331
Views
46
CrossRef citations to date
0
Altmetric
Articles

Obidoxime in acute organophosphate poisoning: 1 – clinical effectiveness

, , , , , & show all
Pages 798-806 | Received 25 May 2009, Accepted 24 Jul 2009, Published online: 24 Sep 2009

References

  • Pawar KS, Bhoite RR, Pillay CP, Chavan SC, Malshikare DS, Garad SG. Continuous pralidoxime infusion versus repeated bolus injection to treat organophosphorus pesticide poisoning: a randomised controlled trial. Lancet 2006; 368:2136–2141.
  • Eddleston M, Eyer P, Worek F, Juszczak E, Adler N, Mohamed F, Senarathna L, Hittarage A, Azher S, Jeganathan K, Jayamanne S, von Meyer L, Dawson AH, Sheriff MH, Buckley NA. Pralidoxime in acute organophosphorus insecticide poisoning – a randomised controlled trial. PLoS Med 2009; 6:e1000104.
  • Rahimi R, Nikfar S, Abdollahi M. Increased morbidity and mortality in acute human organophosphate-poisoned patients treated by oximes: a meta-analysis of clinical trials. Hum Exp Toxicol 2006; 25:157–162.
  • Peter JV, Moran JL, Graham P. Oxime therapy and outcomes in human organophosphate poisoning: an evaluation using meta-analytic techniques. Crit Care Med 2006; 34:502–510.
  • Eyer P. The role of oximes in the management of organophosphorus pesticide poisoning. Toxicol Rev 2003; 22:165–190.
  • Brahmi N, Mokline A, Kouraichi N, Ghorbel H, Blel Y, Thabet H, Hedhili A. Amamou M. Prognostic value of human erythrocyte acetyl cholinesterase in acute organophosphate poisoning. Am J Emerg Med 2006; 24:822–827.
  • Thiermann H, Mast U, Klimmek R, Eyer P, Hibler A, Pfab R, Felgenhauer N, Zilker T. Cholinesterase status, pharmacokinetics and laboratory findings during obidoxime therapy in organophosphate poisoned patients. Hum Exp Toxicol 1997; 16:473–480.
  • Singh G, Mahajan R, Whig J. The importance of electrodiagnostic studies in acute organophosphate poisoning. J Neurol Sci 1998; 157:191–200.
  • Besser R, Weilemann LS, Gutmann L. Efficacy of obidoxime in human organophosphorus poisoning: determination by neuromuscular transmission studies. Muscle Nerve 1995; 18:15–22.
  • Eddleston M, Eyer P, Worek F, Mohamed F, Senarathna L, von Meyer L, Juszczak E, Hittarage A, Azhar S, Dissanayake W, Sheriff MH, Szinicz L, Dawson AH, Buckley NA. Differences between organophosphorus insecticides in human self-poisoning: a prospective cohort study. Lancet 2005; 366:1452–1459.
  • Eddleston M, Szinicz L, Eyer P, Buckley N. Oximes in acute organophosphorus pesticide poisoning: a systematic review of clinical trials. QJM 2002; 95:275–283.
  • Eyer F, Eyer P. Enzyme-based assay for quantification of paraoxon in blood of parathion poisoned patients. Hum Exp Toxicol 1998; 17:645–651.
  • Willems JL, De Bisschop HC, Verstraete AG, Declerck C, Christiaens Y, Vanscheeuwyck P, Buylaert WA, Vogelaers D, Colardyn F. Cholinesterase reactivation in organophosphorus poisoned patients depends on the plasma concentrations of the oxime pralidoxime methylsulphate and of the organophosphate. Arch Toxicol 1993; 67:79–84.
  • Eyer F, Roberts DM, Buckley NA, Eddleston M, Thiermann H, Worek F, Eyer P. Extreme variability in the formation of chlorpyrifos oxon (CPO) in patients poisoned by chlorpyrifos (CPF). Biochem Pharmacol 2009; 78:531–537.
  • Casey PB, Gosden E, Blakely L, Thompson JP, Vale JA. Plasma pralidoxime concentrations following bolus injection and continuous infusion. Przeglad Lekarski 1995; 52:203.
  • Worek F, Mast U, Kiderlen D, Diepold C, Eyer P. Improved determination of acetylcholinesterase activity in human whole blood. Clin Chim Acta 1999; 288:73–90.
  • Spöhrer U, Eyer P. Separation of geometrical syn/anti isomers of obidoxime by ion-pair high-performance liquid chromatography. J Chrom A 1995; 693:55–61.
  • Thiermann H, Radtke M, Spöhrer U, Klimmek R, Eyer P. Pharmacokinetics of atropine in dogs after i.m. injection with newly developed dry/wet combination autoinjectors containing HI 6 or HLö 7. Arch Toxicol 1996; 70:293–299.
  • Thiermann H, Worek F, Eyer P, Eyer F, Felgenhauer N, Zilker T. Obidoxime in acute organophosphate poisoning: 2 – PK/PD relationships. Clin Toxicol 2009; 47 DOI: 10.1080/15563650903206836.
  • Eddleston M, Dawson A, Karalliedde L, Dissanayake W, Hittarage A, Azher S, Buckley NA. Early management after self-poisoning with an organophosphorus or carbamate pesticide – a treatment protocol for junior doctors. Crit Care 2004; 8:R391–R397.
  • Zilker T, Hibler A. Treatment of severe parathion poisoning. In: Szinicz L, Eyer P, Klimmek R, eds. Role of Oximes in the Treatment of Anticholinesterase Agent Poisoning. Heidelberg: Spektrum, Akademischer Verlag; 1996:9–17.
  • Eddleston M, Eyer P, Worek F, Sheriff MH, Buckley NA. Predicting outcome using butyrylcholinesterase activity in organophosphorus pesticide self-poisoning. QJM 2008; 101:467–474.
  • Eyer F, Meischner V, Kiderlen D, Thiermann H, Worek F, Haberkorn M, Felgenhauer N, Zilker T, Eyer P. Human parathion poisoning. A toxicokinetic analysis. Toxicol Rev 2003; 22:143–163.
  • Senanayake N, Karalliedde L. Neurotoxic effects of organophosphorus insecticides. An intermediate syndrome. N Engl J Med 1987; 316:761–763.
  • Lotti M. Clinical toxicology of anticholinesterase agents in humans. In: Krieger RI, ed. Handbook of Pesticide Toxicology. Vol. 2. San Diego, CA: Academic Press; 2001:1043–1085.
  • De Bleecker J, Van den Neucker K, Colardyn F. Intermediate syndrome in organophosphorus poisoning: a prospective study. Crit Care Med 1993; 21:1706–1711.
  • Jayawardane P, Dawson AH, Weerasinghe V, Karalliedde L, Buckley NA, Senanayake N. The spectrum of intermediate syndrome following acute organophosphate poisoning: a prospective cohort study from Sri Lanka. PLoS Med 2008; 5:e147.
  • Boelcke G, Creutzfeldt W, Erdmann WD, Gaaz JW, Jacob G. Studies on liver toxicity of obidoxim (Toxogonin) in humans. Dtsch Med Wochenschr 1970; 95:1175–1178.
  • Johnson MK, Jacobsen D, Meredith TJ, Eyer P, Heath AJ, Ligtenstein DA, Marrs TC, Szinicz L, Vale A, Haines JA. Evaluation of antidotes for poisoning by organophosphorus pesticides. Emerg. Med 2000; 12:22–37.
  • Eyer P, Szinicz L, Thiermann H, Worek F, Zilker T. Testing of antidotes for organophosphorus compounds: experimental procedures and clinical reality. Toxicology 2007; 233:108–119.
  • Thiermann H, Szinicz L, Eyer P, Felgenhauer N, Zilker T, Worek F. Lessons to be learnt from organophosphorus pesticide poisoning for the treatment of nerve agent poisoning. Toxicology 2007; 233:145–154.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.