Vitamin D limits inflammation-linked microRNA expression in adipocytes in vitro and in vivo: A new mechanism for the regulation of inflammation by vitamin D

References

• Trayhurn P, Beattie JH. Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc Nutr Soc. 2001;60:329–339. doi:10.1079/PNS200194. PMID:11681807
   PubMed Web of Science ®Google Scholar
• Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol. 2011;29:415–445. doi:10.1146/annurev-immunol-031210-101322. PMID:21219177
   PubMed Web of Science ®Google Scholar
• Proenca AR, Sertie RA, Oliveira AC, et al. New concepts in white adipose tissue physiology. Braz J Med Biol Res. 2014. doi:10.1590/1414-431X20132911. PMID:24604427
   PubMed Web of Science ®Google Scholar
• Arner P, Kulyte A. MicroRNA regulatory networks in human adipose tissue and obesity. Nat Rev Endocrinol. 2015;11:276–288. doi:10.1038/nrendo.2015.25. PMID:25732520
   PubMed Web of Science ®Google Scholar
• Ge Q, Brichard S, Yi X, et al. microRNAs as a new mechanism regulating adipose tissue inflammation in obesity and as a novel therapeutic strategy in the metabolic syndrome. J Immunol Res. 2014;2014:987285. doi:10.1155/2014/987285. PMID:24741638
   PubMed Web of Science ®Google Scholar
• Hulsmans M, De Keyzer D, Holvoet P. MicroRNAs regulating oxidative stress and inflammation in relation to obesity and atherosclerosis. Faseb J. 2011;25:2515–2527. doi:10.1096/fj.11-181149. PMID:21507901
   PubMed Web of Science ®Google Scholar
• Krol J, Loedige I, Filipowicz W. The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet. 2010;11:597–610. doi:10.1038/nrg2843. PMID:20661255
   PubMed Web of Science ®Google Scholar
• Ortega FJ, Moreno-Navarrete JM, Pardo G, et al. MiRNA expression profile of human subcutaneous adipose and during adipocyte differentiation. PLoS One. 2010;5:e9022. doi:10.1371/journal.pone.0009022. PMID:20126310
   PubMed Web of Science ®Google Scholar
• Oger F, Gheeraert C, Mogilenko D, et al. Cell-specific dysregulation of microRNA expression in obese white adipose tissue. J Clin Endocrinol Metab. 2014;99:2821–2833. doi:10.1210/jc.2013-4259. PMID:24758184
   PubMed Web of Science ®Google Scholar
• Ortega FJ, Moreno M, Mercader JM, et al. Inflammation triggers specific microRNA profiles in human adipocytes and macrophages and in their supernatants. Clin Epigenetics. 2015;7:49. doi:10.1186/s13148-015-0083-3. PMID:25926893
   PubMed Web of Science ®Google Scholar
• Karkeni E, Astier J, Tourniaire F, et al. Obesity-associated inflammation induces microRNA-155 expression in adipocytes and adipose tissue: outcome on adipocyte function. J Clin Endocrinol Metab. 2016;101:1615–1626. doi:10.1210/jc.2015-3410. PMID:26829440
   PubMed Web of Science ®Google Scholar
• Landrier JF, Karkeni E, Marcotorchino J, et al. Vitamin D modulates adipose tissue biology: possible consequences for obesity? Proc Nutr Soc. 2016;75:38–46. doi:10.1017/S0029665115004164. PMID:26564334
   PubMed Web of Science ®Google Scholar
• Garcia OP, Long KZ, Rosado JL. Impact of micronutrient deficiencies on obesity. Nutr Rev. 2009;67:559–572. doi:10.1111/j.1753-4887.2009.00228.x. PMID:19785688
   PubMed Web of Science ®Google Scholar
• Kaidar-Person O, Person B, Szomstein S, et al. Nutritional deficiencies in morbidly obese patients: a new form of malnutrition? Part A: vitamins. Obes Surg. 2008;18:870–876. doi:10.1007/s11695-007-9349-y. PMID:18465178
   PubMed Web of Science ®Google Scholar
• Marcotorchino J, Tourniaire F, Landrier JF. Vitamin D, adipose tissue, and obesity. Horm Mol Biol Clin Investig. 2013;15:123–128. doi:10.1515/hmbci-2013-0027. PMID:25436739
   PubMedGoogle Scholar
• Mezza T, Muscogiuri G, Sorice GP, et al. Vitamin D deficiency: a new risk factor for type 2 diabetes? Ann Nutr Metab. 2012;61:337–348. doi:10.1159/000342771. PMID:23208163
   PubMed Web of Science ®Google Scholar
• Gao D, Trayhurn P, Bing C. 1,25-Dihydroxyvitamin D3 inhibits the cytokine-induced secretion of MCP-1 and reduces monocyte recruitment by human preadipocytes. Int J Obes (Lond). 2012;37:357–365. doi:10.1038/ijo.2012.53. PMID:22508334
   PubMed Web of Science ®Google Scholar
• Lorente-Cebrian S, Eriksson A, Dunlop T, et al. Differential effects of 1alpha,25-dihydroxycholecalciferol on MCP-1 and adiponectin production in human white adipocytes. Eur J Nutr. 2012;51:335–342. doi:10.1007/s00394-011-0218-z. PMID:21701898
   PubMed Web of Science ®Google Scholar
• Marcotorchino J, Gouranton E, Romier B, et al. Vitamin D reduces the inflammatory response and restores glucose uptake in adipocytes. Mol Nutr Food Res. 2012;56:1771–1782. doi:10.1002/mnfr.201200383. PMID:23065818
   PubMed Web of Science ®Google Scholar
• Wamberg L, Cullberg KB, Rejnmark L, et al. Investigations of the anti-inflammatory effects of vitamin D in adipose tissue: results from an in vitro study and a randomized controlled trial. Horm Metab Res. 2013;45:456–462. doi:10.1055/s-0032-1331746. PMID:23322512
   PubMed Web of Science ®Google Scholar
• Mutt SJ, Karhu T, Lehtonen S, et al. Inhibition of cytokine secretion from adipocytes by 1,25-dihydroxyvitamin D(3) via the NF-kappaB pathway. Faseb J. 2012;26:4400–4407. doi:10.1096/fj.12-210880. PMID:22798425
   PubMed Web of Science ®Google Scholar
• Zoico E, Franceschetti G, Chirumbolo S, et al. Phenotypic shift of adipocytes by cholecalciferol and 1alpha,25 dihydroxycholecalciferol in relation to inflammatory status and calcium content. Endocrinology. 2014;155:4178–4188. doi:10.1210/en.2013-1969. PMID:25153146
   PubMed Web of Science ®Google Scholar
• Karkeni E, Marcotorchino J, Tourniaire F, et al. Vitamin D limits chemokine expression in adipocytes and macrophage migration in vitro and in male mice. Endocrinology. 2015;156:1782–1793. doi:10.1210/en.2014-1647. PMID:25730105
   PubMed Web of Science ®Google Scholar
• Tang T, Zhang J, Yin J, et al. Uncoupling of inflammation and insulin resistance by NF-kappaB in transgenic mice through elevated energy expenditure. J Biol Chem. 2010;285:4637–4644. doi:10.1074/jbc.M109.068007. PMID:20018865
   PubMed Web of Science ®Google Scholar
• Faraoni I, Antonetti FR, Cardone J, et al. miR-155 gene: a typical multifunctional microRNA. Biochim Biophys Acta. 2009;1792:497–505. doi:10.1016/j.bbadis.2009.02.013. PMID:19268705
   PubMed Web of Science ®Google Scholar
• Masaki S, Ohtsuka R, Abe Y, et al. Expression patterns of microRNAs 155 and 451 during normal human erythropoiesis. Biochem Biophys Res Commun. 2007;364:509–514. doi:10.1016/j.bbrc.2007.10.077. PMID:17964546
   PubMed Web of Science ®Google Scholar
• O'Connell RM, Taganov KD, Boldin MP, et al. MicroRNA-155 is induced during the macrophage inflammatory response. Proc Natl Acad Sci U S A. 2007;104:1604–1609. doi:10.1073/pnas.0610731104. PMID:17242365
   PubMed Web of Science ®Google Scholar
• Gironella M, Seux M, Xie MJ, et al. Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development. Proc Natl Acad Sci U S A. 2007;104:16170–16175. doi:10.1073/pnas.0703942104. PMID:17911264
   PubMed Web of Science ®Google Scholar
• Kluiver J, Poppema S, de Jong D, et al. BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas. J Pathol. 2005;207:243–249. doi:10.1002/path.1825. PMID:16041695
   PubMed Web of Science ®Google Scholar
• Gaudet AD, Fonken LK, Gushchina LV, et al. miR-155 Deletion in Female Mice Prevents Diet-Induced Obesity. Sci Rep. 2016;6:22862. doi:10.1038/srep22862. PMID:26953132
   PubMed Web of Science ®Google Scholar
• Taganov KD, Boldin MP, Chang KJ, et al. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A. 2006;103:12481–12486. doi:10.1073/pnas.0605298103. PMID:16885212
   PubMed Web of Science ®Google Scholar
• Nahid MA, Pauley KM, Satoh M, et al. miR-146a is critical for endotoxin-induced tolerance: IMPLICATION IN INNATE IMMUNITY. J Biol Chem. 2009;284:34590–34599. doi:10.1074/jbc.M109.056317. PMID:19840932
   PubMed Web of Science ®Google Scholar
• Perry MM, Williams AE, Tsitsiou E, et al. Divergent intracellular pathways regulate interleukin-1beta-induced miR-146a and miR-146b expression and chemokine release in human alveolar epithelial cells. FEBS Lett. 2009;583:3349–3355. doi:10.1016/j.febslet.2009.09.038. PMID:19786024
   PubMed Web of Science ®Google Scholar
• Bhatt K, Lanting LL, Jia Y, et al. Anti-Inflammatory role of MicroRNA-146a in the pathogenesis of diabetic nephropathy. J Am Soc Nephrol. 2016;27:2277–2288. doi:10.1681/ASN.2015010111. PMID:26647423
   PubMed Web of Science ®Google Scholar
• Luo N, Garvey WT, Wang D-Z, et al. MicroRNA-150 regulates lipid metabolism and inflammatory response. J Metabolic Synd. 2013;2:131. doi:10.4172/2167-0943.1000131
   Google Scholar
• Ying W, Tseng A, Chang RC, et al. miR-150 regulates obesity-associated insulin resistance by controlling B cell functions. Sci Rep. 2016;6:20176. doi:10.1038/srep20176. PMID:26833392
   PubMed Web of Science ®Google Scholar
• Moles R, Bellon M, Nicot C. STAT1: A Novel Target of miR-150 and miR-223 Is Involved in the Proliferation of HTLV-I-Transformed and ATL Cells. Neoplasia. 2015;17:449–462. doi:10.1016/j.neo.2015.04.005. PMID:26025667
   PubMed Web of Science ®Google Scholar
• Chen Y, Zhang J, Ge X, et al. Vitamin D receptor inhibits nuclear factor kappaB activation by interacting with IkappaB kinase beta protein. J Biol Chem. 2013;288:19450–19458. doi:10.1074/jbc.M113.467670. PMID:23671281
   PubMed Web of Science ®Google Scholar
• Chen Y, Liu W, Sun T, et al. 1,25-Dihydroxyvitamin D promotes negative feedback regulation of TLR signaling via targeting microRNA-155-SOCS1 in macrophages. J Immunol. 2013;190:3687–95. doi:10.4049/jimmunol.1203273. PMID:23436936
   PubMed Web of Science ®Google Scholar
• Kutmon M, Coort SL, de Nooijer K, et al. Integrative network-based analysis of mRNA and microRNA expression in 1,25-dihydroxyvitamin D3-treated cancer cells. Genes Nutr. 2015;10:484. doi:10.1007/s12263-015-0484-0.
   PubMed Web of Science ®Google Scholar
• Ma Y, Hu Q, Luo W, et al. 1alpha,25(OH)2D3 differentially regulates miRNA expression in human bladder cancer cells. J Steroid Biochem Mol Biol. 2015;148:166–171. doi:10.1016/j.jsbmb.2014.09.020. PMID:25263658
   PubMed Web of Science ®Google Scholar
• Guan H, Liu C, Chen Z, et al. 1,25-Dihydroxyvitamin D3 up-regulates expression of hsa-let-7a-2 through the interaction of VDR/VDRE in human lung cancer A549 cells. Gene. 2013;522:142–146. doi:10.1016/j.gene.2013.03.065. PMID:23566834
   PubMed Web of Science ®Google Scholar
• Landrier JF, Gouranton E, El Yazidi C, et al. Adiponectin expression is induced by vitamin E via a peroxisome proliferator-activated receptor gamma-dependent mechanism. Endocrinology. 2009;150:5318–5325. doi:10.1210/en.2009-0506. PMID:19833717
   PubMed Web of Science ®Google Scholar
• Landrier JF, Malezet-Desmoulins C, Reboul E, et al. Comparison of different vehicles to study the effect of tocopherols on gene expression in intestinal cells. Free Radic Res. 2008;42:523–530. doi:10.1080/10715760802098859. PMID:18484416
   PubMed Web of Science ®Google Scholar
• Marcotorchino J, Tourniaire F, Astier J, et al. Vitamin D protects against diet-induced obesity by enhancing fatty acid oxidation. J Nutr Biochem. 2014;25:1077–1083. doi:10.1016/j.jnutbio.2014.05.010. PMID:25052163
   PubMed Web of Science ®Google Scholar
• Tourniaire F, Romier-Crouzet B, Lee JH, et al. Chemokine expression in inflamed adipose tissue is mainly mediated by NF-kappaB. PLoS One. 2013;8:e66515. doi:10.1371/journal.pone.0066515. PMID:23824685
   PubMed Web of Science ®Google Scholar