An epigenome-wide association analysis of cardiac autonomic responses among a population of welders

References

• Fuster V. Global burden of cardiovascular disease: time to implement feasible strategies and to monitor results. J Am Coll Cardiol 2014; 64:520-2; PMID:25082587; http://dx.doi.org/10.1016/j.jacc.2014.06.1151
   PubMed Web of Science ®Google Scholar
• Yusuf S, Reddy S, Ounpuu S, Anand S. Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization. Circulation 2001; 104:2746-53; PMID:11723030; http://dx.doi.org/10.1161/hc4601.099487
   PubMed Web of Science ®Google Scholar
• Mensah GA, Brown DW. An overview of cardiovascular disease burden in the United States. Health Aff (Millwood) 2007; 26:38-48; PMID:17211012; http://dx.doi.org/10.1377/hlthaff.26.1.38
   PubMed Web of Science ®Google Scholar
• Shen MJ, Zipes DP. Role of the autonomic nervous system in modulating cardiac arrhythmias. Circ Res 2014; 114:1004-21; PMID:24625726; http://dx.doi.org/10.1161/CIRCRESAHA.113.302549
   PubMed Web of Science ®Google Scholar
• Heart rate variability for risk stratification of life-threatening arrhythmias. American College of Cardiology Cardiovascular Technology Assessment Committee. J Am Coll Cardiol 1993; 22:948-50; PMID:8354837; http://dx.doi.org/10.1016/0735-1097(93)90217-O
   PubMedGoogle Scholar
• Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 1996; 93:1043-65; PMID:8598068; http://doi.org/10.1161/01.CIR.93.5.1043
   PubMed Web of Science ®Google Scholar
• Colhoun HM, Francis DP, Rubens MB, Underwood SR, Fuller JH. The association of heart-rate variability with cardiovascular risk factors and coronary artery calcification: a study in type 1 diabetic patients and the general population. Diabetes Care 2001; 24:1108-14; PMID:11375379; http://dx.doi.org/10.2337/diacare.24.6.1108
   PubMed Web of Science ®Google Scholar
• Tsuji H, Venditti FJ, Jr., Manders ES, Evans JC, Larson MG, Feldman CL, Levy D. Reduced heart rate variability and mortality risk in an elderly cohort. The Framingham Heart Study. Circulation 1994; 90:878-83; PMID:8044959; http://dx.doi.org/10.1161/01.CIR.90.2.878
   PubMed Web of Science ®Google Scholar
• Gold DR, Litonjua A, Schwartz J, Lovett E, Larson A, Nearing B, Allen G, Verrier M, Cherry R, Verrier R. Ambient pollution and heart rate variability. Circulation 2000; 101:1267-73; PMID:10725286; http://dx.doi.org/10.1161/01.CIR.101.11.1267
   PubMed Web of Science ®Google Scholar
• de Hartog JJ, Lanki T, Timonen KL, Hoek G, Janssen NA, Ibald-Mulli A, Peters A, Heinrich J, Tarkiainen TH, van Grieken R, et al. Associations between PM2.5 and heart rate variability are modified by particle composition and beta-blocker use in patients with coronary heart disease. Environ Health Perspect 2009; 117:105-11; PMID:19165395; http://dx.doi.org/10.1289/ehp.11062
   PubMed Web of Science ®Google Scholar
• Jia X, Song X, Shima M, Tamura K, Deng F, Guo X. Acute effect of ambient ozone on heart rate variability in healthy elderly subjects. J Expo Sci Environ Epidemiol 2011; 21:541-7; PMID:21522190; http://dx.doi.org/10.1038/jes.2011.18
   PubMed Web of Science ®Google Scholar
• Feng W, He X, Chen M, Deng S, Qiu G, Li X, Liu C, Li J, Deng Q, Huang S, et al. Urinary metals and heart rate variability: a cross-sectional study of urban adults in Wuhan, China. Environ Health Perspect 2015; 123:217-22; PMID:25356836; http://dx.doi.org/10.1289/ehp.123-A217
   PubMed Web of Science ®Google Scholar
• Marroni F, Pfeufer A, Aulchenko YS, Franklin CS, Isaacs A, Pichler I, Wild SH, Oostra BA, Wright AF, Campbell H, et al. A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. Circ Cardiovasc Genet 2009; 2:322-8; PMID:20031603; http://dx.doi.org/10.1161/CIRCGENETICS.108.833806
   PubMed Web of Science ®Google Scholar
• Arking DE, Pfeufer A, Post W, Kao WH, Newton-Cheh C, Ikeda M, West K, Kashuk C, Akyol M, Perz S, et al. A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization. Nat Genet 2006; 38:644-51; PMID:16648850; http://dx.doi.org/10.1038/ng1790
   PubMed Web of Science ®Google Scholar
• Kile ML, Fang S, Baccarelli AA, Tarantini L, Cavallari J, Christiani DC. A panel study of occupational exposure to fine particulate matter and changes in DNA methylation over a single workday and years worked in boilermaker welders. Environ Health 2013; 12:47; PMID:23758843; http://dx.doi.org/10.1186/1476-069X-12-47
   PubMed Web of Science ®Google Scholar
• Madrigano J, Baccarelli A, Mittleman MA, Sparrow D, Spiro A, 3rd, Vokonas PS, Cantone L, Kubzansky L, Schwartz J. Air pollution and DNA methylation: interaction by psychological factors in the VA Normative Aging Study. Am J Epidemiol 2012; 176:224-32; PMID:22798479; http://dx.doi.org/10.1093/aje/kwr523
   PubMed Web of Science ®Google Scholar
• Umukoro PE, Cavallari JM, Fang SC, Lu C, Lin X, Mittleman MA, Christiani DC. Short-term metal particulate exposures decrease cardiac acceleration and deceleration capacities in welders: a repeated-measures panel study. Occup Environ Med 2016; 73:91-6; PMID:26644456; http://dx.doi.org/10.1136/oemed-2015-103052
   PubMed Web of Science ®Google Scholar
• Cavallari JM, Eisen EA, Fang SC, Schwartz J, Hauser R, Herrick RF, Christiani DC. PM2.5 metal exposures and nocturnal heart rate variability: a panel study of boilermaker construction workers. Environ Health 2008; 7:36; PMID:18613971; http://dx.doi.org/10.1186/1476-069X-7-36
   PubMed Web of Science ®Google Scholar
• Fan T, Fang SC, Cavallari JM, Barnett IJ, Wang Z, Su L, Byun HM, Lin X, Baccarelli AA, Christiani DC. Heart rate variability and DNA methylation levels are altered after short-term metal fume exposure among occupational welders: a repeated-measures panel study. BMC Public Health 2014; 14:1279; PMID:25512264; http://dx.doi.org/10.1186/1471-2458-14-1279
   PubMed Web of Science ®Google Scholar
• Bjarnadottir TK, Fredriksson R, Hoglund PJ, Gloriam DE, Lagerstrom MC, Schioth HB. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics 2004; 84:23-33; PMID:15203201; http://dx.doi.org/10.1016/j.ygeno.2003.12.004
   PubMed Web of Science ®Google Scholar
• Vanti WB, Nguyen T, Cheng R, Lynch KR, George SR, O'Dowd BF. Novel human G-protein-coupled receptors. Biochem Biophys Res Commun 2003; 305:67-71; PMID:12732197; http://dx.doi.org/10.1016/S0006-291X(03)00709-5
   PubMed Web of Science ®Google Scholar
• Bohnekamp J, Schoneberg T. Cell adhesion receptor GPR133 couples to Gs protein. J Biol Chem 2011; 286:41912-6; PMID:22025619; http://dx.doi.org/10.1074/jbc.C111.265934
   PubMed Web of Science ®Google Scholar
• Rockman HA, Koch WJ, Lefkowitz RJ. Seven-transmembrane-spanning receptors and heart function. Nature 2002; 415:206-12; PMID:11805844; http://dx.doi.org/10.1038/415206a
   PubMed Web of Science ®Google Scholar
• Xiang Y, Kobilka BK. Myocyte adrenoceptor signaling pathways. Science 2003; 300:1530-2; PMID:12791980; http://dx.doi.org/10.1126/science.1079206
   PubMed Web of Science ®Google Scholar
• Koch WJ, Rockman HA, Samama P, Hamilton RA, Bond RA, Milano CA, Lefkowitz RJ. Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. Science 1995; 268:1350-3; PMID:7761854; http://dx.doi.org/10.1126/science.7761854
   PubMed Web of Science ®Google Scholar
• Robinson RB, Siegelbaum SA. Hyperpolarization-activated cation currents: from molecules to physiological function. Annu Rev Physiol 2003; 65:453-80; PMID:12471170; http://dx.doi.org/10.1146/annurev.physiol.65.092101.142734
   PubMed Web of Science ®Google Scholar
• Kuhnert F, Mancuso MR, Shamloo A, Wang HT, Choksi V, Florek M, Su H, Fruttiger M, Young WL, Heilshorn SC, et al. Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124. Science 2010; 330:985-9; PMID:21071672; http://dx.doi.org/10.1126/science.1196554
   PubMed Web of Science ®Google Scholar
• Patra C, van Amerongen MJ, Ghosh S, Ricciardi F, Sajjad A, Novoyatleva T, Mogha A, Monk KR, Muhlfeld C, Engel FB. Organ-specific function of adhesion G protein-coupled receptor GPR126 is domain-dependent. Proc Natl Acad Sci U S A 2013; 110:16898-903; PMID:24082093; http://dx.doi.org/10.1073/pnas.1304837110
   PubMed Web of Science ®Google Scholar
• Gouveia LO, Sobral J, Vicente AM, Ferro JM, Oliveira SA. Replication of the CELSR1 association with ischemic stroke in a Portuguese case-control cohort. Atherosclerosis 2011; 217:260-2; PMID:21511255; http://dx.doi.org/10.1016/j.atherosclerosis.2011.03.022
   PubMed Web of Science ®Google Scholar
• Qi L, Ma J, Qi Q, Hartiala J, Allayee H, Campos H. Genetic risk score and risk of myocardial infarction in Hispanics. Circulation 2011; 123:374-80; PMID:21242481; http://dx.doi.org/10.1161/CIRCULATIONAHA.110.976613
   PubMed Web of Science ®Google Scholar
• Newton-Cheh C, Guo CY, Wang TJ, O'Donnell C J, Levy D, Larson MG. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. BMC Med Genet 2007; 8(Suppl 1):S7; PMID:17903306; http://dx.doi.org/10.1186/1471-2350-8-S1-S7
   PubMedGoogle Scholar
• Jones PA. Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet 2012; 13:484-92; PMID:22641018; http://dx.doi.org/10.1038/nrg3230
   PubMed Web of Science ®Google Scholar
• Payer B, Lee JT. X chromosome dosage compensation: how mammals keep the balance. Annu Rev Genet 2008; 42:733-72; PMID:18729722; http://dx.doi.org/10.1146/annurev.genet.42.110807.091711
   PubMed Web of Science ®Google Scholar
• Jones PA. The DNA methylation paradox. Trends Genet 1999; 15:34-7; PMID:10087932; http://dx.doi.org/10.1016/S0168-9525(98)01636-9
   PubMed Web of Science ®Google Scholar
• Bauer A, Kantelhardt JW, Barthel P, Schneider R, Makikallio T, Ulm K, Hnatkova K, Schomig A, Huikuri H, Bunde A, et al. Deceleration capacity of heart rate as a predictor of mortality after myocardial infarction: cohort study. Lancet 2006; 367:1674-81; PMID:16714188; http://dx.doi.org/10.1016/S0140-6736(06)68735-7
   PubMed Web of Science ®Google Scholar
• Kantelhardt JW, Bauer A, Schumann AY, Barthel P, Schneider R, Malik M, Schmidt G. Phase-rectified signal averaging for the detection of quasi-periodicities and the prediction of cardiovascular risk. Chaos 2007; 17:015112; PMID:17411269; http://dx.doi.org/10.1063/1.2430636
   PubMedGoogle Scholar
• Ruhrberg C, Hajibagheri MA, Parry DA, Watt FM. Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin. J Cell Biol 1997; 139:1835-49; PMID:9412476; http://dx.doi.org/10.1083/jcb.139.7.1835
   PubMed Web of Science ®Google Scholar
• Matsumoto K, Ikeda M, Sato Y, Kuruma H, Kamata Y, Nishimori T, Tomonaga T, Nomura F, Egawa S, Iwamura M. Loss of periplakin expression is associated with pathological stage and cancer-specific survival in patients with urothelial carcinoma of the urinary bladder. Biomed Res 2014; 35:201-6; PMID:24942859; http://dx.doi.org/10.2220/biomedres.35.201
   PubMed Web of Science ®Google Scholar
• Matsumoto K, Ikeda M, Matsumoto T, Nagashio R, Nishimori T, Tomonaga T, Nomura F, Sato Y, Kitasato H, Iwamura M. Serum periplakin as a potential biomarker for urothelial carcinoma of the urinary bladder. Asian Pac J Cancer Prev 2014; 15:9927-31; PMID:25520130; http://dx.doi.org/10.7314/APJCP.2014.15.22.9927
   PubMedGoogle Scholar
• Ghanemi A. Targeting G protein coupled receptor-related pathways as emerging molecular therapies. Saudi Pharm J 2015; 23:115-29; PMID:25972730; http://dx.doi.org/10.1016/j.jsps.2013.07.007
   PubMed Web of Science ®Google Scholar
• Exner DV, Reiffel JA, Epstein AE, Ledingham R, Reiter MJ, Yao Q, Duff HJ, Follmann D, Schron E, Greene HL, et al. Beta-blocker use and survival in patients with ventricular fibrillation or symptomatic ventricular tachycardia: the Antiarrhythmics Versus Implantable Defibrillators (AVID) trial. J Am Coll Cardiol 1999; 34:325-33; PMID:10440140; http://dx.doi.org/10.1016/S0735-1097(99)00234-X
   PubMed Web of Science ®Google Scholar
• Umukoro PE, Fan T, Zhang J, Cavallari JM, Fang SC, Lu C, Lin X, Mittleman MA, Schmidt G, Christiani DC. Long-Term Metal PM2.5 Exposures Decrease Cardiac Acceleration and Deceleration Capacities in Welders. J Occup Environ Med 2016; 58:227-31; PMID:26949871; http://dx.doi.org/10.1097/JOM.0000000000000661
   PubMed Web of Science ®Google Scholar
• Houseman EA, Accomando WP, Koestler DC, Christensen BC, Marsit CJ, Nelson HH, Wiencke JK, Kelsey KT. DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinformatics 2012; 13:86; PMID:22568884; http://dx.doi.org/10.1186/1471-2105-13-86
   PubMed Web of Science ®Google Scholar
• Aryee MJ, Jaffe AE, Corrada-Bravo H, Ladd-Acosta C, Feinberg AP, Hansen KD, Irizarry RA. Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays. Bioinformatics 2014; 30:1363-9; PMID:24478339; http://dx.doi.org/10.1093/bioinformatics/btu049
   PubMed Web of Science ®Google Scholar
• Teschendorff AE, Marabita F, Lechner M, Bartlett T, Tegner J, Gomez-Cabrero D, Beck S. A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data. Bioinformatics 2013; 29:189-96; PMID:23175756; http://dx.doi.org/10.1093/bioinformatics/bts680
   PubMed Web of Science ®Google Scholar
• Johnson WE, Li C, Rabinovic A. Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics 2007; 8:118-27; PMID:16632515; http://dx.doi.org/10.1093/biostatistics/kxj037
   PubMed Web of Science ®Google Scholar
• Devlin B, Roeder K. Genomic control for association studies. Biometrics 1999; 55:997-1004; PMID:11315092; http://dx.doi.org/10.1111/j.0006-341X.1999.00997.x
   PubMed Web of Science ®Google Scholar