Evaluation of neuroprotective and anti-amnesic effects of the chloroform fraction of Nigella sativa L. on scopolamine-induced memory impairment in rats

References

• Abbasnezhad, A., et al., 2015. The effects of hydroalcoholic extract of Nigella sativa seed on oxidative stress in hippocampus of STZ-induced diabetic rats. Avicenna journal of phytomedicine, 5 (4), 333.
   PubMed Web of Science ®Google Scholar
• Abd-El-Fattah, M.A., Abdelakader, N.F., and Zaki, H.F., 2014. Pyrrolidine dithiocarbamate protects against scopolamine-induced cognitive impairment in rats. European journal of pharmacology, 723, 330–338.
   PubMed Web of Science ®Google Scholar
• AbdulAzeez, T., et al., 2020. Nigella sativa oil attenuates aluminum-induced behavioral changes, oxidative stress and cortico-hippocampal neuronal degeneration in rats. Journal of African association of physiological sciences, 8 (1), 23–33.
   Google Scholar
• Akhtar, M., et al., 2013. Neuroprotective effects of chloroform and petroleum ether extracts of Nigella sativa seeds in stroke model of rat. Journal of pharmacy & bioallied sciences, 5 (2), 119–125.
   PubMedGoogle Scholar
• Al-Majed, A.A., Al-Omar, F.A., and Nagi, M.N., 2006. Neuroprotective effects of thymoquinone against transient forebrain ischemia in the rat hippocampus. European journal of pharmacology, 543 (1-3), 40–47.
   PubMed Web of Science ®Google Scholar
• Alhebshi, A., et al., 2014. Thymoquinone protects cultured hippocampal and human induced pluripotent stem cells-derived neurons against α-synuclein-induced synapse damage. Neuroscience letters, 570, 126–131.
   PubMed Web of Science ®Google Scholar
• Alijani, S., and Simal-Gandara, 2021. Therapeutic effects of nigella sativa and Cannabis sativa seeds on multiple sclerosis. Clinical surgery, 5 (4), 1–5.
   Google Scholar
• Ansari, M., et al., 2020. Nigella sativa L., supplementary plant with anticholinesterase effect for cognition problems: a kinetic study. Current aging science, 13 (2), 129–135.
   PubMedGoogle Scholar
• Asiaei, F., et al., 2017. Neuroprotective effects of Nigella sativa extract upon the hippocampus in PTU-induced hypothyroidism juvenile rats: a stereological study. Metabolic brain disease, 32 (5), 1755–1765.
   PubMed Web of Science ®Google Scholar
• Benzie, I.F., and Strain, J.J., 1996. The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Analytical biochemistry, 239 (1), 70–76.
   PubMed Web of Science ®Google Scholar
• Bonjoch, N. P., and Tamayo, P. R., 2001. Protein content quantification by Bradford method. In: Handbook of plant ecophysiology techniques. Netherlands: Springer, 283–295.
   Google Scholar
• Ebrahimi, S.S., et al., 2017. Thymoquinone exerts neuroprotective effect in animal model of Parkinson’s disease. Toxicology letters, 276, 108–114.
   PubMed Web of Science ®Google Scholar
• El-Dakhakhny, M., Mady, N.I., and Halim, M.A., 2000. Nigella sativa L. oil protects against induced hepatotoxicity and improves serum lipid profile in rats. Arzneimittel-Forschung, 50 (9), 832–836.
   PubMed Web of Science ®Google Scholar
• El-Marasy, S.A., et al., 2012. Effect of Nigella sativa and wheat germ oils on scopolamine-induced memory impairment in rats. Bulletin of faculty of pharmacy, Cairo University, 50 (2), 81–88.
   Google Scholar
• Elibol, B., et al., 2020. Thymoquinone administration ameliorates Alzheimer’s disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta1–42 infused rat model. Phytomedicine, 79, 153324.
   PubMed Web of Science ®Google Scholar
• Gholamnezhad, Z., Havakhah, S., and Boskabady, M.H., 2016. Preclinical and clinical effects of Nigella sativa and its constituent, thymoquinone: A review. Journal of ethnopharmacology, 190, 372–386.
   PubMed Web of Science ®Google Scholar
• Hamidkhaniha, S., et al., 2019. Effect of pretreatment with intracerebroventricular injection of minocycline on morphine‐induced memory impairment in passive avoidance test: Role of P‐CREB and c‐Fos expression in the dorsal hippocampus and basolateral amygdala regions. Clinical and experimental pharmacology & physiology, 46 (8), 711–722.
   PubMed Web of Science ®Google Scholar
• Hobbenaghi, R., et al., 2014. Neuroprotective effects of Nigella sativa extract on cell death in hippocampal neurons following experimental global cerebral ischemia-reperfusion injury in rats. Journal of the neurological sciences, 337 (1-2), 74–79.
   PubMed Web of Science ®Google Scholar
• Hosseini, M., et al., 2015. Effects of the hydro-alcoholic extract of Nigella sativa on scopolamine-induced spatial memory impairment in rats and its possible mechanism. Chinese journal of integrative medicine, 21 (6), 438–444.
   PubMed Web of Science ®Google Scholar
• Hosseinzadeh, H., et al., 2007. Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus. Phytomedicine, 14 (9), 621–627.
   PubMed Web of Science ®Google Scholar
• Imam, A., et al., 2018. Nigella sativa conserved hippocampal oxidative and neurogenic activities to salvage neuro-cognitive integrities in chlorpyrifos insult. Scientific African, 1, e00008.
   Google Scholar
• Karami-Mohajeri, S., et al., 2021. Protective effect of Zataria multiflora Boiss. and its main compound, rosmarinic acid, against malathion induced oxidative stress and apoptosis in HepG2 cells. Journal of environmental science health, part B, 56 (4), 1–10.
   PubMed Web of Science ®Google Scholar
• Khodamoradi, M., et al., 2017. Effects of hydroalcoholic extract of soy on learning, memory and synaptic plasticity deficits induced by seizure in ovariectomized rats. Basic and clinical neuroscience, 8 (5), 395–403.
   PubMedGoogle Scholar
• Kim, D.H., et al., 2006. Gomisin A improves scopolamine-induced memory impairment in mice. European journal of pharmacology, 542 (1–3), 129–135.
   PubMed Web of Science ®Google Scholar
• Liu, X., M., Abd El-Aty, A., and Shim, J.-H., 2011. Various extraction and analytical techniques for isolation and identification of secondary metabolites from Nigella sativa seeds. Mini Reviews in medicinal chemistry, 11 (11), 947–955.
   PubMed Web of Science ®Google Scholar
• Mahmoudvand, H., et al., 2014a. In vitro lethal effects of various extracts of Nigella sativa seed on hydatid cyst protoscoleces. Iranian journal of basic medical sciences, 17 (12), 1001.
   PubMed Web of Science ®Google Scholar
• Mahmoudvand, H., et al., 2014b. Evaluation of antileishmanial activity and cytotoxicity of the extracts of Berberis vulgaris and Nigella sativa against Leishmania tropica. Isrn pharmacology, 2014 (4), 1–6.
   Google Scholar
• Mahmoudvand, H., et al., 2015. Leishmanicidal and cytotoxic activities of Nigella sativa and its active principle, thymoquinone. Pharmaceutical Biology, 53 (7), 1052–1057.
   PubMed Web of Science ®Google Scholar
• Mandalaneni, K., Rayi, A., and Jillella, D.V., 2022. Stroke reperfusion injury (StatPearls) [Internet]. StatPearls Publishing.
   Google Scholar
• Mandegary, A., et al., 2014. Anticholinesterase, antioxidant, and neuroprotective effects of Tripleurospermum disciforme and Dracocephalum multicaule. Journal of ayurveda and integrative medicine, 5 (3), 162–166.
   PubMedGoogle Scholar
• Mohamed, A.B., Mohamed, A.Z., and Aly, S. 2020. Effect of thymoquinone against aluminum chloride-induced Alzheimer-like model in rats: a neurophysiological and behavioral study. The medical journal of Cairo university, 88 (3), 355–365.
   Google Scholar
• Norsharina, I., et al., 2013. Anti-aggregation effects of thymoquinone against Alzheimers-amyloid in vitro. Journal of medicinal plants research, 7 (31), 2280–2288.
   Google Scholar
• Noudeh, G.D., et al., 2010. Antitumor and antibacterial activity of four fractions from Heracleum persicum Desf. and Cinnamomum zeylanicum Blume. Journal of medicinal plants research, 4 (21), 2176–2180.
   Google Scholar
• Ozarowski, M., et al., 2013. Rosmarinus officinalis L. leaf extract improves memory impairment and affects acetylcholinesterase and butyrylcholinesterase activities in rat brain. Fitoterapia, 91, 261–271.
   PubMed Web of Science ®Google Scholar
• Paxinos, G., and Watson, C., 2006. The rat brain in stereotaxic coordinates: hard cover edition. 6th ed. San Diego: Elsevier, Academic Press.
   Google Scholar
• Pottoo, F.H., et al., 2022. Thymoquinone: Review of its potential in the treatment of neurological diseases. Pharmaceuticals, 15 (4), 408.
   Web of Science ®Google Scholar
• Qaid, E.Y.A., et al., 2020. Role of antioxidants in hypoxia-induced learning and memory deficit. International medical journal, 27 (1), 62–66.
   Google Scholar
• Sahak, M.K.A., et al., 2013. Nigella sativa oil enhances the spatial working memory performance of rats on a radial arm maze. Evidence-based complementary and alternative medicine, 2013, 1–5.
   Web of Science ®Google Scholar
• Samareh Fekri, M., et al., 2018. Protective effect of standardized extract of Myrtus communis L.(myrtle) on experimentally bleomycin-induced pulmonary fibrosis: biochemical and histopathological study. Drug and chemical toxicology, 41 (4), 408–414.
   PubMed Web of Science ®Google Scholar
• Sayeed, M.S.B., et al., 2013. The effect of Nigella sativa Linn. seed on memory, attention and cognition in healthy human volunteers. Journal of ethnopharmacology, 148 (3), 780–786.
   PubMed Web of Science ®Google Scholar
• Sayeed, M.S.B., et al., 2014. Nigella sativa L. seeds modulate mood, anxiety and cognition in healthy adolescent males. Journal of ethnopharmacology, 152 (1), 156–162.
   PubMed Web of Science ®Google Scholar
• Selkoe, D.J., and Hardy, J., 2016. The amyloid hypothesis of Alzheimer’s disease at 25 years. EMBO molecular medicine, 8 (6), 595–608.
   PubMed Web of Science ®Google Scholar
• Sharififar, F., et al., 2012. Essential oil and methanolic extract of Zataria multiflora Boiss with anticholinesterase effect. Pakistan journal of biological sciences, 15 (1), 49–53.
   PubMedGoogle Scholar
• Sheibani, V., et al., 2019. Zataria multiflora Boiss. extract improves spatial memory and learning capacity in scopolamine-induced amnesic rats. Avicenna journal of phytomedicine, 9 (6), 587.
   PubMed Web of Science ®Google Scholar
• Silva, A.F.C., et al., 2020. Mechanism of action and the biological activities of Nigella sativa oil components. Food bioscience, 38, 100783.
   Web of Science ®Google Scholar
• Taheri, F., et al., 2019. Amelioration of prenatal lead-induced learning and memory impairments by methanolic extract of Zataria multiflora in male rats. Basic and clinical neuroscience journal, 10 (2), 175–184.
   Google Scholar
• Vafaee, F., et al., 2015. The effects of Nigella sativa hydro-alcoholic extract on memory and brain tissues oxidative damage after repeated seizures in rats. Iranian journal of pharmaceutical research, 14 (2), 547.
   PubMed Web of Science ®Google Scholar
• Van Strien, N., Cappaert, N., and Witter, M., 2009. The anatomy of memory: an interactive overview of the parahippocampal–hippocampal network. Nature reviews neuroscience, 10 (4), 272–282.
   PubMed Web of Science ®Google Scholar
• Wee, H.-Y., et al., 2015. Hyperbaric oxygen effects on neuronal apoptosis associations in a traumatic brain injury rat model. The journal of surgical research, 197 (2), 382–389.
   PubMed Web of Science ®Google Scholar
• Yang, Z., et al., 2009. Clinical and experimental pharmacology and physiology. Clinical and experimental pharmacology & physiology, 36 (8), 790–796.
   PubMedGoogle Scholar
• Zhao, L., 2020. Alzheimer’s disease facts and figures. Journal of Alzheimers dement, 16, 391–460.
   Web of Science ®Google Scholar