Placental NEGR1 DNA methylation is associated with BMI and neurodevelopment in preschool-age children

References

• Halfon N, Larson K, Slusser W. Associations between obesity and comorbid mental health, developmental, and physical health conditions in a nationally representative sample of US children aged 10 to 17. Acad Pediatr. 2013 Feb;13(1):6–13.
   PubMed Web of Science ®Google Scholar
• Koyuncuoğlu Güngör N. Overweight and obesity in children and adolescents. J Clin Res Pediatr Endocrinol. 2014 Sep;6(3):129–143.
   PubMed Web of Science ®Google Scholar
• Cortese S, Moreira-Maia CR, St Fleur D, et al. Association between ADHD and obesity: a systematic review and meta-analysis. Am J Psychiatry. 2016 Jan;173(1):34–43.
   PubMed Web of Science ®Google Scholar
• Zheng Z, Zhang L, Li S, et al. Association among obesity, overweight and autism spectrum disorder: a systematic review and meta-analysis. Sci Rep. 2017 Sep 15;7(1):11697.
   PubMedGoogle Scholar
• Roh E, Kim M-S. Brain regulation of energy metabolism. Endocrinol Metab. 2016 Dec;31(4):519–524.
   Google Scholar
• Locke AE, Kahali B, Berndt SI, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015 Feb 12;518(7538):197–206.
   PubMed Web of Science ®Google Scholar
• Samaan Z, Anand SS, Anand S, et al. The protective effect of the obesity-associated rs9939609 A variant in fat mass- and obesity-associated gene on depression. Mol Psychiatry. 2013 Dec;18(12):1281–1286.
   PubMed Web of Science ®Google Scholar
• Reilly JJ, Armstrong J, Dorosty AR, et al. Early life risk factors for obesity in childhood: cohort study. BMJ. 2005 Jun 11;330(7504):1357.
   PubMedGoogle Scholar
• Sucksdorff M, Lehtonen L, Chudal R, et al. Preterm birth and poor fetal growth as risk factors of attention-deficit/hyperactivity disorder. Pediatrics. 2015 Sep;136(3):e599–608.
   PubMed Web of Science ®Google Scholar
• Miller SL, Huppi PS, Mallard C. The consequences of fetal growth restriction on brain structure and neurodevelopmental outcome. J Physiol. 2017;594(4):807–823.
   Web of Science ®Google Scholar
• Ruchat S-M, Houde -A-A, Voisin G, et al. Gestational diabetes mellitus epigenetically affects genes predominantly involved in metabolic diseases. Epigenetics. 2013 Sep;8(9):935–943.
   PubMed Web of Science ®Google Scholar
• Mitsuya K, Parker AN, Liu L, et al. Alterations in the placental methylome with maternal obesity and evidence for metabolic regulation. PLoS ONE. [Internet]. 2017 Oct 18 [cited 2019 Apr 29];12(10):e0186115. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646778/
   PubMed Web of Science ®Google Scholar
• Cardenas A, Gagné-Ouellet V, Allard C, et al. Placental DNA methylation adaptation to maternal glycemic response in pregnancy. Diabetes. 2018 Aug;67(8):1673–1683.
   PubMed Web of Science ®Google Scholar
• Altmäe S, Segura MT, Esteban FJ, et al. Maternal pre-pregnancy obesity is associated with altered placental transcriptome. PLoS ONE [Internet]. 2017 Jan 26 [cited 2019 Feb 13];12(1):e0169223. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5268451/
   PubMed Web of Science ®Google Scholar
• Moore LD, Le T, Fan G. DNA methylation and its basic function. Neuropsychopharmacology. 2013 Jan;38(1):23–38.
   PubMed Web of Science ®Google Scholar
• Sanz R, Ferraro GB, Fournier AE. IgLON cell adhesion molecules are shed from the cell surface of cortical neurons to promote neuronal growth. J Biol Chem. 2015 Feb 13;290(7):4330–4342.
   PubMed Web of Science ®Google Scholar
• Schäfer M, Bräuer AU, Savaskan NE, et al. Neurotractin/kilon promotes neurite outgrowth and is expressed on reactive astrocytes after entorhinal cortex lesion. Mol Cell Neurosci. 2005 Aug;29(4):580–590.
   PubMed Web of Science ®Google Scholar
• Szczurkowska J, Pischedda F, Pinto B, et al. NEGR1 and FGFR2 cooperatively regulate cortical development and core behaviours related to autism disorders in mice. Brain J Neurol. 2018 Sep 1;141(9):2772–2794.
   Google Scholar
• Pischedda F, Szczurkowska J, Cirnaru MD, et al. A cell surface biotinylation assay to reveal membrane-associated neuronal cues: negr1 regulates dendritic arborization. Mol Cell Proteomics MCP. 2014 Mar;13(3):733–748.
   PubMed Web of Science ®Google Scholar
• Boender AJ, van Gestel MA, Garner KM, et al. The obesity‐associated gene Negr1 regulates aspects of energy balance in rat hypothalamic areas. Physiol Rep. [Internet]. 2014 Jul 22 [cited 2019 Jan 22];2(7):e12083. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187548/
   PubMedGoogle Scholar
• Bernhard F, Landgraf K, Klöting N, et al. Functional relevance of genes implicated by obesity genome-wide association study signals for human adipocyte biology. Diabetologia. 2013 Feb;56(2):311–322.
   PubMed Web of Science ®Google Scholar
• Walley AJ, Jacobson P, Falchi M, et al. Differential coexpression analysis of obesity-associated networks in human subcutaneous adipose tissue. Int J Obes 2005. 2012 Jan;36(1):137–147.
   Google Scholar
• Wheeler E, Huang N, Bochukova E, et al. Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity. Nat Genet. 2013 May;45(5):513–517.
   PubMed Web of Science ®Google Scholar
• Willer CJ, Speliotes EK, Loos RJF, et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet. 2009 Jan;41(1):25–34.
   PubMed Web of Science ®Google Scholar
• Gamero-Villarroel C, González LM, Gordillo I, et al. Impact of NEGR1 genetic variability on psychological traits of patients with eating disorders. Pharmacogenomics J. 2015 Jun;15(3):278–283.
   PubMed Web of Science ®Google Scholar
• Sniekers S, Stringer S, Watanabe K, et al. Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence. Nat Genet. 2017 Jul;49(7):1107–1112.
   PubMed Web of Science ®Google Scholar
• Hyde CL, Nagle MW, Tian C, et al. Identification of 15 genetic loci associated with risk of major depression in individuals of European descent. Nat Genet. 2016;48(9):1031–1036.
   PubMed Web of Science ®Google Scholar
• Karis K, Eskla K-L, Kaare M, et al. Altered expression profile of IgLON family of neural cell adhesion molecules in the dorsolateral prefrontal cortex of schizophrenic patients. Front Mol Neurosci. 2018;11:8.
   PubMed Web of Science ®Google Scholar
• Dennis EL, Jahanshad N, Braskie MN, et al. Obesity gene NEGR1 associated with white matter integrity in healthy young adults. NeuroImage. 2014 Nov 15;102(02):548–557.
   PubMedGoogle Scholar
• Noh K, Lee H, Choi T-Y, et al. Negr1 controls adult hippocampal neurogenesis and affective behaviors. Mol Psychiatry. 2019 Aug 16;24(8):1189–1205.
   PubMed Web of Science ®Google Scholar
• Singh K, Jayaram M, Kaare M, et al. Neural cell adhesion molecule Negr1 deficiency in mouse results in structural brain endophenotypes and behavioral deviations related to psychiatric disorders. Sci Rep [Internet]. 2019 Apr 1 [cited 2019 Apr 17];9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443666/
   Web of Science ®Google Scholar
• Boyer CE, Carlson AG, Pasnak R. Object and size awareness in preschool-age children. Percept Mot Skills. 2012 Feb;114(1):29–42.
   PubMed Web of Science ®Google Scholar
• Tatangelo G, McCabe M, Mellor D, et al. A systematic review of body dissatisfaction and sociocultural messages related to the body among preschool children. Body Image. 2016 Sep;1(18):86–95.
   Google Scholar
• Reinblatt SP, Leoutsakos J-MS, Mahone EM, et al. Association between binge eating and attention-deficit/hyperactivity disorder in two pediatric community mental health clinics. Int J Eat Disord. 2015 Jul;48(5):505–511.
   PubMed Web of Science ®Google Scholar
• Hestetun I, Svendsen MV, Oellingrath IM. Associations between overweight, peer problems, and mental health in 12–13-year-old Norwegian children. Eur Child Adolesc Psychiatry. 2015 Mar;24(3):319–326.
   PubMed Web of Science ®Google Scholar
• Tiffin PA, Arnott B, Moore HJ, et al. Modelling the relationship between obesity and mental health in children and adolescents: findings from the health survey for England 2007. Child Adolesc Psychiatry Ment Health. 2011 Oct 7;5:31.
   PubMedGoogle Scholar
• Griffiths LJ, Dezateux C, Hill A. Is obesity associated with emotional and behavioural problems in children? Findings from the Millennium Cohort Study. Int J Pediatr Obes. 2011 Jun;6(2Part2):e423–32.
   PubMedGoogle Scholar
• Sawyer MG, Miller-Lewis L, Guy S, et al. Is there a relationship between overweight and obesity and mental health problems in 4- to 5-year-old Australian children? Ambul Pediatr Off J Ambul Pediatr Assoc. 2006 Dec;6(6):306–311.
   PubMedGoogle Scholar
• Nahum Sacks K, Friger M, Shoham-Vardi I, et al. Prenatal exposure to gestational diabetes mellitus as an independent risk factor for long-term neuropsychiatric morbidity of the offspring. Am J Obstet Gynecol. 2016;215(3):380.e1–7.
   PubMed Web of Science ®Google Scholar
• Xiang AH, Wang X, Martinez MP, et al. Association of maternal diabetes with autism in offspring. JAMA. 2015 Apr 14;313(14):1425–1434.
   PubMed Web of Science ®Google Scholar
• Xiang AH, Wang X, Martinez MP, et al. Maternal gestational diabetes mellitus, type 1 diabetes, and type 2 diabetes during pregnancy and risk of ADHD in offspring. Diabetes Care. 2018;41(12):2502–2508.
   PubMed Web of Science ®Google Scholar
• Côté S, Gagné-Ouellet V, Guay S-P, et al. PPARGC1α gene DNA methylation variations in human placenta mediate the link between maternal hyperglycemia and leptin levels in newborns. Clin Epigenetics. 2016;8:72.
   PubMed Web of Science ®Google Scholar
• Katsuoka F, Yamamoto M. Small Maf proteins (MafF, MafG, MafK): history, structure and function. Gene. 2016 Jul 25;586(2):197–205.
   PubMed Web of Science ®Google Scholar
• Töröcsik B, Angelastro JM, Greene LA. The basic region and leucine zipper transcription factor MafK is a new nerve growth factor-responsive immediate early gene that regulates neurite outgrowth. J Neurosci. 2002 Oct 15;22(20):8971–8980.
   PubMed Web of Science ®Google Scholar
• Gabory A, Roseboom TJ, Moore T, et al. Placental contribution to the origins of sexual dimorphism in health and diseases: sex chromosomes and epigenetics. Biol Sex Differ. 2013 Mar 21;4(1):5.
   PubMedGoogle Scholar
• Matsuda KI, Mori H, Kawata M. Epigenetic mechanisms are involved in sexual differentiation of the brain. Rev Endocr Metab Disord. 2012 Sep;13(3):163–171.
   PubMed Web of Science ®Google Scholar
• Guillemette L, Allard C, Lacroix M, et al. Genetics of glucose regulation in gestation and growth (Gen3G): a prospective prebirth cohort of mother–child pairs in Sherbrooke, Canada. BMJ Open [Internet]. 2016 Feb 3 [cited 2018 Dec 13];6(2):e010031. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746442/
   PubMed Web of Science ®Google Scholar
• Canadian Diabetes Association. Canadian diabetes association 2008 clinical practice guidelines for the prevention and management of diabetes in Canada. 2008;32(Supp 1)
   Google Scholar
• Ezpeleta L, Granero R, la Osa N, et al. Psychometric properties of the strengths and difficulties questionnaire3–4 in 3-year-old preschoolers. Compr Psychiatry. 2013 Apr;54(3):282–291.
   PubMed Web of Science ®Google Scholar
• Goodman R. Psychometric properties of the strengths and difficulties questionnaire. J Am Acad Child Adolesc Psychiatry. 2001 Nov;40(11):1337–1345.
   PubMed Web of Science ®Google Scholar
• Goodman A, Goodman R. Strengths and difficulties questionnaire as a dimensional measure of child mental health. J Am Acad Child Adolesc Psychiatry. 2009 Apr;48(4):400–403.
   PubMed Web of Science ®Google Scholar
• Goodman A, Goodman R. Population mean scores predict child mental disorder rates: validating SDQ prevalence estimators in Britain. J Child Psychol Psychiatry. 2011;52(1):100–108.
   PubMed Web of Science ®Google Scholar
• Goodman R, Renfrew D, Ka A, et al. Predicting type of psychiatric disorder from strengths and Difficulties questionnaire (SDQ) scores in child mental health clinics in London and Dhaka. Eur Child Adolesc Psychiatry. 2000;9(2):129-134.
   Google Scholar
• Pidsley R, Zotenko E, Peters TJ, et al. Critical evaluation of the illumina methylationEPIC BeadChip microarray for whole-genome DNA methylation profiling. Genome Biol. 2016 07;17(1):208.
   PubMed Web of Science ®Google Scholar
• Rahmani E, Zaitlen N, Baran Y, et al. Sparse PCA corrects for cell-type heterogeneity in epigenome-wide association studies. Nat Methods. 2016 May;13(5):443–445.
   PubMed Web of Science ®Google Scholar
• Du P, Zhang X, Huang -C-C, et al. Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis. BMC Bioinformatics. 2010;11(1):587.
   PubMedGoogle Scholar
• Sousa ARS, de Staff AC, Johnsen GM, et al. Evaluation of four commonly used normalizer genes for the study of decidual gene expression. Placenta. 2016 Jul;43:9–12.
   PubMed Web of Science ®Google Scholar