Safety of sodium hyaluronate eye drop with C12-benzalkonium chloride

References

• The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye Workshop (2007). Ocul Surf 2007;5:75–92.
   PubMed Web of Science ®Google Scholar
• Friedman NJ. Impact of dry eye disease and treatment on quality of life. Curr Opin Ophthalmol 2010;21:310–316.
   PubMed Web of Science ®Google Scholar
• Watanabe H. Significance of mucin on the ocular surface. Cornea 2002;21:S17–S22.
   PubMed Web of Science ®Google Scholar
• Miljanovic B, Dana R, Sullivan DA, et al. Impact of dry eye syndrome on vision-related quality of life. Am J Ophthalmol 2007;143:409–415.
   PubMed Web of Science ®Google Scholar
• Nakamura M, Sato N, Chikama TI, et al. Hyaluronan facilitates corneal epithelial wound healing in diabetic rats. Exp Eye Res 1997;64:1043–1050.
   PubMed Web of Science ®Google Scholar
• Troiano P, Monaco G. Effect of hypotonic 0.4% hyaluronic acid drops in dry eye patients: a cross-over study. Cornea 2008;27:1126–1130.
   PubMed Web of Science ®Google Scholar
• Ayaki M, Iwasawa A, Niwano Y. Cytotoxicity assays of new artificial tears containing 2-methacryloyloxyethyl phosphorylcholine polymer for ocular surface cells. Jpn J Ophthalmol 2011;55:541–546.
   PubMed Web of Science ®Google Scholar
• Furrer P, Mayer JM, Gurny R. Ocular tolerance of preservatives and alternatives. Eur J Pharm Biopharm 2002;53:263–280.
   PubMed Web of Science ®Google Scholar
• Burgalassi S, Chetoni P, Monti D, et al. Cytotoxicity of potential ocular permeation enhancers evaluated on rabbit and human corneal epithelial cell lines. Toxicol Lett 2001;122:1–8.
   PubMed Web of Science ®Google Scholar
• Debbasch C, Brignole F, Pisella PJ, et al. Quaternary ammoniums and other preservatives’ contribution in oxidative stress and apoptosis on Chang conjunctival cells. Invest Ophthalmol Vis Sci 2001;42:642–652.
   PubMed Web of Science ®Google Scholar
• Pfister RR, Burstein N. The effects of ophthalmic drugs, vehicles, and preservatives on corneal epithelium: a scanning electron microscope study. Invest Ophthalmol 1976;15:246–259.
   PubMedGoogle Scholar
• Nakashima M, Nakamura T, Teshima M, et al. Breakdown evaluation of corneal epithelial barrier caused by antiallergic eyedrops using an electrophysiologic method. J Ocul Pharmacol Ther 2008;24:43–51.
   PubMed Web of Science ®Google Scholar
• Uematsu M, Kumagami T, Kusano M, et al. Acute corneal epithelial change after instillation of benzalkonium chloride evaluated using a newly developed in vivo corneal transepithelial electric resistance measurement method. Ophthalmic Res 2007;39:308–314.
   PubMed Web of Science ®Google Scholar
• Kusano M, Uematsu M, Kumagami T, et al. Evaluation of acute corneal barrier change induced by topically applied preservatives using corneal transepithelial electric resistance in vivo. Cornea 2010;29:80–85.
   PubMed Web of Science ®Google Scholar
• Onizuka N, Uematsu M, Kusano M, et al. Influence of different additives and their concentrations on corneal toxicity and antimicrobial effect of benzalkonium chloride. Cornea 2014;33:521–526.
   PubMed Web of Science ®Google Scholar
• Uematsu M, Kumagami T, Shimoda K, et al. Influence of alkyl chain length of benzalkonium chloride on acute corneal epithelial toxicity. Cornea 2010;29:1296–1301.
   PubMed Web of Science ®Google Scholar
• Baudouin C, Labbé A, Liang H, et al. Preservatives in eyedrops: the good, the bad and the ugly. Prog Retin Eye Res 2010;29:312–334.
   PubMed Web of Science ®Google Scholar
• Chrai SS, Makoid MC, Eriksen SP, et al. Drop size and initial dosing frequency problems of topically applied ophthalmic drugs. J Pharm Sci 1974;63:333–338.
   PubMed Web of Science ®Google Scholar
• Draize JH , Woodard G , Calvery HO. Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes. J Pharmacol Exp Ther 1944;82:377–390.
   Web of Science ®Google Scholar
• Kruszewski FH, Walker TL, DiPasquale LC. Evaluation of a human corneal epithelial cell line as an in vitro model for assessing ocular irritation. Fundam Appl Toxicol 1997;36:130–140.
   PubMedGoogle Scholar
• Furrer P, Plazonnet B, Mayer JM, et al. Application of in vivo confocal microscopy to the objective evaluation of ocular irritation induced by surfactants. Int J Pharm 2000;207:89–98.
   PubMed Web of Science ®Google Scholar
• Prinsen MK. The chicken enucleated eye test (CEET): a practical (pre)screen for the assessment of eye irritation/corrosion potential of test materials. Food Chem Toxicol 1996;34:291–296.
   PubMed Web of Science ®Google Scholar
• Monti D, Chetoni P, Burgalassi S, et al. Increased corneal hydration induced by potential ocular penetration enhancers: assessment by differential scanning calorimetry (DSC) and by desiccation. Int J Pharm 2002;232:139–147.
   PubMed Web of Science ®Google Scholar
• Göbbels M, Spitznas M. Influence of artificial tears on corneal epithelium in dry-eye syndrome. Graefes Arch Clin Exp Ophthalmol 1989;227:139–141.
   PubMed Web of Science ®Google Scholar
• Ishibashi T, Yokoi N, Kinoshita S. Comparison of the short-term effects on the human corneal surface of topical timolol maleate with and without benzalkonium chloride. J Glaucoma 2003;12:486–490.
   PubMed Web of Science ®Google Scholar
• Pauloin T, Dutot M, Warnet JM, et al. In vitro modulation of preservative toxicity: high molecular weight hyaluronan decreases apoptosis and oxidative stress induced by benzalkonium chloride. Eur J Pharm Sci 2008;34:263–273.
   PubMed Web of Science ®Google Scholar
• Aragona P, Di SG, Ferreri F, et al. Sodium hyaluronate eye drops of different osmolarity for the treatment of dry eye in Sjogren’s syndrome patients. Br J Ophthalmol 2002;86:879–884.
   PubMed Web of Science ®Google Scholar
• Yu F, Liu X, Zhong Y, et al. Sodium hyaluronate decreases ocular surface toxicity induced by benzalkonium chloride-preserved latanoprost: an in vivo study. Invest Ophthalmol Vis Sci 2013;54:3385–3393.
   PubMed Web of Science ®Google Scholar