Exploring the potential of minoxidil tretinoin liposomal based hydrogel for topical delivery in the treatment of androgenic alopecia

References

• Gupta AK, Mays RR, Versteeg SG, et al. Efficacy of off-label topical treatments for the management of androgenetic alopecia: a review. Clin Drug Investig 2019;39:233–239.
   PubMed Web of Science ®Google Scholar
• Joshi R, Shokri T, Baker A, et al. Alopecia and techniques in hair restoration: an overview for the cosmetic surgeon. Oral Maxillofac Surg 2019;23:123–131.
   PubMedGoogle Scholar
• Davis DS, Callender VD. Review of quality of life studies in women with alopecia. Int J Women Dermatol. 2018;4:18–22.
   PubMedGoogle Scholar
• Ghanaat M. Types of hair loss and treatment options, including the novel low-level light therapy and its proposed mechanism. South Med J 2010;103:917–921.
   PubMed Web of Science ®Google Scholar
• Yasuda M, Hagigeorges D, Ibler E, et al. The Medical and Psychosocial Associations of Alopecia: recognizing hair loss as more than a cosmetic concern. Am J Clin Dermatol 2019;20:195–200.
   PubMed Web of Science ®Google Scholar
• Goh C. Systemic therapies for scarring and non-scarring Alopecia. In: Yamauchi PS, ed. Biologic and systemic agents in dermatology. Cham: Springer International Publishing; 2018:495–515.
   Google Scholar
• Sung CT, Juhasz MLW, Mesinkovska NA. The efficacy of topical minoxidil for non-scarring alopecia: a systematic review. J Drugs Dermatol 2019;18:155–160.
   PubMed Web of Science ®Google Scholar
• Lee SW, Juhasz MLW, Mobasher P, et al. A Systematic Review of Topical Finasteride in the Treatment of Androgenetic Alopecia in Men and Women. J Drugs Dermatol 2018;17:457–463.
   PubMed Web of Science ®Google Scholar
• Motofei IG, Rowland DL, Baconi DL, et al. Androgenetic alopecia; drug safety and therapeutic strategies. Expert Opin Drug Saf 2018;17:407–412.
   PubMed Web of Science ®Google Scholar
• Kanti V, Messenger A, Dobos G, et al. Evidence-based (S3) guideline for the treatment of androgenetic alopecia in women and in men – short version. J Eur Acad Dermatol Venereol 2018;32:11–22.
   PubMed Web of Science ®Google Scholar
• Choi N, Shin S, Song SU, Sung JH. Minoxidil promotes hair growth through stimulation of growth factor release from adipose-derived stem cells. Int J Mol Sci 2018;19:1–15.
   Web of Science ®Google Scholar
• Messenger AG, Rudegren J. Minoxidil: mechanisms of action on hair growth. Br J Dermatol 2004;150:186–194.
   PubMed Web of Science ®Google Scholar
• Shin HS, Lee SH, Kim KH, et al. Efficacy of 5% minoxidil versus combined 5% minoxidil and 0.01% tretinoin for male pattern hair loss. Am J Clin Dermatol 2009;8:285–290.
   Web of Science ®Google Scholar
• Pereira MN, Ushirobira CY, Cunha-Filho MSS, et al. Nanotechnology advances for hair loss. Ther Deliv 2018;9:593–604.
   PubMed Web of Science ®Google Scholar
• Zarkesh K. Preparation and Physicochemical Characterization of Topical Niosomal Formulation of Minoxidil and Tretinoin. Glob J Pharm Pharm Sci 2018;3:1–6.
   Google Scholar
• Padois K, Cantiéni C, Bertholle V, et al. Solid lipid nanoparticles suspension versus commercial solutions for dermal delivery of minoxidil. Int J Pharm 2011;416:300–304.
   PubMed Web of Science ®Google Scholar
• Lopedota A, Denora N, Laquintana V, et al. Alginate-based hydrogel containing minoxidil/hydroxypropyl-β-cyclodextrin inclusion complex for topical alopecia treatment. J Pharm Sci 2018;107:1046–1054.
   PubMed Web of Science ®Google Scholar
• Tricarico D, Maqoud F, Curci A, et al. Characterization of minoxidil/hydroxypropyl-β-cyclodextrin inclusion complex in aqueous alginate gel useful for alopecia management: Efficacy evaluation in male rat. Eur J Pharm Biopharm 2017;122:146–157.
   PubMed Web of Science ®Google Scholar
• Uprit S, Kumar R, Roy A, Pare A. Preparation and characterization of minoxidil loaded nanostructured lipid carrier gel for effective treatment of alopecia. Saudi Pharm J 2013;21:379–385.
   PubMed Web of Science ®Google Scholar
• Wang W, Chen L, Huang X, Shao A. Preparation and characterization of minoxidil loaded nanostructured lipid carriers. AAPS PharmSciTech 2016;18:509–516.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Brown MB, Jones SA. The effects of particle properties on nanoparticle drug retention and release in dynamic minoxidil foams. Int J Pharm 2010;383:277–284.
   PubMed Web of Science ®Google Scholar
• Mura S, Pirot F, Manconi M, et al. Liposomes and niosomes as potential cariers for dermal delivery of minoxidil. J Drug Target 2007;15:101–108.
   PubMed Web of Science ®Google Scholar
• Kumar P, Singh S, Handa V, Kathuria H. Oleic acid nanovesicles of minoxidil for enhanced follicular delivery. Medicines 2018;5:103–118.
   Google Scholar
• Alireza S, Pishrochi S, Jafari Z. Formulation and in-vitro evaluation of tretinoin microemulsion as a potential carrier for dermal drug delivery. Iran J Pharm Res 2013;12:599–609.
   PubMed Web of Science ®Google Scholar
• Brisaert M, Gabriëls M, Matthijs V, Plaizier-Vercammen J. Liposomes with tretinoin: a physical and chemical evaluation. J Pharm Biomed Anal 2001;26:909–917.
   PubMed Web of Science ®Google Scholar
• Valenti D, Ennas G, Manconi M, et al. Liposomes for (trans)dermal delivery of tretinoin: influence of drug concentration and vesicle composition. J Drug Deliv Sci Technol 2015;18:309–313.
   Google Scholar
• Mandawgade SD, Patravale VB. Development of SLNs from natural lipids: application to topical delivery of tretinoin. Int J Pharm 2008;363:132–138.
   PubMed Web of Science ®Google Scholar
• Shah KA, Date AA, Joshi MD, Patravale VB. Solid lipid nanoparticles (SLN) of tretinoin: potential in topical delivery. Int J Pharm 2007;345:163–171.
   PubMed Web of Science ®Google Scholar
• Raza K, Singh B, Lohan S, et al. Nano-lipoidal carriers of tretinoin with enhanced percutaneous absorption, photostability, biocompatibility and anti-psoriatic activity. Int J Pharm 2013;456:65–72.
   PubMed Web of Science ®Google Scholar
• Das S, Ng WK, Kanaujia P, et al. Formulation design, preparation and physicochemical characterizations of solid lipid nanoparticles containing a hydrophobic drug: effects of process variables. Colloids Surf B Biointerfaces 2011;88:483–489.
   PubMed Web of Science ®Google Scholar
• Ascenso A, Salgado A, Euletério C, et al. In vitro and in vivo topical delivery studies of tretinoin-loaded ultradeformable vesicles. Eur J Pharm Biopharm 2014;88:48–55.
   PubMed Web of Science ®Google Scholar
• Rahman SA, Abdelmalak NS, Badawi A, et al. Formulation of tretinoin-loaded topical proniosomes for treatment of acne: In-vitro characterization, skin irritation test and comparative clinical study. Drug Deliv 2015;22:731–739.
   PubMed Web of Science ®Google Scholar
• Lapteva M, Möller M, Gurny R, Kalia YN. Self-assembled polymeric nanocarriers for the targeted delivery of retinoic acid to the hair follicle. Nanoscale 2015;7:18651–18662.
   PubMed Web of Science ®Google Scholar
• Manca ML, Manconi M, Nacher A, et al. Development of novel diolein-niosomes for cutaneous delivery of tretinoin: Influence of formulation and in vitro assessment. Int J Pharm 2014;477:176–186.
   PubMedGoogle Scholar
• Ashtikar M, Nagarsekar K, Fahr A. Transdermal delivery from liposomal formulations – Evolution of the technology over the last three decades. J Control Release 2016;242:126–140.
   PubMed Web of Science ®Google Scholar
• Sun W, Zhang N, Li A, et al. Preparation and evaluation of N3-O-toluyl-fluorouracil-loaded liposomes. Int J Pharm 2008;353:243–250.
   PubMed Web of Science ®Google Scholar
• Boulmedarat L, Grossiord JL, Fattal E, Bochot A. Influence of methyl-β-cyclodextrin and liposomes on rheological properties of Carbopol® 974P NF gels. Int J Pharm 2003;254:59–64.
   PubMed Web of Science ®Google Scholar
• Flores FC, de Lima JA, da Silva CR, et al. Hydrogels containing nanocapsules and nanoemulsions of tea tree oil provide antiedematogenic effect and improved skin wound healing. J Nanosci Nanotechnol 2014;15:800–809.
   Web of Science ®Google Scholar
• Nayak K, Katiyar SS, Kushwah V, Jain S. Coenzyme Q10 and retinaldehyde co-loaded nanostructured lipid carriers for efficacy evaluation in wrinkles. J Drug Target 2018;26:333–344.
   PubMed Web of Science ®Google Scholar
• Moghaddam AA, Ahad A, Aqil M, et al. Ibuprofen loaded nano-ethanolic liposomes carbopol gel system: In vitro characterization and anti-inflammatory efficacy assessment in Wistar rats. J Polym Eng 2018;38:291–298.
   Web of Science ®Google Scholar
• Ahad A, Al-Saleh AA, Al-Mohizea AM, et al. Pharmacodynamic study of eprosartan mesylate-loaded transfersomes Carbopol®gel under Dermaroller®on rats with methyl prednisolone acetate-induced hypertension. Biomed Pharmacother 2017;89:177–184.
   PubMed Web of Science ®Google Scholar
• Vinardell MP, Mitjans M. Alternative methods for eye and skin irritation tests: an overview. J. Pharm Sci 2006;97:46–59.
   Web of Science ®Google Scholar
• Alshahrani SM, Lu W, Park J-B, et al. Stability-enhanced hot-melt extruded amorphous solid dispersions via combinations of Soluplus® and HPMCAS-HF. AAPS PharmSciTech 2015;16:824–834.
   PubMed Web of Science ®Google Scholar
• Bao J, Xue X, Li K, et al. Competing Stereocomplexation and Homocrystallization of Poly(l -lactic acid)/Poly(d -lactic acid) racemic mixture: effects of miscible blending with other polymers. J Phys Chem B 2017;121:6934–6943.
   PubMed Web of Science ®Google Scholar
• Meng F, Trivino A, Prasad D, Chauhan H. Investigation and correlation of drug polymer miscibility and molecular interactions by various approaches for the preparation of amorphous solid dispersions. Eur J Pharm Sci 2015;71:12–24.
   PubMed Web of Science ®Google Scholar
• Pan P, Bao J, Han L, et al. Stereocomplexation of high-molecular-weight enantiomeric poly(lactic acid)s enhanced by miscible polymer blending with hydrogen bond interactions. Polymer 2016;98:80–87.
   Web of Science ®Google Scholar
• Benne N, van Duijn J, Lozano Vigario F, et al. Anionic 1,2-distearoyl-sn-glycero-3-phosphoglycerol (DSPG) liposomes induce antigen-specific regulatory T cells and prevent atherosclerosis in mice. J Control Release 2018;291:135–146.
   PubMed Web of Science ®Google Scholar
• Sakdiset P, Okada A, Todo H, Sugibayashi K. Selection of phospholipids to design liposome preparations with high skin penetration-enhancing effects. J Drug Deliv Sci Technol 2018;44:58–64.
   Web of Science ®Google Scholar
• Khachane PV, Jain AS, Dhawan VV, et al. Cationic nanoemulsions as potential carriers for intracellular delivery. Saudi Pharm. J 2015;23:188–194.
   PubMed Web of Science ®Google Scholar
• Sant VP, Nagarsenker MS, Rao SGA, Gude RP. Enhancement of anti-metastatic activity of pentoxifylline by encapsulation in conventional liposomes and sterically stabilized liposomes in murine experimental B16F10 melanoma model. J Pharm Pharmacol 2000;52:1461–1466.
   PubMed Web of Science ®Google Scholar
• Bhuptani RS, Jain AS, Makhija DT, et al. Soluplus based polymeric micelles and mixed micelles of lornoxicam: Design, characterization and In vivo efficacy studies in rats. Indian J Pharm Educ Res 2016;50:277–286.
   Web of Science ®Google Scholar
• Saroja C, Lakshmi PK. Formulation and optimization of fenofibrate lipospheres using Taguchi’s experimental design. Acta Pharm 2013;63:71–83.
   PubMed Web of Science ®Google Scholar
• Castangia I, Manca ML, Matricardi P, et al. Effect of diclofenac and glycol intercalation on structural assembly of phospholipid lamellar vesicles. Int J Pharm 2013;456:1–9.
   PubMed Web of Science ®Google Scholar
• Vanić Ž, Hurler J, Ferderber K, et al. Novel vaginal drug delivery system: deformable propylene glycol liposomes-in-hydrogel. J Liposome Res 2014;24:27–36.
   PubMed Web of Science ®Google Scholar
• Elsayed MMA, Abdallah OY, Naggar VF, Khalafallah NM. PG-liposomes: novel lipid vesicles for skin delivery of drugs. J Pharm Pharmacol 2007;59:1447–1450.
   PubMed Web of Science ®Google Scholar
• Elmoslemany RM, Abdallah OY, El-Khordagui LK, Khalafallah NM. propylene glycol liposomes as a topical delivery system for miconazole nitrate: comparison with conventional liposomes. AAPS PharmSciTech 2012;13:723–731.
   PubMed Web of Science ®Google Scholar
• Yamaguchi T, Nomura M, Matsuoka T, Koda S. Effects of frequency and power of ultrasound on the size reduction of liposome. Chem Phys Lipids 2009;160:58–62.
   PubMed Web of Science ®Google Scholar
• Sebaaly C, Greige-Gerges H, Stainmesse S, et al. Effect of composition, hydrogenation of phospholipids and lyophilization on the characteristics of eugenol-loaded liposomes prepared by ethanol injection method. Food Biosci 2016;15:1–10.
   Web of Science ®Google Scholar
• Park SN, Lee MH, Kim SJ, Yu ER. Preparation of quercetin and rutin-loaded ceramide liposomes and drug-releasing effect in liposome-in-hydrogel complex system. Biochem Biophys Res Commun 2013;435:361–366.
   PubMed Web of Science ®Google Scholar
• Pan TL, Wang PW, Aljuffali IA, et al. The impact of urban particulate pollution on skin barrier function and the subsequent drug absorption. J Dermatol Sci 2015;78:51–60.
   PubMed Web of Science ®Google Scholar
• Fluhr JW, Darlenski R, Angelova-Fischer I, et al. Skin irritation and sensitization: mechanisms and new approaches for risk assessment. Skin Pharmacol Physiol 2008;21:124–135.
   PubMed Web of Science ®Google Scholar
• Robinson MK, Perkins MA. A strategy for skin irritation testing. Am J Contact Dermat 2002;13:21–29.
   PubMedGoogle Scholar
• Draelos ZD. Hydrogel barrier/repair creams and contact dermatitis. Am J Contact Dermat 2000;11:222–225.
   PubMedGoogle Scholar