References
- Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richarson JA, Kozlowski GP, Wilson S, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 1998; 92:573-85, 1 page following 696; PMID:9491897; https://doi.org/10.1016/S0092-8674(00)80949-6
- de Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett FS, et al. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci USA 1998; 95:322-7; PMID:9419374; https://doi.org/10.1073/pnas.95.1.322
- Sakurai T. The role of orexin in motivated behaviours. Nat Rev Neurosci 2014; 15:719-31; PMID:25301357; https://doi.org/10.1038/nrn3837
- Fortuyn HA, Swinkels S, Buitelaar J, Renier WO, Furer JW, Rijnders CA, Hodiamont PP, Overeem S. High prevalence of eating disorders in narcolepsy with cataplexy: a case-control study. Sleep 2008; 31:335-41; PMID:18363309; https://doi.org/10.1093/sleep/31.3.335
- Arnulf I, Leu-Semenescu S. Sleepiness in Parkinson's disease. Parkinsonism Relat Disord 2009; 15 Suppl 3:S101-4; PMID:20082966; https://doi.org/10.1016/S1353-8020(09)70792-8
- Wienecke M, Werth E, Poryazova R, Baumann-Vogel H, Bassetti CL, Weller M, Waldvogel D, Storch A, Baumann CR. Progressive dopamine and hypocretin deficiencies in Parkinson's disease: is there an impact on sleep and wakefulness? J Sleep Res 2012; 21:710-7; PMID:22747735; https://doi.org/10.1111/j.1365-2869.2012.01027.x
- Sakurai T, Mieda M, Tsujino N. The orexin system: roles in sleep/wake regulation. Ann N Y Acad Sci 2010; 1200:149-61; PMID:20633143; https://doi.org/10.1111/j.1749-6632.2010.05513.x
- Nishino S, Okuro M. Emerging treatments for narcolepsy and its related disorders. Expert Opin Emerg Drugs 2010; 15:139-58; PMID:20166851; https://doi.org/10.1517/14728210903559852
- Chow M, Cao M. The hypocretin/orexin system in sleep disorders: preclinical insights and clinical progress. Nat Sci Sleep 2016; 8:81-6; PMID:27051324
- Schuld A, Hebebrand J, Geller F, Pollmächer T. Increased body-mass index in patients with narcolepsy. Lancet 2000; 355:1274-5; PMID:10770327; https://doi.org/10.1016/S0140-6736(05)74704-8
- Poli F, Plazzi G, Di Dalmazi G, Ribichini D, Vicennati V, Pizza F, Mignot E, Montagna P, Pasquali R, Pagotto U. Body mass index-independent metabolic alterations in narcolepsy with cataplexy. Sleep 2009; 32:1491-7; PMID:19928388; https://doi.org/10.1093/sleep/32.11.1491
- Heier MS, Jansson TS, Gautvik KM. Cerebrospinal fluid hypocretin 1 deficiency, overweight, and metabolic dysregulation in patients with narcolepsy. J Clin Sleep Med 2011; 7:653-8; PMID:22171205
- Beitinger PA, Fulda S, Dalal MA, Wehrle R, Keckeis M, Wetter TC, Han F, Pollmächer T, Schuld A. Glucose tolerance in patients with narcolepsy. Sleep 2012; 35:231-6; PMID:22294813; https://doi.org/10.5665/sleep.1628
- Yamamoto Y, Ueta Y, Date Y, Nakazato M, Hara Y, Serino R, Nomura M, Shibuya I, Matsukura S, Yamashita H. Down regulation of the prepro-orexin gene expression in genetically obese mice. Brain Res Mol Brain Res 1999; 65:14-22; PMID:10036303; https://doi.org/10.1016/S0169-328X(98)00320-9
- Yamamoto Y, Ueta Y, Serino R, Nomura M, Shibuya I, Yamashita H. Effects of food restriction on the hypothalamic prepro-orexin gene expression in genetically obese mice. Brain Res Bull 2000; 51:515-21; PMID:10758342; https://doi.org/10.1016/S0361-9230(99)00271-3
- Kessler BA, Stanley EM, Frederick-Duus D, Fadel J. Age-related loss of orexin/hypocretin neurons. Neuroscience 2011; 178:82-8; PMID:21262323; https://doi.org/10.1016/j.neuroscience.2011.01.031
- Hunt NJ, Rodriguez ML, Waters KA, Machaalani R. Changes in orexin (hypocretin) neuronal expression with normal aging in the human hypothalamus. Neurobiol Aging 2015; 36:292-300; PMID:25212464; https://doi.org/10.1016/j.neurobiolaging.2014.08.010
- Hayakawa K, Hirosawa M, Tabei Y, Arai D, Tanaka S, Murakami N, Yagi S, Shiota K. Epigenetic switching by the metabolism-sensing factors in the generation of orexin neurons from mouse embryonic stem cells. J Biol Chem 2013; 288:17099-110; PMID:23625921; https://doi.org/10.1074/jbc.M113.455899
- Hardivillé S, Hart GW. Nutrient regulation of signaling, transcription, and cell physiology by O-GlcNAcylation. Cell Metab 2014; 20:208-13; PMID:25100062; https://doi.org/10.1016/j.cmet.2014.07.014
- Nagel AK, Ball LE. O-GlcNAc transferase and O-GlcNAcase: achieving target substrate specificity. Amino Acids 2014; 46:2305-16; PMID:25173736; https://doi.org/10.1007/s00726-014-1827-7
- Sakabe K, Wang Z, Hart GW. Beta-N-acetylglucosamine (O-GlcNAc) is part of the histone code. Proc Natl Acad Sci USA 2010; 107:19915-20; PMID:21045127; https://doi.org/10.1073/pnas.1009023107
- Hanover JA, Krause MW, Love DC. Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation. Nat Rev Mol Cell Biol 2012; 13:312-21; PMID:22522719; https://doi.org/10.1038/nrm3334
- Hirosawa M, Hayakawa K, Yoneda C, Arai D, Shiota H, Suzuki T, Tanaka S, Dohmae N, Shiota K. Novel O-GlcNAcylation on Ser(40) of canonical H2A isoforms specific to viviparity. Sci Rep 2016; 6:31785; PMID:27615797; https://doi.org/10.1038/srep31785
- Shiota K. DNA methylation profiles of CpG islands for cellular differentiation and development in mammals. Cytogenet Genome Res 2004; 105:325-34; PMID:15237220; https://doi.org/10.1159/000078205
- Lieb JD, Beck S, Bulyk ML, Farnham P, Hattori N, Henikoff S, Liu XS, Okumura K, Shiota K, Ushijima T, et al. Applying whole-genome studies of epigenetic regulation to study human disease. Cytogenet Genome Res 2006; 114:1-15; PMID:16717444; https://doi.org/10.1159/000091922
- Shiota K, Kogo Y, Ohgane J, Imamura T, Urano A, Nishino K, Tanaka S, Hattori N. Epigenetic marks by DNA methylation specific to stem, germ and somatic cells in mice. Genes Cells 2002; 7:961-9; PMID:12296826; https://doi.org/10.1046/j.1365-2443.2002.00574.x
- Yagi S, Hirabayashi K, Sato S, Li W, Takahashi Y, Hirakawa T, Wu G, Hattori N, Ohgane J, Tanaka S, et al. DNA methylation profile of tissue-dependent and differentially methylated regions (T-DMRs) in mouse promoter regions demonstrating tissue-specific gene expression. Genome Res 2008; 18:1969-78; PMID:18971312; https://doi.org/10.1101/gr.074070.107
- Ikegami K, Ohgane J, Tanaka S, Yagi S, Shiota K. Interplay between DNA methylation, histone modification and chromatin remodeling in stem cells and during development. Int J Dev Biol 2009; 53:203-14; PMID:19412882; https://doi.org/10.1387/ijdb.082741ki
- Reinke SO, Lehmer G, Hinderlich S, Reutter W. Regulation and pathophysiological implications of UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) as the key enzyme of sialic acid biosynthesis. Biol Chem 2009; 390:591-9; PMID:19426133; https://doi.org/10.1515/BC.2009.073
- Yamanaka A, Beuckmann CT, Willie JT, Hara J, Tsujino N, Mieda M, Tominaga M, Yagami K, Sugiyama F, Goto K, et al. Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron 2003; 38:701-13; PMID:12797956; https://doi.org/10.1016/S0896-6273(03)00331-3
- Cai XJ, Evans ML, Lister CA, Leslie RA, Arch JR, Wilson S, Williams G. Hypoglycemia activates orexin neurons and selectively increases hypothalamic orexin-B levels: responses inhibited by feeding and possibly mediated by the nucleus of the solitary tract. Diabetes 2001; 50:105-12; PMID:11147774; https://doi.org/10.2337/diabetes.50.1.105
- Tsujino N, Sakurai T. Orexin/hypocretin: a neuropeptide at the interface of sleep, energy homeostasis, and reward system. Pharmacol Rev 2009; 61:162-76; PMID:19549926; https://doi.org/10.1124/pr.109.001321
- Nishino I, Carrillo-Carrasco N, Argov Z. GNE myopathy: current update and future therapy. J Neurol Neurosurg Psychiatry 2015; 86:385-92; PMID:25002140; https://doi.org/10.1136/jnnp-2013-307051
- Ohtake A, Daikoku S, Suzuki K, Ito Y, Kanie O. Analysis of the cellular dynamics of fluorescently tagged glycosphingolipids by using a nanoliquid chromatography-tandem mass spectrometry platform. Anal Chem 2013; 85:8475-82; PMID:23895632; https://doi.org/10.1021/ac401632t
- Tanaka S, Kodama T, Nonaka T, Toyoda H, Arai M, Fukazawa M, Honda Y, Honda M, Mignot E. Transcriptional regulation of the hypocretin/orexin gene by NR6A1. Biochem Biophys Res Commun 2010; 403:178-83; PMID:21056546; https://doi.org/10.1016/j.bbrc.2010.11.001
- Cai D. Neuroinflammation and neurodegeneration in overnutrition-induced diseases. Trends Endocrinol Metab 2013; 24:40-7; PMID:23265946; https://doi.org/10.1016/j.tem.2012.11.003
- Depner CM, Stothard ER, Wright KP. Metabolic consequences of sleep and circadian disorders. Curr Diab Rep 2014; 14:507; PMID:24816752; https://doi.org/10.1007/s11892-014-0507-z
- Maru I, Ohta Y, Murata K, Tsukada Y. Molecular cloning and identification of N-acyl- d-glucosamine 2-epimerase from porcine kidney as a renin-binding protein. J Biol Chem 1996; 271:16294-9; PMID:8663114; https://doi.org/10.1074/jbc.271.27.16294
- Takahashi S, Takahashi K, Kaneko T, Ogasawara H, Shindo S, Kobayashi M. Human renin-binding protein is the enzyme N-acetyl- d-glucosamine 2-epimerase. J Biochem 1999; 125:348-53; PMID:9990133; https://doi.org/10.1093/oxfordjournals.jbchem.a022293
- Reinke SO, Eidenschink C, Jay CM, Hinderlich S. Biochemical characterization of human and murine isoforms of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE). Glycoconj J 2009; 26:415-22; PMID:18815882; https://doi.org/10.1007/s10719-008-9189-6
- Angata T, Varki A. Chemical diversity in the sialic acids and related alpha-keto acids: an evolutionary perspective. Chem Rev 2002; 102:439-69; PMID:11841250; https://doi.org/10.1021/cr000407m
- Irie A, Koyama S, Kozutsumi Y, Kawasaki T, Suzuki A. The molecular basis for the absence of N-glycolylneuraminic acid in humans. J Biol Chem 1998; 273:15866-71; PMID:9624188; https://doi.org/10.1074/jbc.273.25.15866
- Irie A, Suzuki A. CMP-N-Acetylneuraminic acid hydroxylase is exclusively inactive in humans. Biochem Biophys Res Commun 1998; 248:330-3; PMID:9675135; https://doi.org/10.1006/bbrc.1998.8946
- Gambetta MC, Müller J. A critical perspective of the diverse roles of O-GlcNAc transferase in chromatin. Chromosoma 2015; 124:429-42; PMID:25894967; https://doi.org/10.1007/s00412-015-0513-1
- Barnes DE, Yaffe K. The projected effect of risk factor reduction on Alzheimer's disease prevalence. Lancet Neurol 2011; 10:819-28; PMID:21775213; https://doi.org/10.1016/S1474-4422(11)70072-2
- Ninomiya T. Diabetes mellitus and dementia. Curr Diab Rep 2014; 14:487; PMID:24623199; https://doi.org/10.1007/s11892-014-0487-z
- Bornstein NM, Brainin M, Guekht A, Skoog I, Korczyn AD. Diabetes and the brain: issues and unmet needs. Neurol Sci 2014; 35:995-1001; PMID:24777546; https://doi.org/10.1007/s10072-014-1797-2
- Pirola L, Balcerczyk A, Okabe J, El-Osta A. Epigenetic phenomena linked to diabetic complications. Nat Rev Endocrinol 2010; 6:665-75; PMID:21045787; https://doi.org/10.1038/nrendo.2010.188
- Ahrlund-Richter L, De Luca M, Marshak DR, Munsie M, Veiga A, Rao M. Isolation and production of cells suitable for human therapy: challenges ahead. Cell Stem Cell 2009; 4:20-6; PMID:19058776; https://doi.org/10.1016/j.stem.2008.11.012
- Sandoe J, Eggan K. Opportunities and challenges of pluripotent stem cell neurodegenerative disease models. Nat Neurosci 2013; 16:780-9; PMID:23799470; https://doi.org/10.1038/nn.3425
- Merkle FT, Maroof A, Wataya T, Sasai Y, Studer L, Eggan K, Schier AF. Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells. Development 2015; 142:633-43; PMID:25670790; https://doi.org/10.1242/dev.117978
- Kirouac DC, Zandstra PW. The systematic production of cells for cell therapies. Cell Stem Cell 2008; 3:369-81; PMID:18940729; https://doi.org/10.1016/j.stem.2008.09.001
- Teo AK, Wagers AJ, Kulkarni RN. New opportunities: harnessing induced pluripotency for discovery in diabetes and metabolism. Cell Metab 2013; 18:775-91; PMID:24035588; https://doi.org/10.1016/j.cmet.2013.08.010
- Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131:861-72; PMID:18035408; https://doi.org/10.1016/j.cell.2007.11.019
- Mizuseki K, Sakamoto T, Watanabe K, Muguruma K, Ikeya M, Nishiyama A, Arakawa A, Suemori H, Nakatsuji N, Kawasaki H, et al. Generation of neural crest-derived peripheral neurons and floor plate cells from mouse and primate embryonic stem cells. Proc Natl Acad Sci USA 2003; 100:5828-33; PMID:12724518; https://doi.org/10.1073/pnas.1037282100
- Wong CG, Sung SSJ, Sweeley CC. Analysis and structural characterization of amino sugars by gas-liquid chromatography and mass spectrometry. Methods in Carbohydrate Chemistry (Whistler RL, and BeMiller JN, eds) Vol. VIII; Academic Press:1980:p 55-65
- Fondy TP, Emlich CA. Haloacetamido analogues of 2-amino-2-deoxy-d-mannose. Syntheses and effects on tumor-bearing mice. J Med Chem 1981; 24:848-52; PMID:7277392; https://doi.org/10.1021/jm00139a016
- Beychok S, Ashwell G, Kabat EA. Optical activity and conformation of carbohydrates part III. Preparation and opticalactivity of methyl 2-acetamido-2-deoxy-α- and β-d-mannopyranosides and the corresponding furanosides. Carbohydr Res 1971; 17:19-24; https://doi.org/10.1016/S0008-6215(00)81538-4
- Buskas T, Garegg PJ, Konradsson P, Maloisel JL. Facile preparation of glycosyl donors for oligosaccharide synthesis: 2-azido-2-deoxyhexopyranosyl building blocks. Tetrahedron: Asymmetry 1994; 5:2187-94; https://doi.org/10.1016/S0957-4166(00)86294-1
- Humphrey AJ, Fremann C, Critchley P, Malykh Y, Schauer R, Bugg TDH. Biological properties of N-acyl and N-haloacetyl neuraminic acids: processing by enzymes of sialic acid metabolism, and interaction with influenza virus. Bioorg Med Chem 2002; 10:3175-85; PMID:12150863; https://doi.org/10.1016/S0968-0896(02)00213-4
- Hadfield AF, Mella SL, Sartorelli AC. N-acetyl-d-mannosamine analogues as potential inhibitors of sialic acid biosynthesis. J Pharm Sci 1983; 72:748-51; PMID:6577183; https://doi.org/10.1002/jps.2600720709
- Hasegawa A, Tanahashi E, Hioki Y, Kiso M. Synthesis of 2-acetamido-2-deoxy-5-thio-α-d-mannopyranose. Carbohydr Res 1983; 122:168-173; https://doi.org/10.1016/0008-6215(83)88416-X
- Pravdić N, Fletcher HG. The behavior of 2-acetamido-2-deoxy-d-mannose with isopropenyl acetate in the presence of p-toluenesulfonic acid. I. Isolation and identification of derivatives of 2-amino-d-glucal (2-amino-1,2-dideoxy- d-arabino-hex-1-enopyranose) and of other products. J Org Chem 1967; 32:1806-10; PMID:6047395; https://doi.org/10.1021/jo01281a022
- Angelino NJ, Bernacki RJ, Sharma M, Dodson-Simmons O, Korytnyk W. Versatile intermediates in the selective modification of the amino function of 2-amino-2-deoxy-d-mannopyranose and the 3-position of 2-acetamido-2-deoxy-d-mannose: potential membrane modifiers in neoplastic control. Carbohydr Res 1995; 276:99-115; PMID:8536261; https://doi.org/10.1016/0008-6215(95)00154-L
- Noé L, Kucherov G. YASS: enhancing the sensitivity of DNA similarity search. Nucleic Acids Res 2005; 33:W540-3; PMID:15980530; https://doi.org/10.1093/nar/gki478