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Review Article

High-throughput sequencing provides an insight into the hepatotoxicity mechanism of MC-LR in HepG2 cells

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Pages 1-10 | Received 13 Dec 2016, Accepted 09 Apr 2017, Published online: 03 May 2017

References

  • Adamovsky O, Moosova Z, Pekarova M, et al. (2015). Immunomodulatory potency of microcystin, an important water-polluting cyanobacterial toxin. Environ Sci Technol 49:12457–64
  • Alverca E, Andrade M, Dias E, et al. (2009). Morphological and ultrastructural effects of microcystin-LR from Microcystis aeruginosa extract on a kidney cell line. Toxicon 54:283–94
  • Audic S, Claverie JM. (1997). The significance of digital gene expression profiles. Genome Res 7:986–95
  • Arvelo MB, Cooper JT, Longo C, et al. (2002). A20 protects mice from D-galactosamine/lipopolysaccharide acute toxic lethal hepatitis. Hepatology 35:535–43
  • Azevedo SMFO, Carmichael WW, Jochimsen EM, et al. (2002). Human intoxication by microcystins during renal dialysis treatment in Caruaru-Brazil. Toxicology 181:441–6
  • Benjamini Y, Yekutieli D. (2001). The control of the false discovery rate in multiple testing under dependency. Ann Stat 29:1165–88
  • Boyle EI, Weng S, Gollub J, et al. (2004). GO: TermFinder–open source software for accessing gene ontology information and finding significantly enriched gene ontology terms associated with a list of genes. Bioinformatics 20:3710–15
  • Brzuzan P, Florczyk M, Łakomiak A, Woźny M. (2016). Illumina sequencing reveals aberrant expression of microRNAs and their variants in whitefish (Coregonus lavaretus) liver after exposure to microcystin-LR. PloS One 11:e0158899
  • Calin GA, Croce CM. (2006). MicroRNA signatures in human cancers. Nat Rev Cancer 6:857–66
  • Campos A, Vasconcelos V. (2010). Molecular mechanisms of microcystin toxicity in animal cells. Int J Mol Sci 11:268–87
  • Casquilho NV, Carvalho GMC, Alves JLCR, et al. (2011). LASSBio 596 per os, avoids pulmonary and hepatic inflammation induced by microcystin-LR. Toxicon 58:195–201
  • Carmichael WW, Azevedo SM, An JS, et al. (2001). Human fatalities from cyanobacteria: chemical and biological evidence for cyanotoxins. Environ Health Perspect 109:663–8
  • Costa V, Aprile M, Esposito R, Ciccodicola A. (2013). RNA-Seq and human complex diseases: recent accomplishments and future perspectives. Eur J Hum Genet 21:134–42
  • Costantini S, Bernardo GD, Cammarota M, et al. (2013). Gene expression signature of human HepG2 cell line. Gene 518:335–45
  • De Valck D, Heyninck K, Van Criekinge W, et al. (1997). A20 inhibits NF-κB activation independently of binding to 14-3-3 proteins. Biochem Biophys Res Co 238:590–4
  • Dias E, Louro H, Pinto M, et al. (2014). Genotoxicity of microcystin-LR in in vitro and in vivo experimental models. BioMed Res Int 2014:949521. doi:10.1155/2014/949521
  • Feng G, Abdalla M, Li Y, Bai Y. (2011). NF-κB mediates the induction of Fas receptor and Fas ligand by microcystin-LR in HepG2 cells. Mol Cell Biochem 352:209–19
  • Fu W, Chen J, Wang X, Xu L. (2005). Altered expression of p53, Bcl-2 and Bax induced by microcystin-LR in vivo and in vitro. Toxicon 46:171–7
  • Gan N, Sun X, Song L. (2010). Activation of Nrf2 by microcystin-LR provides advantages for liver cancer cell growth. Chem Res Toxicol 23:1477–84
  • Gan N, Mi L, Sun X, et al. (2010). Sulforaphane protects microcystin-LR-induced toxicity through activation of the Nrf2-mediated defensive response. Toxicol Appl Pharm 247:129–37
  • Gant T, Marcxylo E. (2015). miRNAs in toxicology: the link to epigenetic effects. Toxicol Lett 238:S24
  • Harke MJ, Gobler CJ. (2013). Global transcriptional responses of the toxic cyanobacterium, Microcystis aeruginosa, to nitrogen stress, phosphorus stress, and growth on organic matter. PLoS One 8:69834
  • Hoeger SJ, Hitzfeld BC, Dietrich DR. (2005). Occurrence and elimination of cyanobacterial toxins in drinking water treatment plants. Toxicol Appl Pharmacol 203:231–42
  • Hudder A, Song W, O'Shea KE, Walsh PJ. (2007). Toxicogenomic evaluation of microcystin-LR treated with ultrasonic irradiation. Toxicol Appl Pharm 220:357–64
  • Ji Y, Lu G, Chen G, et al. (2011). Microcystin-LR induces apoptosis via NF-κB/iNOS pathway in INS-1 cells. Int J Mol Sci 12:4722–34
  • Jin S, Antinore MJ, Lung FD, et al. (2000). The GADD45 inhibition of Cdc2 kinase correlates with GADD45-mediated growth suppression. J Biol Chem 275:16602–8
  • Jin Q, Pan L, Liu T, Hu F. (2015). RNA-seq based on transcriptome reveals differ genetic expressing in Chlamys farreri exposed to carcinogen PAHs. Environ Toxicol Pharm 39:313–20
  • Jovanovic M, Rooney MS, Mertins P, et al. (2015). Dynamic profiling of the protein life cycle in response to pathogenes. Science 347:1038–259
  • Kanehisa M, Goto S, Kawashima S, et al. (2004). The KEGG resource for deciphering the genome. Nucleic Acids Res 32:277–80
  • Kanehisa M, Goto S, Furumichi M, et al. (2010). KEGG for representation and analysis of molecular networks involving diseases and drugs. Nucleic Acids Res 38:355–60
  • Kullak-Ublick GA, Beuers U, Paumgartner G. (1996). Molecular and functional characterization of bile acid transport in human hepatoblastoma HepG2 cells. Hepatology 23:1053–60
  • Lennington JB, Coppola G, Kataoka-Sasaki Y, et al. (2016). Transcriptome analysis of the human striatum in Tourette syndrome. Biol Psychiat 79:372–82
  • Li X, Liu Y, Song L, Liu J. (2003). Responses of antioxidant systems in the hepatocytes of common carp (Cyprinus carpio L.) to the toxicity of microcystin-LR. Toxicon 42:85–9
  • Li X, Ma J. (2017). Mitochondria and lysosomes play a key role in HepG2 cell apoptosis induced by microcystin-LR. Toxin Rev 36:63–72
  • Li R, Li Y, Kristiansen K, Wang J. (2008). SOAP: short oligonucleotide alignment program. Bioinformatics 24:713–14
  • Li JJ, Bricker PJ, Biggin MD. (2014). System wide analyses have underestimated protein abundances and the importance of transcription in mammals. Peer J 2:270
  • Li JJ, Biggin MD. (2015). Statistics requantitates the central dogma. Science 347:1066–7
  • Liu Y, Xie P, Qiu T, et al. (2010). Microcystin extracts induce ultrastructural damage and biochemical disturbance in male rabbit testis. Environ Toxicol 25:9–17
  • Liu Y, Morley M, Brandimarto J, et al. (2015). RNA-Seq identifies novel myocardial gene expression signatures of heart failure. Genomics 105:83–9
  • Liu J, Wang H, Wang B, et al. (2016). Microcystin-LR promotes proliferation by activating Akt/S6K1 pathway and disordering apoptosis and cell cycle associated proteins phosphorylation in HL7702 cells. Toxicol Lett 240:214–25
  • Livak KJ, Schmittgen TD. (2001). Analysis of relative gene expression data using real-time quantitative PCR and 2(-Delta Delta Ct) method. Methods 25:402–8
  • Ma J, Feng Y, Xie W, Li X. (2015). PP2A (PR65) in silver carp: cDNA cloning and expression analysis. J Biochem Mol Toxicol 29:399–409
  • Ma J, Feng Y, Liu Y, Li X. (2016). PUMA and survivin are involved in the apoptosis of HepG2 cells induced by microcystin-LR via mitochondria-mediated pathway. Chemosphere 157:241–9
  • Ma J, Li X. (2016). MicroRNAs are involved in the toxicity of microcystins. Toxin Rev [Epub ahead of print]. doi:10.1080/15569543.2016.1258713
  • Mersch-Sundermann V, Knasmuller S, Wu XJ, et al. (2004). Use of a human-derived liver cell line for the detection of cytoprotective, antigenotoxic and cogenotoxic agents. Toxicology 198:329–40
  • Mortazavi A, William BA, McCue K, et al. (2008). Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat Methods 5:621–8
  • Peffers MJ, Fang Y, Cheung K, et al. (2015). Transcriptome analysis of ageing in uninjured human achilles tendon. Arthritis Res Ther 17:1–18
  • Rastogi RP, Sinha RP, Incharoensakdi A. (2014). The cyanotoxin–microcystins: current overview. Rev Environ Sci Bio Technol 13:215–49
  • Rogers ED, Henry TB, Twiner MJ, et al. (2011). Global gene expression profiling in larval zebrafish exposed to microcystin-LR and Microcystis reveals endocrine disrupting effects of cyanobacteria. Environ Sci Technol 45:1962–9
  • Runnegar MT, Kong S, Berndt N. (1993). Protein phosphatase inhibition and in vivo hepatotoxicity of microcystins. Am J Physiol 265:224–30
  • Svirčev Z, Krstic S, Miladinovmikov M, et al. (2009). Freshwater cyanobacterial blooms and primary liver cancer epidemiological studies in Serbia. J Environ Sci Health C 27:36–55
  • Svirčev Z, Baltić V, Gantar M, et al. (2010). Molecular aspects of microcystin-induced hepatotoxicity and hepatocarcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 28:39–59
  • Sambrook J, Russel DV. (2001). Molecular cloning: a laboratory manual. 3rd ed., vol. 1. New York: Cold Spring Harbor Laboratory, 13–17
  • Stone D, Bress W. (2007). Addressing public health risks for cyanobacteria in recreational freshwaters: the Oregon and Vermont framework. Integr Environ Assess Manag 3:137–43
  • Tachi M, Imanishi SY, Harada KI. (2007). Phosphoprotein analysis for investigation of in vivo relationship between protein phosphatase inhibitory activities and acute hepatotoxicity of microcystin-LR. Environ Toxicol 22:620–9
  • Ueno Y, Nagata S, Tsutsumi T, et al. (1996). Detection of microcystins, a blue-green algal hepatotoxin, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay. Carcinogenesis 17:1317–21
  • Ufelmann H, Kruger T, Luckas B, Schrenk D. (2012). Human and rat hepatocyte toxicity and protein phosphatase 1 and 2A inhibitory activity of naturally occurring desmethyl-microcystins and nodularins. Toxicology 293:59–67
  • Wang Z, Gerstein M, Snyder M. (2009). RNA-Seq: a revolutionary tool for transcriptomics. Nat Rev Genet 10:57–63
  • Wang L, Feng Z, Wang X, et al. (2010). DEGseq: an R package for identifying differentially expressed genes from RNA-seq data. Bioinformatics 26:136–8
  • Wei L, Sun B, Song L, Nie P. (2008). Gene expression profiles in liver of zebrafish treated with microcystin-LR. Environ Toxicol Pharmacol 26:6–12
  • Wood R. (2016). Acute animal and human poisonings from cyanotoxin exposure—A review of the literature. Environ Int 91:276–82
  • Ye J, Fang L, Zheng H, et al. (2006). WEGO: a web tool for plotting GO annotations. Nucleic Acids Res 34:293–7
  • Young MD, Wakefield MJ, Smyth GK, Oshlack A. (2010). Method gene ontology analysis for RNA-seq: accounting for selection bias. Genome Biol 11:R14
  • Zeller P, Quenault H, Huguet A, et al. (2012). Transcriptomic comparison of cyanotoxin variants in a human intestinal model revealed major differences in oxidative stress response: effects of MC-RR and MC-LR on Caco-2 cells. Ecotox Environ Safe 82:13–21
  • Zhang BH, Pan XP, Cobb GP, Anderson TA. (2007). microRNAs as oncogenes and tumor suppressors. Dev Biol 302:1–12
  • Zhang X, Xie P, Zhang X, et al. (2013). Toxic effects of microcystin-LR on the HepG2 cell line under hypoxic and normoxic conditions. J Appl Toxicol 33:1180–6
  • Zhou M, Tu WW, Xu J. (2015). Mechanisms of microcystin-LR-induced cytoskeletal disruption in animal cells. Toxicon 101:92–100

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