LINE-1 methylation is positively associated with healthier lifestyle but inversely related to body fat mass in healthy young individuals

References

• Martinez JA, Milagro FI, Claycombe KJ, Schalinske KL. Epigenetics in adipose tissue, obesity, weight loss, and diabetes. Adv Nutr 2014; 5:71-81; PMID:24425725; http://dx.doi.org/10.3945/an.113.004705
   PubMed Web of Science ®Google Scholar
• Weisenberger DJ, Campan M, Long TI, Kim M, Woods C, Fiala E, Ehrlich M, Laird PW. Analysis of repetitive element DNA methylation by MethyLight. Nucleic Acids Res 2005; 33:6823-36; PMID:16326863; http://dx.doi.org/10.1093/nar/gki987
   PubMed Web of Science ®Google Scholar
• Baylin SB, Ohm JE. Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction? Nat Rev Cancer 2006; 6:107-16; PMID:16491070; http://dx.doi.org/10.1038/nrc1799
   PubMed Web of Science ®Google Scholar
• Woo HD, Kim J. Global DNA hypomethylation in peripheral blood leukocytes as a biomarker for cancer risk: a meta-analysis. PLoS One 2012; 7:e34615; PMID:22509334; http://dx.doi.org/10.1371/journal.pone.0034615
   PubMed Web of Science ®Google Scholar
• Robertson KD. DNA methylation and human disease. Nat Rev Genet 2005; 6:597-610; PMID:16136652; http://dx.doi.org/10.1038/nrg1655
   PubMed Web of Science ®Google Scholar
• Garcia-Lacarte M, Milagro FI, Zulet MA, Martinez JA, Mansego ML. LINE-1 methylation levels, a biomarker of weight loss in obese subjects, are influenced by dietary antioxidant capacity. Redox Rep 2015; PMID:26197243.
   PubMedGoogle Scholar
• Nicoletti CF, Nonino CB, De Oliveira BA, Pinhel MA, Mansego ML, Milagro FI, Zulet MA, Martinez JA. DNA Methylation and Hydroxymethylation Levels in Relation to Two Weight Loss Strategies: Energy-Restricted Diet or Bariatric Surgery. Obes Surg 2015.
   PubMed Web of Science ®Google Scholar
• Cordero P, Campion J, Milagro FI, Goyenechea E, Steemburgo T, Javierre BM, Martinez JA. Leptin and TNF-α promoter methylation levels measured by MSP could predict the response to a low-calorie diet. J Physiol Biochem 2011; 67:463-70; PMID:21465273; http://dx.doi.org/10.1007/s13105-011-0084-4
   PubMed Web of Science ®Google Scholar
• Hermsdorff HH, Mansego ML, Campion J, Milagro FI, Zulet MA, Martinez JA. TNF-α promoter methylation in peripheral white blood cells: relationship with circulating TNFalpha, truncal fat and n-6 PUFA intake in young women. Cytokine 2013; 64:265-71; PMID:23796695; http://dx.doi.org/10.1016/j.cyto.2013.05.028
   PubMed Web of Science ®Google Scholar
• Warnberg J, Nova E, Moreno LA, Romeo J, Mesana MI, Ruiz JR, Ortega FB, Sjostrom M, Bueno M, Marcos A. Inflammatory proteins are related to total and abdominal adiposity in a healthy adolescent population: the AVENA Study. Am J Clin Nutr 2006; 84:505-12; PMID:16960163
   PubMed Web of Science ®Google Scholar
• Moreno LA, Quintela I, Fleta J, Sarria A, Roda L, Giner A, Bueno M. Postprandial triglyceridemia in obese and non-obese adolescents. Importance of body composition and fat distribution. J Pediatr Endocrinol Metab 2001; 14:193-202; PMID:11305798
   PubMed Web of Science ®Google Scholar
• Whitworth JA, Chalmers J. World health organisation-international society of hypertension (WHO/ISH) hypertension guidelines. Clin Exp Hypertens 2004; 26:747-52; PMID:15702630; http://dx.doi.org/10.1081/CEH-200032152
   PubMed Web of Science ®Google Scholar
• Ainsworth BE, Haskell WL, Whitt MC, Irwin ML, Swartz AM, Strath SJ, O'Brien WL, Bassett DR, Jr., Schmitz KH, Emplaincourt PO, et al. Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc 2000; 32:S498-504; PMID:10993420; http://dx.doi.org/10.1097/00005768-200009001-00009
   PubMed Web of Science ®Google Scholar
• Ainsworth BE, Haskell WL, Herrmann SD, Meckes N, Bassett DR, Jr., Tudor-Locke C, Greer JL, Vezina J, Whitt-Glover MC, Leon AS. 2011 Compendium of Physical Activities: a second update of codes and MET values. Med Sci Sports Exerc 2011; 43:1575-81; PMID:21681120; http://dx.doi.org/10.1249/MSS.0b013e31821ece12
   PubMed Web of Science ®Google Scholar
• Tremblay AJ, Morrissette H, Gagne JM, Bergeron J, Gagne C, Couture P. Validation of the Friedewald formula for the determination of low-density lipoprotein cholesterol compared with β-quantification in a large population. Clin Biochem 2004; 37:785-90; PMID:15329317; http://dx.doi.org/10.1016/j.clinbiochem.2004.03.008
   PubMed Web of Science ®Google Scholar
• Castelli WP. Cholesterol and lipids in the risk of coronary artery disease–the Framingham Heart Study. Can J Cardiol 1988; 4 Suppl A:5A-10A; PMID:3179802
   PubMed Web of Science ®Google Scholar
• Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28:412-9; PMID:3899825; http://dx.doi.org/10.1007/BF00280883
   PubMed Web of Science ®Google Scholar
• Navarro-Blasco I, Alvarez-Galindo JI. Selenium content of Spanish infant formulae and human milk: influence of protein matrix, interactions with other trace elements and estimation of dietary intake by infants. J Trace Elem Med Biol 2004; 17:277-89; PMID:15139390; http://dx.doi.org/10.1016/S0946-672X(04)80030-0
   PubMed Web of Science ®Google Scholar
• Wojdacz TK, Dobrovic A. Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation. Nucleic Acids Res 2007; 35:e41; PMID:17289753; http://dx.doi.org/10.1093/nar/gkm013
   PubMed Web of Science ®Google Scholar
• Tse MY, Ashbury JE, Zwingerman N, King WD, Taylor SA, Pang SC. A refined, rapid and reproducible high resolution melt (HRM)-based method suitable for quantification of global LINE-1 repetitive element methylation. BMC Res Notes 2011; 4:565; PMID:22204640; http://dx.doi.org/10.1186/1756-0500-4-565
   PubMedGoogle Scholar
• Willett WC, Howe GR, Kushi LH. Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr 1997; 65:1220S-8S; discussion 9S-31S; PMID:9094926
   PubMed Web of Science ®Google Scholar
• Kulis M, Esteller M. DNA methylation and cancer. Adv Genet 2010; 70:27-56; PMID:20920744; http://dx.doi.org/10.1016/B978-0-12-380866-0.60002-2
   PubMed Web of Science ®Google Scholar
• Jirtle RL, Skinner MK. Environmental epigenomics and disease susceptibility. Nat Rev Genet 2007; 8:253-62; PMID:17363974; http://dx.doi.org/10.1038/nrg2045
   PubMed Web of Science ®Google Scholar
• El-Maarri O, Walier M, Behne F, Van Uum J, Singer H, Diaz-Lacava A, Nusgen N, Niemann B, Watzka M, Reinsberg J, et al. Methylation at global LINE-1 repeats in human blood are affected by gender but not by age or natural hormone cycles. PLoS One 2011; 6:e16252; PMID:21311577; http://dx.doi.org/10.1371/journal.pone.0016252
   PubMed Web of Science ®Google Scholar
• Tajuddin SM, Amaral AF, Fernandez AF, Rodriguez-Rodero S, Rodriguez RM, Moore LE, Tardon A, Carrato A, Garcia-Closas M, Silverman DT, et al. Genetic and non-genetic predictors of LINE-1 methylation in leukocyte DNA. Environ Health Perspect 2013; 121:650-6; PMID:23552396
   PubMed Web of Science ®Google Scholar
• Tapp HS, Commane DM, Bradburn DM, Arasaradnam R, Mathers JC, Johnson IT, Belshaw NJ. Nutritional factors and gender influence age-related DNA methylation in the human rectal mucosa. Aging Cell 2013; 12:148-55; PMID:23157586; http://dx.doi.org/10.1111/acel.12030
   PubMed Web of Science ®Google Scholar
• Zhang FF, Cardarelli R, Carroll J, Fulda KG, Kaur M, Gonzalez K, Vishwanatha JK, Santella RM, Morabia A. Significant differences in global genomic DNA methylation by gender and race/ethnicity in peripheral blood. Epigenetics 2011; 6:623-9; PMID:21739720; http://dx.doi.org/10.4161/epi.6.5.15335
   PubMed Web of Science ®Google Scholar
• Zhang FF, Morabia A, Carroll J, Gonzalez K, Fulda K, Kaur M, Vishwanatha JK, Santella RM, Cardarelli R. Dietary patterns are associated with levels of global genomic DNA methylation in a cancer-free population. J Nutr 2011; 141:1165-71; PMID:21525250; http://dx.doi.org/10.3945/jn.110.134536
   PubMed Web of Science ®Google Scholar
• Jones PA, Liang G. Rethinking how DNA methylation patterns are maintained. Nat Rev Genet 2009; 10:805-11; PMID:19789556; http://dx.doi.org/10.1038/nrg2651
   PubMed Web of Science ®Google Scholar
• Ruiz-Hernandez A, Kuo CC, Rentero-Garrido P, Tang WY, Redon J, Ordovas JM, Navas-Acien A, Tellez-Plaza M. Environmental chemicals and DNA methylation in adults: a systematic review of the epidemiologic evidence. Clin Epigenetics 2015; 7:55; PMID:25984247; http://dx.doi.org/10.1186/s13148-015-0055-7
   PubMed Web of Science ®Google Scholar
• Breitling LP, Yang R, Korn B, Burwinkel B, Brenner H. Tobacco-smoking-related differential DNA methylation: 27K discovery and replication. Am J Hum Genet 2011; 88:450-7; PMID:21457905; http://dx.doi.org/10.1016/j.ajhg.2011.03.003
   PubMed Web of Science ®Google Scholar
• Liu F, Killian JK, Yang M, Walker RL, Hong JA, Zhang M, Davis S, Zhang Y, Hussain M, Xi S, et al. Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate. Oncogene 2010; 29:3650-64; PMID:20440268; http://dx.doi.org/10.1038/onc.2010.129
   PubMed Web of Science ®Google Scholar
• Lee KW, Pausova Z. Cigarette smoking and DNA methylation. Front Genet 2013; 4:132; PMID:23882278
   PubMedGoogle Scholar
• Lind L, Penell J, Luttropp K, Nordfors L, Syvanen AC, Axelsson T, Salihovic S, Van Bavel B, Fall T, Ingelsson E, et al. Global DNA hypermethylation is associated with high serum levels of persistent organic pollutants in an elderly population. Environ Int 2013; 59:456-61; PMID:23933504; http://dx.doi.org/10.1016/j.envint.2013.07.008
   PubMed Web of Science ®Google Scholar
• White AJ, Sandler DP, Bolick SC, Xu Z, Taylor JA, DeRoo LA. Recreational and household physical activity at different time points and DNA global methylation. Eur J Cancer 2013; 49:2199-206; PMID:23473616; http://dx.doi.org/10.1016/j.ejca.2013.02.013
   PubMed Web of Science ®Google Scholar
• Dominguez-Salas P, Cox SE, Prentice AM, Hennig BJ, Moore SE. Maternal nutritional status, C(1) metabolism and offspring DNA methylation: a review of current evidence in human subjects. Proc Nutr Soc 2012; 71:154-65; PMID:22124338; http://dx.doi.org/10.1017/S0029665111003338
   PubMed Web of Science ®Google Scholar
• Bhutani N, Burns DM, Blau HM. DNA demethylation dynamics. Cell 2011; 146:866-72; PMID:21925312; http://dx.doi.org/10.1016/j.cell.2011.08.042
   PubMed Web of Science ®Google Scholar
• Delgado-Cruzata L, Zhang W, McDonald JA, Tsai WY, Valdovinos C, Falci L, Wang Q, Crew KD, Santella RM, Hershman DL, et al. Dietary modifications, weight loss, and changes in metabolic markers affect global DNA methylation in Hispanic, African American, and Afro-Caribbean breast cancer survivors. J Nutr 2015; 145:783-90; PMID:25833781; http://dx.doi.org/10.3945/jn.114.202853
   PubMed Web of Science ®Google Scholar
• Agodi A, Barchitta M, Quattrocchi A, Maugeri A, Vinciguerra M. DAPK1 Promoter Methylation and Cervical Cancer Risk: A Systematic Review and a Meta-Analysis. PLoS One 2015; 10:e0135078; PMID:26267895; http://dx.doi.org/10.1371/journal.pone.0135078
   PubMedGoogle Scholar
• Terry MB, Delgado-Cruzata L, Vin-Raviv N, Wu HC, Santella RM. DNA methylation in white blood cells: association with risk factors in epidemiologic studies. Epigenetics 2011; 6:828-37; PMID:21636973; http://dx.doi.org/10.4161/epi.6.7.16500
   PubMed Web of Science ®Google Scholar
• Piyathilake CJ, Badiga S, Alvarez RD, Partridge EE, Johanning GL. A lower degree of PBMC L1 methylation is associated with excess body weight and higher HOMA-IR in the presence of lower concentrations of plasma folate. PLoS One 2013; 8:e54544; PMID:23358786; http://dx.doi.org/10.1371/journal.pone.0054544
   PubMed Web of Science ®Google Scholar
• McCullough LE, Mendez MA, Miller EE, Murtha AP, Murphy SK, Hoyo C. Associations between prenatal physical activity, birth weight, and DNA methylation at genomically imprinted domains in a multiethnic newborn cohort. Epigenetics 2015; 10:597-606; PMID:25928716; http://dx.doi.org/10.1080/15592294.2015.1045181
   PubMed Web of Science ®Google Scholar
• Perng W, Villamor E, Shroff MR, Nettleton JA, Pilsner JR, Liu Y, Diez-Roux AV. Dietary intake, plasma homocysteine, and repetitive element DNA methylation in the Multi-Ethnic Study of Atherosclerosis (MESA). Nutr Metab Cardiovasc Dis 2014; 24:614-22; PMID:24477006; http://dx.doi.org/10.1016/j.numecd.2013.11.011
   PubMed Web of Science ®Google Scholar
• Zhu ZZ, Hou L, Bollati V, Tarantini L, Marinelli B, Cantone L, Yang AS, Vokonas P, Lissowska J, Fustinoni S, et al. Predictors of global methylation levels in blood DNA of healthy subjects: a combined analysis. Int J Epidemiol 2012; 41:126-39; PMID:20846947; http://dx.doi.org/10.1093/ije/dyq154
   PubMed Web of Science ®Google Scholar
• Kim KY, Kim DS, Lee SK, Lee IK, Kang JH, Chang YS, Jacobs DR, Steffes M, Lee DH. Association of low-dose exposure to persistent organic pollutants with global DNA hypomethylation in healthy Koreans. Environ Health Perspect 2010; 118:370-4; PMID:20064773; http://dx.doi.org/10.1289/ehp.0901131
   PubMed Web of Science ®Google Scholar
• Campion J, Milagro FI, Goyenechea E, Martinez JA. TNF-α promoter methylation as a predictive biomarker for weight-loss response. Obesity (Silver Spring) 2009; 17:1293-7; PMID:19584886
   PubMed Web of Science ®Google Scholar
• Xu X, Su S, Barnes VA, De Miguel C, Pollock J, Ownby D, Shi H, Zhu H, Snieder H, Wang X. A genome-wide methylation study on obesity: differential variability and differential methylation. Epigenetics 2013; 8:522-33; PMID:23644594; http://dx.doi.org/10.4161/epi.24506
   PubMed Web of Science ®Google Scholar
• Kim M, Long TI, Arakawa K, Wang R, Yu MC, Laird PW. DNA methylation as a biomarker for cardiovascular disease risk. PLoS One 2010; 5:e9692; PMID:20300621; http://dx.doi.org/10.1371/journal.pone.0009692
   PubMed Web of Science ®Google Scholar
• Stenvinkel P, Karimi M, Johansson S, Axelsson J, Suliman M, Lindholm B, Heimburger O, Barany P, Alvestrand A, Nordfors L, et al. Impact of inflammation on epigenetic DNA methylation - a novel risk factor for cardiovascular disease? J Intern Med 2007; 261:488-99; PMID:17444888; http://dx.doi.org/10.1111/j.1365-2796.2007.01777.x
   PubMed Web of Science ®Google Scholar