A systematic review of the bioprospecting potential of Lonomia spp. (Lepidoptera: Saturniidae)

References

• Abella, H., et al., 1999. Manual de diagnóstico – tratamento de acidentes por lonomia. Porto Alegre, Brazil: Governo do Estado do Rio Grande do Sul. Secretria de Saúde. Fundação Estadual de Produção e Pesquisa em Saúde.
   Google Scholar
• Aguilar, I., et al., 2014. Coral snake antivenom produced in chickens (Gallus domesticus). Revista do Instituto de Medicina Tropical de Sao Paulo, 56 (1), 61–66.
   PubMed Web of Science ®Google Scholar
• Alvarenga, L.M., et al., 2014. Engineering venom’s toxin-neutralizing antibody fragments and its therapeutic potential. Toxins, 6 (8), 2541–2567.
   PubMed Web of Science ®Google Scholar
• Alvarenga, Z., 1912. Taturana. In: Anais do VIII congresso Brasileiro de medicina cirúrgica. Belo Horizonte, Brazil: A Taturana, 132–135.
   Google Scholar
• Alvarez-Flores, M.P., et al., 2006. Losac, a factor X activator from Lonomia obliqua bristle extract: its role in the pathophysiological mechanisms and cell survival. Biochemical and biophysical research communications, 343 (4), 1216–1223.
   PubMed Web of Science ®Google Scholar
• Alvarez-Flores, M.P., et al., 2011. Losac, the first hemolin that exhibits procogulant activity through selective factor X proteolytic activation. The journal of biological chemistry, 286 (9), 6918–6928.
   PubMed Web of Science ®Google Scholar
• Alvarez-Flores, M.P., et al., 2019. Neuroprotective effect of rLosac on supplement-deprived mouse cultured cortical neurons involves maintenance of monocarboxylate transporter MCT2 protein levels. Journal of neurochemistry, 148 (1), 80–96.
   PubMed Web of Science ®Google Scholar
• Alvarez-Flores, M.P., et al., 2012. Mechanisms implicated in cell proliferation and cell survival induced by recombinant losac, a cell adhesion molecule from Lonomia oblique. Toxicon, 60 (2), 142–143.
   Web of Science ®Google Scholar
• Andrade, R.D.O., 2017. Espinhos repletos de veneno. Revista Pesquisa FAPESP, 62–63.
   Google Scholar
• Andrade, S.A., et al., 2012. Reversal of the anticoagulant and anti-hemostatic effect of low molecular weight heparin by direct prothrombin activation. Brazilian journal of medical and biological research, 45 (10), 929–934.
   PubMed Web of Science ®Google Scholar
• Angelo, M., 2017. Casanare epicentro de los accidentes con oruga lonomia. Yopal, Colombia: Prensa Libre Casanare.
   Google Scholar
• Araújo, A.S., et al., 2010. Brazilian IgY-Bothrops antivenom: studies on the development of a process in chicken egg yolk. Toxicon, 55 (4), 739–744.
   PubMed Web of Science ®Google Scholar
• Arias, E., 2019. Antiveneno lonómico polivalente. Biomédica, 39 (3), 38–39.
   Google Scholar
• Arocha-Piñango, C.L., 1967. Fibrinolisis producida por contacto con orugas : comunicación preliminar. Acta Cientifica Venezolana, 18 (5), 136–139.
   PubMedGoogle Scholar
• Arsanios, D.M., et al., 2020. Acute kidney injury secondary to Lonomia envenomation. Case report and literature review, 61 (2), 72–85.
   Google Scholar
• Bernardi, L., et al., 2019. Lonomia obliqua bristle extract modulates Rac1 activation, membrane dynamics and cell adhesion properties. Toxicon, 162, 32–39.
   PubMed Web of Science ®Google Scholar
• Bordon, K.C.F., et al., 2020. From animal poisons and venoms to medicines: achievements, challenges and perspectives in drug discovery. Frontiers in pharmacology, 11, 1132.
   PubMed Web of Science ®Google Scholar
• Bosch, R.V., et al., 2016. Hemolin triggers cell survival on fibroblasts in response to serum deprivation by inhibition of apoptosis. Biomedicine & pharmacotherapy = biomedecine & pharmacotherapie, 82, 537–546.
   PubMed Web of Science ®Google Scholar
• Brechlin, R., 2017. Sechs neue arten der gattung Lonomia walker, 1855 (Lepidoptera: Sarurniidae). Entomo-Satsphingia, 10 (1), 22–31.
   Google Scholar
• Camargo, A.C., et al., 2012. Bradykinin-potentiating peptides: Beyond captopril. Toxicon, 59 (4), 516–523. 10.1016/j.toxicon.2011.07.013
   PubMed Web of Science ®Google Scholar
• Caovilla, J.J., and Barros, E.J., 2004. Efficacy of two different doses of antilonomic serum in the resolution of hemorrhagic syndrome resulting from envenoming by Lonomia obliqua caterpillars: a randomized controlled trial. Toxicon, 43 (7), 811–818.
   PubMed Web of Science ®Google Scholar
• Carmo, A.C., et al., 2012. Expression of an antiviral protein from Lonomia obliqua hemolymph in baculovirus/insect cell system. Antiviral research, 94 (2), 126–130.
   PubMed Web of Science ®Google Scholar
• Carmo, A.C., et al., 2015. Discovery of a new antiviral protein isolated Lonomia obliqua analysed by bioinformatics and real-time approaches. Cytotechnology, 67 (6), 1011–1022.
   PubMed Web of Science ®Google Scholar
• Carrijo-Carvalho, L.C., and Chudzinski-Tavassi, A.M., 2007. The venom of the Lonomia caterpillar: an overview. Toxicon, 49 (6), 741–757.
   PubMed Web of Science ®Google Scholar
• Chudzinski-Tavassi, A., Carrijo-Carvalho, L., et al., 2010. Procoagulant factors from Lonomia caterpillars. In: R.M. Kini ed. Toxins and hemostasis. Dordrecht, Netherlands: Springer, 559–574.
   Google Scholar
• Chudzinski-Tavassi, A., and Zannin, M., 2011. Aspectos clínicos y epidemiológicos del envenenamiento por Lonomia obliqua. In: G. D’Suze, G. Burguete, and J. Solís, eds. Emergenciais por animales ponzoñosos en las Américas. Ciudad de México: Instituto Bioclon, 303–321.
   Google Scholar
• Chudzinski-Tavassi, A.M., et al., 2010. A lipocalin sequence signature modulates cell survival. FEBS letters, 584 (13), 2896–2900.
   PubMed Web of Science ®Google Scholar
• Coll-Sangrona, E., and Arocha-Piñango, C.L., 1998. Fibrinolytic action on fresh human clots of whole body extracts and two semipurified fractions from Lonomia achelous caterpillar. Brazilian journal of medical and biological research, 31 (6), 779–784.
   PubMed Web of Science ®Google Scholar
• Correa, O., 2018. Entregan recomendaciones para no tener accidentes con la oruga venenosa en Yopal. El Diario del Llano, 13 Sep.
   Google Scholar
• Cushman, D.W., et al., 1977. Design of potent competitive inhibitors of angiotensin-converting enzyme. Carboxyalkanoyl and mercaptoalkanoyl amino acids. Biochemistry, 16 (25), 5484–5491. 10.1021/bi00644a014
   PubMed Web of Science ®Google Scholar
• Da Silva, S.L., et al., 2014. Animal Toxins and Their Advantages in Biotechnology and Pharmacology. BioMed Research International, 2014, 1–2. 10.1155/2014/951561
   Web of Science ®Google Scholar
• Da Silva, W.D., 2003. Development and clinical use of antilonomic serum. Journal of toxicology, 22 (1), 61–68.
   Web of Science ®Google Scholar
• Da Silva, W.D., et al., 1996a. Development of an antivenom against toxins of Lonomia obliqua caterpillars. Toxicon, 34 (9), 1045–1049.
   PubMed Web of Science ®Google Scholar
• Da Silva, W.D., et al., 1996b. Anti-lonomia serum: an antivenom produced to neutralize the hemorrhagic disorder induced by a caterpillar toxin. Toxicon, 34 (1), 18.
   Google Scholar
• De Roodt, A., Salomon, O., and Orduna, T., 2000. Accidentes por lepidopteros con especial referencia a Lonomia sp. Medicina, 60 (6), 964–972.
   PubMedGoogle Scholar
• Do Nascimento, S., et al., 2016. A new lysozyme found in the haemolymph from pupae of Lonomia obliqua (Lepidoptera: Saturniidae). Trends in antomology, 12, 13–23.
   Google Scholar
• Dos Anjos, I., 2019. Caracterização biológica do extrato de cerdas de Lonomia descimoni (Lepidópteros, Saturniidae) e eficácia da soroterapia no envenenamento experimental. São Paulo, Brazil: Secretaia de Estado da Saúde de São Paulo.
   Google Scholar
• El Pilón., 2018. Alarma en el Cesar por caso confirmado de oruga venenosa. El Pilón, 3 Dec, pp. 1–5.
   Google Scholar
• Ferreira, S.H., and Rocha e Silva, M., 1965. Potentiation of bradykinin and eledoisin by BPF (bradykinin potentiating factor) fromBothrops jararaca venom. Experientia, 21 (6), 347–349. 10.1007/BF02144709
   PubMedGoogle Scholar
• Ferreira, S.H., et al., 1970. Activity of Various Fractions of Bradykinin Potentiating Factor against Angiotensin I Converting Enzyme. Nature, 225 (5230), 379–380. 10.1038/225379a0
   PubMed Web of Science ®Google Scholar
• Ferreira Junior, R.S., et al., 2010. New nanostructured silica adjuvant (SBA-15) employed to produce antivenom in young sheep using Crotalus durissus terrificus and Apis mellifera venoms detoxified by cobalt-60. Journal of toxicology and environmental health, Part A, 73 (13–14), 926–933.
   PubMed Web of Science ®Google Scholar
• Fritzen, M., et al., 2005. A prothrombin activator (Lopap) modulating inflammation, coagulation and cell survival mechanisms. Biochemical and biophysical research communications, 333 (2), 517–523.
   PubMed Web of Science ®Google Scholar
• FUNASA., 2001. Manual de diagnóstico e tratamento de acidentes por animais peçonhentos. Brasília, Brazil: FUNASA.
   Google Scholar
• Gamborgi, G.P., et al., 2012. Influência dos fatores abióticos sobre casos de acidentes provocados por Lonomia obliqua. Hygeia – Revista Brasileira de Geografia Médica e da Saúde, 8 (14), 201–208.
   Google Scholar
• Garcia, C., 2017. Analytical test on the environmental constraints related to accidents with the Lonomia obliqua walker 1855, in Southern Brazil. Journal of ecosystem & ecography, 3 (3), 125.
   Google Scholar
• Gonçalves, L.R., et al., 2007. Efficacy of serum therapy on the treatment of rats experimentally envenomed by bristle extract of the caterpillar Lonomia obliqua: comparison with epsilon-aminocaproic acid therapy. Toxicon, 50 (3), 349–356.
   PubMed Web of Science ®Google Scholar
• Gouveia, A.I.D.C.B., 2004. Bioprospecção de toxinas presentes na hemolinfa e extrato de cerdas da lagarta Lonomia obliqua. Master’s thesis. Repositório Institucional – Rede Paraná Acervo.
   Google Scholar
• Greco, K.N., et al., 2009. Antiviral activity of the hemolymph of Lonomia obliqua (Lepidoptera: Saturniidae). Antiviral research, 84 (1), 84–90.
   PubMed Web of Science ®Google Scholar
• Grimaldi, D., and Engel, M. S., Evolution of the Insects (1st ed., p. 772)., Cambridge University Press 2005. 772, 1st Ed., Diversity and Evolution.
   Google Scholar
• Guerrero, B., et al., 2001. Thrombolytic effect of lonomin V in a rabbit jugular vein thrombosis model. Blood coagulation & fibrinolysis, 12 (7), 521–529.
   PubMed Web of Science ®Google Scholar
• Guerrero, B., et al., 2011. The effects of Lonomin V, a toxin from the caterpillar (Lonomia achelous), on hemostasis parameters as measured by platelet function. Toxicon, 58 (4), 293–303.
   PubMed Web of Science ®Google Scholar
• Guerrero, B., et al., 1999. Effect on platelet FXIII and partial characterization of Lonomin V, a proteolytic enzyme from Lonomia achelous caterpillars. Thrombosis research, 93 (5), 243–252.
   PubMed Web of Science ®Google Scholar
• Guerrero, B., and Arocha-Piñango, C.L., 1992. Activation of human prothrombin by the venom of (Cramer) caterpillars. Thrombosis research, 66 (2–3), 169–177.
   PubMed Web of Science ®Google Scholar
• Guerrero, B.A., Arocha-Piñango, C.L., and Juan, A.G.A., 1997. Degradation of human factor XIII by Lonomin V, a purified fraction of Lonomia achelous caterpillar venom. Thrombosis research, 87 (2), 171–181.
   PubMed Web of Science ®Google Scholar
• Hayashida, P.Y., Da Silva Junior, P.I., and Mendonça, R.Z., 2019. Lonomia obliqua’s hemolymph: new horizons to antibiotics. Toxicon, 168, S28–S29.
   Web of Science ®Google Scholar
• Heinen, T.E., and Da Veiga, A.B., 2011. Arthropod venoms and cancer. Toxicon, 57 (4), 497–511.
   PubMed Web of Science ®Google Scholar
• Heinen, T.E., et al., 2014. Effects of Lonomia obliqua caterpillar venom upon the proliferation and viability of cell lines. Cytotechnology, 66 (1), 63–74.
   PubMed Web of Science ®Google Scholar
• Instituto Nacional de Salud., 2019. INS Colombia realizó su rendición de cuentas vigencia 2019. Available from: https://www.ins.gov.co/Noticias/Paginas/INS-Colombia-realizó-su-Rendición-de-Cuentas-vigencia-2019-.aspx [Accessed 18 May 2020].
   Google Scholar
• Linares, A., 2017. Ponen bajo la lupa a plaga de orugas venenosas. El Tiempo, 7 Jul, pp. 1–5.
   Google Scholar
• Liu, J., et al., 2017. Preparation and neutralization efficacy of IgY antibodies raised against Deinagkistrodon acutus venom. The journal of venomous animals and toxins including tropical diseases, 23, 22.
   PubMed Web of Science ®Google Scholar
• Lucena, S., et al., 2008. The action of Lonomin V (Lonomia achelous) on fibronectin functional properties. Thrombosis research, 121 (5), 653–661.
   PubMed Web of Science ®Google Scholar
• Maranga, L., et al., 2003. Enhancement of Sf-9 cell growth and longevity through supplementation of culture medium with hemolymph. Biotechnology progress, 19 (1), 58–63.
   PubMed Web of Science ®Google Scholar
• Marques, L., 1999. Estudo imonoquimico do veneno da largata lonomia obliqua e desenvolvimento de um ELISA (‘enzyme-linked immunosorbent assay’) para detecção do veneno. Master’s thesis. Universidade Estadual de Campinas (UNICAMP).
   Google Scholar
• Mayence, C., et al., 2018. Lonomia caterpillar envenoming in French Guiana reversed by the Brazilian antivenom: a successful case of international cooperation for a rare but deadly tropical hazard. Toxicon, 151, 74–78.
   PubMed Web of Science ®Google Scholar
• Mendonça, R.Z., et al., 2009. Study of kinetic parameters for the production of recombinant rabies virus glycoprotein. Cytotechnology, 60 (1–3), 143–151.
   PubMed Web of Science ®Google Scholar
• Mendonça, R.Z., et al., 2008. Enhancing effect of a protein from Lonomia obliqua hemolymph on recombinant protein production. Cytotechnology, 57 (1), 83–91.
   PubMed Web of Science ®Google Scholar
• Ministerio de Salud y Protección Social., 2014., Resolución 1302. Bogotá, Colombia: Ministerio de Salud y Protección Social.
   Google Scholar
• Ministerio de Salud y Protección Social., 2015., Resolución 1241. Bogotá, Colombia: Ministerio de Salud y Protección Social.
   Google Scholar
• Ministerio de Salud y Protección Social., 2016., Resolución 1478. Bogotá, Colombia: Ministerio de Salud y Protección Social.
   Google Scholar
• Ministerio de Salud y Protección Social, 2017a. Colombia amplía reservas de antídoto contra veneno de oruga. Available from: https://www.minsalud.gov.co/Paginas/Colombia-amplia-reservas-de-antidoto-contra-veneno-de-oruga.aspx [Accessed 24 Mar 2021].
   Google Scholar
• Ministerio de Salud y Protección Social., 2017b., Resolución 1209. Bogotá, Colombia: Ministerio de Salud y Protección Social.
   Google Scholar
• Ministerio de Salud y Protección Social., 2018., Resolución 1487. Bogotá, Colombia: Ministerio de Salud y Protección Social.
   Google Scholar
• Mohamed Abd El-Aziz, Garcia Soares., and Stockand 2019. Snake Venoms in Drug Discovery: Valuable Therapeutic Tools for Life Saving. Toxins, 11 (10), 564 10.3390/toxins11100564
   PubMed Web of Science ®Google Scholar
• Moher, D., et al., 2009. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Medicine, 6 (7), e1000097.
   PubMed Web of Science ®Google Scholar
• Pardo, L., and Amarillo-Suárez, A., 2018. Modelación de la probabilidad de ocurrencia de accidentes atribuidos a orugas del género Lonomia y descripción de su hábitat en el departamento de Casanare, Colombia. Colombia: Facultad de Estudios Ambientales y Rurales, Pontificia Universidad Javeriana.
   Google Scholar
• Pasqualoto, K.F.M., Carrijo-Carvalho, L.C., and Chudzinski-Tavassi, A.M., 2013. Rational development of novel leads from animal secretion based on coagulation and cell targets: 1. In silico analysis to explore a peptide derivative as lipocalins’ signature. Toxicon, 69, 200–210.
   PubMed Web of Science ®Google Scholar
• Peña-Vásquez, W., et al., 2016. Niña con erucismo hemorrágico por Lonomia spp. Revista peruana de medicina experimental y salud publica, 33 (4), 819–823.
   PubMedGoogle Scholar
• Perilla-Colmenares, P., and Aldana-Barbosa, R., 2010. Protocolo de vigilancia epidemiologica en salud publica en el departamento de casanare: accidente lonomico. Yopal, Colombia: Secretaria de Salud Departamental.
   Google Scholar
• Piñango, C.L., and Guerrero, B., 2003. Síndrome hemorrágico producido por contacto con orugas: estudios clínicos y experimentales: revisión. Investigacion clinica, 44 (2), 155–163.
   PubMedGoogle Scholar
• Pineda, D., et al., 2001. Síndrome hemorrágico por contacto con orugas del género Lonomia (Saturniidae) en Casanare, Colombia: informe de dos casos. Biomédica, 21 (4), 328–332.
   Google Scholar
• Prezoto, B.C., et al., 2002. Antithrombotic effect of Lonomia obliqua caterpillar bristle extract on experimental venous thrombosis. Brazilian journal of medical and biological research, 35 (6), 703–712.
   PubMed Web of Science ®Google Scholar
• Quintana, M.A., et al., 2017. Stinging caterpillars from the genera Podalia, Leucanella and Lonomia in Misiones, Argentina: a preliminary comparative approach to understand their toxicity. Comparative biochemistry and physiology, 202, 55–62.
   Google Scholar
• Raffoul, T., et al., 2005. Performance evaluation of CHO-K1 cell in culture medium supplemented with hemolymph. Brazilian archives of biology and technology, 48 (SPE), 85–95.
   Google Scholar
• Redacción El Tiempo., 2001. A la caza de la oruga venenosa. El Tiempo, 31 Aug, 1–3.
   Google Scholar
• Redacción, P.M.D., 2018. Alertan por un churrusco más peligroso que la víbora. Periodico del Meta, 2 Jun.
   Google Scholar
• Reis, C.V., et al., 2006. Lopap, a prothrombin activator from Lonomia obliqua belonging to the lipocalin family: recombinant production, biochemical characterization and structure-function insights. The Biochemical Journal, 398 (2), 295–302.
   PubMedGoogle Scholar
• Rocha-Campos, A.C.M., et al., 2001. Specific heterologous F(ab’)2 antibodies revert blood incoagulability resulting from envenoming by Lonomia obliqua caterpillars. The American journal of tropical medicine and hygiene, 64 (5–6), 283–289.
   PubMed Web of Science ®Google Scholar
• Sánchez, M.N., et al., 2015. Accidentes causados por la oruga Lonomia obliqua (Walker, 1855): un problema emergente. Medicina, 75 (5), 328–333.
   PubMedGoogle Scholar
• Sano-Martins, I.S., et al., 2018. Effectiveness of Lonomia antivenom in recovery from the coagulopathy induced by Lonomia orientoandensis and Lonomia casanarensis caterpillars in rats. PLoS Neglected Tropical Diseases, 12 (8), e0006721.
   PubMed Web of Science ®Google Scholar
• Sato, A.C., et al., 2016. Exploring the in vivo wound healing effects of a recombinant hemolin from the caterpillar Lonomia obliqua. The journal of venomous animals and toxins including tropical diseases, 22, 36.
   PubMed Web of Science ®Google Scholar
• Seabrooks, L., and Hu, L., 2017. Insects: an underrepresented resource for the discovery of biologically active natural products. Acta Pharmaceutica Sinica B, 7 (4), 409–426. doi: 10.1016/j.apsb.2017.05.001
   PubMed Web of Science ®Google Scholar
• Sousa, Á.P., Moraes, R.H., and Mendonça, R.Z., 2015. Improved replication of the baculovirus Anticarsia gemmatalis nucleopolyhedrovirus (AgMNPV) in vitro using proteins from Lonomia obliqua hemolymph. Cytotechnology, 67 (2), 331–342.
   PubMed Web of Science ®Google Scholar
• Souza, A.P., et al., 2005. Purification and characterization of an anti-apoptotic protein isolated from Lonomia obliqua hemolymph. Biotechnology progress, 21 (1), 99–105.
   PubMed Web of Science ®Google Scholar
• Tamimi, N.A., and Ellis, P., 2009. Drug development: from concept to marketing!. Nephron clinical practice, 113 (3), c125–c131.
   PubMedGoogle Scholar
• Veiga, A.B.G., et al., 2005. A catalog for the transcripts from the venomous structures of the caterpillar Lonomia obliqua: identification of the proteins potentially involved in the coagulation disorder and hemorrhagic syndrome. Gene, 355, 11–27.
   PubMed Web of Science ®Google Scholar
• Vieira, H.L., et al., 2010. Improvement of recombinant protein production by an anti-apoptotic protein from hemolymph of Lonomia obliqua. Cytotechnology, 62 (6), 547–555.
   PubMed Web of Science ®Google Scholar
• Waismam, K., et al., 2009. Lopap: a non-inflammatory and cytoprotective molecule in neutrophils and endothelial cells. Toxicon, 53 (6), 652–659.
   PubMed Web of Science ®Google Scholar
• Yunker, C.E., Vaughn, J.L., and Cory, J., 1967. Adaptation of an insect cell line (Grace’s Antheraea cells) to medium free of insect hemolymph. Science, 155 (3769), 1565–1566.
   PubMed Web of Science ®Google Scholar
• Zamboni, C.B., et al., 2019. Multielemental analyses of Lonomia obliqua (Lepidoptera, Saturniidae) caterpillar using EDXRF and INAA techniques. X-Ray spectrometry, 48 (5), 465–475.
   Web of Science ®Google Scholar
• Zarbin, P.H., et al., 2007. Sex pheromone of Lonomia obliqua: daily rhythm of production, identification, and synthesis. Journal of chemical ecology, 33 (3), 555–565.
   PubMed Web of Science ®Google Scholar