78
Views
8
CrossRef citations to date
0
Altmetric
Research Article

Corneal Epithelial Testing Strategies for Safety Evaluation of Ophthalmic Formulations

, , , , &
Pages 311-327 | Published online: 10 Oct 2008

REFERENCES

  • Brantom PG, Bruner LH, Chamberlain M, De Silva O, Dupuis J, Earl LK, Lovell DP, Pape WJW, Uttley M, Bagley DM, Baker FW, Bracher M, Courtellemont P, Declercq L, Freeman S, Steiling W, Walker AP, Carr GJ, Dami N, Thomas G, Harbell J, Jones PA, Pfannenbecker U, Southee JA, Tcheng M, Argembeaux H, Castelli D, Clothier R, Esdaile DJ, Itigaki H, Jung K, Kasai Y, Kojima H, Kristen U, Larnicol M, Lewis RW, Marenus K, Moreno O, Peterson A, Rasmussen ES, Robles C, Stern M. A summary report of the COLIPA international validation study on alternatives to the Draize rabbit eye irritation test. Toxicology in Vitro 1997; 11: 141–179.
  • Stokes, WS. The interagency coordinating committee on the validation of alternative methods (ICCVAM): recent progress in the evaluation of alternative toxicity testing methods. In: Salem H, Katz SA, eds. Alternative Toxicological Methods; New York, New York: CRC Press; 2003:15–30.
  • Ubels JL, Clousing DP. In vitro alternatives to the use of animals in ocular toxicology testing. The Ocular Surface 2005; 3: 126–142.
  • Reader SJ, Blackwell V, O'Hara R, Clothier RH, Griffen G, Balls M. Neutral red release from pre-loaded cells as an in vitro approach to testing for eye irritancy potential. Toxicol In Vitro 1990; 4: 264–266.
  • Kahn CR, Young E, Lee IH, Rhim JS. Human corneal epithelial primary cultures and cell lines with extended life span: in vitro model for ocular studies. Invest Ophthalmol Vis Sci 1993; 34: 3429–3441.
  • Ward SL, Walker TL, Dimitrijevich SD. Evaluation of chemically induced toxicity using an in vitro model of human corneal epithelium. Toxicol in Vitro 1997; 11: 121–139.
  • McCarey BE, Reaves TA. Noninvasive measurement of corneal epithelial permeability. Curr Eye Res 1995; 14: 505–510.
  • Fujihara T, Nagano T, Nakamura M, Shirasawa E. Establishment of a rabbit short-term dry eye model. J Ocular Pharmacol Ther 1995; 11: 503–508.
  • Ubels JL, Aupperlee MD, Meadows DL. Artificial tear solution and protection of the corneal epithelium from desiccation. Cutan Ocul Toxicol 2002; 21: 273–281.
  • Lopez Bernal D, Ubels JL. Quantitative evaluation of the corneal epithelial barrier: effect of artificial tears and preservatives. Curr Eye Res 1991; 10: 645–656.
  • Lopez Bernal D, Ubels JL. Artificial tear composition and promotion of recovery of the damaged corneal epithelium. Cornea 1993; 12: 115–120.
  • Zanvit A, Meunier P, Clothier R, Ward R, Buiatti-Tcheng M. Ocular irritancy assessment of cosmetics formulations and ingredients: fluorescein leakage test. Toxicol in Vitro 1999; 13: 385–391.
  • Shaw AJ, Clothier RH, Balls M, Bateman ND. Predicting ocular irritancy and recovery from injury using Madin-Darby canine kidney cells. Toxicol in Vitro 1991; 5: 569–571.
  • Burstein NL, Klyce SD. Electrophysiologic and morphologic effects of ophthalmic preparations on rabbit cornea epithelium. Invest Ophthalmol Vis Sci 1977; 16: 899–911.
  • Osgood TB. Surfactant ethoxylation and use of anti-irritant additives in reducing surfactant toxicity to the corneal epithelium: a comparison of in vitro and in vivo methods. M.S. Thesis, Medical College of Wisconsin, Milwaukee, WI, 1993.
  • Nussenblatt RB, Bron A, Chambers W, McCulley JP, Pericoi M, Ubels JL, Edelhauser HF. Ophthalmologic perspectives on eye irritation testing. J Toxicol–Cut and Ocular Toxicol 1998; 17: 103–109.
  • Jester JV. Extent of corneal injury as a biomarker for hazard assessment and the development of alternative models to the Draize rabbit eye test. Cut Ocular Toxicol 2006; 25: 41–54.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.