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Cutaneous and Ocular Toxicology Volume 28, 2009 - Issue 1
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Research Article

Assessing ocular irritation potential using a modified ex vivo rabbit eye test

James V. JesterGavin Herbert Eye Institute and Department of Biomedical Engineering, University of California, Irvine, Orange, California, USACorrespondence[email protected]
,
Larry LamGavin Herbert Eye Institute and Department of Biomedical Engineering, University of California, Irvine, Orange, California, USA
&
Andrew WahlertGavin Herbert Eye Institute and Department of Biomedical Engineering, University of California, Irvine, Orange, California, USA
Pages 32-36 | Received 18 Oct 2008, Accepted 15 Jan 2009, Published online: 01 Mar 2009

References

  • Heywood R, James RW. Toward objectivity in the assessment of eye irritation. J Soc Cosmet Chem (1978); 29:25.
  • Bruner LH. Ocular irritation. In: Frazier JM, ed. In Vitro Toxicity Testing. Applications to Safety Evaluation. New York: Marcel Dekker, 1992.
  • Weil CS, Scala RA. Study of intra- and interlaboratory variability in the results of rabbit eye and skin irritation tests. Toxicol Appl Pharmacol (1971); 19:276–360.
  • Marzulli FN, Simon ME. Eye irritation from topically applied drugs and cosmetics: precinical studies. Am J Optom Arch Am Acad Optom (1971); 48:61–79.
  • Freeberg FE, Hooker DT, Griffith JF. Correlation of animal eye data with human experience for household products. Cutan Ocul Toxicol (1986); 5:115–123.
  • Rowan AN. The future of animals in research and training. The search for alternative. Fundam Appl Toxicol (1984); 4:508–516.
  • Jester JV. Extent of corneal injury as a biomarker for hazard assessment and the development of alternative models to the Draize rabbit eye test. Cutan Ocul Toxicol (2006); 25:41–54.
  • Maurer JK, Parker RD, Jester JV. Extent of initial corneal injury as the mechanistic basis for ocular irritation: key findings and recommendations for the development of alternative assays. Regul Toxicol Pharmacol (2002); 36:106–117.
  • NOTOX Safety and Environmental Research. HPV Assessment Report on p-Toluenesulphonic acid CAS No. 104-15-4, 2007. www.epa.gov/hpv/pubs/summaries/ ptolacid/c16597.pdf February 7, 2009 accessed.
  • Jester JV, Li HF, Petroll WM, Parker RD, Cavanagh HD, Carr GJ, Smith B, Maurer JK. Area and depth of surfactant-induced corneal injury correlates with cell death. Invest Ophthalmol Vis Sci (1998); 39:922–936.
  • Jester JV, Li L, Molai A, Maurer JK. Extent of initial corneal injury as a basis for alternative eye irritation tests. Toxicol In Vitro (2001); 15:115–130.
  • Jester JV, Molai A, Petroll WM, Parker RD, Carr GJ, Cavanagh HD, Maurer JK. Quantitative characterization of acid- and alkali-induced corneal injury in the low-volume eye test. Toxicol Pathol (2000); 28:668–678.
  • Jester JV, Petroll WM, Bean J, Parker RD, Carr GJ, Cavanagh HD, Maurer JK. Area and depth of surfactant-induced corneal injury predicts extent of subsequent ocular responses. Invest Ophthalmol Vis Sci (1998); 39:2610–2625.
  • Maurer JK, Parker RD. Microscopic changes with acetic acid and sodium hydroxide in the rabbit low-volume eye test. Toxicol Pathol (2000); 28:679–687.
  • Cooper KJ, Earl LK, Harbell J, Raabe H. Prediction of ocular irritancy of prototype shampoo formulations by the isolated rabbit eye (IRE) test and bovine corneal opacity and permeability (BCOP) assay. Toxicol In Vitro (2001); 15:95–103.
  • Maurer JK, Parker RD. Light microscopic comparison of surfactant-induced eye irritation in rabbits and rats at three hours and recovery/day 35. Toxicol Pathol (1996); 24:403–411.

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