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Research Articles

The protective effects of betanin on titanium dioxide (TiO2) nanoparticle exposure in rats

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 92-101 | Received 16 Jun 2023, Accepted 02 Dec 2023, Published online: 18 Dec 2023

References

  • Aebi, H., 1984. Catalase in vitro assay methods. Methods in enzymology, 105, 121–126.
  • Bettini, S., et al., 2017. Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon. Scientific reports, 7 (1), 40373.
  • Cadenas, E., 1989. Biochemistry of oxygen toxicity. Annual review of biochemistry, 58 (1), 79–110.
  • Cardiff, R., Miller, C.H., and Munn, R.J., 2014. Manual hematoxylin and eosin staining of mouse tissue sections. Cold Spring Harbor protocols, 2014 (6), 655–658.
  • Clifford, T., et al., 2015. The potential benefits of red beetroot supplementation in health and disease. Nutrients, 7 (4), 2801–2822.
  • Costa, L.G., et al., 2003. Paraoxonase (PON 1) as a biomarker of susceptibility for organophosphate toxicity. Biomarkers: biochemical indicators of exposure, response, and susceptibility to chemicals, 8 (1), 1–12.
  • da Silva et al., 2019. Betanin, a natural food additive: stability, bioavailability, antioxidant and preservative ability assessments. Molecules, 24 (3), 458. https://doi.org/10.3390/molecules24030458.
  • Erel, O., 2004. A novel automated method to measure total antioxidant response against potent free radical reactions. Clinical biochemistry, 37 (2), 112–119.
  • Erel, O., 2005. A new automated colourimetric method for measuring total oxidant status. Clinical biochemistry, 38 (12), 1103–1111.
  • Erel, O., and Neselioglu, S., 2014. A novel and automated assay for thiol/disulphide homeostasis. Clinical biochemistry, 47 (18), 326–332.
  • Farabegoli, F., et al., 2017. Betalains increase vitexin-2-O-xyloside cytotoxicity in CaCo-2 cancer cells. Food chemistry, 218, 356–364.
  • González-Ponce, H.A., et al., 2018. Natural dietary pigments: potential mediators against hepatic damage induced by over-the-counter non-steroidal anti-inflammatory and analgesic drugs. Nutrients, 10 (2), 117.
  • Guerrero-Rubio, M.A., et al., 2019. Extension of life-span using an RNAi model and in vivo antioxidant effect of Opuntia fruit extracts and pure betalains in Caenorhabditis elegans. Food chemistry, 274, 840–847.
  • IARC., 2018. List of classifications by cancer sites with sufficient or limited evidence in humans. Volumes 1 to 123. IARC Monographs, 1–9. Available from: https://monographs.iarc.fr/wp-content/uploads/2018/07/Table4.pdf.
  • Karakurt, O., Çagirci, G., and Akdemir, R., 2012. Paraoksonaz ve ateroskleroz. Turkiye Klinikleri cardiovascular sciences, 24 (2), 128–133.
  • Klewicka, E., et al., 2012. Protective effect of lactofermented red beetroot juice against aberrant crypt foci formation, the genotoxicity of fecal water and oxidative stress induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine in rats model. Environmental toxicology and pharmacology, 34 (3), 895–904.
  • Krajka-Kuźniak, V., et al., 2012. Beetroot juice protects against N-nitrosodiethylamine-induced liver injury in rats. Food and chemical toxicology, 50 (6), 2027–2033.
  • Kujawska, M., et al., 2009. Protective effect of red beetroot against carbon tetrachloride- and N-nitroso diethylamine-induced oxidative stress in rats. Journal of agricultural and food chemistry, 57 (6), 2570–2575.
  • Kulasekaran, C., et al., 2020. Immunohistochemical detection of 8-hydroxydeoxyguanosine: a biomarker of oxidative DNA damage in oral submucous fibrosis. Journal of oral and maxillofacial pathology, 24 (3), 536–541.
  • Liu, K., Lin, X., and Zhao, J., 2013. Toxic effects of the interaction of titanium dioxide nanoparticles with chemicals or physical factors. International journal of nanomedicine, 8, 2509–2520.
  • Ohkawa, H., Ohishi, N., and Yagi, K., 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical biochemistry, 95 (2), 351–358.
  • Peters, R.J.B., et al., 2014. Characterization of titanium dioxide nanoparticles in food products: Analytical methods to define nanoparticles. Journal of agricultural and food chemistry, 62 (27), 6285–6293.
  • Proquin, H., et al., 2018. Gene expression profiling in the colon of mice exposed to food additive titanium dioxide (E171). Food and chemical toxicology, 111, 153–165.
  • Raish, M., et al., 2019. Beetroot juice alleviates isoproterenol-induced myocardial damage by reducing oxidative stress, inflammation, and apoptosis in rats. 3 Biotech, 9 (4), 147.
  • Sakihama, Y., et al., 2012. Beetroot betalain inhibits peroxynitrite-mediated tyrosine nitration and DNA strand cleavage. Free radical research, 46 (1), 93–99.
  • Schneider, C.A., et al., 2012. NIH ımage to ImageJ: 25 years of image analysis. Nature methods, 9 (7), 671–675.
  • Shi, H., et al., 2013. Titanium dioxide nanoparticles: A review of current toxicological data. Particle and fibre toxicology, 10 (1), 15.
  • Skocaj, M., et al., 2011. Titanium dioxide in our everyday life; ıs it safe? Radiology and oncology, 45 (4), 227–247.
  • Slimen, I.B., Najar, T., and Abderrabba, M., 2017. Chemical and antioxidant properties of betalains. Journal of agricultural and food chemistry, 65 (4), 675–689.
  • Song, B., et al., 2016. Contribution of oxidative stress to TiO2 nanoparticle-induced toxicity. Environmental toxicology and pharmacology, 48, 130–140.
  • Vaculova, A., and Zhivotovsky, B., 2008. Caspases: determination of their activities in apoptotic cells. Methods in enzymology, 442, 157–181.
  • Valko, M., et al., 2007. Free radicals and antioxidants in normal physiological functions and human disease. The international journal of biochemistry & cell biology, 39 (1), 44–84.
  • Vulić, J.J., et al., 2013. Antiradical, antimicrobial and cytotoxic activities of commercial beetroot pomace. Food & function, 4 (5), 713–721.
  • Zhang, C., et al., 2015. Induction of size-dependent breakdown of blood-milk barrier in lactating mice by TiO2 nanoparticles. PLoS One, 10 (4), e0122591.
  • Zielińska-Przyjemska, M., et al., 2009. In vitro effects of beetroot juice and chips on oxidative metabolism and apoptosis in neutrophils from obese individuals. Phytotherapy research, 23 (1), 49–55.

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