Poly(2-oxazoline)-Containing Triblock Copolymers: Synthesis and Applications

References

• Seeliger, W.; Aufderhaar, E.; Diepers, W.; Feinauer, R.; Nehring, R.; Thier, W.; Hellmann, H. Recent Syntheses and Reactions of Cyclic Imidic Esters. Angew. Chem. Int. Ed. Engl. 1966, 5, 875–888.
   PubMed Web of Science ®Google Scholar
• Tomalia, D. A.; Sheetz, D. P. Homopolymerization of 2-Alkyl- and 2-Aryl-2-Oxazolines. J. Polym. Sci. A-1 Polym. Chem. 1966, 4, 2253–2265.
   Web of Science ®Google Scholar
• Bassiri, T. G.; Levy, A.; Litt, M. Polymerization of Cyclic Imino Ethers. I. Oxazolines. J. Polym. Sci. B Polym. Lett. 1967, 5, 871–879.
   Web of Science ®Google Scholar
• Kagiya, T.; Narisawa, S.; Maeda, T.; Fukui, K. Ring‐Opening Polymerization of 2‐Substituted 2‐Oxazolines. J. Polym. Sci. B Polym. Lett. 1966, 4, 441–445.
   Web of Science ®Google Scholar
• Hoogenboom, R. Poly(2-Oxazoline)s: A Polymer Class with Numerous Potential Applications. Angew. Chem. Int. Ed. Engl. 2009, 48, 7978–7994.
   PubMed Web of Science ®Google Scholar
• Knop, K.; Hoogenboom, R.; Fischer, D.; Schubert, U. S. Poly(Ethylene Glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives. Angew. Chem. Int. Ed. Engl. 2010, 49, 6288–6308.
   PubMed Web of Science ®Google Scholar
• Luxenhofer, R.; Han, Y.; Schulz, A.; Tong, J.; He, Z.; Kabanov, A. V.; Jordan, R. Poly(2-Oxazoline)s as Polymer Therapeutics. Macromol. Rapid Commun. 2012, 33, 1613–1631.
   PubMed Web of Science ®Google Scholar
• Schlaad, H.; Diehl, C.; Gress, A.; Meyer, M.; Demirel, A. L.; Nur, Y.; Bertin, A. Poly(2-Oxazoline)s as Smart Bioinspired Polymers. Macromol. Rapid Commun. 2010, 31, 511–525.
   PubMed Web of Science ®Google Scholar
• Weber, C.; Hoogenboom, R.; Schubert, U. S. Temperature Responsive Bio-Compatible Polymers Based on Poly(Ethylene Oxide) and Poly(2-Oxazoline)s. Prog. Polym. Sci. 2012, 37, 686–714.
   Web of Science ®Google Scholar
• Verbraeken, B.; Monnery, B. D.; Lava, K.; Hoogenboom, R. The Chemistry of Poly(2-Oxazoline)s. Eur. Polym. J. 2017, 88, 451–469.
   Web of Science ®Google Scholar
• Lava, K.; Verbraeken, B.; Hoogenboom, R. Poly(2-Oxazoline)s and Click Chemistry: A Versatile Toolbox toward Multi-Functional Polymers. Eur. Polym. J. 2015, 65, 98–111.
   Web of Science ®Google Scholar
• Tasdelen, M. A.; Kahveci, M. U.; Yagci, Y. Telechelic Polymers by Living and Controlled/Living Polymerization Methods. Prog. Polym. Sci. 2011, 36, 455–567.
   Web of Science ®Google Scholar
• Bates, C. M.; Bates, F. S. 50th Anniversary Perspective: Block Polymers – Pure Potential. Macromolecules 2017, 50, 3–22.
   Web of Science ®Google Scholar
• Schacher, F. H.; Rupar, P. A.; Manners, I. Functional Block Copolymers: Nanostructured Materials with Emerging Applications. Angew. Chem. Int. Ed. 2012, 51, 7898–7921.
   PubMed Web of Science ®Google Scholar
• Kobayashi, S.; Igarashi, T.; Moriuchi, Y.; Saegusa, T. Block Copolymers from Cyclic Imino Ethers: A New Class of Nonionic Polymer Surfactant. Macromolecules 1986, 19, 535–541.
   Web of Science ®Google Scholar
• Bonné, T. B.; Lüdtke, K.; Jordan, R.; Papadakis, C. M. Effect of Polymer Architecture of Amphiphilic Poly(2-Oxazoline) Copolymers on the Aggregation and Aggregate Structure. Macromol. Chem. Phys. 2007, 208, 1402–1408.
   Web of Science ®Google Scholar
• Jaksch, S.; Schulz, A.; Di, Z.; Luxenhofer, R.; Jordan, R.; Papadakis, C. M. Amphiphilic Triblock Copolymers from Poly(2-Oxazoline) with Different Hydrophobic Blocks: Changes of the Micellar Structures upon Addition of a Strongly Hydrophobic Cancer Drug. Macromol. Chem. Phys. 2016, 217, 1448–1456.
   Web of Science ®Google Scholar
• Schulz, A.; Jaksch, S.; Schubel, R.; Wegener, E.; Di, Z.; Han, Y.; Meister, A.; Kressler, J.; Kabanov, A. V.; Luxenhofer, R.; Papadakis, C. M.; Jordan, R. Drug-Induced Morphology Switch in Drug Delivery Systems Based on Poly(2-Oxazoline)s. ACS Nano 2014, 8, 2686–2696.
   PubMed Web of Science ®Google Scholar
• Seo, Y.; Schulz, A.; Han, Y.; He, Z.; Bludau, H.; Wan, X.; Tong, J.; Bronich, T. K.; Sokolsky, M.; Luxenhofer, R.; Jordan, R.; Kabanov, A. V. Poly(2-Oxazoline) Block Copolymer Based Formulations of Taxanes: Effect of Copolymer and Drug Structure, Concentration, and Environmental Factors. Polym. Adv. Technol. 2015, 26, 837–850.
   Web of Science ®Google Scholar
• Luxenhofer, R.; Schulz, A.; Roques, C.; Li, S.; Bronich, T. K.; Batrakova, E. V.; Jordan, R.; Kabanov, A. V. Doubly Amphiphilic Poly(2-Oxazoline)s as High-Capacity Delivery Systems for Hydrophobic Drugs. Biomaterials 2010, 31, 4972–4979.
   PubMed Web of Science ®Google Scholar
• Han, Y.; He, Z.; Schulz, A.; Bronich, T. K.; Jordan, R.; Luxenhofer, R.; Kabanov, A. V. Synergistic Combinations of Multiple Chemotherapeutic Agents in High Capacity Poly(2-Oxazoline) Micelles. Mol. Pharm. 2012, 9, 2302–2313.
   PubMed Web of Science ®Google Scholar
• Luxenhofer, R.; Sahay, G.; Schulz, A.; Alakhova, D.; Bronich, T. K.; Jordan, R.; Kabanov, A. V. Structure–Property Relationship in Cytotoxicity and Cell Uptake of Poly(2-Oxazoline) Amphiphiles. J. Control. Release 2011, 153, 73–82.
   PubMed Web of Science ®Google Scholar
• Cai, G.; Litt, M. H. Preparation and Characterization of Phenyl and Undecyl Oxazoline Block Copolymers. J. Polym. Sci. A Polym. Chem. 1989, 27, 3603–3618.
   Web of Science ®Google Scholar
• Cai, G.; Litt, M. H.; Krieger, I. M. Surface Properties and Abhesion of Undecyl Oxazoline Block and Homopolymers. J. Polym. Sci. B Polym. Phys. 1991, 29, 773–784.
   Web of Science ®Google Scholar
• Kempe, K.; Baumgaertel, A.; Hoogenboom, R.; Schubert, U. S. Design of New Amphiphilic Triblock Copoly(2-Oxazoline)s Containing a Fluorinated Segment. J. Polym. Sci. A Polym. Chem. 2010, 48, 5100–5108.
   Web of Science ®Google Scholar
• Kempe, K.; Hoogenboom, R.; Hoeppener, S.; Fustin, C.-A.; Gohy, J.-F.; Schubert, U. S. Discovering New Block Terpolymer Micellar Morphologies. Chem. Commun. (Camb.) 2010, 46, 6455–6457.
   PubMed Web of Science ®Google Scholar
• Mansfeld, U.; Hoeppener, S.; Kempe, K.; Schumers, J.-M.; Gohy, J.-F.; Schubert, U. S. Tuning the Morphology of Triblock Terpoly(2-Oxazoline)s Containing a 2-Phenyl-2-Oxazoline Block with Varying Fluorine Content. Soft Matter 2013, 9, 5966–5974.
   Web of Science ®Google Scholar
• Liu, Y.; Wang, Y.; Wang, Y.; Lu, J.; Piñón, V.; Weck, M. Shell Cross-Linked Micelle-Based Nanoreactors for the Substrate-Selective Hydrolytic Kinetic Resolution of Epoxides. J. Am. Chem. Soc. 2011, 133, 14260–14263.
   PubMed Web of Science ®Google Scholar
• Lu, J.; Dimroth, J.; Weck, M. Compartmentalization of Incompatible Catalytic Transformations for Tandem Catalysis. J. Am. Chem. Soc. 2015, 137, 12984–12989.
   PubMed Web of Science ®Google Scholar
• Lee, L.-C.; Lu, J.; Weck, M.; Jones, C. W. Acid–Base Bifunctional Shell Cross-Linked Micelle Nanoreactor for One-Pot Tandem Reaction. ACS Catal. 2016, 6, 784–787.
   Web of Science ®Google Scholar
• Hoogenboom, R.; Wiesbrock, F.; Huang, H.; Leenen, M. A. M.; Thijs, H. M. L.; van Nispen, S. F. G. M.; van der Loop, M.; Fustin, C.-A.; Jonas, A. M.; Gohy, J.-F.; Schubert, U. S. Microwave-Assisted Cationic Ring-Opening Polymerization of 2-Oxazolines: A Powerful Method for the Synthesis of Amphiphilic Triblock Copolymers. Macromolecules 2006, 39, 4719–4725.
   Web of Science ®Google Scholar
• Hoogenboom, R.; Wiesbrock, F.; Leenen, M. A. M.; Thijs, H. M. L.; Huang, H.; Fustin, C.-A.; Guillet, P.; Gohy, J.-F.; Schubert, U. S. Synthesis and Aqueous Micellization of Amphiphilic Tetrablock Ter- and Quarterpoly(2-Oxazoline)s. Macromolecules 2007, 40, 2837–2843.
   Web of Science ®Google Scholar
• Kranenburg, J. M.; Thijs, H. M. L.; Tweedie, C. A.; Hoeppener, S.; Wiesbrock, F.; Hoogenboom, R.; Van Vliet, K. J.; Schubert, U. S. Correlating the Mechanical and Surface Properties with the Composition of Triblock Copoly(2-Oxazoline)s. J. Mater. Chem 2009, 19, 222–229.
   Web of Science ®Google Scholar
• Baeten, E.; Verbraeken, B.; Hoogenboom, R.; Junkers, T. Continuous Poly(2-Oxazoline) Triblock Copolymer Synthesis in a Microfluidic Reactor Cascade. Chem. Commun. 2015, 51, 11701–11704.
   PubMed Web of Science ®Google Scholar
• Fustin, C.-A.; Huang, H.; Hoogenboom, R.; Wiesbrock, F.; Jonas, A. M.; Schubert, U. S.; Gohy, J.-F. Evaporation Induced Micellization of Poly(2-Oxazoline) Multiblock Copolymers on Surfaces. Soft Matter 2007, 3, 79–82.
   Web of Science ®Google Scholar
• Krumm, C.; Fik, C. P.; Meuris, M.; Dropalla, G. J.; Geltenpoth, H.; Sickmann, A.; Tiller, J. C. Well-Defined Amphiphilic Poly(2-Oxazoline) ABA-Triblock Copolymers and Their Aggregation Behavior in Aqueous Solution. Macromol. Rapid Commun. 2012, 33, 1677–1682.
   PubMed Web of Science ®Google Scholar
• Krumm, C.; Konieczny, S.; Dropalla, G. J.; Milbradt, M.; Tiller, J. C. Amphiphilic Polymer Conetworks Based on End Group Cross-Linked Poly(2-Oxazoline) Homo- and Triblock Copolymers. Macromolecules 2013, 46, 3234–3245.
   Web of Science ®Google Scholar
• Schmidt, M.; Raidt, T.; Ring, S.; Gielke, S.; Gramse, C.; Wilhelm, S.; Katzenberg, F.; Krumm, C.; Tiller, J. C. Investigations on “near Perfect” Poly(2-Oxazoline) Based Amphiphilic Polymer Conetworks with a Crystallizable Block. Eur. Polym. J. 2017, 88, 562–574.
   Web of Science ®Google Scholar
• McAlvin, J. E.; Fraser, C. L. Metal-Centered Star Block Copolymers: Amphiphilic Iron Tris(Bipyridine)-Centered Polyoxazolines and Their Chemical Fragmentation to Bipyridine-Centered BAB Triblock Copolymers. Macromolecules 1999, 32, 1341–1347.
   Web of Science ®Google Scholar
• Hruby, M.; Filippov, S. K.; Panek, J.; Novakova, M.; Mackova, H.; Kucka, J.; Vetvicka, D.; Ulbrich, K. Polyoxazoline Thermoresponsive Micelles as Radionuclide Delivery Systems. Macromol. Biosci. 2010, 10, 916–924.
   PubMed Web of Science ®Google Scholar
• Bogomolova, A.; Filippov, S. K.; Starovoytova, L.; Angelov, B.; Konarev, P.; Sedlacek, O.; Hruby, M.; Stepanek, P. Study of Complex Thermosensitive Amphiphilic Polyoxazolines and Their Interaction with Ionic Surfactants. Are Hydrophobic, Thermosensitive, and Hydrophilic Moieties Equally Important? J. Phys. Chem. B 2014, 118, 4940–4950.
   PubMed Web of Science ®Google Scholar
• Hoogenboom, R.; Monnery, B. Method for the Preparation of Uniform, High Molar Mass Cyclic Imino Ether Polymers. 2016, WO2016008817A1, https://patents.google.com/patent/WO2016008817A1/en.
   Google Scholar
• Rueda, J. C.; Asmad, M.; Ruiz, V.; Komber, H.; Zschoche, S.; Voit, B. Synthesis and Characterization of New Bi-Sensitive Copoly(2-Oxazolines). Des. Monomers Polym. 2015, 18, 761–769.
   Google Scholar
• Zschoche, S.; Rueda, J. C.; Binner, M.; Komber, H.; Janke, A.; Appelhans, D.; Voit, B. Temperature- and pH-Dependent Aggregation Behavior of Hydrophilic Dual-Sensitive Poly(2-Oxazoline)s Block Copolymers as Latent Amphiphilic Macromolecules. Eur. Polym. J. 2017, 88, 623–635.
   Web of Science ®Google Scholar
• Kim, C.; Lee, S. C.; Kang, S. W.; Kwon, I. C.; Jeong, S. Y. Phase-Transition Characteristics of Amphiphilic Poly(2-Ethyl-2-Oxazoline)/Poly(ε-Caprolactone) Block Copolymers in Aqueous Solutions. J. Polym. Sci. B Polym. Phys. 2000, 38, 2400–2408.
   Web of Science ®Google Scholar
• Wang, C.-H.; Hsiue, G.-H. New Amphiphilic Poly(2-Ethyl-2-Oxazoline)/Poly(l-Lactide) Triblock Copolymers. Biomacromolecules 2003, 4, 1487–1490.
   PubMed Web of Science ®Google Scholar
• Wang, C.-H.; Fan, K.-R.; Hsiue, G.-H. Enzymatic Degradation of PLLA-PEOz-PLLA Triblock Copolymers. Biomaterials 2005, 26, 2803–2811.
   PubMed Web of Science ®Google Scholar
• Marx, L.; Volet, G.; Amiel, C. Well-Defined Polyoxazoline-Based Alkoxyamines as Efficient Macroinitiators in Nitroxide-Mediated Radical Polymerization of Styrene. J. Polym. Sci. A Polym. Chem. 2011, 49, 4785–4793.
   Web of Science ®Google Scholar
• Sahn, M.; Yildirim, T.; Dirauf, M.; Weber, C.; Sungur, P.; Hoeppener, S.; Schubert, U. S. LCST Behavior of Symmetrical PNiPAm-b-PEtOx-b-PNiPAm Triblock Copolymers. Macromolecules 2016, 49, 7257–7267.
   Web of Science ®Google Scholar
• Sahn, M.; Stafast, L. M.; Dirauf, M.; Bandelli, D.; Weber, C.; Schubert, U. S. LCST Behavior of Poly(2-Ethyl-2-Oxazoline) Containing Diblock and Triblock Copolymers. Eur. Polym. J. 2018, 100, 57–66.
   Web of Science ®Google Scholar
• Volet, G.; Lav, T.-X.; Babinot, J.; Amiel, C. Click-Chemistry: An Alternative Way to Functionalize Poly(2-Methyl-2-Oxazoline). Macromol. Chem. Phys. 2011, 212, 118–124.
   Web of Science ®Google Scholar
• Chen, L. Q.; Zhang, L. M.; Chen, J. J.; Yang, J.; Li, R. X. Self-Assembly and Drug Delivery Behaviors of a Novel Thermo-Sensitive Block Glycopolymer. Chin. Sci. Bull. 2010, 55, 4187–4196.
   Google Scholar
• Saegusa, T.; Kobayashi, S. Oligomers Derived from 2-Oxazolines. J. Macromol. Sci. Part A 1984, 21, 1021–1034.
   Web of Science ®Google Scholar
• Dworak, A.; Schulz, R. C. Star Polymers and Block Copolymers of 2-Oxazolines Using Chloroformates as Initiators. Makromol. Chem. 1991, 192, 437–445.
   Web of Science ®Google Scholar
• Zhong, Z.; Feijen, J.; Lok, M. C.; Hennink, W. E.; Christensen, L. V.; Yockman, J. W.; Kim, Y.-H.; Kim, S. W. Low Molecular Weight Linear Polyethylenimine-b-Poly(Ethylene Glycol)-b-Polyethylenimine Triblock Copolymers: Synthesis, Characterization, and In Vitro Gene Transfer Properties. Biomacromolecules 2005, 6, 3440–3448.
   PubMed Web of Science ®Google Scholar
• Miyamoto, M.; Aoi, K.; Yamanaka, H.; Saegusa, T. Preparation of Block Copolymer Consisting of Poly(2-Methyl-2-Oxazoline) and Poly(Propylene Oxide) Blocks. A New Nonionic Surfactant. Polym. J. 1992, 24, 405–409.
   Web of Science ®Google Scholar
• Brissault, B.; Kichler, A.; Leborgne, C.; Jarroux, N.; Cheradame, H.; Guis, C. Amphiphilic Poly[(Propylene Glycol)‐Block‐(2‐Methyl‐2‐Oxazoline)] Copolymers for Gene Transfer in Skeletal Muscle. ChemMedChem 2007, 2, 1202–1207.
   PubMed Web of Science ®Google Scholar
• Saegusa, T.; Ikeda, H. Preparation of Block Copolymer of 2-Oxazoline and Butadiene. Macromolecules 1973, 6, 805–808.
   Web of Science ®Google Scholar
• Celebi, O.; Lee, C. H.; Lin, Y.; McGrath, J. E.; Riffle, J. S. Synthesis and Characterization of Polyoxazoline–Polysulfone Triblock Copolymers. Polymer 2011, 52, 4718–4726.
   Web of Science ®Google Scholar
• Van Caeter, P.; Goethals, E. J.; Gancheva, V.; Velichkova, R. Synthesis and Bulk Properties of Poly(Tetrahydrofuran)–Poly(2-Methyl-2-Oxazoline) ABA Triblock Copolymers. Polym. Bull. 1997, 39, 589–596.
   Web of Science ®Google Scholar
• Cheradame, H.; Sassatelli, M.; Pomel, C.; Sanh, A.; Gau-Racine, J.; Bacri, L.; Auvray, L.; Guégan, P. Tuning Macromolecular Structures of Synthetic Vectors for Gene Therapy. Macromol. Symp. 2008, 261, 167–181.
   Google Scholar
• Rasolonjatovo, B.; Gomez, J.-P.; Même, W.; Gonçalves, C.; Huin, C.; Bennevault-Celton, V.; Le Gall, T.; Montier, T.; Lehn, P.; Cheradame, H.; Midoux, P.; Guégan, P. Poly(2-Methyl-2-Oxazoline)-b-Poly(Tetrahydrofuran)-b-Poly(2-Methyl-2-Oxazoline) Amphiphilic Triblock Copolymers: Synthesis, Physicochemical Characterizations, and Hydrosolubilizing Properties. Biomacromolecules 2015, 16, 748–756.
   PubMed Web of Science ®Google Scholar
• Gonçalves, C.; Gomez, J.-P.; Même, W.; Rasolonjatovo, B.; Gosset, D.; Nedellec, S.; Hulin, P.; Huin, C.; Le Gall, T.; Montier, T.; Lehn, P.; Pichon, C.; Guégan, P.; Cheradame, H.; Midoux, P. Curcumin/Poly(2-Methyl-2-Oxazoline-b-Tetrahydrofuran-b-2-Methyl-2-Oxazoline) Formulation: An Improved Penetration and Biological Effect of Curcumin in F508del-CFTR Cell Lines. Eur. J. Pharm. Biopharm. 2017, 117, 168–181.
   PubMed Web of Science ®Google Scholar
• Rasolonjatovo, B.; Pitard, B.; Haudebourg, T.; Bennevault, V.; Guégan, P. Synthesis of Tetraarm Star Block Copolymer Based on Polytetrahydrofuran and Poly(2-Methyl-2-Oxazoline) for Gene Delivery Applications. Eur. Polym. J. 2017, 88, 689–700.
   Web of Science ®Google Scholar
• Nardin, C.; Hirt, T.; Leukel, J.; Meier, W. Polymerized ABA Triblock Copolymer Vesicles. Langmuir 2000, 16, 1035–1041.
   Web of Science ®Google Scholar
• Lörcher, S.; Meier, W. Cosolvent Fractionation of PMOXA-b-PDMS-b-PMOXA: Bulk Separation of Triblocks from Multiblocks. Eur. Polym. J. 2017, 88, 575–585.
   Web of Science ®Google Scholar
• Itel, F.; Chami, M.; Najer, A.; Lörcher, S.; Wu, D.; Dinu, I. A.; Meier, W. Molecular Organization and Dynamics in Polymersome Membranes: A Lateral Diffusion Study. Macromolecules 2014, 47, 7588–7596.
   Web of Science ®Google Scholar
• Hyo-Jick, C.; Evan, B.; Carlo, D. M. Synthesis and Characterization of Nanoscale Biomimetic Polymer Vesicles and Polymer Membranes for Bioelectronic Applications. Nanotechnology 2005, 16, S143.
   Web of Science ®Google Scholar
• Meier, W.; Nardin, C.; Winterhalter, M. Reconstitution of Channel Proteins in (polymerized) ABA Triblock Copolymer Membranes. Angew. Chem. Int. Ed. Engl. 2000, 39, 4599–4602.
   PubMed Web of Science ®Google Scholar
• Kumar, M.; Grzelakowski, M.; Zilles, J.; Clark, M.; Meier, W. Highly Permeable Polymeric Membranes Based on the Incorporation of the Functional Water Channel Protein Aquaporin Z. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 20719–20724.
   PubMed Web of Science ®Google Scholar
• Najer, A.; Wu, D.; Bieri, A.; Brand, F.; Palivan, C. G.; Beck, H.-P.; Meier, W. Nanomimics of Host Cell Membranes Block Invasion and Expose Invasive Malaria Parasites. ACS Nano 2014, 8, 12560–12571.
   PubMed Web of Science ®Google Scholar
• Onaca, O.; Hughes, D. W.; Balasubramanian, V.; Grzelakowski, M.; Meier, W.; Palivan, C. G. SOD Antioxidant Nanoreactors: Influence of Block Copolymer Composition on the Nanoreactor Efficiency. Macromol. Biosci. 2010, 10, 531–538.
   PubMed Web of Science ®Google Scholar
• Axthelm, F.; Casse, O.; Koppenol, W. H.; Nauser, T.; Meier, W.; Palivan, C. G. Antioxidant Nanoreactor Based on Superoxide Dismutase Encapsulated in Superoxide-Permeable Vesicles. J. Phys. Chem. B 2008, 112, 8211–8217.
   PubMed Web of Science ®Google Scholar
• Spulber, M.; Najer, A.; Winkelbach, K.; Glaied, O.; Waser, M.; Pieles, U.; Meier, W.; Bruns, N. Photoreaction of a Hydroxyalkyphenone with the Membrane of Polymersomes: A Versatile Method to Generate Semipermeable Nanoreactors. J. Am. Chem. Soc. 2013, 135, 9204–9212.
   PubMed Web of Science ®Google Scholar
• Langowska, K.; Palivan, C. G.; Meier, W. Polymer Nanoreactors Shown to Produce and Release Antibiotics Locally. Chem. Commun. (Camb.) 2013, 49, 128–130.
   PubMed Web of Science ®Google Scholar
• Theogarajan, L.; Desai, S.; Baldo, M.; Scholz, C. Versatile Synthesis of Self-Assembling ABA Triblock Copolymers with Polymethyloxazoline A-Blocks and a Polysiloxane B-Block Decorated with Supramolecular Receptors. Polym. Int. 2008, 57, 660–667.
   Web of Science ®Google Scholar
• Theogarajan, L.; Li, H.; Busse, K.; Desai, S.; Kressler, J.; Scholz, C. Self-Assembly of ABA Triblock Copolymers Based on Functionalized Polydimethylsiloxane and Polymethyloxazoline. Polym. Int. 2010, 59, 1191–1198.
   Web of Science ®Google Scholar
• Stoenescu, R.; Meier, W. Vesicles with Asymmetric Membranes from Amphiphilic ABC Triblock Copolymers. Chem. Commun. 2002, 0, 3016–3017. http://pubs.rsc.org/en/content/articlelanding/2002/cc/b209352a#!divAbstract.
   Web of Science ®Google Scholar
• Konishcheva, E. V.; Zhumaev, U. E.; Meier, W. P. PEO-b-PCL-b-PMOXA Triblock Copolymers: From Synthesis to Microscale Polymersomes with Asymmetric Membrane. Macromolecules 2017, 50, 1512–1520.
   Web of Science ®Google Scholar
• Petrova, S.; Venturini, C. G.; Jäger, A.; Jäger, E.; Černoch, P.; Kereïche, S.; Kováčik, L.; Raška, I.; Štěpánek, P. Novel Thermo-Responsive Double-Hydrophilic and Hydrophobic MPEO-b-PEtOx-b-PCL Triblock Terpolymers: Synthesis, Characterization and Self-Assembly Studies. Polymer 2015, 59, 215–225.
   Web of Science ®Google Scholar
• Kourti, M.-E.; Fega, E.; Pitsikalis, M. Block Copolymers Based on 2-Methyl- and 2-Phenyl-Oxazoline by Metallocene-Mediated Cationic Ring-Opening Polymerization: Synthesis and Characterization. Polym. Chem. 2016, 7, 2821–2835.
   Web of Science ®Google Scholar
• Isaacman, M. J.; Barron, K. A.; Theogarajan, L. S. Clickable Amphiphilic Triblock Copolymers. J. Polym. Sci.; Part A: Polym. Chem. 2012, 50, 2319–2329.
   PubMed Web of Science ®Google Scholar
• Osawa, S.; Osada, K.; Hiki, S.; Dirisala, A.; Ishii, T.; Kataoka, K. Polyplex Micelles with Double-Protective Compartments of Hydrophilic Shell and Thermoswitchable Palisade of Poly(Oxazoline)-Based Block Copolymers for Promoted Gene Transfection. Biomacromolecules 2016, 17, 354–361.
   PubMed Web of Science ®Google Scholar
• Rudolph, T.; Lühe, M. V. D.; Hartlieb, M.; Norsic, S.; Schubert, U. S.; Boisson, C.; D’Agosto, F.; Schacher, F. H. Toward Anisotropic Hybrid Materials: Directional Crystallization of Amphiphilic Polyoxazoline-Based Triblock Terpolymers. ACS Nano 2015, 9, 10085–10098.
   PubMed Web of Science ®Google Scholar
• Wang, X.; Li, X.; Li, Y.; Zhou, Y.; Fan, C.; Li, W.; Ma, S.; Fan, Y.; Huang, Y.; Li, N.; Liu, Y. Synthesis, Characterization and Biocompatibility of Poly(2-Ethyl-2-Oxazoline)-Poly(D,L-Lactide)-Poly(2-Ethyl-2-Oxazoline) Hydrogels. Acta Biomater. 2011, 7, 4149–4159.
   PubMed Web of Science ®Google Scholar
• Wang, C.-H.; Hwang, Y.-S.; Chiang, P.-R.; Shen, C.-R.; Hong, W.-H.; Hsiue, G.-H. Extended Release of Bevacizumab by Thermosensitive Biodegradable and Biocompatible Hydrogel. Biomacromolecules 2012, 13, 40–48.
   PubMed Web of Science ®Google Scholar