98
Views
1
CrossRef citations to date
0
Altmetric
Research Articles

Early effects of intravitreal anti-VEGF agents on cornea and visual acuity in patients with diabetic retinopathy

, , &
Pages 213-218 | Received 23 Jan 2023, Accepted 03 Jul 2023, Published online: 13 Jul 2023

References

  • Cheung N, Mitchell P, Wong TY. Diabetic retinopathy. Lancet. 2010;376(9735):124–136. doi: 10.1016/S0140-6736(09)62124-3.
  • Browning DJ, Stewart MW, Lee C. Diabetic macular edema: evidence-based management. Indian J Ophthalmol. 2018;66(12):1736–1750. doi: 10.4103/ijo.IJO_1240_18.
  • Ferro Desideri L, Traverso CE, Nicolò M. An update on conbercept to treat wet age-related macular degeneration. Drug Today. 2020;56(5):311–320.
  • Gan L, Fagerholm P, Palmblad J. Vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in the regulation of corneal neovascularization and wound healing. Acta Ophthalmol Scand. 2004;82(5):557–563. doi: 10.1111/j.1600-0420.2004.00312.x.
  • Guzel H, Bakbak B, Koylu MT, et al. The effect and safety of intravitreal injection of ranibizumab and bevacizumab on the corneal endothelium in the treatment of diabetic macular edema. Cutan Ocul Toxicol. 2017;36(1):5–8. doi: 10.3109/15569527.2016.1140177.
  • Rusovici R, Sakhalkar M, Chalam KV. Evaluation of cytotoxicity of bevacizumab on VEGF-enriched corneal endothelial cells. Mol Vision. 2011;17:3339–3346.
  • Pacella E, Pacella F, La Torre G, et al. Testing the effectiveness of intravitreal ranibizumab during 12 months of follow-up in venous occlusion treatment. Clin Ter. 2012;163(6):e413-422–e422.
  • Bayar SA, Altinors DD, Kucukerdonmez C, et al. Severe corneal changes following intravitreal injection of bevacizumab. Ocul Immunol Inflamm. 2010;18(4):268–274. doi: 10.3109/09273948.2010.490630.
  • Skeie JM, Aldrich BT, Goldstein AS, et al. Proteomic analysis of corneal endothelial cell-descemet membrane tissues reveals influence of insulin dependence and disease severity in type 2 diabetes mellitus. PloS One. 2018;13(3):e0192287. doi: 10.1371/journal.pone.0192287.
  • Saini JS, Mittal S. In vivo assessment of corneal endothelial function in diabetes mellitus. Arch Ophthalmol. 1996;114(6):649–653. doi: 10.1001/archopht.1996.01100130641001.
  • Bayhan HA, Aslan Bayhan S, Can I. Comparison of Central corneal thickness measurements with three new optical devices and a standard ultrasonic pachymeter. Int J Ophthalmol. 2014;7(2):302–308.
  • Módis L, Jr., Szalai E, Kertész K, et al. Evaluation of the corneal endothelium in patients with diabetes mellitus type I and II. Histol Histopathol. 2010;25(12):1531–1537.
  • Inoue K, Kato S, Inoue Y, et al. The corneal endothelium and thickness in type II diabetes mellitus. Jpn J Ophthalmol. 2002;46(1):65–69. doi: 10.1016/s0021-5155(01)00458-0.
  • Pont C, Ascaso FJ, Grzybowski A, et al. Corneal endothelial cell density during diabetes mellitus and ocular diabetes complications treatment. J Fr Ophtalmol. 2020;43(8):794–798. doi: 10.1016/j.jfo.2019.12.003.
  • Aldrich BT, Schlötzer-Schrehardt U, Skeie JM, et al. Mitochondrial and morphologic alterations in native human corneal endothelial cells associated with diabetes mellitus. Invest Ophthalmol Vis Sci. 2017;58(4):2130–2138. doi: 10.1167/iovs.16-21094.
  • Chen C, Zhou Q, Li Z, et al. Hyperglycemia induces corneal endothelial dysfunction through attenuating mitophagy. Exp Eye Res. 2022;215:108903. doi: 10.1016/j.exer.2021.108903.
  • Omay E, Elgin U, Sen E, et al. The early effects of intravitreal anti vascular endothelial growth factor agents on intraocular pressure and Central corneal thickness. Int Ophthalmol. 2016;36(5):665–670. doi: 10.1007/s10792-016-0171-1.
  • Mathew PT, David S, Thomas N. Endothelial cell loss and Central corneal thickness in patients with and without diabetes after manual small incision cataract surgery. Cornea. 2011;30(4):424–428. doi: 10.1097/ICO.0b013e3181eadb4b.
  • Kang KH, Song MY, Kim KY, et al. Corneal endothelial cell changes after femtosecond Laser-Assisted cataract surgery in diabetic and nondiabetic patients. Eye Contact Lens. 2021;47(12):664–669. doi: 10.1097/ICL.0000000000000823.
  • Chancellor J, Soliman MK, Shoults CC, et al. Intraoperative complications and visual outcomes of cataract surgery in diabetes mellitus: a multicenter database study. Am J Ophthalmol. 2021;225:47–56. doi: 10.1016/j.ajo.2020.12.027.
  • Ziadi M, Moiroux P, d’Athis P, et al. Assessment of induced corneal hypoxia in diabetic patients. Cornea. 2002;21(5):453–457. doi: 10.1097/00003226-200207000-00004.
  • Santos AR, Santos T, Alves D, et al. Characterization of initial stages of diabetic macular edema. Ophthalmic Res. 2019;62(4):203–210. doi: 10.1159/000499117.
  • Fujiwara A, Kanzaki Y, Kimura S, et al. En face image-based classification of diabetic macular edema using swept source optical coherence tomography. Sci Rep. 2021;11(1):7665. doi: 10.1038/s41598-021-87440-3.
  • Acan D, Calan M, Er D, et al. The prevalence and systemic risk factors of diabetic macular edema: a cross-sectional study from Turkey. BMC Ophthalmol. 2018;18(1):91. doi: 10.1186/s12886-018-0753-y.
  • Chatziralli I, Papadakou P, Dimitriou E, et al. The effect of intravitreal anti-vascular endothelial growth factor injections on corneal endothelium in patients with diabetic macular oedema. Cutan Ocul Toxicol. 2021;40(2):66–69. doi: 10.1080/15569527.2021.1887886.
  • Kuroiwa DAK, Malerbi FK, Regatieri CVS. New insights in resistant diabetic macular edema. Ophthalmologica. 2021;244(6):485–494. doi: 10.1159/000516614.
  • Nicholson L, Ramu J, Chan EW, et al. Retinal nonperfusion characteristics on ultra-widefield angiography in eyes with severe nonproliferative diabetic retinopathy and proliferative diabetic retinopathy. JAMA Ophthalmol. 2019;137(6):626–631. doi: 10.1001/jamaophthalmol.2019.0440.
  • Abdolrahimzadeh S, Gharbiya M, Formisano M, et al. Anti-Vascular endothelial growth factor intravitreal therapy and macular ganglion cell layer thickness in patients with neovascular age-related macular degeneration. Curr Eye Res. 2019;44(9):1000–1005. doi: 10.1080/02713683.2019.1610179.
  • Lee R, Wong TY, Sabanayagam C. Epidemiology of diabetic retinopathy, diabetic macular edema and related vision loss. Eye Vis (Lond). 2015;2:17. doi: 10.1186/s40662-015-0026-2.
  • Trovato Battagliola E, Pacella F, Malvasi M, et al. Risk factors in central retinal vein occlusion: a multi-center case-control study conducted on the italian population: demographic, environmental, systemic, and ocular factors that increase the risk for major thrombotic events in the retinal venous system. Eur J Ophthalmol. 2022;32(5):2801–2809. doi: 10.1177/11206721211064469.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.