Association of ergot alkaloids with conidiation in Aspergillus fumigatus

LITERATURE CITED

• Adams TH, Boylan MT, Timberlake WE. 1988. brlA is necessary and sufficient to direct conidiophore development in Aspergillus nidulans. Cell 54:353–362.
   Google Scholar
• ———, Deising H, ———. 1990. brlA requires both zinc fingers to induce development. Mol Cell Biol 10:1815–1817.
   Google Scholar
• ———, Wieser JK, Yu J-H. 1998. Asexual sporulation in Aspergillus nidulans. Microbiol Mol Biol Rev 62:35–54.
   Google Scholar
• Ball OJ-P, Miles CO, Prestidge RA. 1997. Ergopeptine alkaloids and Neotyphodium lolii-mediated resistance in perennial ryegrass against adult Heteronychus arator (Coleoptera, Scarabaeidae). J Econ Entomol 90:1382–1391.
   Google Scholar
• Bok JW, Keller NP. 2004. LaeA, a regulator of secondary metabolism in Aspergillus spp. Eukaryot Cell 3:527–535.
   Google Scholar
• ———, Balajee SA, Marr KA, Andes D, Nielsen KF, Frisvad JC, Keller NP. 2005. LaeA, a regulator of morphogenetic fungal virulence factors. Eukaryot Cell 4:1574–1582.
   Google Scholar
• Boylan MT, Mirabito PM, Willett CE, Zimmerman CR, Timberlake WT. 1987. Isolation and physical characterization of three essential conidiation genes from Aspergillus nidulans. Mol Cell Biol 7:3113–3118.
   Google Scholar
• Calvo AM, Wilson RA, Bok JW, Keller NP. 2002. Relationship between secondary metabolism and fungal development. Microbiol Mol Biol Rev 66:447–459.
   Google Scholar
• Chang YC, Timberlake WE. 1992. Identification of Aspergillus brlA response elements selection in yeast. Genetics 133:29–38.
   Google Scholar
• Clay K, Cheplick GP. 1989. Effect of ergot alkaloids from fungal endophyte-infected grasses on fall armyworm (Spodoptera frguperda). J Chem Ecol 15:169–182.
   Google Scholar
• ———, Schardl C. 2002. Evolutionary origins and ecological consequences of endophyte symbiosis with grasses. Am Nat 160:S99–S127.
   Google Scholar
• Clutterbuck AJ. 1969. A mutational analysis of conidial development in Aspergillus nidulans. Genetics 63:317–327.
   Google Scholar
• Cole GT. 1986. Models of cell differentiation in conidial fungi. Microbiol Rev 96:95–132.
   Google Scholar
• Cole RJ, Kirksey JW, Dorner JW, Wilson DM, Johnson JC Jr, Johnson AN, Bedell DM, Springer JP, Chexal KK, Clardy JC, Cox RH. 1977. Mycotoxins produced by Aspergillus fumigatus species isolated from molded silage. J Agric Food Chem 25:826–830.
   Google Scholar
• Coyle CM, Panaccione DG. 2005. An ergot alkaloid biosynthesis gene and clustered hypothetical genes from Aspergillus fumigatus. Appl Environ Microbiol 71:3112–3118.
   Google Scholar
• Flieger M, Wurst M, Shelby R. 1997. Ergot alkaloids—sources, structures and analytical methods. Folia Microbiol 42:3–30.
   Google Scholar
• Fraser RS. 1993. Pulmonary aspergillosis: pathologic and pathogenetic features. Pathol An 28:231–277.
   Google Scholar
• Gröger D, Floss HG. 1998. Biochemistry of ergot alkaloids—achievements and challenges. Alkaloids 50:171–218.
   Google Scholar
• Hicks JK, Yu J-H, Keller NP, Adams TH. 1997. Aspergillus sporulation and mycotoxin production both require inactivation of the FadA Gα protein-dependent signaling pathway. EMBO J 16:4916–4923.
   Google Scholar
• Mah J-H, ———. 2006. Upstream and downstream regulation of asexual development in Aspergillus fumigatus. Euk Cell 5:1585–1595.
   Google Scholar
• Murray FR, Latch GCM, Scott DB. 1992. Surrogate transformation of perennial ryegrass, Lolium perenne, using genetically modified Acremonium endophyte. Mol Gen Genet 233:1–9.
   Google Scholar
• Nierman WC, Pain A, Anderson MJ, et al. 2005. Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature 438:1151–1156.
   Google Scholar
• Orbach MJ. 1994. A cosmid with a HyR marker for fungal library construction and screening. Gene 150:159–162.
   Google Scholar
• Panaccione DG. 2005. Origins and significance of ergot alkaloid diversity in fungi. FEMS Microbiol Lett 25:9–17.
   Google Scholar
• ———, Coyle CM. 2005. Abundant respirable ergot alkaloids from the common airborne fungus Aspergillus fumigatus. Appl Environ Microbiol 71:3106–3111.
   Google Scholar
• ———, Johnson RD, Wang J, Young CA, Damrongkool P, Scott B, Schardl CL. 2001. Elimination of ergovaline from a grass-Neotyphodium endophyte symbiosis by genetic modification of the endophyte. Proc Nat Acad Sci USA 98:12820–12825.
   Google Scholar
• ———, Cipoletti JR, Sedlock AB, Blemings KP, Schardl CL, Machado C, Seidel GE. 2006. Effects of ergot alkaloids on food preference and satiety in rabbits, as assessed with gene knockout endophytes in perennial ryegrass (Lolium perenne). J Agric Food Chem 54:4582–4587.
   Google Scholar
• Pertz H. 1996. Naturally occurring clavines: antagonism/partial agonism at 5-HT2A receptors and antagonism at α1-adrenoceptors in blood vessels. Planta Med 62:387–392.
   Google Scholar
• ———, Eich E. 1999. Ergot alkaloids and their derivatives as ligands for serotoninergic, dopaminergic, and adrenergic receptors. In: Kren V, Cvak L, eds. Ergot: the genus Claviceps. Amsterdam, The Netherlands: Harwood Academic Publishers. p 411–440.
   Google Scholar
• Prade RA, Timberlake WE. 1993. The Aspergillus nidulans brlA regulatory locus consists of overlapping transcription units that are individually required for conidiophore development. EMBO J 12:2439–2447.
   Google Scholar
• Schardl CL, Panaccione DG, Tudzynski P. 2006. Ergot alkaloids—biology and molecular biology. Alkaloids 62: 45–86.
   Google Scholar
• Schwarz G, Eich E. 1983. Influence of ergot alkaloids on growth of Streptomyces purpurascens and production of its secondary metabolites. Planta Med 47:212–214.
   Google Scholar
• Sheppard DC, Doedt T, Chiang LY, Kim HS, Chen D, Nierman WC, Filler SG. 2005. The Aspergillus fumigatus StuA protein governs the up-regulation of a discrete transcriptional program during the acquisition of developmental competence. Mol Biol Cell 16:5866–5879.
   Google Scholar
• Shimizu K, Keller NP. 2001. Genetic involvement of a cAMP-dependent protein kinase in a G protein signaling pathway regulating morphological and chemical transitions in Aspergillus nidulans. Genetics 157:591–600.
   Google Scholar
• Spilsbury JF, Wilkinson S. 1961. The isolation of festuclavine and two new clavine alkaloids from Aspergillus fumigatus Fres. J Chem Soc 5:2085–2091.
   Google Scholar
• Timberlake WE, Boylan MT, Cooley MB, Mirabito PM, O’Hara EB, Willett CE. 1985. Rapid identification of mutation-complementing restriction fragments from Aspergillus nidulans cosmids. Exp Mycol 9:351–355.
   Google Scholar
• Unsöld IA, Li S-M. 2006. Reverse prenylation in the biosynthesis of fumigaclavine C in Aspergillus fumigatus: gene expression, purification, and characterization of the fumigaclavine C synthase FGAPT1. ChemBioChem 7:158–164.
   Google Scholar