Differential DNA methylation in blood as a mediator of the association between cigarette smoking and bladder cancer risk among postmenopausal women

References

• Centers for Disease Control and Prevention (US). How tobacco smoke causes disease: the biology and behavioral basis for smoking-attributable disease: a report of the surgeon general [Internet]. Atlanta (GA): Centers for Disease Control and Prevention (US); 2010. Available from: http://www.ncbi.nlm.nih.gov/books/NBK53017/
   Google Scholar
• Zhang Y, Zhu C, Curado MP, et al. Changing patterns of bladder cancer in the USA: evidence of heterogeneous disease. BJU Int. 2012;109:52–56.
   PubMed Web of Science ®Google Scholar
• Freedman ND, Silverman DT, Hollenbeck AR, et al. Association between smoking and risk of bladder cancer among men and women. JAMA. 2011;306:737–745.
   PubMed Web of Science ®Google Scholar
• Sanli O, Dobruch J, Knowles MA, et al. Bladder cancer. Nat Rev Dis Primer. 2017;3:17022.
   PubMed Web of Science ®Google Scholar
• Barbosa ALA, Vermeulen SHHM, Aben KK, et al. Smoking intensity and bladder cancer aggressiveness at diagnosis. PLoS One. 2018;13:e0194039.
   PubMed Web of Science ®Google Scholar
• Pietzak EJ, Mucksavage P, Guzzo TJ, et al. Heavy cigarette smoking and aggressive bladder cancer at initial presentation. Urology. 2015;86:968–972.
   PubMed Web of Science ®Google Scholar
• Soria F, Marra G, Capoun O, et al. Prevention of bladder cancer incidence and recurrence: tobacco use. Curr Opin Urol. 2018;28:80.
   PubMed Web of Science ®Google Scholar
• Florescu A, Ferrence R, Einarson T, et al. Methods for quantification of exposure to cigarette smoking and environmental tobacco smoke: focus on developmental toxicology. Ther Drug Monit. 2009;31:14–30.
   PubMed Web of Science ®Google Scholar
• Besaratinia A, Tommasi S. Genotoxicity of tobacco smoke-derived aromatic amines and bladder cancer: current state of knowledge and future research directions. Faseb J. 2013;27:2090–2100.
   PubMed Web of Science ®Google Scholar
• Besaratinia A, Cockburn M, Tommasi S. Alterations of DNA methylome in human bladder cancer. Epigenetics. 2013;8:1013–1022.
   PubMed Web of Science ®Google Scholar
• Ma Y, Li MD. Establishment of a strong link between smoking and cancer pathogenesis through DNA methylation analysis. Sci Rep. [Internet]. 2017 [cited 2018 Sep 5];7. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431893/
   Web of Science ®Google Scholar
• Luch A. Nature and nurture – lessons from chemical carcinogenesis. Nat Rev Cancer. 2005;5:113.
   PubMed Web of Science ®Google Scholar
• Zeegers MPA, Tan FES, Dorant E, et al. The impact of characteristics of cigarette smoking on urinary tract cancer risk. Cancer. 2000;89:630–639.
   PubMed Web of Science ®Google Scholar
• Shenker NS, Ueland PM, Polidoro S, et al. DNA methylation as a long-term biomarker of exposure to tobacco smoke. Epidemiol Camb Mass. 2013;24:712–716.
   PubMed Web of Science ®Google Scholar
• Gao X, Jia M, Zhang Y, et al. DNA methylation changes of whole blood cells in response to active smoking exposure in adults: a systematic review of DNA methylation studies. Clin Clin Epigenet. 2015;7:113.
   PubMed Web of Science ®Google Scholar
• Philibert RA, Beach SRH, Lei M-K, et al. Changes in DNA methylation at the aryl hydrocarbon receptor repressor may be a new biomarker for smoking. Clin Clin Epigenet. 2013;5:19.
   PubMed Web of Science ®Google Scholar
• Fasanelli F, Baglietto L, Ponzi E, et al. Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts. Nat Commun. [Internet]. 2015;6. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682166/
   PubMed Web of Science ®Google Scholar
• Joehanes R, Just AC, Marioni RE, et al. Epigenetic signatures of cigarette smoking. Circ Cardiovasc Genet. 2016;9:436–447.
   PubMed Web of Science ®Google Scholar
• Zeilinger S, Kühnel B, Klopp N, et al. Tobacco smoking leads to extensive genome-wide changes in DNA methylation. PloS One. 2013;8:e63812.
   PubMed Web of Science ®Google Scholar
• Tsaprouni LG, Yang T-P, Bell J, et al. Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation. Epigenetics. 2014;9:1382–1396.
   PubMed Web of Science ®Google Scholar
• Shenker NS, Polidoro S, van Veldhoven K, et al. Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking. Hum Mol Genet. 2013;22:843–851.
   PubMed Web of Science ®Google Scholar
• Sun YV, Smith AK, Conneely KN, et al. Epigenomic association analysis identifies smoking-related DNA methylation sites in African Americans. Hum Genet. 2013;132:1027–1037.
   PubMed Web of Science ®Google Scholar
• Wan ES, Qiu W, Baccarelli A, et al. Cigarette smoking behaviors and time since quitting are associated with differential DNA methylation across the human genome. Hum Mol Genet. 2012;21:3073–3082.
   PubMed Web of Science ®Google Scholar
• Harlid S, Xu Z, Panduri V, et al. CpG sites associated with cigarette smoking: analysis of epigenome-wide data from the sister study. Environ Health Perspect. 2014;122:673–678.
   PubMed Web of Science ®Google Scholar
• Kõks G, Uudelepp M-L, Limbach M, et al. Smoking-induced expression of the GPR15 gene indicates its potential role in chronic inflammatory pathologies. Am J Pathol. 2015;185:2898–2906.
   PubMed Web of Science ®Google Scholar
• Brenet F, Moh M, Funk P, et al. DNA methylation of the first exon is tightly linked to transcriptional silencing. Plos One. 2011;6:e14524.
   PubMed Web of Science ®Google Scholar
• Bauer M, Linsel G, Fink B, et al. A varying T cell subtype explains apparent tobacco smoking induced single CpG hypomethylation in whole blood. Clin Clin Epigenet. 2015;7:81.
   PubMed Web of Science ®Google Scholar
• Kõks S, Kõks G. Activation of GPR15 and its involvement in the biological effects of smoking. Exp Biol Med. 2017;242:1207–1212.
   PubMed Web of Science ®Google Scholar
• Nguyen LP, Pan J, Dinh TT, et al. Role and species–specific expression of colon T cell homing receptor GPR15 in colitis. Nat Immunol. 2015;16:207–213.
   PubMed Web of Science ®Google Scholar
• Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646–674.
   PubMed Web of Science ®Google Scholar
• Qian B-Z, Pollard JW. Macrophage diversity enhances tumor progression and metastasis. Cell. 2010;141:39–51.
   PubMed Web of Science ®Google Scholar
• Zudaire E, Cuesta N, Murty V, et al. The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers. J Clin Invest. 2008;118:640–650.
   PubMed Web of Science ®Google Scholar
• Wan M, Bennett BD, Pittman GS, et al. Identification of smoking-associated differentially methylated regions using reduced representation bisulfite sequencing and cell type-specific enhancer activation and gene expression. Environ Health Perspect. 2018;126:047015.
   PubMed Web of Science ®Google Scholar
• Zhang -D-D, Wang W-T, Xiong J, et al. Long noncoding RNA LINC00305 promotes inflammation by activating the AHRR-NF-κB pathway in human monocytes. Sci Rep. 2017;7:46204.
   PubMed Web of Science ®Google Scholar
• Goldman M, Craft B, Brooks AN, et al. The UCSC xena platform for cancer genomics data visualization and interpretation. bioRxiv. 2018;326470. Available from: https://www.biorxiv.org/content/10.1101/326470v1.full
   Google Scholar
• Jordahl KM, Randolph TW, Song X, et al. Genome-wide DNA methylation in pre-diagnostic blood and bladder cancer risk in the women’s health initiative. Cancer Epidemiol Prev Biomark. 2018;27(6):689–695.
   PubMed Web of Science ®Google Scholar
• Marsit CJ, Koestler DC, Christensen BC, et al. DNA methylation array analysis identifies profiles of blood-derived DNA methylation associated with bladder cancer. J Clin Oncol. 2011;29:1133–1139.
   PubMed Web of Science ®Google Scholar
• Olkhov-Mitsel E, Savio AJ, Kron KJ, et al. Epigenome-wide DNA methylation profiling identifies differential methylation biomarkers in high-grade bladder cancer. Transl Oncol. 2017;10:168–177.
   PubMed Web of Science ®Google Scholar
• Yang X, Gao L, Zhang S. Comparative pan-cancer DNA methylation analysis reveals cancer common and specific patterns. Brief Bioinform. 2017;18:761–773.
   PubMed Web of Science ®Google Scholar
• Hays J, Hunt JR, Hubbell FA, et al. The women’s health initiative recruitment methods and results. Ann Epidemiol. 2003;13:S18–77.
   PubMed Web of Science ®Google Scholar
• Ambatipudi S, Cuenin C, Hernandez-Vargas H, et al. Tobacco smoking-associated genome-wide DNA methylation changes in the EPIC study. Epigenomics. 2016;8:599–618.
   PubMed Web of Science ®Google Scholar
• Du P, Zhang X, Huang -C-C, et al. Comparison of beta-value and M-value methods for quantifying methylation levels by microarray analysis. BMC Bioinformatics. 2010;11:587.
   PubMed Web of Science ®Google Scholar
• Dedeurwaerder S, Defrance M, Bizet M, et al. A comprehensive overview of infinium human Methylation450 data processing. Brief Bioinform. 2014;15:929–941.
   PubMed Web of Science ®Google Scholar
• Li D, Xie Z, Le Pape M, et al. An evaluation of statistical methods for DNA methylation microarray data analysis. BMC Bioinformatics. 2015;16:217.
   PubMed Web of Science ®Google Scholar
• Houseman EA, Molitor J, Marsit CJ. Reference-free cell mixture adjustments in analysis of DNA methylation data. Bioinformatics. 2014;30:1431–1439.
   PubMed Web of Science ®Google Scholar
• VanderWeele TJ, Vansteelandt S. Odds ratios for mediation analysis for a dichotomous outcome. Am J Epidemiol. 2010;172:1339–1348.
   PubMed Web of Science ®Google Scholar
• VanderWeele T. Explanation in causal inference: methods for mediation and interaction. Oxford (NY): Oxford University Press; 2015.
   Google Scholar