Topical hyaluronan alone promotes corneal epithelial cell migration whereas combination with benzalkonium chloride impairs epithelial wound healing

References

• Weissmann B, Meyer K. The structure of hyalobiuronic acid and of hyaluronic acid from umbilical cord. J Am Chem Soc 1954;76:1753–1757.
   Web of Science ®Google Scholar
• Fraser JRE, Laurent TC, Laurent U. Hyaluronan: its nature, distribution, functions and turnover. J Intern Med 1997;242:27–33.
   PubMed Web of Science ®Google Scholar
• Meyer K, Palmer JW. The polysaccharide of the vitreous humor. J Biol Chem 1934;107:629–634.
   Google Scholar
• Meyer K, Smyth EM, Dawson MH. The isolation of a mucopolysaccharide synovial fluid. J Biol Chem 1939;128:319–327.
   Google Scholar
• Meyer K, Chaffee E, Hobby GL, et al. Hyaluronidases of bacterial and animal origin. J Exp Med 1941;73:309–326.
   PubMedGoogle Scholar
• Aya KL, Stern R. Hyaluronan in wound healing: rediscovering a major player. Wound Repair Regen 2014;22:579–593.
   PubMed Web of Science ®Google Scholar
• Jiang D, Liang J, Noble PW. Hyaluronan in tissue injury and repair. Annu Rev Cell Dev Biol 2007;23:435–461.
   PubMed Web of Science ®Google Scholar
• West D, Hampson I, Arnold F, et al. Angiogenesis induced by degradation products of hyaluronic acid. Science 1985;228:1324–1326.
   PubMed Web of Science ®Google Scholar
• Slevin M, Kumar S, Gaffney J. Angiogenic oligosaccharides of hyaluronan induce multiple signaling pathways affecting vascular endothelial cell mitogenic and wound healing responses. J Biol Chem 2002;277:41046–41059.
   PubMed Web of Science ®Google Scholar
• Saikia P, Roychowdhury S, Bellos D, et al. Hyaluronic acid 35 normalizes TLR4 signaling in Kupffer cells from ethanol-fed rats via regulation of microRNA291b and its target Tollip. Sci Rep 2017;7:15671.
   PubMed Web of Science ®Google Scholar
• Bollyky PL, Wu RP, Falk BA, et al. ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors. Proc Natl Acad Sci USA 2011;108:7938–7943.
   PubMed Web of Science ®Google Scholar
• Nishida T, Nakamura M, Mishima H, et al. Hyaluronan stimulates corneal epithelial migration. Exp Eye Res 1990;53:753–758.
   Web of Science ®Google Scholar
• Kretz FTA, Limberger IJ, Auffarth GU. Corneal endothelial cell coating during phacoemulsification using a new dispersive hyaluronic acid ophthalmic viscosurgical device. J Cataract Refract Surg 2014;40:1879–1884.
   PubMed Web of Science ®Google Scholar
• Sparavigna A, Fino P, Tenconi B, et al. A new dermal filler made of cross-linked and auto-cross-linked hyaluronic acid in the correction of facial aging defects. J Cosmet Dermatol 2014;13:307–314.
   PubMed Web of Science ®Google Scholar
• Palmieri B, Rottigni V, Iannitti T. Preliminary study of highly cross-linked hyaluronic acid-based combination therapy for management of knee osteoarthritis-related pain. Drug Des Devel Ther 2013;7:7–12.
   PubMed Web of Science ®Google Scholar
• Martins M, Azoia NG, Shimanovich U, et al. Design of novel BSA/hyaluronic acid nanodispersions for transdermal pharma purposes. Mol Pharmaceutics 2014;11:1479–1488.
   PubMed Web of Science ®Google Scholar
• Tashiro T, Seino S, Sato T, et al. Oral administration of polymer hyaluronic acid alleviates symptoms of knee osteoarthritis: a double-blind, placebo-controlled study over a 12-month period. Sci World J 2012;2012:167928.
   Google Scholar
• Kawada C, Kimura M, Masuda Y, et al. Oral administration of hyaluronan prevents skin dryness and epidermal thickening in ultraviolet irradiated hairless mice. J Photochem Photobiol B Biol 2015;153:215–221.
   PubMed Web of Science ®Google Scholar
• Cagini C, Torroni G, Fiore T, et al. Tear film stability in Sjögren syndrome patients treated with hyaluronic acid versus crosslinked hyaluronic acid-based eye drops. J Ocul Pharmacol Ther 2017;33:539–542.
   PubMed Web of Science ®Google Scholar
• Nakamura M, Hikida M, Nakano T. Concentration and molecular weight dependency of rabbit corneal epithelial wound healing on hyaluronan. Curr Eye Res 1992;11:981–986.
   PubMed Web of Science ®Google Scholar
• Zheng X, Goto T, Shiraishi A, et al. In vitro efficacy of ocular surface lubricants against dehydration. Cornea 2013;32:1260–1264.
   PubMed Web of Science ®Google Scholar
• Nakamura M, Mishima H, Nishida T, et al. Binding of hyaluronan to plasma fibronectin increases the attachment of corneal epithelial cells to a fibronectin matrix. J Cell Physiol 1994;159:415–422.
   PubMed Web of Science ®Google Scholar
• Stapleton F, Alves M, Bunya VY, et al. TFOS DEWS II epidemiology report. Ocul Surf 2017;15:334–368.
   PubMed Web of Science ®Google Scholar
• Nagai N, Murao T, Okamoto N, et al. Comparison of corneal wound healing rates after instillation of commercially available latanoprost and travoprost in rat debrided corneal epithelium. J Oleo Sci 2010;59:135–141.
   PubMed Web of Science ®Google Scholar
• Lin Z, Liu X, Zhou T, et al. A mouse dry eye model induced by topical administration of benzalkonium chloride. Mol Vis 2011;17:257–264.
   PubMed Web of Science ®Google Scholar
• Liu X, Yu F-F, Zhong Y-M, et al. Therapeutic effects of sodium hyaluronate on ocular surface damage induced by benzalkonium chloride preserved anti-glaucoma medications. Chin Med J 2015;128:2444–2449.
   PubMed Web of Science ®Google Scholar
• Yu F, Liu X, Zhong Y, et al. Sodium hyaluronate decreases ocular surface toxicity induced by benzalkonium chloride-preserved latanoprost: an in vivo study. Invest Ophthalmol Vis Sci 2013;54:3385–3393.
   PubMed Web of Science ®Google Scholar
• Nagai N, Ito Y, Okamoto N, et al. In vitro evaluation of corneal damages after instillation of eye drops using rat debrided corneal epithelium: changes in corneal damage of benzalkonium chloride by addition of thickening agent. Yakugaku Zasshi 2012;132:837–843.
   PubMed Web of Science ®Google Scholar
• Wu CL, Chou HC, Li JM, et al. Hyaluronic acid-dependent protection against alkali-burned human corneal cells. Electrophoresis 2013;34:1–28.
   PubMed Web of Science ®Google Scholar
• Asada H, Takaoka-Shichijo Y, Nakamura M, et al. Optimization of benzalkonium chloride concentration in 0.0015% Tafluprost ophthalmic solution from the points of ocular surface safety and preservative efficacy. Yakugaku Zasshi 2010;130:867–871.
   PubMed Web of Science ®Google Scholar
• Saika S, Shiraishi A, Liu CY, et al. Role of lumican in the corneal epithelium during wound healing. J Biol Chem 2000;275:2607–2612.
   PubMed Web of Science ®Google Scholar
• Sumioka T, Okada Y, Reinach PS, et al. Impairment of corneal epithelial wound healing in a TRPV1-deficient mouse. Invest Ophthalmol Vis Sci 2014;55:3295–3302.
   PubMed Web of Science ®Google Scholar
• Ayaki M, Iwasawa A, Niwano Y. Cell viability score as an integrated indicator for cytotoxicity of benzalkonium chloride-containing antiglaucoma eyedrops. Biocontrol Sci 2012;17:121–128.
   PubMed Web of Science ®Google Scholar
• Shirai K, Okada Y, Cheon DJ, et al. Effects of the loss of conjunctival Muc16 on corneal epithelium and stroma in mice. Invest Ophthalmol Vis Sci 2014;55:3626–3637.
   PubMed Web of Science ®Google Scholar
• Desbenoit N, Hamm G, Liang H, et al. A new safety concern for glaucoma treatment demonstrated by mass spectrometry imaging of benzalkonium chloride distribution in the eye, an experimental study in rabbits. PLoS One 2012;7:e50180.
   PubMed Web of Science ®Google Scholar
• Tseng C, Hung Y, Chen ZY, et al. Synergistic effect of artificial tears containing epigallocatechin gallate and hyaluronic acid for the treatment of rabbits with dry eye syndrome. PLoS One 2016;11:e0157982.
   PubMed Web of Science ®Google Scholar
• Okada Y, Saika S, Shirai K, et al. JNK MAPK signaling contributes in vivo to injury-induced corneal epithelial migration. Ophthalmic Res 2009;42:185–192.
   PubMed Web of Science ®Google Scholar
• Rönkkö S, Vellonen K, Järvinen K, et al. Human corneal cell culture models for drug toxicity studies. Drug Deliv and Transl Res 2016;6:660–675.
   PubMed Web of Science ®Google Scholar
• Denion E, Charlot F, Béraud G. A 5-minute interval between two dilating eye drops increases their effect. Optom Vis Sci 2017;94:838–844.
   PubMed Web of Science ®Google Scholar
• Salzillo R, Schiraldi C, Corsuto L, et al. Optimization of hyaluronan-based eye drop formulations. Carbohydr Polym 2016;153:275–283.
   PubMed Web of Science ®Google Scholar
• Campo GM, D’Ascola A, Avenoso A, et al. Glycosaminoglycans reduce oxidative damage induced by copper (Cu + 2), iron (Fe + 2) and hydrogen peroxide (H2O2) in human fibroblast cultures. Glycoconj J 2003;20:133–141.
   Web of Science ®Google Scholar