Epigenetic effects of selenium and their implications for health

References

• Dawson MA, Kouzarides T. Cancer epigenetics: from mechanism to therapy. Cell 2012; 150:12-27; PMID:22770212; http://dx.doi.org/10.1016/j.cell.2012.06.013
   PubMed Web of Science ®Google Scholar
• Bell JT, Tsai PC, Yang TP, Pidsley R, Nisbet J, Glass D, Mangino M, Zhai G, Zhang F, Valdes A, et al. Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population. PLoS Genet 2012; 8:e1002629; PMID:22532803; http://dx.doi.org/10.1371/journal.pgen.1002629
   PubMed Web of Science ®Google Scholar
• Tsai PC, Spector TD, Bell JT. Using epigenome-wide association scans of DNA methylation in age-related complex human traits. Epigenomics 2012; 4:511-26; PMID:23130833; http://dx.doi.org/10.2217/epi.12.45
   PubMed Web of Science ®Google Scholar
• Arai E, Kanai Y. DNA methylation profiles in precancerous tissue and cancers: carcinogenetic risk estimation and prognostication based on DNA methylation status. Epigenomics 2010; 2:467-81; PMID:22121905; http://dx.doi.org/10.2217/epi.10.16
   PubMed Web of Science ®Google Scholar
• Timp W, Feinberg AP. Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host. Nat Rev Cancer 2013; 13:497-510; PMID:23760024; http://dx.doi.org/10.1038/nrc3486
   PubMed Web of Science ®Google Scholar
• Dozmorov MG, Wren JD, Alarcon-Riquelme ME. Epigenomic elements enriched in the promoters of autoimmunity susceptibility genes. Epigenetics 2014; 9:276-85; PMID:24213554; http://dx.doi.org/10.4161/epi.27021
   PubMed Web of Science ®Google Scholar
• Hasler R, Feng Z, Backdahl L, Spehlmann ME, Franke A, Teschendorff A, Rakyan VK, Down TA, Wilson GA, Feber A, et al. A functional methylome map of ulcerative colitis. Genome Res 2012; 22:2130-7; PMID:22826509; http://dx.doi.org/10.1101/gr.138347.112
   PubMed Web of Science ®Google Scholar
• Nilsson E, Jansson PA, Perfilyev A, Volkov P, Pedersen M, Svensson MK, Poulsen P, Ribel-Madsen R, Pedersen NL, Almgren P, et al. Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes. Diabetes 2014; 63:2962-76; PMID:24812430; http://dx.doi.org/10.2337/db13-1459
   PubMed Web of Science ®Google Scholar
• Whayne TF. Epigenetics in the development, modification, and prevention of cardiovascular disease. Mol Biol Rep 2014; PMID:25205125; http://dx.doi.org/10.1007/s11033-014-3727-z
   PubMed Web of Science ®Google Scholar
• McKay JA, Mathers JC. Diet induced epigenetic changes and their implications for health. Acta Physiol 2011; 202:103-18; PMID:21401888; http://dx.doi.org/10.1111/j.1748-1716.2011.02278.x
   PubMed Web of Science ®Google Scholar
• Schwenk RW, Vogel H, Schurmann A. Genetic and epigenetic control of metabolic health. Mol Metab 2013; 2:337-47; PMID:24327950; http://dx.doi.org/10.1016/j.molmet.2013.09.002
   PubMed Web of Science ®Google Scholar
• Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigo R, Gladyshev VN. Characterization of mammalian selenoproteomes. Science 2003; 300:1439-43; PMID:12775843; http://dx.doi.org/10.1126/science.1083516
   PubMed Web of Science ®Google Scholar
• Papp LV, Lu J, Holmgren A, Khanna KK. From selenium to selenoproteins: synthesis, identity, and their role in human health. Antioxid Redox Signal 2007; 9:775-806; PMID:17508906; http://dx.doi.org/10.1089/ars.2007.1528
   PubMed Web of Science ®Google Scholar
• Yant LJ, Ran Q, Rao L, Van Remmen H, Shibatani T, Belter JG, Motta L, Richardson A, Prolla TA. The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults. Free Radic Biol Med 2003; 34:496-502; PMID:12566075; http://dx.doi.org/10.1016/S0891-5849(02)01360-6
   PubMed Web of Science ®Google Scholar
• Conrad M, Jakupoglu C, Moreno SG, Lippl S, Banjac A, Schneider M, Beck H, Hatzopoulos AK, Just U, Sinowatz F, et al. Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. Mol Cell Biol 2004; 24:9414-23; PMID:15485910; http://dx.doi.org/10.1128/MCB.24.21.9414-9423.2004
   PubMed Web of Science ®Google Scholar
• Bosl MR, Takaku K, Oshima M, Nishimura S, Taketo MM. Early embryonic lethality caused by targeted disruption of the mouse selenocysteine tRNA gene (Trsp). Proc Natl Acad Sci U S A 1997; 94:5531-4; PMID:9159106; http://dx.doi.org/10.1073/pnas.94.11.5531
   PubMed Web of Science ®Google Scholar
• Schoenmakers E, Agostini M, Mitchell C, Schoenmakers N, Papp L, Rajanayagam O, Padidela R, Ceron-Gutierrez L, Doffinger R, Prevosto C, et al. Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans. J Clin Invest 2010; 120:4220-35; PMID:21084748; http://dx.doi.org/10.1172/JCI43653
   PubMed Web of Science ®Google Scholar
• Steinbrenner H, Speckmann B, Sies H. Toward understanding success and failures in the use of selenium for cancer prevention. Antioxid Redox Signal 2013; 19:181-91; PMID:23421468; http://dx.doi.org/10.1089/ars.2013.5246
   PubMed Web of Science ®Google Scholar
• Fairweather-Tait SJ, Bao Y, Broadley MR, Collings R, Ford D, Hesketh JE, Hurst R. Selenium in human health and disease. Antioxid Redox Signal 2011; 14:1337-83; PMID:20812787; http://dx.doi.org/10.1089/ars.2010.3275
   PubMed Web of Science ®Google Scholar
• Rayman MP. The use of high-selenium yeast to raise selenium status: how does it measure up? Br J Nutr 2004; 92:557-73; PMID:15522125; http://dx.doi.org/10.1079/BJN20041251
   PubMed Web of Science ®Google Scholar
• Xia Y, Hill KE, Byrne DW, Xu J, Burk RF. Effectiveness of selenium supplements in a low-selenium area of China. Ame J Clin Nutr 2005; 81:829-34; PMID:15817859
   PubMed Web of Science ®Google Scholar
• Hurst R, Armah CN, Dainty JR, Hart DJ, Teucher B, Goldson AJ, Broadley MR, Motley AK, Fairweather-Tait SJ. Establishing optimal selenium status: results of a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 2010; 91:923-31; PMID:20181815; http://dx.doi.org/10.3945/ajcn.2009.28169
   PubMed Web of Science ®Google Scholar
• Rayman MP, Stranges S. Epidemiology of selenium and type 2 diabetes: can we make sense of it? Free Radic Biol Med 2013; 65:1557-64; PMID:23597503; http://dx.doi.org/10.1016/j.freeradbiomed.2013.04.003
   PubMed Web of Science ®Google Scholar
• Weekley CM, Harris HH. Which form is that? The importance of selenium speciation and metabolism in the prevention and treatment of disease. Chem Soc Rev 2013; 42:8870-94; PMID:24030774; http://dx.doi.org/10.1039/c3cs60272a
   PubMed Web of Science ®Google Scholar
• Schomacher L. Mammalian DNA demethylation: multiple faces and upstream regulation. Epigenetics 2013; 8:679-84; PMID:23803967; http://dx.doi.org/10.4161/epi.24977
   PubMed Web of Science ®Google Scholar
• Arai Y, Ohgane J, Yagi S, Ito R, Iwasaki Y, Saito K, Akutsu K, Takatori S, Ishii R, Hayashi R, et al. Epigenetic assessment of environmental chemicals detected in maternal peripheral and cord blood samples. J Reprod Dev 2011; 57:507-17; PMID:21606628; http://dx.doi.org/10.1262/jrd.11-034A
   PubMed Web of Science ®Google Scholar
• Zeng H, Yan L, Cheng WH, Uthus EO. Dietary selenomethionine increases exon-specific DNA methylation of the p53 gene in rat liver and colon mucosa. J Nutr 2011; 141:1464-8; PMID:21653573; http://dx.doi.org/10.3945/jn.111.140715
   PubMed Web of Science ®Google Scholar
• Uthus EO, Ross SA, Davis CD. Differential effects of dietary selenium (se) and folate on methyl metabolism in liver and colon of rats. Biol Trace Elem Res 2006; 109:201-14; PMID:16632891; http://dx.doi.org/10.1385/BTER:109:3:201
   PubMed Web of Science ®Google Scholar
• Davis CD, Uthus EO, Finley JW. Dietary selenium and arsenic affect DNA methylation in vitro in Caco-2 cells and in vivo in rat liver and colon. J Nutr 2000; 130:2903-9; PMID:11110844
   PubMed Web of Science ®Google Scholar
• Armstrong KM, Bermingham EN, Bassett SA, Treloar BP, Roy NC, Barnett MP. Global DNA methylation measurement by HPLC using low amounts of DNA. Biotechnol J 2011; 6:113-7; PMID:21053336; http://dx.doi.org/10.1002/biot.201000267
   PubMed Web of Science ®Google Scholar
• Xiang N, Zhao R, Song G, Zhong W. Selenite reactivates silenced genes by modifying DNA methylation and histones in prostate cancer cells. Carcinogenesis 2008; 29:2175-81; PMID:18676679; http://dx.doi.org/10.1093/carcin/bgn179
   PubMed Web of Science ®Google Scholar
• Pilsner JR, Hall MN, Liu X, Ahsan H, Ilievski V, Slavkovich V, Levy D, Factor-Litvak P, Graziano JH, Gamble MV. Associations of plasma selenium with arsenic and genomic methylation of leukocyte DNA in Bangladesh. Environ Health Perspect 2011; 119:113-8; PMID:21205583; http://dx.doi.org/10.1289/ehp.1001937
   PubMed Web of Science ®Google Scholar
• Pinto A, Speckmann B, Heisler M, Sies H, Steinbrenner H. Delaying of insulin signal transduction in skeletal muscle cells by selenium compounds. J Inorg Biochem 2011; 105:812-20; PMID:21497580; http://dx.doi.org/10.1016/j.jinorgbio.2011.03.010
   PubMed Web of Science ®Google Scholar
• Hurst R, Hooper L, Norat T, Lau R, Aune D, Greenwood DC, Vieira R, Collings R, Harvey LJ, Sterne JA, et al. Selenium and prostate cancer: systematic review and meta-analysis. Am J Clin Nutr 2012; 96:111-22; PMID:22648711; http://dx.doi.org/10.3945/ajcn.111.033373
   PubMed Web of Science ®Google Scholar
• Diwadkar-Navsariwala V, Prins GS, Swanson SM, Birch LA, Ray VH, Hedayat S, Lantvit DL, Diamond AM. Selenoprotein deficiency accelerates prostate carcinogenesis in a transgenic model. Proc Natl Acad Sci U S A 2006; 103:8179-84; PMID:16690748; http://dx.doi.org/10.1073/pnas.0508218103
   PubMed Web of Science ®Google Scholar
• Uthus E, Begaye A, Ross S, Zeng H. The von Hippel-Lindau (VHL) tumor-suppressor gene is down-regulated by selenium deficiency in Caco-2 cells and rat colon mucosa. Biol Trace Elem Res 2011; 142:223-31; PMID:20632125; http://dx.doi.org/10.1007/s12011-010-8764-4
   PubMed Web of Science ®Google Scholar
• Giles RH, Lolkema MP, Snijckers CM, Belderbos M, van der Groep P, Mans DA, van Beest M, van Noort M, Goldschmeding R, van Diest PJ, et al. Interplay between VHL/HIF1alpha and Wnt/beta-catenin pathways during colorectal tumorigenesis. Oncogene 2006; 25:3065-70; PMID:16407833; http://dx.doi.org/10.1038/sj.onc.1209330
   PubMed Web of Science ®Google Scholar
• Hughes DJ, Fedirko V, Jenab M, Schomburg L, Meplan C, Freisling H, Bueno-de-Mesquita HB, Hybsier S, Becker NP, Czuban M, et al. Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort. Int J Cancer 2014; 136:1149-61; PMID: 25042282; http://dx.doi.org/10.1002/ijc.29071
   PubMed Web of Science ®Google Scholar
• Tapp HS, Commane DM, Bradburn DM, Arasaradnam R, Mathers JC, Johnson IT, Belshaw NJ. Nutritional factors and gender influence age-related DNA methylation in the human rectal mucosa. Aging Cell 2013; 12:148-55; PMID:23157586; http://dx.doi.org/10.1111/acel.12030
   PubMed Web of Science ®Google Scholar
• Yang G, Zhu Y, Dong X, Duan Z, Niu X, Wei J. TLR2-ICAM1-Gadd45alpha axis mediates the epigenetic effect of selenium on DNA methylation and gene expression in Keshan disease. Biol Trace Elem Res 2014; 159:69-80; PMID:24811888; http://dx.doi.org/10.1007/s12011-014-9985-8
   PubMed Web of Science ®Google Scholar
• Chen J. An original discovery: selenium deficiency and Keshan disease (an endemic heart disease). Asia Pac J Clin Nut 2012; 21:320-6; PMID:22705420
   PubMed Web of Science ®Google Scholar
• Bera S, De Rosa V, Rachidi W, Diamond AM. Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemoprevention? Mutagenesis 2013; 28:127-34; PMID:23204505; http://dx.doi.org/10.1093/mutage/ges064
   PubMed Web of Science ®Google Scholar
• Nasr MA, Fedele MJ, Esser K, Diamond AM. GPx-1 modulates Akt and P70S6K phosphorylation and Gadd45 levels in MCF-7 cells. Free Radic Biol Med 2004; 37:187-95; PMID:15203190; http://dx.doi.org/10.1016/j.freeradbiomed.2004.04.038
   PubMed Web of Science ®Google Scholar
• Jung HJ, Kim HL, Kim YJ, Weon JI, Seo YR. A novel chemopreventive mechanism of selenomethionine: enhancement of APE1 enzyme activity via a Gadd45a, PCNA and APE1 protein complex that regulates p53-mediated base excision repair. Oncol Rep 2013; 30:1581-6; PMID:23846616
   PubMed Web of Science ®Google Scholar
• Fiala ES, Staretz ME, Pandya GA, El-Bayoumy K, Hamilton SR. Inhibition of DNA cytosine methyltransferase by chemopreventive selenium compounds, determined by an improved assay for DNA cytosine methyltransferase and DNA cytosine methylation. Carcinogenesis 1998; 19:597-604; PMID:9600343; http://dx.doi.org/10.1093/carcin/19.4.597
   PubMed Web of Science ®Google Scholar
• Cox R. Selenite: a good inhibitor of rat-liver DNA methylase. Biochem Int 1985; 10:63-9; PMID:3985987
   PubMedGoogle Scholar
• de Miranda JX, Andrade FD, Conti AD, Dagli ML, Moreno FS, Ong TP. Effects of selenium compounds on proliferation and epigenetic marks of breast cancer cells. J Trace Elem Med Biol 2014; 28:486-91; http://dx.doi.org/10.1016/j.jtemb.2014.06.017
   PubMed Web of Science ®Google Scholar
• Du J, Patel DJ. Structural biology-based insights into combinatorial readout and crosstalk among epigenetic marks. Biochim Biophys Acta 2014; 1839:719-27; PMID:24747177; http://dx.doi.org/10.1016/j.bbagrm.2014.04.011
   PubMed Web of Science ®Google Scholar
• Falkenberg KJ, Johnstone RW. Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders. Nat Rev Drug Discov 2014; 13:673-91; PMID:25131830; http://dx.doi.org/10.1038/nrd4360
   PubMed Web of Science ®Google Scholar
• Lee JI, Nian H, Cooper AJ, Sinha R, Dai J, Bisson WH, Dashwood RH, Pinto JT. Alpha-keto acid metabolites of naturally occurring organoselenium compounds as inhibitors of histone deacetylase in human prostate cancer cells. Cancer Prev Res 2009; 2:683-93; PMID:19584079; http://dx.doi.org/10.1158/1940-6207.CAPR-09-0047
   PubMed Web of Science ®Google Scholar
• Desai D, Salli U, Vrana KE, Amin S. SelSA, selenium analogs of SAHA as potent histone deacetylase inhibitors. Bioorg Med Chem Lett 2010; 20:2044-7; PMID:20167479; http://dx.doi.org/10.1016/j.bmcl.2009.07.068
   PubMed Web of Science ®Google Scholar
• Gowda R, Madhunapantula SV, Desai D, Amin S, Robertson GP. Selenium-containing histone deacetylase inhibitors for melanoma management. Cancer Biol Ther 2012; 13:756-65; PMID:22669577; http://dx.doi.org/10.4161/cbt.20558
   PubMed Web of Science ®Google Scholar
• Kassam S, Goenaga-Infante H, Maharaj L, Hiley CT, Juliger S, Joel SP. Methylseleninic acid inhibits HDAC activity in diffuse large B-cell lymphoma cell lines. Cancer Chemother Pharmacol 2011; 68:815-21; PMID:21519842; http://dx.doi.org/10.1007/s00280-011-1649-1
   PubMed Web of Science ®Google Scholar
• Narayan V, Ravindra KC, Liao C, Kaushal N, Carlson BA, Prabhu KS. Epigenetic regulation of inflammatory gene expression in macrophages by selenium. J Nutr Biochem 2014; 26:138-45; PMID:25458528; http://dx.doi.org/10.1016/j.jnutbio.2014.09.009
   PubMed Web of Science ®Google Scholar
• Zamamiri-Davis F, Lu Y, Thompson JT, Prabhu KS, Reddy PV, Sordillo LM, Reddy CC. Nuclear factor-kappaB mediates over-expression of cyclooxygenase-2 during activation of RAW 264.7 macrophages in selenium deficiency. Free Radic Biol Med 2002; 32:890-7; PMID:11978490; http://dx.doi.org/10.1016/S0891-5849(02)00775-X
   PubMed Web of Science ®Google Scholar
• Gandhi UH, Kaushal N, Ravindra KC, Hegde S, Nelson SM, Narayan V, Vunta H, Paulson RF, Prabhu KS. Selenoprotein-dependent up-regulation of hematopoietic prostaglandin D2 synthase in macrophages is mediated through the activation of peroxisome proliferator-activated receptor (PPAR) gamma. J Biol Chem 2011; 286:27471-82; PMID:21669866; http://dx.doi.org/10.1074/jbc.M111.260547
   PubMed Web of Science ®Google Scholar
• Ravindra KC, Narayan V, Lushington GH, Peterson BR, Prabhu KS. Targeting of histone acetyltransferase p300 by cyclopentenone prostaglandin Delta(12)-PGJ(2) through covalent binding to Cys(1438). Chem Res Toxicol 2012; 25:337-47; PMID:22141352; http://dx.doi.org/10.1021/tx200383c
   PubMed Web of Science ®Google Scholar
• Speckmann B, Steinbrenner H. Selenium and selenoproteins in inflammatory bowel diseases and experimental colitis. Inflamm Bowel Dis 2014; 20:1110-9; PMID:24694793
   PubMed Web of Science ®Google Scholar
• Anderson OS, Sant KE, Dolinoy DC. Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation. J Nutr Biochem 2012; 23:853-9; PMID:22749138; http://dx.doi.org/10.1016/j.jnutbio.2012.03.003
   PubMed Web of Science ®Google Scholar
• Bekaert B, Cooper ML, Green FR, McNulty H, Pentieva K, Scott JM, Molloy AM, Rayman MP. Effect of selenium status and supplementation with high-selenium yeast on plasma homocysteine and B vitamin concentrations in the UK elderly. Mol Nutr Food Res 2008; 52:1324-33; PMID:18683819; http://dx.doi.org/10.1002/mnfr.200700353
   PubMed Web of Science ®Google Scholar
• Janosikova B, Pavlikova M, Kocmanova D, Vitova A, Vesela K, Krupkova L, Kahleova R, Krijt J, Kraml P, Hyanek J, et al. Genetic variants of homocysteine metabolizing enzymes and the risk of coronary artery disease. Mol Genet Metab 2003; 79:167-75; PMID:12855221; http://dx.doi.org/10.1016/S1096-7192(03)00079-9
   PubMed Web of Science ®Google Scholar
• Tsai MY, Loria CM, Cao J, Kim Y, Siscovick DS, Schreiner PJ, Hanson NQ. Polygenic association with total homocysteine in the post-folic acid fortification era: the CARDIA study. Mol Genet Metab 2009; 98:181-6; PMID:19577940; http://dx.doi.org/10.1016/j.ymgme.2009.05.012
   PubMed Web of Science ®Google Scholar
• Belanger MC, Dewailly E, Berthiaume L, Noel M, Bergeron J, Mirault ME, Julien P. Dietary contaminants and oxidative stress in Inuit of Nunavik. Metabolism 2006; 55:989-95; PMID:16839831; http://dx.doi.org/10.1016/j.metabol.2006.03.007
   PubMed Web of Science ®Google Scholar
• Klapcinska B, Poprzecki S, Danch A, Sobczak A, Kempa K. Selenium levels in blood of upper Silesian population: evidence of suboptimal selenium status in a significant percentage of the population. Biol Trace Elem Res 2005; 108:1-15; PMID:16327055; http://dx.doi.org/10.1385/BTER:108:1-3:001
   PubMed Web of Science ®Google Scholar
• Bates CJ, Thane CW, Prentice A, Delves HT. Selenium status and its correlates in a British national diet and nutrition survey: people aged 65 years and over. J Trace Elem Med Biol 2002; 16:1-8; http://dx.doi.org/10.1016/S0946-672X(02)80002-5
   PubMed Web of Science ®Google Scholar
• Gonzalez S, Huerta JM, Alvarez-Uria J, Fernandez S, Patterson AM, Lasheras C. Serum selenium is associated with plasma homocysteine concentrations in elderly humans. J Nutr 2004; 134:1736-40; PMID:15226462
   PubMed Web of Science ®Google Scholar
• Angelova EA, Atanassova PA, Chalakova NT, Dimitrov BD. Associations between serum selenium and total plasma homocysteine during the acute phase of ischaemic stroke. Eur Neurol 2008; 60:298-303; PMID:18824858; http://dx.doi.org/10.1159/000157884
   PubMed Web of Science ®Google Scholar
• Venn BJ, Grant AM, Thomson CD, Green TJ. Selenium supplements do not increase plasma total homocysteine concentrations in men and women. J Nutr 2003; 133:418-20; PMID:12566477
   PubMed Web of Science ®Google Scholar
• Geillinger KE, Rathmann D, Kohrle J, Fiamoncini J, Daniel H, Kipp AP. Hepatic metabolite profiles in mice with a suboptimal selenium status. J Nutr Biochem 2014; 25:914-22; PMID:24917045; http://dx.doi.org/10.1016/j.jnutbio.2014.04.003
   PubMed Web of Science ®Google Scholar
• Wolf NM, Mueller K, Hirche F, Most E, Pallauf J, Mueller AS. Study of molecular targets influencing homocysteine and cholesterol metabolism in growing rats by manipulation of dietary selenium and methionine concentrations. Br J Nutr 2010; 104:520-32; PMID:20350341; http://dx.doi.org/10.1017/S0007114510000899
   PubMed Web of Science ®Google Scholar
• Uthus EO, Ross SA. Dietary selenium affects homocysteine metabolism differently in Fisher-344 rats and CD-1 mice. J Nutr 2007; 137:1132-6; PMID: 17449570
   PubMed Web of Science ®Google Scholar
• Uthus EO, Yokoi K, Davis CD. Selenium deficiency in Fisher-344 rats decreases plasma and tissue homocysteine concentrations and alters plasma homocysteine and cysteine redox status. J Nutr 2002; 132:1122-8; PMID:12042420
   PubMed Web of Science ®Google Scholar
• Metes-Kosik N, Luptak I, Dibello PM, Handy DE, Tang SS, Zhi H, Qin F, Jacobsen DW, Loscalzo J, Joseph J. Both selenium deficiency and modest selenium supplementation lead to myocardial fibrosis in mice via effects on redox-methylation balance. Mol Nutr Food Res 2012; 56:1812-24; PMID:23097236; http://dx.doi.org/10.1002/mnfr.201200386
   PubMed Web of Science ®Google Scholar
• Yi P, Melnyk S, Pogribna M, Pogribny IP, Hine RJ, James SJ. Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J Biol Chem 2000; 275:29318-23; PMID:10884384; http://dx.doi.org/10.1074/jbc.M002725200
   PubMed Web of Science ®Google Scholar
• James SJ, Melnyk S, Pogribna M, Pogribny IP, Caudill MA. Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology. J Nutr 2002; 132:2361S-6S; PMID:12163693
   PubMed Web of Science ®Google Scholar
• Cornelis MC, Fornage M, Foy M, Xun P, Gladyshev VN, Morris S, Chasman DI, Hu FB, Rimm EB, Kraft P, et al. Genome-wide association study of selenium concentrations. Hum Mol Genet 2014; 24:1469-77; PMID:25343990; http://dx.doi.org/10.1093/hmg/ddu546
   PubMed Web of Science ®Google Scholar
• Jackson MI, Cao J, Zeng H, Uthus E, Combs GF, Jr. S-adenosylmethionine-dependent protein methylation is required for expression of selenoprotein P and gluconeogenic enzymes in HepG2 human hepatocytes. J Biol Chem 2012; 287:36455-64; PMID:22932905; http://dx.doi.org/10.1074/jbc.M112.412932
   PubMed Web of Science ®Google Scholar
• Speckmann B, Walter PL, Alili L, Reinehr R, Sies H, Klotz LO, Steinbrenner H. Selenoprotein P expression is controlled through interaction of the coactivator PGC-1alpha with FoxO1a and hepatocyte nuclear factor 4alpha transcription factors. Hepatology 2008; 48:1998-2006; PMID:18972406; http://dx.doi.org/10.1002/hep.22526
   PubMed Web of Science ®Google Scholar
• Jackson MI, Lunoe K, Gabel-Jensen C, Gammelgaard B, Combs GF, Jr. Metabolism of selenite to selenosugar and trimethylselenonium in vivo: tissue dependency and requirement for S-adenosylmethionine-dependent methylation. J Nutr Biochem 2013; 24:2023-30; PMID:24139672; http://dx.doi.org/10.1016/j.jnutbio.2013.04.007
   PubMed Web of Science ®Google Scholar
• Maciel-Dominguez A, Swan D, Ford D, Hesketh J. Selenium alters miRNA profile in an intestinal cell line: evidence that miR-185 regulates expression of GPX2 and SEPSH2. Mol Nutr Food Res 2013; 57:2195-205; PMID:23934683; http://dx.doi.org/10.1002/mnfr.201300168
   PubMed Web of Science ®Google Scholar
• Imam JS, Buddavarapu K, Lee-Chang JS, Ganapathy S, Camosy C, Chen Y, Rao MK. MicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers. Oncogene 2010; 29:4971-9; PMID:20603620; http://dx.doi.org/10.1038/onc.2010.233
   PubMed Web of Science ®Google Scholar
• Qu F, Cui X, Hong Y, Wang J, Li Y, Chen L, Liu Y, Gao Y, Xu D, Wang Q. MicroRNA-185 suppresses proliferation, invasion, migration, and tumorigenicity of human prostate cancer cells through targeting androgen receptor. Mol Cell Biochem 2013; 377:121-30; PMID:23417242; http://dx.doi.org/10.1007/s11010-013-1576-z
   PubMed Web of Science ®Google Scholar
• Li Q, Wang JX, He YQ, Feng C, Zhang XJ, Sheng JQ, Li PF. MicroRNA-185 regulates chemotherapeutic sensitivity in gastric cancer by targeting apoptosis repressor with caspase recruitment domain. Cell Death Dis 2014; 5:e1197; PMID:24763054; http://dx.doi.org/10.1038/cddis.2014.148
   PubMed Web of Science ®Google Scholar
• Lippman SM, Klein EA, Goodman PJ, Lucia MS, Thompson IM, Ford LG, Parnes HL, Minasian LM, Gaziano JM, Hartline JA, et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). Jama 2009; 301:39-51; PMID:19066370; http://dx.doi.org/10.1001/jama.2008.864
   PubMed Web of Science ®Google Scholar
• Clark LC, Combs GF, Jr., Turnbull BW, Slate EH, Chalker DK, Chow J, Davis LS, Glover RA, Graham GF, Gross EG, et al. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. Jama 1996; 276:1957-63; PMID:8971064; http://dx.doi.org/10.1001/jama.1996.03540240035027
   PubMed Web of Science ®Google Scholar
• Steinbrenner H, Speckmann B, Pinto A, Sies H. High selenium intake and increased diabetes risk: experimental evidence for interplay between selenium and carbohydrate metabolism. J Clin Biochem Nutr 2011; 48:40-5; PMID:21297910; http://dx.doi.org/10.3164/jcbn.11-002FR
   PubMed Web of Science ®Google Scholar