Decreased global DNA hydroxymethylation in neural tube defects: Association with polycyclic aromatic hydrocarbons

References

• Wallingford JB, Niswander LA, Shaw GM, et al. The continuing challenge of understanding, preventing, and treating neural tube defects. Science (New York, NY). 2013 Mar 1;339(6123):1222002. PMID: 23449594.
   Google Scholar
• Agopian AJ, Tinker SC, Lupo PJ, et al. Proportion of neural tube defects attributable to known risk factors. Birth Defects Res Part A Clin Mol Teratol. 2013 Jan;97(1):42–46. PMID: 23427344; eng.
   PubMedGoogle Scholar
• Sram RJ, Binkova B. Molecular epidemiology studies on occupational and environmental exposure to mutagens and carcinogens, 1997-1999. Environ Health Perspect. 2000 Mar;108(Suppl 1):57–70. PMID: 10698723.
   PubMed Web of Science ®Google Scholar
• Ren A, Qiu X, Jin L, et al. Association of selected persistent organic pollutants in the placenta with the risk of neural tube defects. Proc Natl Acad Sci USA. 2011 Aug 2;108(31):12770–12775. PMID: 21768370; eng.
   PubMed Web of Science ®Google Scholar
• Langlois PH, Hoyt AT, Lupo PJ, et al. Maternal occupational exposure to polycyclic aromatic hydrocarbons and risk of neural tube defect-affected pregnancies. Birth Defects Res Part A Clin Mol Teratol. 2012 Sep;94(9):693–700. PMID: 22807044; eng.
   PubMedGoogle Scholar
• Wang B, Jin L, Ren A, et al. Levels of polycyclic aromatic hydrocarbons in maternal serum and risk of neural tube defects in offspring. Environ Sci Technol. 2015 Jan 6;49(1):588–596. PMID: 25488567; eng.
   PubMed Web of Science ®Google Scholar
• Yi D, Yuan Y, Jin L, et al. Levels of PAH-DNA adducts in cord blood and cord tissue and the risk of fetal neural tube defects in a Chinese population. Neurotoxicology. 2015 Jan;46:73–78. PMID: 25522656; eng.
   PubMed Web of Science ®Google Scholar
• Yuan Y, Jin L, Wang L, et al. Levels of PAH-DNA adducts in placental tissue and the risk of fetal neural tube defects in a Chinese population. Reprod Toxicol. 2013 Jun;37:70–75. PMID: 23416326; eng.
   PubMed Web of Science ®Google Scholar
• Lin S, Ren A, Wang L, et al. Oxidative stress and apoptosis in Benzo[a]pyrene-Induced neural tube defects. Free Radic Biol Med. 2018 Feb 20;116:149–158. PMID: 29309894; eng.
   PubMed Web of Science ®Google Scholar
• Ge SQ, Lin SL, Zhao ZH, et al. Epigenetic dynamics and interplay during spermatogenesis and embryogenesis: implications for male fertility and offspring health. Oncotarget 2017 Aug;8;8(32):53804–53818. PMID: 28881852.
   PubMedGoogle Scholar
• Ito S, Shen L, Dai Q, et al. Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science (New York, NY). 2011 Sep 2;333(6047):1300–1303. PMID: 21778364; eng.
   Google Scholar
• Lian CG, Xu Y, Ceol C, et al. Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell. 2012 Sep 14;150(6):1135–1146. PMID: 22980977; eng.
   PubMed Web of Science ®Google Scholar
• Celarain N, Sanchez-Ruiz de Gordoa J, Zelaya MV, et al. TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer’s disease hippocampus. Clin Epigenetics. 2016;8:37. PMID: 27051467; eng.
   PubMed Web of Science ®Google Scholar
• Tian T, Wang L, Shen Y, et al. Hypomethylation of GRHL3 gene is associated with the occurrence of neural tube defects. Epigenomics. 2018 Mar 28. PMID: 29587534; eng.
   Web of Science ®Google Scholar
• Wang L, Lin S, Zhang J, et al. Fetal DNA hypermethylation in tight junction pathway is associated with neural tube defects: A genome-wide DNA methylation analysis. Epigenetics. 2017 Feb;12(2):157–165. PMID: 28059605.
   PubMed Web of Science ®Google Scholar
• Price EM, Penaherrera MS, Portales-Casamar E, et al. Profiling placental and fetal DNA methylation in human neural tube defects. Epigenetics Chromatin. 2016;9:6. PMID: 26889207; Eng.
   PubMed Web of Science ®Google Scholar
• Del Gobbo GF, Price EM, Hanna CW, et al. No evidence for association of MTHFR 677C>T and 1298A>C variants with placental DNA methylation. Clin Epigenetics. 2018;10:34. PMID: 29564022; eng.
   PubMed Web of Science ®Google Scholar
• Toriyama M, Toriyama M, Wallingford JB, et al. Folate-dependent methylation of septins governs ciliogenesis during neural tube closure. Faseb J. 2017 Aug;31(8):3622–3635. PMID: 28432198; eng.
   PubMed Web of Science ®Google Scholar
• Du X, Tian M, Wang X, et al. Cortex and hippocampus DNA epigenetic response to a long-term arsenic exposure via drinking water. Environ Pollut. 2018 Mar;234:590–600. PMID: 29223816.
   PubMed Web of Science ®Google Scholar
• Delatte B, Jeschke J, Defrance M, et al. Genome-wide hydroxymethylcytosine pattern changes in response to oxidative stress. Sci Rep. 2015 Aug 4;5:12714. PMID: 26239807.
   PubMed Web of Science ®Google Scholar
• Yuan Y, Zhang L, Jin L, et al. Markers of macromolecular oxidative damage in maternal serum and risk of neural tube defects in offspring. Free Radic Biol Med. 2015 Mar;80:27–32. PMID: 25542138; eng.
   PubMed Web of Science ®Google Scholar
• Huang Y, Ren A, Wang L, et al. Casp8 hypomethylation and neural tube defects in association with polycyclic aromatic hydrocarbon exposure. Clin Epigenetics. 2019 May 7;11(1):72. PMID: 31064411; eng.
   PubMedGoogle Scholar
• Wei H, Feng Y, Liang F, et al. Role of oxidative stress and DNA hydroxymethylation in the neurotoxicity of fine particulate matter. Toxicology. 2017 Apr 01;380:94–103. PMID: 28153600.
   PubMed Web of Science ®Google Scholar
• Banik A, Kandilya D, Ramya S, et al. Maternal factors that induce epigenetic changes contribute to neurological disorders in offspring. Genes (Basel). 2017 May;8(6):24. PMID: 28538662; eng.
   Web of Science ®Google Scholar
• Condliffe D, Wong A, Troakes C, et al. Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer’s disease brain. Neurobiol Aging. 2014 Aug;35(8):1850–1854. PMID: 24679604; eng.
   PubMed Web of Science ®Google Scholar
• Papale LA, Madrid A, Li S, et al. Early-life stress links 5-hydroxymethylcytosine to anxiety-related behaviors. Epigenetics. 2017 Apr 3;12(4):264–276. PMID: 28128679.
   PubMed Web of Science ®Google Scholar
• Jin SG, Jiang Y, Qiu R, et al. 5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations. Cancer Res. 2011 Dec 15;71(24):7360–7365. PMID: 22052461; eng.
   PubMed Web of Science ®Google Scholar
• Chen K, Zhang J, Guo Z, et al. Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer. Cell Res. 2016 Jan;26(1):103–118. PMID: 26680004; eng.
   PubMed Web of Science ®Google Scholar
• Fu S, Wu H, Zhang H, et al. DNA methylation/hydroxymethylation in melanoma. Oncotarget. 2017 Sep 29;8(44):78163–78173. PMID: 29100458.
   PubMedGoogle Scholar
• Yao B, Lin L, RC S, et al. Genome-wide alteration of 5-hydroxymethylcytosine in a mouse model of fragile X-associated tremor/ataxia syndrome. Hum Mol Genet. 2014 Feb 15;23(4):1095–1107. PMID: 24108107.
   PubMed Web of Science ®Google Scholar
• Branco MR, Ficz G, Reik W. Uncovering the role of 5-hydroxymethylcytosine in the epigenome. Nat Rev Genet. 2011 Nov 15;13(1):7–13. PMID: 22083101.
   PubMed Web of Science ®Google Scholar
• Shi DQ, Ali I, Tang J, et al. New insights into 5hmC DNA modification: generation, distribution and function. Front Genet. 2017;8:100. PMID: 28769976; eng.
   PubMed Web of Science ®Google Scholar
• Szulwach KE, Li X, Li Y, et al. 5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging. Nat Neurosci. 2011 Oct 30;14(12):1607–1616. PMID: 22037496.
   PubMed Web of Science ®Google Scholar
• Wang T, Wu H, Li Y, et al. Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency. Nat Cell Biol. 2013 Jun;15(6):700–711. PMID: 23685628.
   PubMed Web of Science ®Google Scholar
• Nilsen TW, Graveley BR. Expansion of the eukaryotic proteome by alternative splicing. Nature. 2010 Jan 28;463(7280):457–463. PMID: 20110989.
   PubMed Web of Science ®Google Scholar
• Feng J, Shao N, Szulwach KE, et al. Role of Tet1 and 5-hydroxymethylcytosine in cocaine action. Nat Neurosci. 2015 Apr;18(4):536–544. PMID: 25774451.
   PubMed Web of Science ®Google Scholar
• Khare T, Pai S, Koncevicius K, et al. 5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary. Nat Struct Mol Biol. 2012 Oct;19(10):1037–1043. PMID: 22961382; eng.
   PubMed Web of Science ®Google Scholar
• Diotel N, Merot Y, Coumailleau P, et al. 5-hydroxymethylcytosine marks postmitotic neural cells in the adult and developing vertebrate central nervous system. J Comp Neurol. 2017 Feb 15;525(3):478–497. PMID: 27414756; eng.
   PubMed Web of Science ®Google Scholar
• Kriaucionis S, Heintz N. The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science (New York, NY). 2009 May 15;324(5929):929–930. PMID: 19372393; eng.
   Google Scholar
• Thomson JP, Meehan RR. The application of genome-wide 5-hydroxymethylcytosine studies in cancer research. Epigenomics. 2017 Jan;9(1):77–91. PMID: 27936926.
   PubMed Web of Science ®Google Scholar
• Bachman M, Uribe-Lewis S, Yang X, et al. 5-Hydroxymethylcytosine is a predominantly stable DNA modification. Nat Chem 2014 Dec;6(12):1049–1055. PMID: 25411882; eng.
   PubMed Web of Science ®Google Scholar
• Tellez-Plaza M, Tang WY, Shang Y, et al. Association of global DNA methylation and global DNA hydroxymethylation with metals and other exposures in human blood DNA samples. Environ Health Perspect. 2014 Sep;122(9):946–954. PMID: 24769358; eng.
   PubMed Web of Science ®Google Scholar
• Liu S, Jiang J, Li L, et al. Arsenite targets the zinc finger domains of tet proteins and inhibits tet-mediated oxidation of 5-methylcytosine. Environ Sci Technol. 2015 Oct 6;49(19):11923–11931. PMID: 26355596; eng.
   PubMed Web of Science ®Google Scholar
• Cardenas A, Rifas-Shiman SL, Godderis L, et al. Prenatal exposure to mercury: associations with global DNA methylation and hydroxymethylation in cord blood and in childhood. Environ Health Perspect. 2017 Aug 29;125(8):087022. PMID: 28934725; eng.
   PubMed Web of Science ®Google Scholar
• Sanchez-Guerra M, Zheng Y, Osorio-Yanez C, et al. Effects of particulate matter exposure on blood 5-hydroxymethylation: results from the Beijing truck driver air pollution study. Epigenetics. 2015;10(7):633–642. PMID: 25970091; eng.
   PubMed Web of Science ®Google Scholar
• De Nys S, Duca RC, Nawrot T, et al. Temporal variability of global DNA methylation and hydroxymethylation in buccal cells of healthy adults: association with air pollution. Environ Int. 2018 Feb;111:301–308. PMID: 29217223; eng.
   PubMed Web of Science ®Google Scholar
• Zheng H, Zhou X, Li DK, et al. Genome-wide alteration in DNA hydroxymethylation in the sperm from bisphenol A-exposed men. PloS One. 2017;12(6):e0178535. PMID: 28582417; eng.
   PubMed Web of Science ®Google Scholar
• Senyildiz M, Karaman EF, Bas SS, et al. Effects of BPA on global DNA methylation and global histone 3 lysine modifications in SH-SY5Y cells: an epigenetic mechanism linking the regulation of chromatin modifiying genes. Toxicol In Vitro. 2017 Oct;44:313–321. PMID: 28765096; eng.
   PubMed Web of Science ®Google Scholar
• Yuan C, Zhang Y, Liu Y, et al. DNA demethylation mediated by down-regulated TETs in the testes of rare minnow Gobiocypris rarus under bisphenol A exposure. Anal Chem. 2017 Mar;171:355–361. PMID: 28030787; eng.
   Google Scholar
• Abdel-Maksoud FM, Leasor KR, Butzen K, et al. Prenatal exposures of male rats to the environmental chemicals Bisphenol A and Di(2-Ethylhexyl) phthalate impact the sexual differentiation process. Endocrinology. 2015 Dec;156(12):4672–4683. PMID: 26372177; eng.
   PubMed Web of Science ®Google Scholar
• Wyck S, Herrera C, Requena CE, et al. Oxidative stress in sperm affects the epigenetic reprogramming in early embryonic development. Epigenetics Chromatin. 2018 Oct 17;11(1):60. PMID: 30333056; eng.
   PubMedGoogle Scholar
• Farzan SF, Chen Y, Trachtman H, et al. Urinary polycyclic aromatic hydrocarbons and measures of oxidative stress, inflammation and renal function in adolescents: NHANES 2003-2008. Environ Res. 2016 Jan;144(Pt A):149–157. PMID: 26610293.
   PubMed Web of Science ®Google Scholar
• Jangiam W, Tungjai M, Rithidech KN. Induction of chronic oxidative stress, chronic inflammation and aberrant patterns of DNA methylation in the liver of titanium-exposed CBA/CaJ mice. Int J Radiat Biol. 2015 May;91(5):389–398. PMID: 25565558; eng.
   PubMed Web of Science ®Google Scholar
• Morita K, Tokoro M, Hatanaka Y, et al. Peroxiredoxin as a functional endogenous antioxidant enzyme in pronuclei of mouse zygotes. J Reprod Dev. 2018 Apr 13;64(2):161–171. PMID: 29503398; eng.
   PubMed Web of Science ®Google Scholar
• Loch-Caruso R, Hassan I, Harris SM, et al. Trichloroethylene exposure in mid-pregnancy decreased fetal weight and increased placental markers of oxidative stress in rats. Reprod Toxicol. 2018 Nov 20;83:38–45. PMID: 30468822; eng.
   PubMed Web of Science ®Google Scholar
• Chen H, Dzitoyeva S, Manev H. Effect of aging on 5-hydroxymethylcytosine in the mouse hippocampus. Restor Neurol Neurosci. 2012;30(3):237–245. PMID: 22426040; eng.
   PubMed Web of Science ®Google Scholar
• Zhang YW, Wang Z, Xie W, et al. Acetylation enhances TET2 function in protecting against abnormal DNA methylation during oxidative stress. Mol Cell. 2017 Jan 19;65(2):323–335. PMID: 28107650; eng.
   PubMed Web of Science ®Google Scholar
• Coulter JB, O’Driscoll CM, Bressler JP. Hydroquinone increases 5-hydroxymethylcytosine formation through ten eleven translocation 1 (TET1) 5-methylcytosine dioxygenase. J Biol Chem. 2013 Oct 4;288(40):28792–28800. PMID: 23940045.
   PubMed Web of Science ®Google Scholar
• New DA. Whole-embryo culture and the study of mammalian embryos during organogenesis. Biol Rev Camb Philos Soc. 1978 Feb;53(1):81–122. PMID: 352414.
   PubMed Web of Science ®Google Scholar