. Biorg Med Chem Lett 2006; 16: 622–627
   PubMed Web of Science ®Google Scholar
• Kuca K, Patocka J. Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium–oximes. J Enzyme Inhib Med Chem 2004; 19: 39–43
   PubMed Web of Science ®Google Scholar
• Sevelova L, Kuca K, Krejcova G. Antidotal treatment of GF-agent intoxication in mice with new bispyridinium oximes. Toxicology 2005; 207: 1–6
   PubMed Web of Science ®Google Scholar
• Krejcova-Kunesova G, Bartosova L, Kuca K. Signs of cyclosarin-induced neurotoxicity and its pharmacological treatment with quaternary pyridinium-oximes reactivators. Toxicology 2005; 216: 32–40
   PubMed Web of Science ®Google Scholar
• Bartosova L, Kuca K, Jun D, Kunesova G. Bispyridinium oximes as antidotal treatment of cyclosarin poisoning – in vitro and in vivo testing. Inter J Toxicol 2005; 24: 399–402
   PubMed Web of Science ®Google Scholar
• Calic M, Lucic Vrdoljak A, Radic B, Jelic D, Jun D, Kuca K, Kovarik Z. In vitro and in vivo evaluation of pyridinium oximes: mode of interaction with acetylcholinesterase, effect on tabun- and soman-poisoned mice and their cytotoxicity. Toxicology 2006; 219: 85–96
   PubMed Web of Science ®Google Scholar
• Clement JG, Erhardt N. In vitro oxime-induced reactivation of various molecular forms of soman-inhibited acetylcholinesterase in striated muscle from rat, monkey and human. Arch Toxicol 1994; 68: 648–655
   PubMed Web of Science ®Google Scholar
• Worek F, Reiter G, Eyer P, Szinicz L. Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates. Arch Toxicol 2002; 76: 523–529
   PubMed Web of Science ®Google Scholar
• Kuca K, Cabal J, Kassa J. In vitro reactivation of sarin-inhibited brain acetylcholinesterase from various species by various oximes. J Enzyme Inhib Med Chem 2005; 20: 227–232
   PubMed Web of Science ®Google Scholar
• Petroianu GA, Hasan MY, Nurulain SM, Arafat K, Sha Ullah M, Naseer O. Protective agents in acute high-dose organophosphate exposure: comparison of ranitidine with pralidoxime in rats. J Appl Toxicol 2005; 25: 68–73
   PubMed Web of Science ®Google Scholar
• Kuca K, Kassa J. A comparison of the ability of a new bispyridinium oxime -1-(4-hydroxyiminomethylpyridinium) -4- (4- carbamoylpyridinium) butane dibromide and currently used oximes to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods. J Enzyme Inhib Med Chem 2003; 18: 529–535
   PubMed Web of Science ®Google Scholar
• Kuca K, Cabal J, Jun D, Kassa J, Bartosova L, Kuneova G, Dohnal V. Development of new acetylcholinesterase reactivators – antidotes used for treatment of nerve agent poisonings. Biomed Pap 2005; 149: 429–431
   PubMedGoogle Scholar
• Worek F, Eyer P, Szinicz L. Inhibition, reactivation and aging kinetics of cyclohexylmethylphosphonofluoridate-inhibited human cholinesterases. Arch Toxicol 1998; 72: 580–587
   PubMed Web of Science ®Google Scholar