365
Views
9
CrossRef citations to date
0
Altmetric
Review Article

Anticancer and antimicrobial activities of scorpion venoms and their peptides

ORCID Icon
Pages 41-53 | Received 12 Oct 2017, Accepted 05 Dec 2017, Published online: 18 Dec 2017

References

  • Akef, H., et al., 2017. Anti-proliferative effects of Androctonus amoreuxi Scorpion and Cerastes cerastes snake venoms on human prostate cancer cells. Journal of cancer prevention, 22, 40–46.
  • Al Asmari, A.K., and Khan, A.Q., 2016. Investigation of in vivo potential of scorpion venom against skin tumorigenesis in mice via targeting markers associated with cancer development. Drug design, development and therapy, 10, 3387–3397.
  • Almaaytah, A., et al., 2014. Antimicrobial and antibiofilm activity of mauriporin, a multifunctional scorpion venom peptide. International journal of peptide research and therapeutics, 20, 397–408.
  • Almaaytah, A., et al., 2013. Mauriporin, a novel cationic α-helical peptide with selective cytotoxic activity against prostate cancer cell lines from the venom of the scorpion androctonus mauritanicus. International journal of peptide research and therapeutics, 19, 281–293.
  • Almaaytah, A., et al., 2012. Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. Peptides, 35, 291–299.
  • Almaaytah, A., and Albalas, Q., 2014. Scorpion venom peptides with no disulfide bridges: a review. Peptides, 51, 35–45.
  • Arpornsuwan, T., et al., 2014a. Potent and rapid antigonococcal activity of the venom peptide BmKn2 and its derivatives against different Maldi biotype of multidrug-resistant Neisseria gonorrhoeae. Peptides, 53, 315–320.
  • Arpornsuwan, T., et al., 2014b. Anticancer activities of antimicrobial BmKn2 peptides against oral and colon cancer cells. International journal of peptide research and therapeutics, 20, 501–509.
  • Bao, A., et al., 2015. A novel cysteine-free venom peptide with strong antimicrobial activity against antibiotics-resistant pathogens from the scorpion Opistophthalmus glabrifrons. Journal of peptide science, 21, 758–764.
  • Cao, L., et al., 2012a. Antibacterial activity and mechanism of a Scorpion venom peptide derivative in vitro and in vivo. PLoS One, 7, e40135.
  • Cao, L., et al., 2012b. StCT2, a new antibacterial peptide characterized from the venom of the scorpion Scorpiops tibetanus. Peptides, 36, 213–220.
  • Chen, Y., et al., 2012. Anti-HIV-1 activity of a new scorpion venom peptide derivative Kn2-7. PLoS One, 7, e34947.
  • Corzo, G., et al., 2001. Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator. Biochemical journal, 359, 35–45.
  • Cui, Y., et al., 2016. Investigation of the role of disulphide bond in modulating internal motions of BmK AGAP protein by molecular dynamics simulation. Molecular simulation, 42, 771–775.
  • Das Gupta, S., et al., 2013. Bengalin initiates autophagic cell death through ERK-MAPK pathway following suppression of apoptosis in human leukemic U937 cells. Life sciences, 93, 271–276.
  • De Melo, E.T., E., et al., 2015. Structural characterization of a novel peptide with antimicrobial activity from the venom gland of the scorpion Tityus stigmurus: Stigmurin. Peptides, 68, 3–10.
  • DeBin, J.A., Maggio, J.E., and Strichartz, G.R., 1993. Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpion. The American journal of physiology, 264, C361–C369.
  • Deshane, J., Garner, C.C., and Sontheimer, H., 2003. Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2. The Journal of Biological Chemistry, 278, 4135–4144.
  • Díaz-García, A., et al., 2013. In vitro anticancer effect of venom from Cuban scorpion Rhopalurus junceus against a panel of human cancer cell lines. Journal of venom research, 4, 5–12.
  • Du, Q., et al., 2015. AaeAP1 and AaeAP2: Novel antimicrobial peptides from the venom of the scorpion, Androctonus aeneas: structural characterisation, molecular cloning of biosynthetic precursor-encoding cDNAS and engineering of analogues with enhanced antimicrobial and antica. Toxins, 7, 219–237.
  • El-Bitar., et al., 2015. Virocidal activity of Egyptian scorpion venoms against hepatitis C virus. Virology journal, 12, 47
  • Fan, S., et al., 2010. BmKCT toxin inhibits glioma proliferation and tumor metastasis. Cancer letters, 291, 158–166.
  • Gu, Y., et al., 2013. Analgesic-antitumor peptide induces apoptosis and inhibits the proliferation of SW480 human colon cancer cells. Oncology letters, 5, 483–488.
  • Guo, G., et al., 2016. Analgesic-antitumor peptide inhibits the migration and invasion of HepG2 cells by an upregulated VGSC β1 subunit. Tumor biology, 37, 3033–3041.
  • Guo, X., et al., 2013. Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: Evaluation of their antimicrobial and anticancer activities. Biochimie, 95, 1784–1794.
  • Gupta, S.D., et al., 2010. Apoptosis induction in human leukemic cells by a novel protein Bengalin, isolated from Indian black scorpion venom: Through mitochondrial pathway and inhibition of heat shock proteins. Chemico-biological interactions, 183, 293–303.
  • Harrison, P.L., et al., 2016. Characterisation of three alpha-helical antimicrobial peptides from the venom of Scorpio maurus palmatus. Toxicon, 117, 30–36.
  • Hong, W., et al., 2013. Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus. Biomaterials, 34, 3511–3522.
  • Hong, W., et al., 2014. Inhibitory activity and mechanism of two scorpion venom peptides against herpes simplex virus type 1. Antiviral research, 102, 1–10.
  • Huang, R., et al., 2011. Chlorotoxin-modified macromolecular contrast agent for MRI tumor diagnosis. Biomaterials, 32, 5177–5186.
  • Huang, Y., Huang, J., and Chen, Y., 2010. Alpha-helical cationic antimicrobial peptides: Relationships of structure and function. Protein and protein & cell, 1, 143–152.
  • Joseph, B., and George, J., 2012. Scorpion toxins and its applications. International journal of toxicological and pharmacological research, 4, 57–61.
  • Khazim, A., et al., 2016. In vitro analysis of the anticancer properties of scorpion venom in colorectal and breast cancer cell lines. Oncology letters, 11, 1256–1262.
  • Li, Q., et al., 2011. Virucidal activity of a scorpion venom peptide variant mucroporin-M1 against measles, SARS-CoV and influenza H5N1 viruses. Peptides, 32, 1518–1525.
  • Machado, R.J.A., et al., 2016. Characterization of TistH, a multifunctional peptide from the scorpion Tityus stigmurus: Structure, cytotoxicity and antimicrobial activity. Toxicon, 119, 362–370.
  • Nie, Y., et al., 2012. A novel class of antimicrobial peptides from the scorpion Heterometrus spinifer. Peptides, 38, 389–394.
  • Ojeda, P.G., Wang, C.K., and Craik, D.J., 2016. Chlorotoxin: structure, activity, and potential uses in cancer therapy. Biopolymers, 106, 25–36.
  • Ortiz, E., et al., 2015. Scorpion venom components as potential candidates for drug development. Toxicon, 93, 125–135.
  • Ramírez-Carreto, S., et al., 2015. Peptides from the scorpion Vaejovis punctatus with broad antimicrobial activity. Peptides, 73, 51–59.
  • Ramírez-Carreto, S., et al., 2012. Gene cloning and functional characterization of four novel antimicrobial-like peptides from scorpions of the family Vaejovidae. Peptides, 34, 290–295.
  • Rjeibi, I., et al., 2011. Purification, synthesis and characterization of AaCtx, the first chlorotoxin-like peptide from Androctonus australis scorpion venom. Peptides, 32, 656–663.
  • Rodríguez, A., et al., 2014. Characterization of antibacterial and hemolytic activity of synthetic pandinin 2 variants and their inhibition against Mycobacterium tuberculosis. PLoS One, 9, e101742.
  • Rodríguez De La Vega, R.C., and Possani, L.D., 2005. Overview of scorpion toxins specific for Na + channels and related peptides: biodiversity, structure-function relationships and evolution. Toxicon, 46, 831–844.
  • Satitmanwiwat, S., et al., 2016. The scorpion venom peptide BmKn2 induces apoptosis in cancerous but not in normal human oral cells. Biomedicine pharmacotherapy biomedecine pharmacotherapie, 84, 1042–1050.
  • Shao, J.H., et al., 2014. Purification, characterization, and bioactivity of a new analgesic-antitumor peptide from Chinese scorpion Buthus martensii Karsch. Peptides, 53, 89–96.
  • Soroceanu, L., Manning, T.J., and Sontheimer, H., 1999. Modulation of glioma cell migration and invasion using Cl(−) and K(+) ion channel blockers. The journal of neuroscience, 19, 5942–5954.
  • Tong-ngam, P., Roytrakul, S., and Sritanaudomchai, H., 2015. BmKn-2 scorpion venom peptide for killing oral cancer cells by apoptosis. Asian pacific journal of cancer prevention, 16, 2807–2811.
  • Valdez-Cruz, N.A., et al., 2011. Anticoagulants from scorpion venoms. Toxins and hemostasis: from bench to bedside, 255–266.
  • Veiseh, O., et al., 2009. Inhibition of tumor-cell invasion with chlorotoxin-bound superparamagnetic nanoparticles. Small, 5, 256–264.
  • Wu, S., et al., 2014. Genomic and functional characterization of three new venom peptides from the scorpion Heterometrus spinifer. Peptides, 53, 30–41.
  • Xu, T., et al., 2016. Identification of two novel Chlorotoxin derivatives CA4 and CTX-23 with chemotherapeutic and anti-angiogenic potential. Scientific reports, 6, 19799.
  • Yu, F.H., and Catterall, W. a., 2003. Overview of the voltage-gated sodium channel family. Genome biology, 4, 207
  • Zabihollahi, R., et al., 2016. Venom components of Iranian scorpion Hemiscorpius lepturus inhibit the growth and replication of Human Immunodeficiency Virus 1 (HIV-1). Iranian biomedical journal, 20, 259–265.
  • Zeng, X.C., et al., 2013. Three new antimicrobial peptides from the scorpion Pandinus imperator. Peptides, 45, 28–34.
  • Zeng, Z., et al., 2016. A scorpion defensin BmKDfsin4 inhibits hepatitis B virus replication in vitro. Toxins, 8, 124.
  • Zhao, Y., et al., 2011. Analgesic-antitumor peptide inhibits proliferation and migration of SHG-44 human malignant glioma cells. Journal of cellular biochemistry, 112, 2424–2434.
  • Zhao, Z., et al., 2012. Mucroporin-M1 inhibits hepatitis B virus replication by activating the mitogen-activated protein kinase (MAPK) pathway and down-regulating HNF4α in vitro and in vivo. Journal of biological chemistry, 287, 30181–30190.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.