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Original Articles

Influence of timolol, benzalkonium-preserved timolol, and benzalkonium-preserved brimonidine on oxidative stress biomarkers in the tear film

ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 260-268 | Received 02 May 2020, Accepted 18 Jun 2020, Published online: 07 Jul 2020

References

  • Weinreb RN, Aung T, Medeiros FA. The pathophysiology and treatment of glaucoma: a review. JAMA 2014;311:1901–1911.
  • Negri L, Ferreras A, Iester M, Timolol 0. Timolol 0.1% in glaucomatous patients: efficacy, tolerance, and quality of life. J Ophthalmol 2019;2019:4146124–12.
  • Cantor LB. Brimonidine in the treatment of glaucoma and ocular hypertension. Ther Clin Risk Manag 2006;2:337–346.
  • Anwar Z, Wellik SR, Galor A. Glaucoma therapy and ocular surface disease: current literature and recommendations. Curr Opin Ophthalmol 2013; 24:136–143.
  • Leung EW, Medeiros FA, Weinreb RN. Prevalence of ocular surface disease in glaucoma patients. J Glaucoma 2008;17:350–355.
  • Baudouin C, Liang H, Hamard P, et al. The ocular surface of glaucoma patients treated over the long term expresses inflammatory markers related to both T-helper 1 and T-helper 2 pathways. Ophthalmology 2008;115:109–115.
  • Baudouin C, Labbé A, Liang H, et al. Preservatives in eyedrops: the good, the bad and the ugly. Prog Retin Eye Res 2010;29:312–334.
  • Potvin R, Makari S, Rapuano C. Tear film osmolarity and dry eye disease: a review of the literature. Clin Ophthalmol 2015;9:2039–2047.
  • Dogru M, Kojima T, Simsek C, et al. Potential role of oxidative stress in ocular surface inflammation and dry eye disease. Invest Ophthalmol Vis Sci 2018;59:DES163.
  • Ablamowicz AF, Nichols JJ. Concentrations of MUC16 and MUC5AC using three tear collection methods. Mol Vis 2017;23:529–537.
  • Witko-Sarsat V, Friedlander M, Capeillère-Blandin C, et al. Advanced oxidation protein products as a novel marker of oxidative stress in uremia. Kidney Int 1996;49:1304–1313.
  • Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys 1959;82:70–77.
  • Erel O. A new automated colorimetric method for measuring total oxidant status. Clin. Bioche 2005;38:1103–1111.
  • Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem 2004;37:112–119.
  • Dartt DA, Willcox M. Complexity of the tear film: importance in homeostasis and dysfunction during disease. Exp Eye Res 2013;117:1–3.
  • Chen Y, Mehta G, Vasiliou V. Antioxidant defenses in the ocular surface. Ocul Surf 2009;7:176–185.
  • Koh S, Tung CI, Inoue Y, et al. Effects of tear film dynamics on quality of vision. Br J Ophthalmol 2018;102:1615–1620.
  • Valente C, Iester M, Corsi E, et al. Symptoms and signs of tear film dysfunction in glaucomatous patients. J Ocul Pharmacol Ther 2011;27:281–285.
  • Baudouin C, Renard J, Nordmann J, et al. Prevalence and risk factors for ocular surface disease among patients treated over the long term for glaucoma or ocular hypertension. Eur J Ophthalmol 2013;23:47–54.
  • Aguayo BA, Yeung JY, Chan CC, et al. Ocular surface toxicity from glaucoma topical medications and associated preservatives such as benzalkonium chloride (BAK). Expert Opin Drug Metab Toxicol 2016;12:1279–1289.
  • Tu EY. Balancing antimicrobial efficacy and toxicity of currently available topical ophthalmic preservatives. Saudi J Ophthalmol 2014;28:182–187.
  • Steven DW, Alaghband P, Lim KS. Preservatives in glaucoma medication. Br J Ophthalmol 2018;102:1497–1503.
  • Jaenen N, Baudouin C, Pouliquen P, et al. Ocular symptoms and signs with preserved and preservative-free glaucoma medications. Eur J Ophthalmol 2007;3:341–349.
  • Rasmussen CA, Kaufman PL, Kiland JA. Benzalkonium chloride and glaucoma. J Ocul Pharmacol Ther 2014;30:163–169.
  • Brasnu E, Brignole-Baudouin F, Riancho L, et al. In vitro effects of preservative-free tafluprost and preserved latanoprost, travoprost, and bimatoprost in a conjunctival epithelial cell line. Curr Eye Res 2008; 33:303–312.
  • Wu H, Zhang H, Wang C, et al. Genoprotective effect of hyaluronic acid against benzalkonium chloride-induced DNA damage in human corneal epithelial cells. Mol Vis 2011;17:3364–3370.
  • Lushchak VI. Free radicals, reactive oxygen species, oxidative stress and its classification. Chem Biol Interact 2014;224:164–175.
  • Sies H, Berndt C, Jones DP. Oxidative stress. Annu Rev Biochem 2017;86:715–748.
  • Seen S, Tong L. Dry eye disease and oxidative stress. Acta Ophthalmol 2017;96:412–420.
  • Sedlak L, Zych M, Wojnar W, et al. Effect of topical prostaglandin F2α analogs on selected oxidative stress parameters in the tear film. Medicina (Kaunas). 2019;55:366.
  • Izzotti A, Saccà SC, Di Marco B, et al. Antioxidant activity of timolol on endothelial cells and its relevance for glaucoma course. Eye (Lond) 2007;22:445–453.
  • Yu ZK, Chen YN, Aihara M, et al. Effects of β-adrenergic receptor antagonists on oxidative stress in purified rat retinal ganglion cells. Mol Vis 2007;13:833–839.
  • Piste P. Cysteine-master antioxidant. Int J Pharm Chem Biol Sci 2013;3:143–149.
  • Reichmann D, Voth W, Jakob U. Maintaining a healthy proteome during oxidative stress. Mol Cell 2018;69:203–213.
  • Comini MA. Measurement and meaning of cellular thiol:disufhide redox status. Free Radic Res 2016;50:246–271.
  • Forman HJ, Zhang H, Rinna A. Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med 2009;30:1–12.
  • Dickinson DA, Forman HJ. Glutathione in defense and signaling: lessons from a small thiol. Ann N Y Acad Sci 2002;973:488–504.
  • Lu SC. Regulation of glutathione synthesis. Mol Aspects Med 2009;30:42–59.
  • Grek CL, Zhang J, Manevich Y, et al. Causes and consequences of cysteine S-glutathionylation. J Biol Chem 2013;288:26497–26504.
  • Espinosa-Diez C, Miguel V, Mennerich D, et al. Antioxidant responses and cellular adjustments to oxidative stress. Redox Biol 2015;6:183–197.
  • Piwowar A. Zaawansowane produkty utleniania białek. Część I. Mechanizm powstawania, struktura i właściwości. [Advanced Oxidation Protein Products. Part I. Mechanism of the Formation, Characteristics and Property]. Pol Merkur Lek 2010;28:166–169.
  • Di Simplicio P, Franconi F, Frosalí S, et al. Thiolation and nitrosation of cysteines in biological fluids and cells. Amino Acids 2003;25:323–339.
  • Baudouin C, Denoyer A, Desbenoit N, et al. In vitro and in vivo experimental studies on trabecular meshwork degeneration induced by benzalkonium chloride (an American ophthalmological society thesis). Trans Am Ophthalmol Soc 2012;110:40–63.
  • Ighodaro OM, Akinloye OA. First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): their fundamental role in the entire antioxidant defence grid. Alexandria J Med 2018;54:287–293.
  • Wang MT, Murphy PJ, Blades KJ, et al. Comparison of non-invasive tear film stability measurement techniques. Clin Exp Optom 2017;101:13–17.
  • Herbaut A, Liang H, Denoyer A, et al. Tear film analysis and evaluation of optical quality: a review of the literature. J Fr Ophtalmol 2019;42:21–35.
  • Cejková J, Ardan T, Simonová Z, et al. Decreased expression of antioxidant enzymes in the conjunctival epithelium of dry eye (Sjögren’s Syndrome) and its possible contribution to the development of ocular surface oxidative injuries. Histol Histopathol 2008;23:1477–1483.
  • Corrales RM, Galarreta D, Herreras J, et al. Antioxidant enzyme mRNA expression in conjunctival epithelium of healthy human subjects. Can J Ophthalmol 2011;46:35–39.
  • Singh R. Impression cytology of the ocular surface. Br J Ophthalmol 2005;89:1655–1659.
  • Tong L, Thia Z-Z. Update on the role of impression cytology in ocular surface disease. Taiwan J Ophthalmol 2019;9:141.
  • Maciejczyk M, Zalewska A, Ładny JR. Salivary antioxidant barrier, redox status, and oxidative damage to proteins and lipids in healthy children, adults, and the elderly. Oxid Med Cell Longev 2019;2019:4393460

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