Astaxanthin prevents the methotrexate-induced reproductive toxicity by targeting oxidative stress in male mice

References

• Agarwal, A., et al., 2005. Prevention of oxidative stress injury to sperm. Journal of andrology, 26 (6), 654–660.
   Google Scholar
• Agarwal, A., et al., 2014. Effect of oxidative stress on male reproduction. The world journal of men's health, 32 (1), 1–17.
   Google Scholar
• Aitken, R.J., 1997. Molecular mechanisms regulating human sperm function. Molecular human reproduction, 3 (3), 169–173.
   Google Scholar
• Alvarez, J.G., et al., 1987. Spontaneous lipid peroxidation and production of hydrogen peroxide and superoxide in human spermatozoa superoxide dismutase as major enzyme protectant against oxygen toxicity. Journal of andrology, 8 (5), 338–348.
   Google Scholar
• Andrisani, A., et al., 2015. Astaxanthin improves human sperm capacitation by inducing lyn displacement and activation. Marine drugs, 13 (9), 5533–5551.
   Google Scholar
• Aprioku, J.S., 2013. Pharmacology of free radicals and the impact of reactive oxygen species on the testis. Journal of reproduction and infertility, 14 (4), 158.
   Google Scholar
• Asadi, N., et al., 2017. The impact of oxidative stress on testicular function and the role of antioxidants in improving it: a review. Journal of clinical and diagnostic research: JCDR, 11 (5), IE01.
   Google Scholar
• Asghari, M.H., et al., 2017. A review of the protective effect of melatonin in pesticide-induced toxicity. Expert opinion on drug metabolism and toxicology, 13 (5), 545–554.
   Google Scholar
• Bahmanzadeh, M., et al., 2016. Dietary supplementation with astaxanthin may ameliorate sperm parameters and DNA integrity in streptozotocin-induced diabetic rats. Clinical and experimental reproductive medicine, 43 (2), 90–96.
   Google Scholar
• Baninameh, Z., et al., 2016. Urtica dioica attenuate effect of doxorobicin-induced changes on sperm parameters in the mice. International journal of medical research and health sciences, 5 (11), 116–121.
   Google Scholar
• Boyle, P. and Ferlay, J., 2005. Cancer incidence and mortality in Europe, 2004. Annals of oncology, 16 (3), 481–488.
   Google Scholar
• Buege, J.A. and Aust, S.D., 1978. [30] Microsomal lipid peroxidation. Methods in enzymology, 52, 302–310.
   Google Scholar
• Cetinkaya, A., et al., 2006. N-acetylcysteine ameliorates methotrexate-induced oxidative liver damage in rats. Medical science monitor, 12 (8), BR274–BR278.
   Google Scholar
• Chen, Y-H., et al., 2007. Methotrexate conjugated to gold nanoparticles inhibits tumor growth in a syngeneic lung tumor model. Molecular pharmaceutics, 4 (5), 713–722.
   Google Scholar
• Choudhury, R.C. and Palo, A.K., 2004. Modulatory effects of caffeine on methotrexate-induced cytogenotoxicity in mouse bone marrow. Environmental toxicology and pharmacology, 15 (2-3), 79–85.
   Google Scholar
• Coleshowers, C., et al., 2010. Effects of methotrexate on antioxidant enzyme status in a rodent model: peer reviewed original article. Medical technology SA, 24 (1), 4–9.
   Google Scholar
• Dadhania, V., et al., 2010. Intervention of α-lipoic acid ameliorates methotrexate-induced oxidative stress and genotoxicity: a study in rat intestine. Chemico-biological interactions, 183 (1), 85–97.
   Google Scholar
• Dhankhar, J., et al., 2012. Astaxanthin: A potential carotenoid. International journal of pharmaceutical sciences and research, 3 (5), 1246.
   Google Scholar
• Dohle, G.R., 2010. Male infertility in cancer patients: review of the literature. International journal of urology, 17 (4), 327–331.
   Google Scholar
• Fakhri, S., et al., 2017. Astaxanthin as a potent neuroprotective agent. Pajoohande, 21 (6), 356–363.
   Google Scholar
• Fang, Y., et al., 2015. Effects of astaxanthin supplementation on the sperm quality and antioxidant capacity of ram semen during liquid storage. Small ruminant research, 130, 178–182.
   Google Scholar
• Ghobadi, E., et al., 2017. The mechanisms of cyclophosphamide-induced testicular toxicity and the protective agents. Expert opinion on drug metabolism and toxicology, 13 (5), 525–536.
   Google Scholar
• Gil-Guzman, E., et al., 2001. Differential production of reactive oxygen species by subsets of human spermatozoa at different stages of maturation. Human reproduction, 16 (9), 1922–1930.
   Google Scholar
• Gökçe, A., et al., 2011. Protective effects of thymoquinone against methotrexate-induced testicular injury. Human and experimental toxicology, 30 (8), 897–903.
   Google Scholar
• Goth, L., 1991. A simple method for determination of serum catalase activity and revision of reference range. Clinica chimica acta, 196 (2-3), 143–151.
   Google Scholar
• Goto, S., et al., 2001. Efficient radical trapping at the surface and inside the phospholipid membrane is responsible for highly potent antiperoxidative activity of the carotenoid astaxanthin. Biochimica et biophysica acta (BBA)-biomembranes, 1512 (2), 251–258.
   Google Scholar
• Green, D.M., et al., 2009. Fertility of male survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. Journal of clinical oncology, 28 (2), 332–339.
   Google Scholar
• Green, J.M., 2012. Glucarpidase to combat toxic levels of methotrexate in patients. Therapeutics and clinical risk management, 8, 403.
   Google Scholar
• Guerin, M., et al., 2003. Haematococcus astaxanthin: applications for human health and nutrition. Trends in biotechnology, 21 (5), 210–216.
   Google Scholar
• Hassanpour, H., et al., 2017. Comparative expression analysis of HSP70, HSP90, IL-4, TNF, KITLG and KIT-receptor gene between varicocele-induced and non-varicocele testes of dog. International journal of fertility and sterility, 11 (3), 148.
   Google Scholar
• Heidari Khoei, H., et al., 2018. Testicular toxicity and reproductive performance of streptozotocin-induced diabetic male rats: the ameliorating role of silymarin as an antioxidant. Toxin reviews, doi: 10.1080/15569543.2018.1444641
   Google Scholar
• Hussein, G., et al., 2006. Astaxanthin, a carotenoid with potential in human health and nutrition⊥. Journal of natural products, 69 (3), 443–449.
   Google Scholar
• Iwasaki, T. and Tawara, A., 2006. Effects of astaxanthin on eyestrain induced by accommodative dysfunction. Journal of the eye, 23 (6), 829.
   Google Scholar
• Jahnukainen, K., et al., 2011. Testicular function and fertility preservation in male cancer patients. Best practice and research clinical endocrinology and metabolism, 25 (2), 287–302.
   Google Scholar
• Kadivar, A., et al., 2016. Peroxisome proliferator-activated receptors (PPARα, PPARγ and PPARβ/δ) gene expression profile on ram spermatozoa and their relation to the sperm motility Veterinary Research Forum. (Vol. 7: pp. 27): Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
   Google Scholar
• Kajita, M., et al., 2009. The effects of a dietary supplement containing astaxanthin on the accommodation function of the eye in middle-aged and older people. Medical consultation and new remedies, 46, 89–93.
   Google Scholar
• Khan, Z.A., et al., 2012. Methotrexate: a detailed review on drug delivery and clinical aspects. Expert opinion on drug delivery, 9 (2), 151–169.
   Google Scholar
• Kidd, P., 2011. Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential. Alternative medicine review, 16 (4), 355–364.
   Google Scholar
• Marklund, S., and Marklund, G., 1974. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. European journal of biochemistry, 47 (3), 469–474.
   Google Scholar
• Masoudi, A., et al., 2017. Neuroprotective effects of astaxanthin in a rat model of spinal cord injury. Behavioural brain research, 329, 104–110.
   Google Scholar
• Meistrich, M.L., et al., 2009. Male gonadal toxicity. Pediatric blood & cancer, 53 (2), 261–266.
   Google Scholar
• Naguib, Y.M., 2000. Antioxidant activities of astaxanthin and related carotenoids. Journal of agricultural and food chemistry, 48 (4), 1150–1154.
   Google Scholar
• Oktar, S., et al., 2010. Beneficial effect of erdosteine on methotrexate-induced testicular toxicity in mice. Toxicology and industrial health, 26 (7), 433–438.
   Google Scholar
• Öktem, F., et al., 2006. Methotrexate-induced renal oxidative stress in rats: the role of a novel antioxidant caffeic acid phenethyl ester. Toxicology and industrial health, 22 (6), 241–247.
   Google Scholar
• Østerlie, M., et al., 2000. Plasma appearance and distribution of astaxanthin E/Z and R/S isomers in plasma lipoproteins of men after single dose administration of astaxanthin. The journal of nutritional biochemistry, 11 (10), 482–490.
   Google Scholar
• Padmanabhan, S., et al., 2008. Cytotoxic and genotoxic effects of methotrexate in germ cells of male Swiss mice. Mutation research/genetic toxicology and environmental mutagenesis, 655 (1), 59–67.
   Google Scholar
• Padmanabhan, S., et al., 2009. Methotrexate-induced cytotoxicity and genotoxicity in germ cells of mice: intervention of folic and folinic acid. Mutation research/genetic toxicology and environmental mutagenesis, 673 (1), 43–52.
   Google Scholar
• Pectasides, D., et al., 2009. Testicular function in poor‐risk nonseminomatous germ cell tumors treated with methotrexate, paclitaxel, ifosfamide, and cisplatin combination chemotherapy. Journal of andrology, 30 (3), 280–286.
   Google Scholar
• Ramirez, L.Y., et al., 2009. Potential chemotherapy side effects: what do oncologists tell parents? Pediatric blood and cancer, 52 (4), 497–502.
   Google Scholar
• Robien, K., et al., 2005. Pharmacogenetics of folate-related drug targets in cancer treatment. Pharmacogenomics, 6 (7), 673–689.
   Google Scholar
• Rosen, A., et al., 2009. Psychosocial distress in young cancer survivors. Seminars in oncology nursing. Elsevier, 25, 268–277.
   Google Scholar
• Schmiegelow, K., 2009. Advances in individual prediction of methotrexate toxicity: a review. British journal of haematology, 146 (5), 489–503.
   Google Scholar
• Shimidzu, N., et al., 1996. Carotenoids as singlet oxygen quenchers in marine organisms. Fisheries science, 62 (1), 134–137.
   Google Scholar
• Shrestha, S., et al., 2007. Effect of methotrexate (MTX) administration on spermatogenesis: an experimental on animal model. Nepal Medical College Journal, 9 (4), 230–233.
   Google Scholar
• Tabassum, H., et al., 2010. Protective effect of lipoic acid against methotrexate-induced oxidative stress in liver mitochondria. Food and chemical toxicology, 48 (7), 1973–1979.
   Google Scholar
• Torre, L.A., et al., 2015. Global cancer statistics, 2012. CA: a cancer journal for clinicians, 65 (2), 87–108.
   Google Scholar
• Tripathi, D., and Jena, G., 2008. Astaxanthin inhibits cytotoxic and genotoxic effects of cyclophosphamide in mice germ cells. Toxicology, 248 (2-3), 96–103.
   Google Scholar
• Vardi, N., et al., 2009. Antiapoptotic and antioxidant effects of β-carotene against methotrexate-induced testicular injury. Fertility and sterility, 92 (6), 2028–2033.
   Google Scholar
• von der Maase, H., et al., 2005. Long-term survival results of a randomized trial comparing gemcitabine plus cisplatin, with methotrexate, vinblastine, doxorubicin, plus cisplatin in patients with bladder cancer. Journal of clinical oncology, 23 (21), 4602–4608.
   Google Scholar
• WHO, 2010. WHO laboratory manual for the Examination and processing of human semen. Switzerland. WHO Press.
   Google Scholar
• Wolf, A.M., et al., 2010. Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress. The journal of nutritional biochemistry, 21 (5), 381–389.
   Google Scholar
• Yoshihisa, Y. and Shimizu, T., 2014. Astaxanthin, a xanthophyll carotenoid, inhibits ultraviolet‐induced apoptosis in keratinocytes. Experimental dermatology, 23 (3), 178–183.
   Google Scholar
• Yuan, J.P., et al., 2011. Potential health‐promoting effects of astaxanthin: a high‐value carotenoid mostly from microalgae. Molecular nutrition and food research, 55 (1), 150–165.
   Google Scholar
• Yuluğ, E., et al., 2013. Effects of resveratrol on methotrexate-induced testicular damage in rats. The scientific world journal, 2013. doi: 10.1155/2013/489659
   Google Scholar